TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T80975	Vascular endothelial growth factor receptor 2	D07POC	Erlotinib	Approved	176870	C22H23N3O4	393.4	COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC	IC50 = 124700 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	D0E6XR	Dasatinib	Approved	3062316	C22H26ClN7O2S	488	CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	D00PWQ	KENPAULLONE	Patented	3820	C16H11BrN2O	327.17	C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)Br	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B05YET	1-(4-Methoxyphenyl)-3-(3-phenylpyrido[3,4-b]pyrazin-8-yl)urea	Investigative	127030123	C21H17N5O2	371.4	COC1=CC=C(C=C1)NC(=O)NC2=C3C(=CN=C2)N=C(C=N3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B06POE	N-(3-Methoxyphenyl)-3-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-8-amine	Investigative	127030426	C25H25N5O	411.5	COC1=CC=CC(=C1)NC2=C3C(=CN=C2)N=C(C=N3)C4=CC=C(C=C4)N5CCCCC5	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B07JVE	3-Substituted indolin-2-one 11c	Investigative	5329140	C17H17N3O5S	375.4	CC1=C(NC=C1CCC(=O)O)/C=C\\2/C3=C(C=CC(=C3)S(=O)(=O)N)NC2=O	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B09HML	1-[4-(3-Methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-naphthalen-2-ylurea	Investigative	137640242	C24H19N5O	393.4	CC1=C2C(=CC=NC2=NN1)C3=CC=C(C=C3)NC(=O)NC4=CC5=CC=CC=C5C=C4	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B0DB6N	N-[5-Chloro-4-(4-chloro-2-fluoroanilino)-9H-pyrimido[4,5-b]indol-2-yl]-2,2-dimethylpropanamide	Investigative	71583533	C21H18Cl2FN5O	446.3	CC(C)(C)C(=O)NC1=NC2=C(C3=C(N2)C=CC=C3Cl)C(=N1)NC4=C(C=C(C=C4)Cl)F	IC50 = 89100 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B0JK3P	3-(Benzo[b]thiophen-2-yl)-6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazole	Investigative	44414995	C24H24N4S	400.5	CN1CCN(CC1)CC2=CC3=C(C=C2)C4=NNC(=C4C3)C5=CC6=CC=CC=C6S5	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B0RX4G	1-Tert-butyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905330	C17H21N5O2	327.4	CC(C)(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=C(C=C3)OC)OC)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B0WLH8	N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide	Investigative	58056356	C17H12N4O2S	336.4	COC1=C(C=C2C=CC=NC2=C1)NC(=O)C3=CSC4=CN=CN=C43	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B10UOE	N-(4-Cyanophenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamide	Investigative	10905857	C22H22N6O3	418.4	COC1=C(C=C2C(=C1)C(=NC=N2)N3CCN(CC3)C(=O)NC4=CC=C(C=C4)C#N)OC	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B13UPZ	2-(6-Amino-9H-purine-9-yl)-1-(1H-indole-3-yl)ethanone	Investigative	42603880	C15H12N6O	292.3	C1=CC=C2C(=C1)C(=CN2)C(=O)CN3C=NC4=C(N=CN=C43)N	IC50 = 81000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B14NHR	N-(1-Phenylethyl)-4-(2-(6-phenylimidazo[2,1-b]thiazol-5-yl)vinyl)pyrimidin-2-amine	Investigative	44586767	C25H21N5S	423.5	CC(C1=CC=CC=C1)NC2=NC=CC(=N2)/C=C/C3=C(N=C4N3C=CS4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B1A4EI	(8S,16S)-3,16-Dihydroxy-9,10-seco-1,3,5(10)-cholestatrien-9-one	Investigative	9547398	C27H42O3	414.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3C[C@@H]([C@@H]([C@]3(CCC2=O)C)[C@H](C)CCCC(C)C)O	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B1E0HS	1-[4-(3-Methyl-6-oxo-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-(3-methylphenyl)urea	Investigative	136269119	C21H21N5O2	375.4	CC1=CC(=CC=C1)NC(=O)NC2=CC=C(C=C2)C3CC(=O)NC4=NNC(=C34)C	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B1H8YS	2-(Methylthio)-7-chloro-1-thia-3,4,5,6-tetraaza-1H-indene	Investigative	73354897	C5H3ClN4S2	218.7	CSC1=NC2=C(S1)C(=NN=N2)Cl	IC50 = 50118.72 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B1JZB8	N-[4-(3-Ethynylanilino)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide	Investigative	71525285	C26H26N6O	438.5	CC(C)(C)C(=O)NC1=NC2=C(C=C(N2)CCC3=CC=CC=N3)C(=N1)NC4=CC=CC(=C4)C#C	IC50 = 125600 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B1L4PH	3-(3-Ethoxy-4-methoxyphenyl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine	Investigative	52945630	C17H21N5O2	327.4	CCOC1=C(C=CC(=C1)C2=NN(C3=NC=NC(=C23)N)C(C)C)OC	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B1NZF0	Rac-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)propanamide	Investigative	46232552	C20H17Cl2FN2O2	407.3	CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=CC3=CC(=CN=C3C=C2)CCC(=O)N	IC50 = 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B1S9KH	Rac-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)acrylic acid	Investigative	46232554	C20H14Cl2FNO3	406.2	CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=CC3=CC(=CN=C3C=C2)/C=C/C(=O)O	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B1T9NA	(1R,2R)-N-[4-[[4-Amino-1-[4-(4-methylpiperazin-1-yl)cyclohexyl]pyrazolo[3,4-d]pyrimidin-3-yl]methyl]-2-methoxyphenyl]-2-phenylcyclopropane-1-carboxamide	Investigative	44291533	C34H42N8O2	594.7	CN1CCN(CC1)C2CCC(CC2)N3C4=NC=NC(=C4C(=N3)CC5=CC(=C(C=C5)NC(=O)[C@@H]6C[C@H]6C7=CC=CC=C7)OC)N	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B1TV6D	3-Phenyl-N-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-7-amine	Investigative	127031368	C24H23N5	381.5	C1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C4C(=C3)N=CC(=N4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B26CIX	US9422297, Aag145-341	Investigative	129625875	C17H13BrN4	353.2	C1C2=CC=CC=C2C3=C1C(=NC(=N3)N)NC4=CC=C(C=C4)Br	IC50 = 163100 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B2CG5E	4-[[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]-6-methoxyquinazolin-7-yl]oxymethyl]pyridine-2-carbonitrile	Investigative	5330198	C23H16ClN5O4	461.9	COC1=C(C=C2C(=C1)C(=NC=N2)NC3=C(C=CC4=C3OCO4)Cl)OCC5=CC(=NC=C5)C#N	IC50 = 77000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B2CME9	N-(3-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-7-amine	Investigative	127033165	C20H16N4O	328.4	COC1=CC=CC(=C1)NC2=NC=C3C(=C2)N=C(C=N3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B2EZC1	4-(6,7-Dimethoxy-4-quinazolinyl)-N-(4-nitrophenyl)-1-piperazinecarboxamide	Investigative	9911005	C21H22N6O5	438.4	COC1=C(C=C2C(=C1)C(=NC=N2)N3CCN(CC3)C(=O)NC4=CC=C(C=C4)[N+](=O)[O-])OC	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B2HY5R	N-[4-[4-Amino-1-[4-(4-methylpiperazin-1-yl)cyclohexyl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-3-phenylpropanamide	Investigative	6539962	C32H40N8O2	568.7	CN1CCN(CC1)C2CCC(CC2)N3C4=NC=NC(=C4C(=N3)C5=CC(=C(C=C5)NC(=O)CCC6=CC=CC=C6)OC)N	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B2NRQ3	1-[7-(3,4-Dimethoxyphenyl)-1,5-naphthyridin-2-yl]-3-ethylurea	Investigative	53239374	C19H20N4O3	352.4	CCNC(=O)NC1=NC2=C(C=C1)N=CC(=C2)C3=CC(=C(C=C3)OC)OC	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B2PEI5	5-(2-Phenoxyphenyl)-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-4-amine	Investigative	19597518	C23H22N4O	370.4	C1CCC(C1)N2C=C(C3=C(N=CN=C32)N)C4=CC=CC=C4OC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B2U1YO	3,8,13,15,17,18-Hexazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one	Investigative	135929507	C12H8N6O	252.23	C1C2=C(C3=C(C=CC=N3)NC1=O)N4C(=NC=N4)N=C2	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B2UR5E	2-Chloro-6,7-dimethoxy-N-(4-(methylsulfonyl)phenyl)quinazolin-4-amine	Investigative	76310006	C17H16ClN3O4S	393.8	COC1=C(C=C2C(=C1)C(=NC(=N2)Cl)NC3=CC=C(C=C3)S(=O)(=O)C)OC	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B2ZFY9	N4-(3-Bromophenyl)-6-[2-(4-methoxyphenyl)ethyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	44586450	C21H20BrN5O	438.3	COC1=CC=C(C=C1)CCC2=CC3=C(N2)N=C(N=C3NC4=CC(=CC=C4)Br)N	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B2ZJ3E	4-(2-(1-Methyl-4-phenyl-1H-imidazol-5-yl)cyclopropyl)pyrimidin-2-amine	Investigative	44586929	C17H17N5	291.35	CN1C=NC(=C1C2CC2C3=NC(=NC=C3)N)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B2ZJK3	5-Pyridin-4-yl-2-(2,4,6-trichlorophenyl)pyrazol-3-amine	Investigative	56950878	C14H9Cl3N4	339.6	C1=CN=CC=C1C2=NN(C(=C2)N)C3=C(C=C(C=C3Cl)Cl)Cl	IC50 = 87000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B31FKG	3-(2,3-Dihydrobenzofuran-5-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905194	C16H17N5O	295.34	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)OCC4)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B34OQI	1-[7-(1-Methylpyrazol-4-yl)-1,5-naphthyridin-2-yl]-3-(2-phenylethyl)urea	Investigative	53239587	C21H20N6O	372.4	CN1C=C(C=N1)C2=CC3=C(C=CC(=N3)NC(=O)NCCC4=CC=CC=C4)N=C2	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B37LJS	Isoindolinone analog 16	Investigative	5329879	C20H16N2O3S	364.4	C1C2=C(C=CC=C2C(=O)N1)C3=CC=C(C=C3)NS(=O)(=O)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B3B6HI	3-(4-Fluoro-3-methoxyphenyl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905175	C15H16FN5O	301.32	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=C(C=C3)F)OC)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B3IQ0E	3-(4-Nitrophenyl)isothiazolo[5,4-d]pyrimidin-4-amine	Investigative	44414742	C11H7N5O2S	273.27	C1=CC(=CC=C1C2=NSC3=NC=NC(=C23)N)[N+](=O)[O-]	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B3LYC9	4-(1-Methylbenzimidazol-2-yl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine	Investigative	60166135	C22H22N6O	386.4	CN1C2=CC=CC=C2N=C1C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5	IC50 = 69000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B3MX2L	3-Oxoisoindoline-4-carboxamide	Investigative	44579957	C9H8N2O2	176.17	C1C2=C(C(=CC=C2)C(=O)N)C(=O)N1	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B3PA9B	5-(3-Chlorophenyl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-one	Investigative	118723210	C19H17ClN2O4	372.8	COC1=CC(=CC(=C1OC)OC)C2=NC(=CNC2=O)C3=CC(=CC=C3)Cl	IC50 = 56000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B3T9QN	Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44219749	C24H29N7O5	495.5	COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B3VMK0	(S)-3-(4-Amino-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2-methylpropan-1-ol	Investigative	24905335	C17H21N5O3	343.4	C[C@@H](CN1C2=NC=NC(=C2C(=N1)C3=CC(=C(C=C3)OC)OC)N)CO	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B3X2WM	1-(3-Methylphenyl)-3-[4-[3-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridin-4-yl]phenyl]urea	Investigative	137657952	C21H16F3N5O	411.4	CC1=CC(=CC=C1)NC(=O)NC2=CC=C(C=C2)C3=CC=NC4=NNC(=C34)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B3Z1IA	N4-(3-Chloro-4-fluorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	44586490	C20H17ClFN5	381.8	C1=CC=C(C=C1)CCC2=CC3=C(N2)N=C(N=C3NC4=CC(=C(C=C4)F)Cl)N	IC50 = 132100 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B40VFE	N-Benzyl-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamide	Investigative	11729539	C22H25N5O2S	423.5	COC1=C(C=C2C(=C1)C(=NC=N2)N3CCN(CC3)C(=S)NCC4=CC=CC=C4)OC	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B41NUR	1-Isopropyl-3-(3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905169	C15H17N5O	283.33	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=CC=C3)OC)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B43WPI	3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2R)-2,3-dihydroxypropyl]-4-methoxybenzamide	Investigative	57325478	C19H20ClNO4	361.8	COC1=C(C=C(C=C1)C(=O)NC[C@H](CO)O)/C=C/C2=CC=C(C=C2)Cl	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B4G2QZ	Methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44605035	C22H27N7O3	437.5	COC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)N)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B4HX3I	1-Isopropyl-3-(pyrimidin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905171	C12H13N7	255.28	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CN=CN=C3)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B4JU8K	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(2-methoxyethyl)pyrimidine-5-carboxamide	Investigative	25271513	C21H22ClN5O3	427.9	COCCNC(=O)C1=C(N=CN=C1NC2=CC(=C(C=C2)OCC3=CC=CC=C3)Cl)N	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B4K5EC	3-(2-(Hydrazine)quinolin-6-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905228	C17H18N8	334.4	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)N=C(C=C4)NN)N	IC50 = 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B4UG6M	US9296747, Example 4	Investigative	118970902	C19H17N5O	331.4	C1CN(CC2=CN=C(N=C21)NC3=CC=CC=C3)C(=O)C4=CN=CC=C4	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B4WX0K	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-phenylpyrimidine-5-carboxamide	Investigative	25271517	C24H20ClN5O2	445.9	C1=CC=C(C=C1)COC2=C(C=C(C=C2)NC3=NC=NC(=C3C(=O)NC4=CC=CC=C4)N)Cl	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B4XI5E	1-Isopropyl-3-(2-methylquinolin-7-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905219	C18H18N6	318.4	CC1=NC2=C(C=C1)C=CC(=C2)C3=NN(C4=NC=NC(=C34)N)C(C)C	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B4YQZ3	1-(3-Methoxyphenyl)-3-(3-phenylpyrido[3,4-b]pyrazin-8-yl)urea	Investigative	127034308	C21H17N5O2	371.4	COC1=CC=CC(=C1)NC(=O)NC2=C3C(=CN=C2)N=C(C=N3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B54IZK	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(2-(piperidin-1-yl)ethyl)pyrimidine-5-carboxamide	Investigative	25271514	C25H29ClN6O2	481	C1CCN(CC1)CCNC(=O)C2=C(N=CN=C2NC3=CC(=C(C=C3)OCC4=CC=CC=C4)Cl)N	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B57BWQ	4-(2-Methoxyethyl)phenol	Investigative	92516	C9H12O2	152.19	COCCC1=CC=C(C=C1)O	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B58TMC	[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate	Investigative	24753787	C21H22ClN3O6S	479.9	CC1=C(C(=O)OC2=CC(=C(C=C12)Cl)OC(=O)N(C)C)CC3=CC(=CC=C3)NS(=O)(=O)NC	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B59SVD	6-[2-[2-(Dimethylamino)ethylamino]ethylamino]-2-ethylbenzo[de]isoquinoline-1,3-dione	Investigative	71741327	C20H26N4O2	354.4	CCN1C(=O)C2=C3C(=C(C=C2)NCCNCCN(C)C)C=CC=C3C1=O	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B5CGM2	Chembl4208998	Investigative	145965631	C23H22N4O3	402.4	CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)C3=NNC(C3)C4=CC=C(C=C4)OC	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B5J8VH	6-[2-[2-(Dimethylamino)ethylamino]ethylamino]-2-hexadecylbenzo[de]isoquinoline-1,3-dione	Investigative	71741332	C34H54N4O2	550.8	CCCCCCCCCCCCCCCCN1C(=O)C2=C3C(=C(C=C2)NCCNCCN(C)C)C=CC=C3C1=O	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B5J9WE	N-(4-Anilino-5-chloro-9H-pyrimido[4,5-b]indol-2-yl)-2,2-dimethylpropanamide	Investigative	71583530	C21H20ClN5O	393.9	CC(C)(C)C(=O)NC1=NC2=C(C3=C(N2)C=CC=C3Cl)C(=N1)NC4=CC=CC=C4	IC50 = 192000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B5KD4L	(2S)-1-(1H-Indol-3-yl)-3-(5-isoquinolin-6-ylpyridin-3-yl)oxy-propan-2-amine	Investigative	6914611	C25H22N4O	394.5	C1=CC=C2C(=C1)C(=CN2)C[C@@H](COC3=CN=CC(=C3)C4=CC5=C(C=C4)C=NC=C5)N	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B5L1YD	5-Chloro-4-N-(3-fluorophenyl)-9H-pyrimido[4,5-b]indole-2,4-diamine	Investigative	71583529	C16H11ClFN5	327.74	C1=CC(=CC(=C1)F)NC2=NC(=NC3=C2C4=C(N3)C=CC=C4Cl)N	IC50 = 86100 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B5NH8A	Rac-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)-N-methylacrylamide	Investigative	46232512	C21H17Cl2FN2O2	419.3	CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=CC3=CC(=CN=C3C=C2)/C=C/C(=O)NC	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B5P9HU	2-Amino-N-(1-methyl-4-phenyl-1H-imidazol-5-yl)pyrimidine-4-carboxamide	Investigative	44586900	C15H14N6O	294.31	CN1C=NC(=C1NC(=O)C2=NC(=NC=C2)N)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B5UOP1	4-N-(3-Bromophenyl)-7-[(4-chlorophenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	57394880	C19H15BrClN5	428.7	C1=CC(=CC(=C1)Br)NC2=C3C=CN(C3=NC(=N2)N)CC4=CC=C(C=C4)Cl	IC50 = 65300 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B5W0ML	3-[(4-Chloro-3-methylphenoxy)methyl]-4-methoxybenzamide	Investigative	57403494	C16H16ClNO3	305.75	CC1=C(C=CC(=C1)OCC2=C(C=CC(=C2)C(=O)N)OC)Cl	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B5W6SZ	1-(4-(6-Amino-5-((methoxyimino)methyl)pyrimidin-4-yloxy)-3-bromophenyl)-3-methylurea	Investigative	53319941	C14H15BrN6O3	395.21	CNC(=O)NC1=CC(=C(C=C1)OC2=NC=NC(=C2/C=N/OC)N)Br	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B5X8EO	3-(2-Chloroquinolin-3-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905220	C17H15ClN6	338.8	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=CC=CC=C4N=C3Cl)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B5XGQ0	2-Amino-4-(N-methyl-m-bromoanilino)-6-benzyl-pyrrolo[2,3-d]pyrimidine	Investigative	52948634	C20H18BrN5	408.3	CN(C1=CC(=CC=C1)Br)C2=NC(=NC3=C2C=C(N3)CC4=CC=CC=C4)N	IC50 = 89200 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B5XSL9	N4-(3-Fluoro-4-trifluoromethylphenyl)-6-(2,4-dichlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	46886974	C20H13Cl2F4N5	470.2	C1=CC(=C(C=C1NC2=NC(=NC3=C2C=C(N3)CC4=C(C=C(C=C4)Cl)Cl)N)F)C(F)(F)F	IC50 = 113100 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B63LVG	5-Naphthalen-2-ylsulfanyl-9H-pyrimido[4,5-b]indole-2,4-diamine	Investigative	137635618	C20H15N5S	357.4	C1=CC=C2C=C(C=CC2=C1)SC3=CC=CC4=C3C5=C(N=C(N=C5N4)N)N	IC50 = 160300 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B65UQD	2-(1-Methyl-4-phenyl-1H-imidazol-5-yl)[1,3]thiazolo[5,4-d]pyrimidin-7-amine	Investigative	10357919	C15H12N6S	308.4	CN1C=NC(=C1C2=NC3=C(N=CN=C3S2)N)C4=CC=CC=C4	IC50 = 84000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B69YJX	(2-(5-(Isoquinolin-4-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-benzo[d]imidazol-4-yl)methanol	Investigative	135497853	C23H16N6O	392.4	C1=CC=C2C(=C1)C=NC=C2C3=CC4=C(NN=C4N=C3)C5=NC6=C(C=CC=C6N5)CO	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B6A0VO	5-(4-Amino-1-((5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol	Investigative	24905307	C21H17FN8O	416.4	CC1=NN(N=C1CN2C3=NC=NC(=C3C(=N2)C4=CC(=C(C=C4)F)O)N)C5=CC=CC=C5	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B6FPS1	4-N-(3-Bromophenyl)-7-[(2-methylphenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	57396646	C20H18BrN5	408.3	CC1=CC=CC=C1CN2C=CC3=C(N=C(N=C32)N)NC4=CC(=CC=C4)Br	IC50 = 113400 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B6H5PN	Boletopsin C	Investigative	46831715	C20H14O9	398.3	CC(=O)OC1=C2C(=C(C(=C1C3=CC(=C(C=C3)O)O)O)O)C4=CC(=C(C=C4O2)O)O	IC50 = 70700 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B6TCU4	N-(4-Morpholin-4-ylphenyl)-2-phenylpyrido[3,4-b]pyrazin-7-amine	Investigative	127031677	C23H21N5O	383.4	C1COCCN1C2=CC=C(C=C2)NC3=NC=C4C(=C3)N=C(C=N4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B6TJ7W	4-[(2-Chloro-6,7-dimethoxyquinazolin-4-yl)amino]benzenesulfonic acid	Investigative	22693031	C16H14ClN3O5S	395.8	COC1=C(C=C2C(=C1)C(=NC(=N2)Cl)NC3=CC=C(C=C3)S(=O)(=O)O)OC	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B6UF4W	Ethyl 5-amino-3-pyridin-4-yl-1-(2,4,6-trichlorophenyl)pyrazole-4-carboxylate	Investigative	56950741	C17H13Cl3N4O2	411.7	CCOC(=O)C1=C(N(N=C1C2=CC=NC=C2)C3=C(C=C(C=C3Cl)Cl)Cl)N	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B6UT2N	2-(Dimethylamino)ethyl 3-[[5-(1H-indol-5-yl)-2-(trifluoromethoxy)phenyl]carbamoylamino]-4-methoxybenzoate	Investigative	122195143	C28H27F3N4O5	556.5	CN(C)CCOC(=O)C1=CC(=C(C=C1)OC)NC(=O)NC2=C(C=CC(=C2)C3=CC4=C(C=C3)NC=C4)OC(F)(F)F	IC50 = 53000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B76FRE	1-Tert-butyl-3-[7-(3,4-dimethoxyphenyl)-1,5-naphthyridin-2-yl]urea	Investigative	53239375	C21H24N4O3	380.4	CC(C)(C)NC(=O)NC1=NC2=C(C=C1)N=CC(=C2)C3=CC(=C(C=C3)OC)OC	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B7A0CB	N4-(3-Bromophenyl)-2-(naphthalen-2-ylmethyl)-1H-indole-4,6-diamine	Investigative	3008957	C23H18BrN5	444.3	C1=CC=C2C=C(C=CC2=C1)CC3=CC4=C(N3)N=C(N=C4NC5=CC(=CC=C5)Br)N	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B7BLX8	1-(3-Cyanophenyl)-3-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]urea	Investigative	137650604	C21H16N6O	368.4	CC1=C2C(=CC=NC2=NN1)C3=CC=C(C=C3)NC(=O)NC4=CC=CC(=C4)C#N	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B7KX8L	N-(4-Benzyloxy-3-chloro-phenyl)-5-[5-(2-morpholin-4-yl-ethyl)-[1,3,4]oxadiazol-2-yl]-pyrimidine-4,6-diamine	Investigative	25063262	C25H26ClN7O3	508	C1COCCN1CCC2=NN=C(O2)C3=C(N=CN=C3NC4=CC(=C(C=C4)OCC5=CC=CC=C5)Cl)N	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B7N1WR	3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2S)-2,3-dihydroxypropyl]-4-methoxybenzamide	Investigative	57325479	C19H20ClNO4	361.8	COC1=C(C=C(C=C1)C(=O)NC[C@@H](CO)O)/C=C/C2=CC=C(C=C2)Cl	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B7P4NU	N-(3-Ethynylphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine	Investigative	127031076	C21H14N4	322.4	C#CC1=CC(=CC=C1)NC2=NC=CC3=NC(=CN=C32)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B7RLG0	Methyl 7-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenyl]thieno[3,2-b]pyridine-2-carboxylate	Investigative	58172955	C23H18FN3O3S	435.5	CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=NC=C3)C=C(S4)C(=O)OC	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B7S1XJ	4-(4-Amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-2-chlorobenzamide	Investigative	52942235	C15H15ClN6O	330.77	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=C(C=C3)C(=O)N)Cl)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B7SJ2I	1-(2-Fluoro-5-methylphenyl)-3-[4-(3-methyl-6-oxo-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-4-yl)phenyl]urea	Investigative	136269138	C21H20FN5O2	393.4	CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3CC(=O)NC4=NNC(=C34)C	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B7WH9P	N-(5-Ethylsulfonyl-2-methoxyphenyl)-1-(3-pyridin-3-ylphenyl)triazol-4-amine	Investigative	122195480	C22H21N5O3S	435.5	CCS(=O)(=O)C1=CC(=C(C=C1)OC)NC2=CN(N=N2)C3=CC=CC(=C3)C4=CN=CC=C4	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B7XVR3	3-[(E)-2-(4-Chlorophenyl)ethenyl]-4-methoxybenzamide	Investigative	23141469	C16H14ClNO2	287.74	COC1=C(C=C(C=C1)C(=O)N)/C=C/C2=CC=C(C=C2)Cl	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B7XZN5	(E/Z)-4-(2-(3-Phenylthiophen-2-yl)vinyl)pyrimidin-2-amine	Investigative	44586833	C16H13N3S	279.4	C1=CC=C(C=C1)C2=C(SC=C2)/C=C/C3=NC(=NC=C3)N	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B8AL2J	3-[4-(Benzylamino)-3-methoxyphenyl]-1-[4-(4-methylpiperazin-1-yl)cyclohexyl]pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	6539961	C30H38N8O	526.7	CN1CCN(CC1)C2CCC(CC2)N3C4=NC=NC(=C4C(=N3)C5=CC(=C(C=C5)NCC6=CC=CC=C6)OC)N	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B8AW2L	1-Isopropyl-3-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905177	C17H21N5O3	343.4	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=C(C(=C3)OC)OC)OC)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B8BE5L	3-(4-(5,7-Dimethylbenzo[d]oxazol-2-ylamino)phenyl)isoxazolo[5,4-d]pyrimidin-4-amine	Investigative	44414776	C20H16N6O2	372.4	CC1=CC(=C2C(=C1)N=C(O2)NC3=CC=C(C=C3)C4=NOC5=NC=NC(=C45)N)C	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B8MF5X	N-(3-Bromophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Investigative	46887255	C20H17BrN4	393.3	C1=CC=C(C=C1)CCC2=CC3=C(N2)N=CN=C3NC4=CC(=CC=C4)Br	IC50 = 112300 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B8PRL0	Benzamide,n-[4-(2,3-dihydro-1-oxo-1h-isoindol-4-yl)phenyl]-	Investigative	5329878	C21H16N2O2	328.4	C1C2=C(C=CC=C2C(=O)N1)C3=CC=C(C=C3)NC(=O)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B8R9NG	Isoindolinone analog 10j	Investigative	5329908	C24H23N3O2	385.5	CC1=CC(=CC=C1)NC(=O)NC2=C(C=C(C=C2C)C3=C4CNC(=O)C4=CC=C3)C	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B8SJ4Q	(E/Z)-N-Phenyl-4-(2-(6-phenylimidazo[2,1-b]thiazol-5-yl)vinyl)pyrimidin-2-amine	Investigative	44586768	C23H17N5S	395.5	C1=CC=C(C=C1)C2=C(N3C=CSC3=N2)/C=C/C4=NC(=NC=C4)NC5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B8T6XU	5-Chloro-4-N-phenyl-9H-pyrimido[4,5-b]indole-2,4-diamine	Investigative	71583411	C16H12ClN5	309.75	C1=CC=C(C=C1)NC2=NC(=NC3=C2C4=C(N3)C=CC=C4Cl)N	IC50 = 123800 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B90TWU	1-(4-Methoxyphenyl)-3-(2-thieno[3,2-b]pyridin-7-ylsulfanylphenyl)urea	Investigative	122188020	C21H17N3O2S2	407.5	COC1=CC=C(C=C1)NC(=O)NC2=CC=CC=C2SC3=C4C(=NC=C3)C=CS4	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B97RPS	Serotonin hydrochloride	Investigative	160436	C10H13ClN2O	212.67	C1=CC2=C(C=C1O)C(=CN2)CCN.Cl	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B98XBU	4-N-(3-Methyl-5-phenylimidazol-4-yl)pyrimidine-2,4-diamine	Investigative	44586898	C14H14N6	266.3	CN1C=NC(=C1NC2=NC(=NC=C2)N)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B9M3DN	1-Isopropyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905343	C16H19N5O2	313.35	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=C(C=C3)OC)OC)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B9N8WV	N-(2-Aminopyrimidin-4-yl)-1-methyl-4-phenyl-1H-imidazole-5-carboxamide	Investigative	44586899	C15H14N6O	294.31	CN1C=NC(=C1C(=O)NC2=NC(=NC=C2)N)C3=CC=CC=C3	IC50 = 98000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B9S0YQ	1-Ethyl-3-(2-phenylpyrido[3,4-b]pyrazin-5-yl)urea	Investigative	127031075	C16H15N5O	293.32	CCNC(=O)NC1=NC=CC2=NC(=CN=C21)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B9SP2F	(3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)methanol	Investigative	24905344	C15H17N5O	283.33	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC=CC(=C3)CO)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B9VCN0	2-(2-Bromoanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379605	C18H13BrN4O	381.2	C1C2=CN=C(N=C2C3=CC=CC=C3NC1=O)NC4=CC=CC=C4Br	IC50 = 57000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	B9ZPS7	7-[4-({[(2-Fluoro-5-methylphenyl)amino]carbonyl}amino)phenyl]thieno[3,2-b]pyridine-2-carboxylic acid	Investigative	58172942	C22H16FN3O3S	421.4	CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=NC=C3)C=C(S4)C(=O)O	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BA38GP	N-[4-[4-Amino-1-[4-(4-methylpiperazin-1-yl)cyclohexyl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-1-benzofuran-2-carboxamide	Investigative	6539966	C32H36N8O3	580.7	CN1CCN(CC1)C2CCC(CC2)N3C4=NC=NC(=C4C(=N3)C5=CC(=C(C=C5)NC(=O)C6=CC7=CC=CC=C7O6)OC)N	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BA62QX	4-(4-Methyl-1H-indol-5-ylamino)-2-(3-oxo-3-(pyrrolidin-1-yl)prop-1-enyl)thieno[2,3-b]pyridine-5-carbonitrile	Investigative	24766030	C24H21N5OS	427.5	CC1=C(C=CC2=C1C=CN2)NC3=C4C=C(SC4=NC=C3C#N)/C=C/C(=O)N5CCCC5	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BAEK62	Thelephoric acid	Investigative	135464206	C18H8O8	352.2	C1=C2C(=CC(=C1O)O)OC3=C2C(=O)C4=C(C3=O)C5=CC(=C(C=C5O4)O)O	IC50 = 70000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BAG8F6	7-((1H-1,2,4-Triazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazole	Investigative	44414996	C17H13N5S	319.4	C1C2=C(C=C(C=C2)CN3C=NC=N3)C4=C1C(=NN4)C5=CSC=C5	IC50 = 108000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BAJD06	Tert-butyl 2-(2-methyl-3-oxoisoindolin-4-yl)-1H-pyrrole-1-carboxylate	Investigative	16666757	C18H20N2O3	312.4	CC(C)(C)OC(=O)N1C=CC=C1C2=CC=CC3=C2C(=O)N(C3)C	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BATB17	(4S,6R,12E)-6-Bromo-18-hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),12,15,17-tetraene-2,8-dione	Investigative	49842670	C19H23BrO5	411.3	C[C@H]1C[C@H](CC(=O)CCC/C=C/C2=C(C(=CC(=C2)OC)O)C(=O)O1)Br	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BAWH02	US9422297, Aag145-342	Investigative	129625876	C20H20N4	316.4	CC(C)C1=CC=CC=C1NC2=NC(=NC3=C2CC4=CC=CC=C43)N	IC50 = 198500 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BB20UV	6-[2-[2-(Dimethylamino)ethylamino]ethylamino]-2-methylbenzo[de]isoquinoline-1,3-dione	Investigative	71741204	C19H24N4O2	340.4	CN1C(=O)C2=C3C(=C(C=C2)NCCNCCN(C)C)C=CC=C3C1=O	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BB27KW	4-(6-Amino-5-((methoxyimino)methyl)pyrimidin-4-yloxy)phenyl ethylcarbamate	Investigative	44511486	C15H17N5O4	331.33	CCNC(=O)OC1=CC=C(C=C1)OC2=NC=NC(=C2/C=N/OC)N	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BB2S4A	2-((4-Amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one	Investigative	24905149	C28H23N7O2	489.5	CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)CN4C5=NC=NC(=C5C(=N4)C6=CC(=CC=C6)O)N	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BB4I1G	1-(3-Methoxyphenyl)-3-(2-phenylpyrido[3,4-b]pyrazin-5-yl)urea	Investigative	127030427	C21H17N5O2	371.4	COC1=CC=CC(=C1)NC(=O)NC2=NC=CC3=NC(=CN=C32)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BB6J1Q	1-(4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)ethanone	Investigative	24905155	C16H17N5O	295.34	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC=C(C=C3)C(=O)C)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BB6Y2U	3,8,15,17,19-Pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione	Investigative	45379342	C14H9N5O3	295.25	C1C2=CC3=C(NC(=O)NC3=O)N=C2C4=C(C=CC=N4)NC1=O	IC50 = 66000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BB8J4R	3-(Benzo[c][1,2,5]oxadiazol-6-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905165	C14H13N7O	295.3	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=NON=C4C=C3)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BB8R3D	(4S,6R)-6-Chloro-18-hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),15,17-triene-2,8-dione	Investigative	49842671	C19H25ClO5	368.8	C[C@H]1C[C@H](CC(=O)CCCCCC2=C(C(=CC(=C2)OC)O)C(=O)O1)Cl	IC50 = 93000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BBR5M7	1-(3-Ethylphenyl)-3-[4-[3-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridin-4-yl]phenyl]urea	Investigative	137647879	C22H18F3N5O	425.4	CCC1=CC(=CC=C1)NC(=O)NC2=CC=C(C=C2)C3=CC=NC4=NNC(=C34)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BBWJ97	2-Benzyl-N4-(3-bromophenyl)-1H-indole-4,6-diamine	Investigative	3008958	C19H16BrN5	394.3	C1=CC=C(C=C1)CC2=CC3=C(N2)N=C(N=C3NC4=CC(=CC=C4)Br)N	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BBWU45	6-(4-Amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-2(1H)-one	Investigative	24905227	C19H18N6O	346.4	C1CCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CC5=C(C=C4)NC(=O)C=C5)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BBYX32	N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-5-[2-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]ethynyl]-6-methylpyrimidin-4-amine	Investigative	56835161	C31H27ClF2N4O	545	CC1=C(C(=NC=N1)NC2=CC(=C(C=C2)OCC3=CC(=CC=C3)F)Cl)C#CC4=CC(=C(C=C4)CN5CCCC5)F	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BC0G2P	N-[4-(4-Amino-6-methylthieno[2,3-d]pyrimidin-5-yl)phenyl]benzenesulfonamide	Investigative	6539970	C19H16N4O2S2	396.5	CC1=C(C2=C(N=CN=C2S1)N)C3=CC=C(C=C3)NS(=O)(=O)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BC0M4Q	1-{3-[(4-Chloro-3-methylphenoxy)methyl]-4-methoxyphenyl}ethan-1-one	Investigative	2803617	C17H17ClO3	304.8	CC1=C(C=CC(=C1)OCC2=C(C=CC(=C2)C(=O)C)OC)Cl	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BC23WJ	3-(H-Imidazo[1,2-a]pyridin-7-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905246	C15H15N7	293.33	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=NC=CN4C=C3)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BC3K0L	Methyl 3-(piperidin-1-yl)-1H-thieno[2,3-c]pyrazole-5-carboxylate	Investigative	44405987	C13H17N3O2S	279.36	COC(=O)C1=CC2=C(NN=C2S1)CN3CCCCC3	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BC3SD6	N-[4-(4-Amino-6-methylthieno[2,3-d]pyrimidin-5-yl)phenyl]-1H-indole-2-carboxamide	Investigative	6539976	C22H17N5OS	399.5	CC1=C(C2=C(N=CN=C2S1)N)C3=CC=C(C=C3)NC(=O)C4=CC5=CC=CC=C5N4	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BC8U1N	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(4-methoxyphenyl)pyrimidine-5-carboxamide	Investigative	25271518	C25H22ClN5O3	475.9	COC1=CC=C(C=C1)NC(=O)C2=C(N=CN=C2NC3=CC(=C(C=C3)OCC4=CC=CC=C4)Cl)N	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BCF13G	Tert-butyl 6-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-4-ylcarbamate	Investigative	24905231	C22H25N7O2	419.5	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=CN=C4C=C3)NC(=O)OC(C)(C)C)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BCI13X	5-(1-(2,5-Dichlorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-indazole	Investigative	25166659	C16H11Cl2N5	344.2	C1=CC2=C(C=C1C3=CN(N=N3)CC4=C(C=CC(=C4)Cl)Cl)C=NN2	Ki = 126500 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BCL1D4	N-(4-Bromophenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamide	Investigative	10457505	C21H22BrN5O3	472.3	COC1=C(C=C2C(=C1)C(=NC=N2)N3CCN(CC3)C(=O)NC4=CC=C(C=C4)Br)OC	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BCWB03	N-((4-(6-((4-Methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)methyl)(phenyl)methanesulfonamide	Investigative	44414694	C28H31N5O2S2	533.7	CN1CCN(CC1)CC2=CC3=C(C=C2)C4=C(C3)C(=NN4)C5=CSC(=C5)CNS(=O)(=O)CC6=CC=CC=C6	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BCWX43	4-[(2-Chloroquinazolin-4-yl)amino]-N,N-dimethylbenzenesulfonamide	Investigative	76317238	C16H15ClN4O2S	362.8	CN(C)S(=O)(=O)C1=CC=C(C=C1)NC2=NC(=NC3=CC=CC=C32)Cl	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BCX9K5	4-(3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)isoquinoline	Investigative	136118031	C25H20N6O	420.5	CN1C2=C(C=C(C=N2)C3=CN=CC4=CC=CC=C43)C(=N1)C5=NC6=C(C=CC=C6N5)COC	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BCY2T5	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(2-morpholinoethyl)pyrimidine-5-carboxamide	Investigative	25271515	C24H27ClN6O3	483	C1COCCN1CCNC(=O)C2=C(N=CN=C2NC3=CC(=C(C=C3)OCC4=CC=CC=C4)Cl)N	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BD1BX0	N-[4-(3-Chloro-4-fluoroanilino)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide	Investigative	71525284	C24H24ClFN6O	466.9	CC(C)(C)C(=O)NC1=NC2=C(C=C(N2)CCC3=CC=CC=N3)C(=N1)NC4=CC(=C(C=C4)F)Cl	IC50 = 89300 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BD26EW	3-Fluorobenzyl 4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carboxylate	Investigative	25271180	C25H20ClFN4O3	478.9	C1=CC=C(C=C1)COC2=C(C=C(C=C2)NC3=NC=NC(=C3C(=O)OCC4=CC(=CC=C4)F)N)Cl	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BD4G0L	4,8,15,17,19-Pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione	Investigative	45379340	C14H9N5O3	295.25	C1C2=CC3=C(NC(=O)NC3=O)N=C2C4=C(C=CN=C4)NC1=O	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BD58RS	8,15,17,19-Tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2,4,6,11,13(18)-hexaene-9,14,16-trione	Investigative	45379202	C15H10N4O3	294.26	C1C2=CC3=C(NC(=O)NC3=O)N=C2C4=CC=CC=C4NC1=O	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BD58TL	1-Phenyl-3-(2-thieno[3,2-b]pyridin-7-ylsulfanylphenyl)urea	Investigative	122188019	C20H15N3OS2	377.5	C1=CC=C(C=C1)NC(=O)NC2=CC=CC=C2SC3=C4C(=NC=C3)C=CS4	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BD6QZ4	1-Cyclohexyl-3-(4-ethoxy-3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905298	C20H25N5O2	367.4	CCOC1=C(C=C(C=C1)C2=NN(C3=NC=NC(=C23)N)C4CCCCC4)OC	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BD6YR7	N-Phenyl-3-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-8-amine	Investigative	127030425	C24H23N5	381.5	C1CCN(CC1)C2=CC=C(C=C2)C3=NC4=CN=CC(=C4N=C3)NC5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BDJU98	1-Isopropyl-3-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905170	C13H14N6	254.29	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CN=CC=C3)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BDK9R0	Calicoferol C	Investigative	10024683	C28H44O2	412.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3CC[C@@H]([C@]3(CC[C@H]2O)C)[C@H](C)CCC(=C)C(C)C	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BDP61H	N-[(1R)-1-Phenylethyl]-1-(2-phenylethyl)pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	76322048	C21H21N5	343.4	C[C@H](C1=CC=CC=C1)NC2=C3C=NN(C3=NC=N2)CCC4=CC=CC=C4	IC50 = 52500 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BDT2O1	1-Allyl-3-(4-ethoxy-3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905297	C17H19N5O2	325.4	CCOC1=C(C=C(C=C1)C2=NN(C3=NC=NC(=C23)N)CC=C)OC	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BDV8X5	4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-benzenesulfonamide	Investigative	24905338	C14H16N6O2S	332.38	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC=C(C=C3)S(=O)(=O)N)N	IC50 = 98800 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BDX72N	6-Methyl-N-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)methyl)-1H-benzo[d]imidazol-2-amine	Investigative	44414879	C29H31N7S	509.7	CC1=CC2=C(C=C1)N=C(N2)NCC3=CC=C(S3)C4=C5CC6=C(C5=NN4)C=CC(=C6)CN7CCN(CC7)C	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BE45ZP	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N''-(3-morpholinopropanoyl)pyrimidine-5-carbohydrazide	Investigative	44562431	C25H28ClN7O4	526	C1COCCN1CCC(=O)NNC(=O)C2=C(N=CN=C2NC3=CC(=C(C=C3)OCC4=CC=CC=C4)Cl)N	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BE6WK1	2-Butyl-6-[2-[2-(dimethylamino)ethylamino]ethylamino]benzo[de]isoquinoline-1,3-dione	Investigative	71741328	C22H30N4O2	382.5	CCCCN1C(=O)C2=C3C(=C(C=C2)NCCNCCN(C)C)C=CC=C3C1=O	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BE8IC3	1-N-(6-Chloro-[1,3]dioxolo[4,5-g]quinazolin-8-yl)-4-N,4-N-dimethylbenzene-1,4-diamine	Investigative	76335419	C17H15ClN4O2	342.8	CN(C)C1=CC=C(C=C1)NC2=NC(=NC3=CC4=C(C=C32)OCO4)Cl	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BE8O6C	N-[3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-phenyl]-methanesulfonamide	Investigative	24905159	C15H18N6O2S	346.4	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=CC=C3)NS(=O)(=O)C)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BEY1C5	4-[(2-Chloro-6,7-dimethoxyquinazolin-4-yl)amino]benzoic acid	Investigative	22692968	C17H14ClN3O4	359.8	COC1=C(C=C2C(=C1)C(=NC(=N2)Cl)NC3=CC=C(C=C3)C(=O)O)OC	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BF1VW2	pi-103 (Hydrochloride)	Investigative	16739368	C19H17ClN4O3	384.8	C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)O.Cl	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BF32AR	Calicoferol B	Investigative	10047545	C27H44O3	416.6	CC1=C(C=C(C=C1)O)CC[C@@H]2[C@@H](CC[C@]3([C@H]2C[C@@H]([C@@H]3[C@H](C)CCCC(C)C)O)C)O	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BF5E2J	N-(4-Chlorophenyl)-5H-thiochromeno[4,3-d]pyrimidin-2-amine	Investigative	122193774	C17H12ClN3S	325.8	C1C2=CN=C(N=C2C3=CC=CC=C3S1)NC4=CC=C(C=C4)Cl	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BF9T6X	6-(4-Fluorophenyl)-4-(4-methylbenzyl)-3(2H)-pyridazinone	Investigative	2811823	C18H15FN2O	294.3	CC1=CC=C(C=C1)CC2=CC(=NNC2=O)C3=CC=C(C=C3)F	IC50 = 51600 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BFK14D	1-Cyclohexyl-3-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]urea	Investigative	137654848	C20H23N5O	349.4	CC1=C2C(=CC=NC2=NN1)C3=CC=C(C=C3)NC(=O)NC4CCCCC4	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BFOR28	N-[4-[4-Fluoro-3-(trifluoromethyl)anilino]-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide	Investigative	71525287	C25H24F4N6O	500.5	CC(C)(C)C(=O)NC1=NC2=C(C=C(N2)CCC3=CC=CC=N3)C(=N1)NC4=CC(=C(C=C4)F)C(F)(F)F	IC50 = 150900 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BFS3W8	3-(3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)quinoline	Investigative	135497878	C24H18N6O	406.4	COCC1=C2C(=CC=C1)NC(=N2)C3=C4C=C(C=NC4=NN3)C5=CC6=CC=CC=C6N=C5	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BG45QK	7-(2-(4-Methylpiperazin-1-yl)ethyl)-3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazole	Investigative	44414964	C21H24N4S	364.5	CN1CCN(CC1)CCC2=CC3=C(CC4=C3NN=C4C5=CSC=C5)C=C2	IC50 = 143000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BG5LM7	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N,N-diethylpyrimidine-5-carboxamide	Investigative	25271181	C22H24ClN5O2	425.9	CCN(CC)C(=O)C1=C(N=CN=C1NC2=CC(=C(C=C2)OCC3=CC=CC=C3)Cl)N	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BG87SE	15,17-Dimethyl-8,15,17,19-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2,4,6,11,13(18)-hexaene-9,14,16-trione	Investigative	45379203	C17H14N4O3	322.32	CN1C2=C(C=C3CC(=O)NC4=CC=CC=C4C3=N2)C(=O)N(C1=O)C	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BGM42H	Methyl 3-(phenylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylate	Investigative	44405983	C13H11N3O2S	273.31	COC(=O)C1=CC2=C(NN=C2S1)NC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BGR0S1	3-Oxoisoindoline-4-carboxylic acid	Investigative	44579994	C9H7NO3	177.16	C1C2=C(C(=CC=C2)C(=O)O)C(=O)N1	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BH1FA3	6-(4-Amino-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-4H-chromen-4-one	Investigative	24905234	C15H11N5O2	293.28	CN1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)OC=CC4=O)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BH1MY2	Anilinoquinazoline deriv. 31	Investigative	5329029	C18H16ClFN4O3	390.8	COCC(=O)NC1=C(C=C2C(=C1)N=CN=C2NC3=C(C=C(C=C3)Cl)F)OC	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BH1N4K	5-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)pyridine-2-carbonitrile	Investigative	24905341	C14H13N7	279.3	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CN=C(C=C3)C#N)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BH23CB	N-(5-Chloro-1,3-benzodioxol-4-yl)-7-(3-morpholin-4-ylpropoxy)quinazolin-4-amine	Investigative	5330194	C22H23ClN4O4	442.9	C1COCCN1CCCOC2=CC3=C(C=C2)C(=NC=N3)NC4=C(C=CC5=C4OCO5)Cl	IC50 = 91350 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BH3N9X	Polyozellin	Investigative	382514	C22H14O10	438.3	CC(=O)OC1=C2C(=C(C3=C1C4=CC(=C(C=C4O3)O)O)OC(=O)C)C5=CC(=C(C=C5O2)O)O	IC50 = 66000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BH62NI	1-Benzyl-3-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]urea	Investigative	137655849	C21H19N5O	357.4	CC1=C2C(=CC=NC2=NN1)C3=CC=C(C=C3)NC(=O)NCC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BH9N3O	N-(3-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine	Investigative	127033758	C20H16N4O	328.4	COC1=CC=CC(=C1)NC2=NC=CC3=NC(=CN=C32)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BH9Z1C	N-(5-Chloro-1,3-benzodioxol-4-yl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine	Investigative	5330195	C23H25ClN4O5	472.9	COC1=C(C=C2C(=C1)N=CN=C2NC3=C(C=CC4=C3OCO4)Cl)OCCCN5CCOCC5	IC50 = 73820 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BHE0J3	Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(3-fluorophenyl)methyl]amino]-2-oxoacetate;2,2,2-trifluoroacetic acid	Investigative	71459836	C31H32F4N4O7	648.6	CCOC(=O)C(=O)N(CC1=CC(=CC=C1)F)C2=CC3=C(C=C2)OC(CN3C)(C)COC4=CC=C(C=C4)C(=N)N.C(=O)(C(F)(F)F)O	IC50 = 80000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BHK58O	8-Chloro-N-(4-methoxyphenyl)-5H-thiochromeno[4,3-d]pyrimidin-2-amine	Investigative	122193779	C18H14ClN3OS	355.8	COC1=CC=C(C=C1)NC2=NC=C3CSC4=C(C3=N2)C=CC(=C4)Cl	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BHRM84	15,17-Dimethyl-4,8,15,17,19-pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione	Investigative	45379341	C16H13N5O3	323.31	CN1C2=C(C=C3CC(=O)NC4=C(C3=N2)C=NC=C4)C(=O)N(C1=O)C	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BHX37J	2-Amino-4-(m-bromoanilino)-6-(2-methylbenzyl)-7-methyl-pyrrolo[2,3-d]pyrimidine	Investigative	52949915	C21H20BrN5	422.3	CC1=CC=CC=C1CC2=CC3=C(N=C(N=C3N2C)N)NC4=CC(=CC=C4)Br	IC50 = 116300 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BI4K5Q	1-Ethyl-3-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]urea	Investigative	137660584	C16H17N5O	295.34	CCNC(=O)NC1=CC=C(C=C1)C2=CC=NC3=NNC(=C23)C	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BI4M9R	N-(4-(4-Amino-7-(3-(4-hydroxypiperidin-1-yl)prop-1-enyl)thieno[3,2-c]pyridin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide	Investigative	11238420	C32H33N5O3S	567.7	CN1C2=CC=CC=C2C=C1C(=O)NC3=C(C=C(C=C3)C4=CSC5=C4C(=NC=C5/C=C/CN6CCC(CC6)O)N)OC	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BI9T5W	(S)-6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinoline	Investigative	46232509	C17H12Cl2FNO	336.2	C[C@@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=CC3=C(C=C2)N=CC=C3	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BIB1E3	4-(2-(1-Methyl-4-phenyl-1H-imidazol-5-ylamino)ethyl)pyrimidin-2-amine	Investigative	44586928	C16H18N6	294.35	CN1C=NC(=C1NCCC2=NC(=NC=C2)N)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BIE79Y	Isoindolinone analog 20	Investigative	5329884	C23H20N2O2	356.4	CC1=CC(=CC=C1)CC(=O)NC2=CC=C(C=C2)C3=C4CNC(=O)C4=CC=C3	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BIG78W	N-[4-[4-Amino-1-[4-(4-methylpiperazin-1-yl)cyclohexyl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]benzenesulfonamide	Investigative	6539959	C29H36N8O3S	576.7	CN1CCN(CC1)C2CCC(CC2)N3C4=NC=NC(=C4C(=N3)C5=CC(=C(C=C5)NS(=O)(=O)C6=CC=CC=C6)OC)N	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BIT6H3	Chembl4237913	Investigative	2810885	C21H27N3O3	369.5	C1CN(C(=O)N1)CCN(CC(C2=CC=CC=C2)O)CC(C3=CC=CC=C3)O	IC50 = 92700 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BIX19Z	5-Methoxy-15,17-dimethyl-8,15,17,19-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione	Investigative	45379205	C18H16N4O4	352.3	CN1C2=C(C=C3CC(=O)NC4=C(C3=N2)C=CC(=C4)OC)C(=O)N(C1=O)C	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BJ1HE9	(4S,6R,12Z)-6-Chloro-18-hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),12,15,17-tetraene-2,8-dione	Investigative	53324892	C19H23ClO5	366.8	C[C@H]1C[C@H](CC(=O)CCC/C=C\\C2=C(C(=CC(=C2)OC)O)C(=O)O1)Cl	IC50 = 82000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BJ69BN	US9296747, Example 2	Investigative	118970905	C22H23N5O4	421.4	COC1=CC(=CC(=C1OC)OC)NC2=NC=C3CN(CCC3=N2)C(=O)C4=CN=CC=C4	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BJ9E6Q	2-(6-Amino-9H-purin-9-yl)-1-(pyridin-3-yl)ethanone	Investigative	42603881	C12H10N6O	254.25	C1=CC(=CN=C1)C(=O)CN2C=NC3=C(N=CN=C32)N	IC50 = 58000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BJI19Q	1-[4-(3-Methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-propylurea	Investigative	137639044	C17H19N5O	309.4	CCCNC(=O)NC1=CC=C(C=C1)C2=CC=NC3=NNC(=C23)C	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BJY68N	5-Naphthalen-1-ylsulfanyl-9H-pyrimido[4,5-b]indole-2,4-diamine	Investigative	137643005	C20H15N5S	357.4	C1=CC=C2C(=C1)C=CC=C2SC3=CC=CC4=C3C5=C(N=C(N=C5N4)N)N	IC50 = 193100 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BK72AZ	(E/Z)-4-(2-(2-Phenylthiophen-3-yl)vinyl)pyrimidin-2-amine	Investigative	44586868	C16H13N3S	279.4	C1=CC=C(C=C1)C2=C(C=CS2)/C=C/C3=NC(=NC=C3)N	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BKDL60	6-((4-Methylpiperazin-1-yl)methyl)-N-phenyl-1,4-dihydroindeno[1,2-c]pyrazol-3-amine	Investigative	16220227	C22H25N5	359.5	CN1CCN(CC1)CC2=CC3=C(C=C2)C4=C(C3)C(=NN4)NC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BL87WZ	N4-(3-Bromophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	44586449	C20H18BrN5	408.3	C1=CC=C(C=C1)CCC2=CC3=C(N2)N=C(N=C3NC4=CC(=CC=C4)Br)N	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BLB49J	4-[[6-Amino-4-butoxy-5-(2,6-difluorobenzoyl)pyridin-2-yl]amino]benzenesulfonamide	Investigative	5330847	C22H22F2N4O4S	476.5	CCCCOC1=CC(=NC(=C1C(=O)C2=C(C=CC=C2F)F)N)NC3=CC=C(C=C3)S(=O)(=O)N	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BLN69O	3-Acyl-2,6-diaminopyridine deriv. 2p	Investigative	5330830	C20H18F2N4O3S	432.4	CN(C)S(=O)(=O)C1=CC=C(C=C1)NC2=NC(=C(C=C2)C(=O)C3=C(C=CC=C3F)F)N	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BLT7G3	3,4-Dihydro-1,6-naphthyridine analogue 50	Investigative	5330162	C35H45N5O5	615.8	CC(=O)N(CCCCCOCC1=CC=CC=C1)C2=NC=C3CC(C(=NC3=C2)NC(=O)NC(C)(C)C)C4=CC(=CC(=C4)OC)OC	IC50 = 55000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BLW93H	N-(4-(4-Amino-7-(3-(diethylamino)prop-1-enyl)thieno[3,2-c]pyridin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide	Investigative	18451036	C31H33N5O2S	539.7	CCN(CC)C/C=C/C1=CN=C(C2=C1SC=C2C3=CC(=C(C=C3)NC(=O)C4=CC5=CC=CC=C5N4C)OC)N	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BLZ42H	4-[(E)-2-(6-Methylimidazo[2,1-b][1,3]thiazol-5-yl)ethenyl]pyrimidin-2-amine	Investigative	44587324	C12H11N5S	257.32	CC1=C(N2C=CSC2=N1)/C=C/C3=NC(=NC=C3)N	IC50 = 70000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BM2PN7	1-(2,3-Dihydro-1H-inden-2-yl)-3-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]urea	Investigative	137636007	C23H21N5O	383.4	CC1=C2C(=CC=NC2=NN1)C3=CC=C(C=C3)NC(=O)NC4CC5=CC=CC=C5C4	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BM5AO3	2-(((2-Aminophenyl)thio)methyl)quinazolin-4(3H)-one	Investigative	135511450	C15H13N3OS	283.4	C1=CC=C2C(=C1)C(=O)NC(=N2)CSC3=CC=CC=C3N	IC50 = 67000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BM6PB5	1-Cyclopentyl-3-(H-imidazo[1,2-a]pyridin-7-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905148	C17H17N7	319.4	C1CCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CC5=NC=CN5C=C4)N	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BMC31A	1-Benzyl-3-[7-(1-methylpyrazol-4-yl)-1,5-naphthyridin-2-yl]urea	Investigative	52936268	C20H18N6O	358.4	CN1C=C(C=N1)C2=CC3=C(C=CC(=N3)NC(=O)NCC4=CC=CC=C4)N=C2	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BMEZ71	4-N-[4-Fluoro-3-(trifluoromethyl)phenyl]-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	71525249	C20H16F4N6	416.4	C1=CC=NC(=C1)CCC2=CC3=C(N2)N=C(N=C3NC4=CC(=C(C=C4)F)C(F)(F)F)N	IC50 = 124500 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BMJ24B	5-Chloro-4-N-(3-methoxyphenyl)-9H-pyrimido[4,5-b]indole-2,4-diamine	Investigative	54673975	C17H14ClN5O	339.8	COC1=CC=CC(=C1)NC2=NC(=NC3=C2C4=C(N3)C=CC=C4Cl)N	IC50 = 70100 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BMO0H5	6-Chloro-N-(4-methylsulfonylphenyl)-[1,3]dioxolo[4,5-g]quinazolin-8-amine	Investigative	76313719	C16H12ClN3O4S	377.8	CS(=O)(=O)C1=CC=C(C=C1)NC2=NC(=NC3=CC4=C(C=C32)OCO4)Cl	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BMP0C7	Tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44605037	C25H33N7O3	479.6	CC(C)(C)OC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)N)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BMY0V9	4-[(6-Chloro-[1,3]dioxolo[4,5-g]quinazolin-8-yl)amino]-N-(1,3-thiazol-2-yl)benzenesulfonamide	Investigative	76328168	C18H12ClN5O4S2	461.9	C1OC2=C(O1)C=C3C(=C2)C(=NC(=N3)Cl)NC4=CC=C(C=C4)S(=O)(=O)NC5=NC=CS5	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BMY85O	3-(3-(Benzyloxy)-4-methyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905284	C19H17N5O	331.4	CC1=C(C=C(C=C1)C2=C3C(=NC=NC3=NN2)N)OCC4=CC=CC=C4	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BN1U3V	4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorobenzonitrile	Investigative	24905237	C15H13FN6	296.3	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=C(C=C3)C#N)F)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BN74OT	{3-[(5-Methyl-2-Phenyl-1,3-Oxazol-4-Yl)methoxy]phenyl}methanol	Investigative	11140977	C18H17NO3	295.3	CC1=C(N=C(O1)C2=CC=CC=C2)COC3=CC=CC(=C3)CO	IC50 = 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BN9QH5	Methyl 3-oxoisoindoline-4-carboxylate	Investigative	44579993	C10H9NO3	191.18	COC(=O)C1=CC=CC2=C1C(=O)NC2	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BNA26F	(3S,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one	Investigative	71720141	C18H19N3O	293.4	CN1C[C@@H](C(=O)/C(=C/C2=CC=CC=N2)/C1)CC3=CC=CC=N3	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BNH53I	1-(2-Chlorophenyl)-3-(alpha,alpha,alpha-trifluoro-M-tolyl)urea	Investigative	4165705	C14H10ClF3N2O	314.69	C1=CC=C(C(=C1)NC(=O)NC2=CC=CC(=C2)C(F)(F)F)Cl	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BNQ1U5	Tert-butyl N-[(2R)-3-methyl-1-oxo-1-[[4-[3-(trifluoromethyl)anilino]quinazolin-6-yl]amino]butan-2-yl]carbamate	Investigative	137652990	C25H28F3N5O3	503.5	CC(C)[C@H](C(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC=CC(=C3)C(F)(F)F)NC(=O)OC(C)(C)C	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BNV12G	4-(6-Amino-5-((methoxyimino)methyl)pyrimidin-4-yloxy)-N-methylbenzamide	Investigative	44511483	C14H15N5O3	301.3	CNC(=O)C1=CC=C(C=C1)OC2=NC=NC(=C2/C=N/OC)N	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BNX13Z	6-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-2(1H)-one	Investigative	24905226	C17H16N6O	320.3	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)NC(=O)C=C4)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BOA45D	3-(4-Ethoxy-3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905292	C14H15N5O2	285.3	CCOC1=C(C=C(C=C1)C2=C3C(=NC=NC3=NN2)N)OC	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BOE94S	5-[(4-Methylphenyl)thio]-9h-pyrimido[4,5-b]indole-2,4-diamine	Investigative	25218207	C17H15N5S	321.4	CC1=CC=C(C=C1)SC2=CC=CC3=C2C4=C(N=C(N=C4N3)N)N	IC50 = 56300 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BOFD79	Pyrazolopyridazine 1a	Investigative	6263849	C17H13N5	287.32	C1=CC=C(C=C1)C2=C(N=NC3=NNC(=C23)N)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BOIL10	4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenol	Investigative	135947978	C15H17N5O2	299.33	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=C(C=C3)O)OC)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BOKJ71	N-(3-Chloro-4-fluorophenyl)-3-phenylpyrido[3,4-b]pyrazin-8-amine	Investigative	127030124	C19H12ClFN4	350.8	C1=CC=C(C=C1)C2=NC3=CN=CC(=C3N=C2)NC4=CC(=C(C=C4)F)Cl	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BOKW86	2-[(E)-2-(6-Phenylimidazo[2,1-b][1,3]thiazol-5-yl)ethenyl]pyrimidin-4-amine	Investigative	44586829	C17H13N5S	319.4	C1=CC=C(C=C1)C2=C(N3C=CSC3=N2)/C=C/C4=NC=CC(=N4)N	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BOL4E5	N-(4-Chlorophenyl)-8-methoxy-5H-thiochromeno[4,3-d]pyrimidin-2-amine	Investigative	122193777	C18H14ClN3OS	355.8	COC1=CC2=C(C=C1)C3=NC(=NC=C3CS2)NC4=CC=C(C=C4)Cl	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BP86NH	N-(4-(4-Amino-7-(3-(piperidin-4-ylamino)prop-1-enyl)thieno[3,2-c]pyridin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide	Investigative	18451024	C32H34N6O2S	566.7	CN1C2=CC=CC=C2C=C1C(=O)NC3=C(C=C(C=C3)C4=CSC5=C4C(=NC=C5/C=C/CNC6CCNCC6)N)OC	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BP92QR	1-[3-[7-(4-Amino-5-fluoropyrimidin-2-yl)imidazo[1,2-a]pyridin-3-yl]-5-cyclopentyloxyphenyl]-3-(2,2,2-trifluoroethyl)urea	Investigative	68168854	C25H23F4N7O2	529.5	C1CCC(C1)OC2=CC(=CC(=C2)NC(=O)NCC(F)(F)F)C3=CN=C4N3C=CC(=C4)C5=NC=C(C(=N5)N)F	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BPH30Z	15,17-Dimethyl-3,8,15,17,19-pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione	Investigative	45379343	C16H13N5O3	323.31	CN1C2=C(C=C3CC(=O)NC4=C(C3=N2)N=CC=C4)C(=O)N(C1=O)C	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BPHX43	4-N-(4-Chlorophenyl)-6-[(2,5-dimethoxyphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	57392425	C21H20ClN5O2	409.9	COC1=CC(=C(C=C1)OC)CC2=CC3=C(N2)N=C(N=C3NC4=CC=C(C=C4)Cl)N	IC50 = 56700 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BPLH59	4-N-(3-Bromophenyl)-7-[(3,4-dichlorophenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	57398331	C19H14BrCl2N5	463.2	C1=CC(=CC(=C1)Br)NC2=C3C=CN(C3=NC(=N2)N)CC4=CC(=C(C=C4)Cl)Cl	IC50 = 64500 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BPR7V8	6-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-4H-chromen-4-one	Investigative	24905229	C17H15N5O2	321.33	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)OC=CC4=O)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BPY23D	1-(4-Cyanophenyl)-3-(2-thieno[3,2-b]pyridin-7-ylsulfanylphenyl)urea	Investigative	122188021	C21H14N4OS2	402.5	C1=CC=C(C(=C1)NC(=O)NC2=CC=C(C=C2)C#N)SC3=C4C(=NC=C3)C=CS4	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BQ2R3Z	1-Butyl-3-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]urea	Investigative	137647791	C18H21N5O	323.4	CCCCNC(=O)NC1=CC=C(C=C1)C2=CC=NC3=NNC(=C23)C	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BQ37SK	3-Substituted indolin-2-one 16c	Investigative	5329147	C19H18N2O5	354.4	CC1=C(NC(=C1CCC(=O)O)C)/C=C\\2/C3=C(C=CC(=C3)C(=O)O)NC2=O	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BQ5GN3	7-((1H-Imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazole	Investigative	44414322	C18H14N4S	318.4	C1C2=C(C=C(C=C2)CN3C=CN=C3)C4=C1C(=NN4)C5=CSC=C5	IC50 = 147000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BQ5LG8	(3R,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one	Investigative	71718330	C18H19N3O	293.4	CN1C[C@H](C(=O)/C(=C/C2=CC=CC=N2)/C1)CC3=CC=CC=N3	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BQ9Y5W	2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-N-(4-morpholin-4-ylphenyl)acetamide	Investigative	44427518	C32H31N5O4	549.6	COC1=C(C=CC(=C1)C2=CC3=C(C=C2)C(=O)NC4=C(N3)C=CC(=C4)CC(=O)NC5=CC=C(C=C5)N6CCOCC6)N	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BQK70P	3-Substituted indolin-2-one 11b	Investigative	5329139	C18H16N2O5	340.3	CC1=C(NC=C1CCC(=O)O)/C=C\\2/C3=C(C=CC(=C3)C(=O)O)NC2=O	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BQL12C	1-[4-(3-Methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-pentylurea	Investigative	137636465	C19H23N5O	337.4	CCCCCNC(=O)NC1=CC=C(C=C1)C2=CC=NC3=NNC(=C23)C	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BQTO97	N-(4-Methoxyphenethyl)-4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carboxamide	Investigative	25271516	C27H26ClN5O3	504	COC1=CC=C(C=C1)CCNC(=O)C2=C(N=CN=C2NC3=CC(=C(C=C3)OCC4=CC=CC=C4)Cl)N	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BR7D0A	1-[3-(4-Amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)phenyl]ethanone	Investigative	52945845	C16H17N5O	295.34	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=CC=C3)C(=O)C)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BRB7C5	1-[4-(3-Methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-pyridin-2-ylurea	Investigative	137645016	C19H16N6O	344.4	CC1=C2C(=CC=NC2=NN1)C3=CC=C(C=C3)NC(=O)NC4=CC=CC=N4	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BRE29L	8-Chloro-N-phenyl-5H-thiochromeno[4,3-d]pyrimidin-2-amine	Investigative	122193778	C17H12ClN3S	325.8	C1C2=CN=C(N=C2C3=C(S1)C=C(C=C3)Cl)NC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BRL56D	5-Amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarbamoyl)-2-methylphenyl)-1H-pyrazole-4-carboxamide	Investigative	49838879	C21H17FN6O3	420.4	CC1=C(C=C(C=C1)C(=O)NC2=NOC=C2)NC(=O)C3=C(N(N=C3)C4=CC=CC=C4F)N	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BRP6V7	4-[[6-Amino-5-(2,6-difluorobenzoyl)pyridin-2-yl]amino]benzenesulfonamide	Investigative	5330832	C18H14F2N4O3S	404.4	C1=CC(=C(C(=C1)F)C(=O)C2=C(N=C(C=C2)NC3=CC=C(C=C3)S(=O)(=O)N)N)F	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BS0W1X	6-[(2,4-Dichlorophenyl)methyl]-4-N-(3-ethynylphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	46886973	C21H15Cl2N5	408.3	C#CC1=CC(=CC=C1)NC2=NC(=NC3=C2C=C(N3)CC4=C(C=C(C=C4)Cl)Cl)N	IC50 = 85600 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BS15ZX	8-Methoxy-N-phenyl-5H-thiochromeno[4,3-d]pyrimidin-2-amine	Investigative	122193775	C18H15N3OS	321.4	COC1=CC2=C(C=C1)C3=NC(=NC=C3CS2)NC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BS2BR3	3-[(4-Chlorophenoxy)methyl]-4-methoxybenzamide	Investigative	57398315	C15H14ClNO3	291.73	COC1=C(C=C(C=C1)C(=O)N)COC2=CC=C(C=C2)Cl	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BS5T1C	[4-[4-(5-Ethylsulfonyl-2-methoxyanilino)triazol-1-yl]-2-naphthalen-1-ylphenyl]urea	Investigative	122195476	C28H26N6O4S	542.6	CCS(=O)(=O)C1=CC(=C(C=C1)OC)NC2=CN(N=N2)C3=CC(=C(C=C3)NC(=O)N)C4=CC=CC5=CC=CC=C54	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BS9TZ1	N-[4-Fluoro-3-(trifluoromethyl)phenyl]-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Investigative	46887348	C21H16F4N4	400.4	C1=CC=C(C=C1)CCC2=CC3=C(N2)N=CN=C3NC4=CC(=C(C=C4)F)C(F)(F)F	IC50 = 57500 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BSK3G0	4-(3-Chlorobenzamido)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide	Investigative	44405945	C14H11ClN4O2S	334.8	CC1=C2C(=C(SC2=NN1)C(=O)N)NC(=O)C3=CC(=CC=C3)Cl	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BSWL64	3,8,13,17,18-Pentazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one	Investigative	135929526	C13H9N5O	251.24	C1C2=C(C3=C(C=CC=N3)NC1=O)N4C(=CC=N4)N=C2	IC50 = 87000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BT3H1C	N-(4-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine	Investigative	127031384	C20H16N4O	328.4	COC1=CC=C(C=C1)NC2=NC=CC3=NC(=CN=C32)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BT9V1D	N-[4-[4-Amino-1-[4-(4-methylpiperazin-1-yl)cyclohexyl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-2,2-dimethyl-3-phenylpropanamide	Investigative	6539963	C34H44N8O2	596.8	CC(C)(CC1=CC=CC=C1)C(=O)NC2=C(C=C(C=C2)C3=NN(C4=NC=NC(=C34)N)C5CCC(CC5)N6CCN(CC6)C)OC	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BTCK72	6-((4-Methylpiperazin-1-yl)methyl)-3-(3-methylthiophen-2-yl)-1,4-dihydroindeno[1,2-c]pyrazole	Investigative	44414994	C21H24N4S	364.5	CC1=C(SC=C1)C2=C3CC4=C(C3=NN2)C=CC(=C4)CN5CCN(CC5)C	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BTKF20	4-(4-Amino-6-methylthieno[2,3-d]pyrimidin-5-yl)-N-(3-methylphenyl)benzamide	Investigative	6539973	C21H18N4OS	374.5	CC1=CC(=CC=C1)NC(=O)C2=CC=C(C=C2)C3=C(SC4=NC=NC(=C34)N)C	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BTOA20	1-Tert-butyl-3-[7-(1-methylpyrazol-4-yl)-1,5-naphthyridin-2-yl]urea	Investigative	53236670	C17H20N6O	324.4	CC(C)(C)NC(=O)NC1=NC2=C(C=C1)N=CC(=C2)C3=CN(N=C3)C	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BTU2I4	N-(4-(4-Aminoisoxazolo[5,4-d]pyrimidin-3-yl)phenyl)benzamide	Investigative	10246119	C18H13N5O2	331.3	C1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)C3=NOC4=NC=NC(=C34)N	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BTY9A6	1-[4-(3-Methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-naphthalen-1-ylurea	Investigative	137659546	C24H19N5O	393.4	CC1=C2C(=CC=NC2=NN1)C3=CC=C(C=C3)NC(=O)NC4=CC=CC5=CC=CC=C54	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BTZ1F4	1-Cyano-3-(3-methylphenyl)-2-[(5-{6-[(4-methylpiperazin-1-yl)methyl]-1H,4H-indeno[1,2-c]pyrazol-3-yl}thiophen-2-yl)methyl]guanidine	Investigative	44414658	C30H32N8S	536.7	CC1=CC(=CC=C1)NC(=NCC2=CC=C(S2)C3=C4CC5=C(C4=NN3)C=CC(=C5)CN6CCN(CC6)C)NC#N	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BTZ29O	N-[4-[4-Amino-1-[4-(4-methylpiperazin-1-yl)cyclohexyl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]benzamide	Investigative	6539956	C30H36N8O2	540.7	CN1CCN(CC1)C2CCC(CC2)N3C4=NC=NC(=C4C(=N3)C5=CC(=C(C=C5)NC(=O)C6=CC=CC=C6)OC)N	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BU3CK2	Tert-Butyl-2-{5-(4-hydroxyphenethoxy)-1-{5-[4-(methylthio)phenyl]pentyl}-1H-indole-3-yl}ethyl carbamate	Investigative	46888666	C35H44N2O4S	588.8	CC(C)(C)OC(=O)NCCC1=CN(C2=C1C=C(C=C2)OCCC3=CC=C(C=C3)O)CCCCCC4=CC=C(C=C4)SC	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BU4H8C	2-(Dimethylamino)ethyl 4-methoxy-3-[[5-pyrimidin-5-yl-2-(trifluoromethoxy)phenyl]carbamoylamino]benzoate	Investigative	122195145	C24H24F3N5O5	519.5	CN(C)CCOC(=O)C1=CC(=C(C=C1)OC)NC(=O)NC2=C(C=CC(=C2)C3=CN=CN=C3)OC(F)(F)F	IC50 = 51900 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BU53YX	N4-((1-Methyl-4-phenyl-1H-imidazol-5-yl)methyl)pyrimidine-2,4-diamine	Investigative	44586901	C15H16N6	280.33	CN1C=NC(=C1CNC2=NC(=NC=C2)N)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BU9FH7	5-(4-Methoxyphenyl)sulfanyl-9H-pyrimido[4,5-b]indole-2,4-diamine	Investigative	137655519	C17H15N5OS	337.4	COC1=CC=C(C=C1)SC2=CC=CC3=C2C4=C(N=C(N=C4N3)N)N	IC50 = 182200 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BU9QK8	1-[7-(1-Methylpyrazol-4-yl)-1,5-naphthyridin-2-yl]-3-phenylurea	Investigative	53236671	C19H16N6O	344.4	CN1C=C(C=N1)C2=CC3=C(C=CC(=N3)NC(=O)NC4=CC=CC=C4)N=C2	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BUBK49	(1S)-2-(1H-Indol-3-YL)-1-[({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-YL}oxy)methyl]ethylamine	Investigative	6914613	C23H22N4O	370.4	C1=CC=C2C(=C1)C(=CN2)C[C@@H](COC3=CN=CC(=C3)/C=C/C4=CC=NC=C4)N	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BUE5R6	5-Methoxy-8,13,15,17,18-pentazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one	Investigative	135929506	C14H11N5O2	281.27	COC1=CC2=C(C=C1)C3=C(CC(=O)N2)C=NC4=NC=NN34	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BUF63X	N-(4-(4-Amino-7-(3-((1r,4r)-4-aminocyclohexylamino)prop-1-enyl)thieno[3,2-c]pyridin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide	Investigative	11753519	C33H36N6O2S	580.7	CN1C2=CC=CC=C2C=C1C(=O)NC3=C(C=C(C=C3)C4=CSC5=C4C(=NC=C5/C=C/CNC6CCC(CC6)N)N)OC	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BUJ5T8	4-[4-[(E)-3-(4-Fluorophenyl)-3-oxoprop-1-enyl]phenoxy]-N-methylpyridine-2-carboxamide	Investigative	134145603	C22H17FN2O3	376.4	CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)/C=C/C(=O)C3=CC=C(C=C3)F	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BULB17	5-Methoxy-8,15,17,19-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione	Investigative	45379204	C16H12N4O4	324.29	COC1=CC2=C(C=C1)C3=NC4=C(C=C3CC(=O)N2)C(=O)NC(=O)N4	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BUO4L7	4-[(E)-2-(6-Phenylimidazo[2,1-b][1,3]thiazol-5-yl)vinyl]pyrimidine	Investigative	44586794	C17H12N4S	304.4	C1=CC=C(C=C1)C2=C(N3C=CSC3=N2)/C=C/C4=NC=NC=C4	IC50 = 77000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BV52IQ	US9422297, Aag145-340	Investigative	129625874	C17H13ClN4	308.8	C1C2=CC=CC=C2C3=C1C(=NC(=N3)N)NC4=CC=C(C=C4)Cl	IC50 = 132900 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BV9WQ8	N-(4-Ethoxyphenyl)-4-(1-methylbenzimidazol-2-yl)pyrimidin-2-amine	Investigative	60166136	C20H19N5O	345.4	CCOC1=CC=C(C=C1)NC2=NC=CC(=N2)C3=NC4=CC=CC=C4N3C	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BVA18W	[4-[4-Amino-1-[4-(4-methylpiperazin-1-yl)cyclohexyl]pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-phenylmethanone	Investigative	6539955	C29H33N7O	495.6	CN1CCN(CC1)C2CCC(CC2)N3C4=NC=NC(=C4C(=N3)C5=CC=C(C=C5)C(=O)C6=CC=CC=C6)N	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BVW47M	1,3-Dimethyl-7-(1-methylbenzimidazol-2-yl)pyrido[2,3-d]pyrimidine-2,4-dione	Investigative	60165992	C17H15N5O2	321.33	CN1C2=CC=CC=C2N=C1C3=NC4=C(C=C3)C(=O)N(C(=O)N4C)C	IC50 = 85000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BWJ84K	4-(4-Chlorobenzamido)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide	Investigative	44405946	C14H11ClN4O2S	334.8	CC1=C2C(=C(SC2=NN1)C(=O)N)NC(=O)C3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BWP36Z	Chembl4202658	Investigative	145977243	C22H19N5O4	417.4	CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)C3CC(=NN3)C4=CC=C(C=C4)[N+](=O)[O-]	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BX3E9S	7-((1H-1,2,3-Triazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazole	Investigative	44414982	C17H13N5S	319.4	C1C2=C(C=C(C=C2)CN3C=CN=N3)C4=C1C(=NN4)C5=CSC=C5	IC50 = 190000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BX5E6T	2-(5-Isoquinolin-4-yl-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-benzoimidazole-4-carboxylic acid methyl ester	Investigative	136118032	C24H16N6O2	420.4	COC(=O)C1=C2C(=CC=C1)NC(=N2)C3=C4C=C(C=NC4=NN3)C5=CN=CC6=CC=CC=C65	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BX84HQ	4-N-(3-Bromophenyl)-6-[(3,4-dichlorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	3008964	C19H14BrCl2N5	463.2	C1=CC(=CC(=C1)Br)NC2=NC(=NC3=C2C=C(N3)CC4=CC(=C(C=C4)Cl)Cl)N	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BX85AV	6,7,12,16,17-Pentahydroxy-12-(2-oxopropyl)-3,20-dioxapentacyclo[11.7.0.02,10.04,9.014,19]icosa-1(13),2(10),4,6,8,14,16,18-octaen-11-one	Investigative	90655410	C21H14O9	410.3	CC(=O)CC1(C2=C(C3=C(C1=O)C4=CC(=C(C=C4O3)O)O)OC5=CC(=C(C=C52)O)O)O	IC50 = 52000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BXT68J	1-Ethyl-3-[7-(4-methoxyphenyl)-1,5-naphthyridin-2-yl]urea	Investigative	53239373	C18H18N4O2	322.4	CCNC(=O)NC1=NC2=C(C=C1)N=CC(=C2)C3=CC=C(C=C3)OC	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BXW73J	5-(4-Amino-1-((4-phenyloxazol-5-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol	Investigative	24905308	C21H15FN6O2	402.4	C1=CC=C(C=C1)C2=C(OC=N2)CN3C4=NC=NC(=C4C(=N3)C5=CC(=C(C=C5)F)O)N	IC50 = 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BY09TX	US9422297, Aag155-336	Investigative	129625873	C17H13BrN4	353.2	C1C2=CC=CC=C2C3=C1C(=NC(=N3)N)NC4=CC(=CC=C4)Br	IC50 = 167500 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BYA5E9	1-Tert-butyl-3-[7-(4-hydroxy-3-methoxyphenyl)-1,5-naphthyridin-2-yl]urea	Investigative	136065882	C20H22N4O3	366.4	CC(C)(C)NC(=O)NC1=NC2=C(C=C1)N=CC(=C2)C3=CC(=C(C=C3)O)OC	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BYH7T9	7-((4-Isopropylpiperazin-1-yl)methyl)-3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazole	Investigative	44414973	C22H26N4S	378.5	CC(C)N1CCN(CC1)CC2=CC3=C(CC4=C3NN=C4C5=CSC=C5)C=C2	IC50 = 190000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BZ2AF9	N4-(3-Bromo-4-fluorophenyl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	10251852	C20H17BrFN5	426.3	C1=CC=C(C=C1)CCC2=CC3=C(N2)N=C(N=C3NC4=CC(=C(C=C4)F)Br)N	IC50 = 132100 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BZ4F6B	5-[(E)-2-(2-Chloropyrimidin-4-yl)vinyl]-6-phenylimidazo[2,1-b][1,3]thiazole	Investigative	11724734	C17H11ClN4S	338.8	C1=CC=C(C=C1)C2=C(N3C=CSC3=N2)/C=C/C4=NC(=NC=C4)Cl	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BZ57ML	6-[2-[2-(Dimethylamino)ethylamino]ethylamino]-2-hexylbenzo[de]isoquinoline-1,3-dione	Investigative	71741329	C24H34N4O2	410.6	CCCCCCN1C(=O)C2=C3C(=C(C=C2)NCCNCCN(C)C)C=CC=C3C1=O	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BZ7A5X	(E/Z)-4-(2-(4-Phenyl-1H-pyrazol-5-yl)vinyl)pyrimidin-2-amine	Investigative	44586832	C15H13N5	263.3	C1=CC=C(C=C1)C2=C(NN=C2)/C=C/C3=NC(=NC=C3)N	IC50 ~ 100000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BZFX31	US9422297, Aag145-346	Investigative	129625877	C17H13FN4	292.31	C1C2=CC=CC=C2C3=C1C(=NC(=N3)N)NC4=CC(=CC=C4)F	IC50 = 73000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	BZP20S	Rac-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)-N,N-dimethylacrylamide	Investigative	46232513	C22H19Cl2FN2O2	433.3	CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=CC3=CC(=CN=C3C=C2)/C=C/C(=O)N(C)C	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	D05BPX	3-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)phenol	Investigative	16757577	C16H16ClN3O2S	349.8	C1COCCN1C2=NC(=NC3=C2SC=C3)C4=CC(=CC=C4)O.Cl	IC50 = 91000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	D06WGX	A-770041	Investigative	9549184	C34H39N9O3	621.7	CC(=O)N1CCN(CC1)C2CCC(CC2)N3C4=NC=NC(=C4C(=N3)C5=CC(=C(C=C5)NC(=O)C6=CC7=CC=CC=C7N6C)OC)N	IC50 ~ 50000 nM	Poor binder
T80975	Vascular endothelial growth factor receptor 2	D0BS6R	A-420983	Investigative	9549183	C33H39N9O2	593.7	CN1CCN(CC1)C2CCC(CC2)N3C4=NC=NC(=C4C(=N3)C5=CC(=C(C=C5)NC(=O)C6=CC7=CC=CC=C7N6C)OC)N	IC50 ~ 50000 nM	Poor binder