TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T81735	DNA-dependent protein kinase catalytic	D0E6XR	Dasatinib	Approved	3062316	C22H26ClN7O2S	488	CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO	IC50 ~ 50000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	D0R4OM	Trifluoperazine	Approved	5566	C21H24F3N3S	407.5	CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F	IC50 = 100000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	D0W5HK	Sorafenib	Approved	216239	C21H16ClF3N4O3	464.8	CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	D01RYO	Gefitinib	Patented	123631	C22H24ClFN4O3	446.9	COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4	IC50 ~ 50000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	D0YX2B	PMID28460551-Compound-2	Patented	5329102	C22H27FN4O2	398.5	CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\\2/C3=C(C=CC(=C3)F)NC2=O)C	IC50 ~ 50000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	B0CV3O	3-Methyl-2-morpholin-4-yl-6-phenylpyran-4-one	Investigative	16203466	C16H17NO3	271.31	CC1=C(OC(=CC1=O)C2=CC=CC=C2)N3CCOCC3	IC50 ~ 100000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	B2OF9R	3-(4-Nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905261	C11H8N6O2	256.22	C1=CC(=CC=C1C2=C3C(=NC=NC3=NN2)N)[N+](=O)[O-]	IC50 = 100000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	B3JUX6	8-(3-Aminophenyl)-2-morpholin-4-yl-1,3-benzoxazin-4-one	Investigative	127039546	C18H17N3O3	323.3	C1COCCN1C2=NC(=O)C3=C(O2)C(=CC=C3)C4=CC(=CC=C4)N	IC50 = 63500 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	B59YVI	N-[4-(4-Amino-2H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl]-4-phenylbenzamide	Investigative	52949497	C24H18N6O	406.4	C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)NC3=CC=C(C=C3)C4=C5C(=NC=NC5=NN4)N	IC50 = 100000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	B7TFK6	6-(4-Chlorophenyl)-2-morpholin-4-yl-4-ethoxypyridine	Investigative	16203828	C17H19ClN2O2	318.8	CCOC1=CC(=NC(=C1)N2CCOCC2)C3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	B9NJ3Q	4H-Thiopyran-4-one, 2-methyl-6-(4-morpholinyl)-	Investigative	16203710	C10H13NO2S	211.28	CC1=CC(=O)C=C(S1)N2CCOCC2	IC50 ~ 100000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	BA9M8J	4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2,6-difluorobenzaldehyde	Investigative	24905235	C15H13F2N5O	317.29	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=C(C(=C3)F)C=O)F)N	IC50 = 100000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	BBC0W2	4H-Thiopyran-4-one, 2-methyl-6-(1-pyrrolidinyl)-	Investigative	16204163	C10H13NOS	195.28	CC1=CC(=O)C=C(S1)N2CCCC2	IC50 ~ 100000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	BBWU45	6-(4-Amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-2(1H)-one	Investigative	24905227	C19H18N6O	346.4	C1CCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CC5=C(C=C4)NC(=O)C=C5)N	IC50 = 100000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	BC0GP5	6-(4-Methoxyphenyl)-2-morpholin-4-yl-4-methoxypyridine	Investigative	16204255	C17H20N2O3	300.35	COC1=CC=C(C=C1)C2=NC(=CC(=C2)OC)N3CCOCC3	IC50 ~ 100000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	BDLR94	2-Benzylamino-6-methyl-4H-thiopyran-4-one	Investigative	16203711	C13H13NOS	231.32	CC1=CC(=O)C=C(S1)NCC2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	BLN43J	2-Morpholin-4-yl-8-pyridin-3-yl-1,3-benzoxazin-4-one	Investigative	127041034	C17H15N3O3	309.32	C1COCCN1C2=NC(=O)C3=C(O2)C(=CC=C3)C4=CN=CC=C4	IC50 = 78400 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	BLN5Z2	6-(4-Chlorophenyl)-2-morpholin-4-yl-4-methoxypyridine	Investigative	16203827	C16H17ClN2O2	304.77	COC1=CC(=NC(=C1)N2CCOCC2)C3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	BM24CI	3-(3-(2,6-Dichlorobenzyloxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905265	C18H13Cl2N5O	386.2	C1=CC(=CC(=C1)OCC2=C(C=CC=C2Cl)Cl)C3=C4C(=NC=NC4=NN3)N	IC50 = 100000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	BP4TD0	3-Bromo-6-(4-chlorophenyl)-2-morpholin-4-yl-thiopyran-4-	Investigative	16203825	C15H13BrClNO2S	386.7	C1COCCN1C2=C(C(=O)C=C(S2)C3=CC=C(C=C3)Cl)Br	IC50 ~ 100000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	BP62CI	6-(4-Bromophenyl)-3-chloro-2-morpholin-4-yl-4H-thiopyran-	Investigative	16204253	C15H13BrClNO2S	386.7	C1COCCN1C2=C(C(=O)C=C(S2)C3=CC=C(C=C3)Br)Cl	IC50 ~ 100000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	BT2C8R	6-(4-Methoxyphenyl)-2-morpholin-4-ylpyridin-4-ol	Investigative	16204254	C16H18N2O3	286.33	COC1=CC=C(C=C1)C2=CC(=O)C=C(N2)N3CCOCC3	IC50 ~ 100000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	BT6N0R	3-(3-Phenoxyphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905262	C17H13N5O	303.32	C1=CC=C(C=C1)OC2=CC=CC(=C2)C3=C4C(=NC=NC4=NN3)N	IC50 = 100000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	BV34NA	6-(4-Chlorophenyl)-3-methyl-2-morpholin-4-yl-pyran-4-one	Investigative	16203581	C16H16ClNO3	305.75	CC1=C(OC(=CC1=O)C2=CC=C(C=C2)Cl)N3CCOCC3	IC50 ~ 100000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	BV76ZX	2-Morpholin-4-yl-6-(4-morpholin-4-yl-phenyl)-4H-thiopyran-	Investigative	16203823	C19H22N2O3S	358.5	C1COCCN1C2=CC=C(C=C2)C3=CC(=O)C=C(S3)N4CCOCC4	IC50 ~ 100000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	BW5EB0	6-Methyl-2-thiomorpholin-4-yl-4H-thiopyran-4-one	Investigative	16204164	C10H13NOS2	227.4	CC1=CC(=O)C=C(S1)N2CCSCC2	IC50 ~ 100000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	BWE78U	2-Amino-5-(4-amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenol	Investigative	24905281	C16H18N6O	310.35	C1CCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CC(=C(C=C4)N)O)N	IC50 = 100000 nM	Poor binder
T81735	DNA-dependent protein kinase catalytic	BWS24D	3-(4-Biphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905267	C17H13N5	287.32	C1=CC=C(C=C1)C2=CC=C(C=C2)C3=C4C(=NC=NC4=NN3)N	IC50 = 100000 nM	Poor binder