TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T81905	Histamine H2 receptor	D04USC	Ergotidine	Approved	774	C5H9N3	111.15	C1=C(NC=N1)CCN	Ki = 50118.72 nM	Poor binder
T81905	Histamine H1 receptor	D0D9FV	Orphenadrine	Approved	4601	C18H23NO	269.4	CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C	IC50 = 97723.72 nM	Poor binder
T81905	Histamine H1 receptor	D0E1WI	Fentanyl	Approved	3345	C22H28N2O	336.5	CCC(=O)N(C1CCN(CC1)CCC2=CC=CC=C2)C3=CC=CC=C3	IC50 = 147910.84 nM	Poor binder
T81905	Histamine H4 receptor	D01UUD	Pitolisant	Phase 3	9948102	C17H26ClNO	295.8	C1CCN(CC1)CCCOCCCC2=CC=C(C=C2)Cl	Ki ~ 100000 nM	Poor binder
T81905	Histamine H1 receptor	B02ZDR	(4-(3-(4-((2s)-2-Aminopropanoyl)-1-piperazinyl)propoxy)phenyl)(cyclopropyl)methanone	Investigative	12016525	C20H29N3O3	359.5	C[C@@H](C(=O)N1CCN(CC1)CCCOC2=CC=C(C=C2)C(=O)C3CC3)N	Ki = 53703.18 nM	Poor binder
T81905	Histamine H1 receptor	B0E4ST	2-(3,4-Dichlorophenyl)-1H-imidazole-4-ethaneamine	Investigative	44369359	C11H11Cl2N3	256.13	C1=CC(=C(C=C1C2=NC=C(N2)CCN)Cl)Cl	IC50 = 50118.72 nM	Poor binder
T81905	Histamine H1 receptor	B0FLO8	((S)-1-{(S)-1-[3-(4-Acetyl-phenoxy)-propyl]-pyrrolidin-3-ylcarbamoyl}-2-hydroxy-ethyl)-carbamic acid tert-butyl ester	Investigative	44334556	C23H35N3O6	449.5	CC(=O)C1=CC=C(C=C1)OCCCN2CC[C@@H](C2)NC(=O)[C@H](CO)NC(=O)OC(C)(C)C	Ki = 75000 nM	Poor binder
T81905	Histamine H3 receptor	B0K4YO	1-Phenyl-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]sulfonylurea	Investigative	60145630	C19H23N3O4S	389.5	C1CCN(C1)CCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=CC=C3	IC50 = 88600 nM	Poor binder
T81905	Histamine H1 receptor	B29RUX	Adiphenine	Investigative	2031	C20H25NO2	311.4	CCN(CC)CCOC(=O)C(C1=CC=CC=C1)C2=CC=CC=C2	IC50 = 112201.85 nM	Poor binder
T81905	Histamine H2 receptor	B3DFI4	Tert-butyl (2R)-2-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazine-1-carbonyl]pyrrolidine-1-carboxylate	Investigative	44304316	C27H39N3O5	485.6	CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N2CCN(CC2)CCCOC3=CC=C(C=C3)C(=O)C4CC4	Ki = 50118.72 nM	Poor binder
T81905	Histamine H2 receptor	B3MDF6	4-[3-(4-Propionylphenoxy)propyl]-1-piperazinecarboxylic acid ethyl ester	Investigative	44304475	C19H28N2O4	348.4	CCC(=O)C1=CC=C(C=C1)OCCCN2CCN(CC2)C(=O)OCC	Ki = 56234.13 nM	Poor binder
T81905	Histamine H3 receptor	B3Q0MI	1-[7-(3-Chlorophenoxy)heptyl]azepane;oxalic acid	Investigative	127042504	C21H32ClNO5	413.9	C1CCCN(CC1)CCCCCCCOC2=CC(=CC=C2)Cl.C(=O)(C(=O)O)O	Ki ~ 150000 nM	Poor binder
T81905	Histamine H2 receptor	B3U9NE	4'-(3-Pyrrolizinopropoxy)biphenyl-4-carbonitrile	Investigative	18672441	C20H22N2O	306.4	C1CCN(C1)CCCOC2=CC=C(C=C2)C3=CC=C(C=C3)C#N	Ki = 67608.3 nM	Poor binder
T81905	Histamine H2 receptor	B3V5OE	1-[4-[3-[4-(Methylsulfonyl)piperazino]propoxy]phenyl]-1-hexanone	Investigative	44304978	C20H32N2O4S	396.5	CCCCCC(=O)C1=CC=C(C=C1)OCCCN2CCN(CC2)S(=O)(=O)C	Ki = 83176.38 nM	Poor binder
T81905	Histamine H3 receptor	B4LT9B	1-[4-(2-Piperidin-1-ylethoxy)phenyl]sulfonyl-3-[4-(trifluoromethyl)phenyl]urea	Investigative	60145773	C21H24F3N3O4S	471.5	C1CCN(CC1)CCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=C(C=C3)C(F)(F)F	IC50 = 82000 nM	Poor binder
T81905	Histamine H3 receptor	B4MBG1	N-(3-Bromo-4-(2-morpholinoethoxy)phenethyl)-5-bromofuran-2-carboxamide	Investigative	45267022	C19H22Br2N2O4	502.2	C1COCCN1CCOC2=C(C=C(C=C2)CCNC(=O)C3=CC=C(O3)Br)Br	IC50 = 73200 nM	Poor binder
T81905	Histamine H2 receptor	B4T8SX	(2R)-2-Amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-3-(1,3-thiazol-2-yl)propan-1-one	Investigative	44304311	C23H30N4O3S	442.6	C1CC1C(=O)C2=CC=C(C=C2)OCCCN3CCN(CC3)C(=O)[C@@H](CC4=NC=CS4)N	Ki = 97723.72 nM	Poor binder
T81905	Histamine H1 receptor	B4T8SX	(2R)-2-Amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-3-(1,3-thiazol-2-yl)propan-1-one	Investigative	44304311	C23H30N4O3S	442.6	C1CC1C(=O)C2=CC=C(C=C2)OCCCN3CCN(CC3)C(=O)[C@@H](CC4=NC=CS4)N	Ki = 100000 nM	Poor binder
T81905	Histamine H2 receptor	B4TC0A	Ethyl 4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazine-1-carboxylate	Investigative	44304090	C20H28N2O4	360.4	CCOC(=O)N1CCN(CC1)CCCOC2=CC=C(C=C2)C(=O)C3CC3	Ki = 79432.82 nM	Poor binder
T81905	Histamine H4 receptor	B57MBZ	3-(1H-Imidazol-5-yl)propyl N-(3-phenoxypropyl)carbamate	Investigative	73347579	C16H21N3O3	303.36	C1=CC=C(C=C1)OCCCNC(=O)OCCCC2=CN=CN2	Ki ~ 100000 nM	Poor binder
T81905	Histamine H1 receptor	B5EG2J	((S)-1-{(S)-1-[3-(4-Acetyl-phenoxy)-propyl]-pyrrolidin-3-ylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester	Investigative	44333987	C23H35N3O5	433.5	C[C@@H](C(=O)N[C@H]1CCN(C1)CCCOC2=CC=C(C=C2)C(=O)C)NC(=O)OC(C)(C)C	Ki = 60000 nM	Poor binder
T81905	Histamine H1 receptor	B67YHI	6-Chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)quinoline	Investigative	24894134	C22H17Cl2FN4O	443.3	C1CN(CCC1C2=NC(=NO2)C3=C(C=C(C=C3)F)Cl)C4=CN=C5C=CC(=CC5=C4)Cl	IC50 ~ 50000 nM	Poor binder
T81905	Histamine H2 receptor	B7ORB1	1-[4-[3-[4-(Cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-2-(methylamino)ethanone	Investigative	44304067	C20H29N3O3	359.5	CNCC(=O)N1CCN(CC1)CCCOC2=CC=C(C=C2)C(=O)C3CC3	Ki = 79432.82 nM	Poor binder
T81905	Histamine H1 receptor	B7ORB1	1-[4-[3-[4-(Cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-2-(methylamino)ethanone	Investigative	44304067	C20H29N3O3	359.5	CNCC(=O)N1CCN(CC1)CCCOC2=CC=C(C=C2)C(=O)C3CC3	Ki = 100000 nM	Poor binder
T81905	Histamine H2 receptor	B7R3OU	(2R)-2-Amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]butan-1-one	Investigative	44304211	C21H31N3O3	373.5	CC[C@H](C(=O)N1CCN(CC1)CCCOC2=CC=C(C=C2)C(=O)C3CC3)N	Ki = 100000 nM	Poor binder
T81905	Histamine H1 receptor	B7R3OU	(2R)-2-Amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]butan-1-one	Investigative	44304211	C21H31N3O3	373.5	CC[C@H](C(=O)N1CCN(CC1)CCCOC2=CC=C(C=C2)C(=O)C3CC3)N	Ki = 70794.58 nM	Poor binder
T81905	Histamine H3 receptor	B80OPE	Ethyl 1-[2-[4-(phenylcarbamoylsulfamoyl)phenoxy]ethyl]piperidine-4-carboxylate	Investigative	60145774	C23H29N3O6S	475.6	CCOC(=O)C1CCN(CC1)CCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=CC=C3	IC50 = 77900 nM	Poor binder
T81905	Histamine H2 receptor	B8J9VN	1-[4-[3-[4-(Pyridine-3-carbonyl)piperazin-1-yl]propoxy]phenyl]hexan-1-one	Investigative	44304378	C25H33N3O3	423.5	CCCCCC(=O)C1=CC=C(C=C1)OCCCN2CCN(CC2)C(=O)C3=CN=CC=C3	Ki = 60255.96 nM	Poor binder
T81905	Histamine H4 receptor	B9G7JR	3-(1H-Imidazol-5-yl)propyl N-(4-phenoxybutyl)carbamate	Investigative	73347580	C17H23N3O3	317.4	C1=CC=C(C=C1)OCCCCNC(=O)OCCCC2=CN=CN2	Ki ~ 100000 nM	Poor binder
T81905	Histamine H1 receptor	B9HU8R	(+)-(S)-N,N-Dimethyl-2-(3-(1-(pyridin-3-yl)ethyl)benzo[b]thiophen-2-yl)ethanamine	Investigative	11515125	C19H22N2S	310.5	C[C@@H](C1=CN=CC=C1)C2=C(SC3=CC=CC=C32)CCN(C)C	Ki = 79000 nM	Poor binder
T81905	Histamine H2 receptor	B9OP0K	1-[4-[3-[4-(Cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-2-[(2R)-pyrrolidin-2-yl]ethanone	Investigative	44304332	C23H33N3O3	399.5	C1C[C@@H](NC1)CC(=O)N2CCN(CC2)CCCOC3=CC=C(C=C3)C(=O)C4CC4	Ki = 89125.09 nM	Poor binder
T81905	Histamine H1 receptor	B9OP0K	1-[4-[3-[4-(Cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-2-[(2R)-pyrrolidin-2-yl]ethanone	Investigative	44304332	C23H33N3O3	399.5	C1C[C@@H](NC1)CC(=O)N2CCN(CC2)CCCOC3=CC=C(C=C3)C(=O)C4CC4	Ki = 95499.26 nM	Poor binder
T81905	Histamine H4 receptor	BA7O5P	(2R)-5beta-(4-Imidazolyl)-2,5-dihydrofuran-2beta-methanamine	Investigative	10820930	C8H11N3O	165.19	C1=C[C@H](O[C@H]1CN)C2=CN=CN2	EC50 = 75857.76 nM	Poor binder
T81905	Histamine H2 receptor	BB05UQ	Cyclopropyl(4-(3-(4-((2r)-2-(isopropylamino)propanoyl)-1-piperazinyl)propoxy)phenyl)methanone	Investigative	44304056	C23H35N3O3	401.5	C[C@H](C(=O)N1CCN(CC1)CCCOC2=CC=C(C=C2)C(=O)C3CC3)NC(C)C	Ki = 50118.72 nM	Poor binder
T81905	Histamine H3 receptor	BBG4O2	Ethyl 1-[3-[4-(phenylcarbamoylsulfamoyl)phenoxy]propyl]piperidine-4-carboxylate	Investigative	60143590	C24H31N3O6S	489.6	CCOC(=O)C1CCN(CC1)CCCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=CC=C3	IC50 = 91100 nM	Poor binder
T81905	Histamine H4 receptor	BCBH24	1H-Indol-2-yl-[4-[2-[(4-methoxyphenyl)methyl-pyridin-2-ylamino]ethyl]piperazin-1-yl]methanone	Investigative	57402471	C28H31N5O2	469.6	COC1=CC=C(C=C1)CN(CCN2CCN(CC2)C(=O)C3=CC4=CC=CC=C4N3)C5=CC=CC=N5	EC50 = 104712.85 nM	Poor binder
T81905	Histamine H2 receptor	BD0Y9J	4-[3-[4-(4-Pyridinyl)phenoxy]propyl]piperazine-1-carboxylic acid ethyl ester	Investigative	44335222	C21H27N3O3	369.5	CCOC(=O)N1CCN(CC1)CCCOC2=CC=C(C=C2)C3=CC=NC=C3	Ki = 57543.99 nM	Poor binder
T81905	Histamine H3 receptor	BE9W0I	1-Cyclohexyl-3-[4-(2-piperidin-1-ylethoxy)phenyl]sulfonylurea	Investigative	60145771	C20H31N3O4S	409.5	C1CCC(CC1)NC(=O)NS(=O)(=O)C2=CC=C(C=C2)OCCN3CCCCC3	IC50 = 53800 nM	Poor binder
T81905	Histamine H4 receptor	BG0S4N	6-(4-Fluorophenyl)-7-methyl-4-(4-methylpiperazin-1-yl)pyrrolo[2,3-d]pyrimidin-2-amine	Investigative	71519499	C18H21FN6	340.4	CN1CCN(CC1)C2=NC(=NC3=C2C=C(N3C)C4=CC=C(C=C4)F)N	Ki = 67870 nM	Poor binder
T81905	Histamine H2 receptor	BJ40GP	(2R)-2-Amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-3-(1H-imidazol-5-yl)propan-1-one	Investigative	44304719	C23H31N5O3	425.5	C1CC1C(=O)C2=CC=C(C=C2)OCCCN3CCN(CC3)C(=O)[C@@H](CC4=CN=CN4)N	Ki = 89125.09 nM	Poor binder
T81905	Histamine H1 receptor	BJ40GP	(2R)-2-Amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-3-(1H-imidazol-5-yl)propan-1-one	Investigative	44304719	C23H31N5O3	425.5	C1CC1C(=O)C2=CC=C(C=C2)OCCCN3CCN(CC3)C(=O)[C@@H](CC4=CN=CN4)N	Ki = 95499.26 nM	Poor binder
T81905	Histamine H4 receptor	BJT04R	N-[(4-Methoxyphenyl)methyl]-2-(4-methylpiperazin-1-yl)-6-phenylpyrimidin-4-amine	Investigative	112936352	C23H27N5O	389.5	CN1CCN(CC1)C2=NC(=CC(=N2)NCC3=CC=C(C=C3)OC)C4=CC=CC=C4	Ki = 72443.6 nM	Poor binder
T81905	Histamine H2 receptor	BKN1R4	4-[3-(4'-Methoxy-4-biphenylyloxy)propyl]piperazine-1-carboxylic acid ethyl ester	Investigative	44335350	C23H30N2O4	398.5	CCOC(=O)N1CCN(CC1)CCCOC2=CC=C(C=C2)C3=CC=C(C=C3)OC	Ki = 100000 nM	Poor binder
T81905	Histamine H2 receptor	BL9QI4	(2R)-2-Amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-4,4-dimethylpentan-1-one	Investigative	44304357	C24H37N3O3	415.6	CC(C)(C)C[C@H](C(=O)N1CCN(CC1)CCCOC2=CC=C(C=C2)C(=O)C3CC3)N	Ki = 57543.99 nM	Poor binder
T81905	Histamine H2 receptor	BM15XS	4-[3-[4-[N-(Tert-Butoxycarbonyl)-D-alanyl]piperazino]propoxy]phenylcyclopropyl ketone	Investigative	44304752	C25H37N3O5	459.6	C[C@H](C(=O)N1CCN(CC1)CCCOC2=CC=C(C=C2)C(=O)C3CC3)NC(=O)OC(C)(C)C	Ki = 83176.38 nM	Poor binder
T81905	Histamine H2 receptor	BM78SH	4-[3-[4-(3-Thienyl)phenoxy]propyl]piperazine-1-carboxylic acid ethyl ester	Investigative	44335172	C20H26N2O3S	374.5	CCOC(=O)N1CCN(CC1)CCCOC2=CC=C(C=C2)C3=CSC=C3	Ki = 97723.72 nM	Poor binder
T81905	Histamine H2 receptor	BN9XC0	Ethyl 4-[3-[4-(1H-imidazol-5-yl)phenoxy]propyl]piperazine-1-carboxylate	Investigative	44335428	C19H26N4O3	358.4	CCOC(=O)N1CCN(CC1)CCCOC2=CC=C(C=C2)C3=CN=CN3	Ki = 69183.1 nM	Poor binder
T81905	Histamine H1 receptor	BO0QU4	(1-{(S)-1-[3-(4-Acetyl-phenoxy)-propyl]-pyrrolidin-3-ylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester	Investigative	44334281	C23H35N3O5	433.5	C[C@H](C(=O)N[C@H]1CCN(C1)CCCOC2=CC=C(C=C2)C(=O)C)NC(=O)OC(C)(C)C	Ki = 56000 nM	Poor binder
T81905	Histamine H2 receptor	BO2I5Y	1-{4-[3-((S)-3-Amino-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone	Investigative	44334521	C15H22N2O2	262.35	CC(=O)C1=CC=C(C=C1)OCCCN2CC[C@@H](C2)N	Ki = 50000 nM	Poor binder
T81905	Histamine H1 receptor	BO2I5Y	1-{4-[3-((S)-3-Amino-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone	Investigative	44334521	C15H22N2O2	262.35	CC(=O)C1=CC=C(C=C1)OCCCN2CC[C@@H](C2)N	Ki = 90000 nM	Poor binder
T81905	Histamine H4 receptor	BO3Y2C	6-(4-Fluorophenyl)-N,7-dimethyl-4-(4-methylpiperazin-1-yl)pyrrolo[2,3-d]pyrimidin-2-amine	Investigative	71519500	C19H23FN6	354.4	CNC1=NC2=C(C=C(N2C)C3=CC=C(C=C3)F)C(=N1)N4CCN(CC4)C	Ki ~ 100000 nM	Poor binder
T81905	Histamine H3 receptor	BOQK19	1-(2,5-Dichlorophenyl)-3-[4-(2-piperidin-1-ylethoxy)phenyl]sulfonylurea	Investigative	60145772	C20H23Cl2N3O4S	472.4	C1CCN(CC1)CCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=C(C=CC(=C3)Cl)Cl	IC50 = 93600 nM	Poor binder
T81905	Histamine H4 receptor	BP2LA6	1H-Indol-2-yl-[4-[2-[2-[(4-methoxyphenyl)methyl-pyridin-2-ylamino]ethyl-methylamino]ethyl]piperazin-1-yl]methanone	Investigative	57402472	C31H38N6O2	526.7	CN(CCN1CCN(CC1)C(=O)C2=CC3=CC=CC=C3N2)CCN(CC4=CC=C(C=C4)OC)C5=CC=CC=N5	EC50 ~ 100000 nM	Poor binder
T81905	Histamine H3 receptor	BP6IN4	N-(3-Bromo-4-(2-morpholinoethoxy)phenethyl)-1H-pyrrole-2-carboxamide	Investigative	45266943	C19H24BrN3O3	422.3	C1COCCN1CCOC2=C(C=C(C=C2)CCNC(=O)C3=CC=CN3)Br	IC50 = 59200 nM	Poor binder
T81905	Histamine H2 receptor	BQDY04	(3R)-3-Amino-4-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-4-oxobutanenitrile	Investigative	44304003	C21H28N4O3	384.5	C1CC1C(=O)C2=CC=C(C=C2)OCCCN3CCN(CC3)C(=O)[C@@H](CC#N)N	Ki = 72443.6 nM	Poor binder
T81905	Histamine H4 receptor	BS9H6L	2-[2-(3H-Imidazol-4-yl)-ethyl]-pyridine	Investigative	11206058	C10H11N3	173.21	C1=CC=NC(=C1)CCC2=CN=CN2	EC50 = 58884.37 nM	Poor binder
T81905	Histamine H2 receptor	BSLC85	N,N-Dimethyl-4-[1-oxo-2-(2-pyrrolidin-1-ylethyl)-3,4-dihydroisoquinolin-6-yl]benzamide	Investigative	25218397	C24H29N3O2	391.5	CN(C)C(=O)C1=CC=C(C=C1)C2=CC3=C(C=C2)C(=O)N(CC3)CCN4CCCC4	Ki ~ 55000 nM	Poor binder
T81905	Histamine H4 receptor	BU2D1Q	4-[4-(Dimethylamino)phenyl]-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine	Investigative	90645156	C16H23N7	313.4	CN1CCN(CC1)C2=NC(=NC(=N2)N)C3=CC=C(C=C3)N(C)C	Ki = 64490 nM	Poor binder
T81905	Histamine H3 receptor	BV21SP	1-Cyano-3-[[(2S,5S)-5-(1H-imidazol-5-yl)oxolan-2-yl]methyl]-2-methylguanidine	Investigative	10879463	C11H16N6O	248.28	CN=C(NC[C@@H]1CC[C@H](O1)C2=CN=CN2)NC#N	EC50 ~ 100000 nM	Poor binder
T81905	Histamine H2 receptor	BVEL93	(1-{(S)-1-[3-(4-Acetyl-phenoxy)-propyl]-pyrrolidin-3-ylcarbamoyl}-2-hydroxy-ethyl)-carbamic acid tert-butyl ester	Investigative	44334252	C23H35N3O6	449.5	CC(=O)C1=CC=C(C=C1)OCCCN2CC[C@@H](C2)NC(=O)[C@@H](CO)NC(=O)OC(C)(C)C	Ki = 100000 nM	Poor binder
T81905	Histamine H1 receptor	BVEL93	(1-{(S)-1-[3-(4-Acetyl-phenoxy)-propyl]-pyrrolidin-3-ylcarbamoyl}-2-hydroxy-ethyl)-carbamic acid tert-butyl ester	Investigative	44334252	C23H35N3O6	449.5	CC(=O)C1=CC=C(C=C1)OCCCN2CC[C@@H](C2)NC(=O)[C@@H](CO)NC(=O)OC(C)(C)C	Ki = 80000 nM	Poor binder
T81905	Histamine H2 receptor	BWKY50	4-[3-(4-beta-Alanylpiperazino)propoxy]phenylcyclopropyl ketone	Investigative	10451094	C20H29N3O3	359.5	C1CC1C(=O)C2=CC=C(C=C2)OCCCN3CCN(CC3)C(=O)CCN	Ki = 100000 nM	Poor binder
T81905	Histamine H2 receptor	BWY42X	Ethyl 4-[3-[4-(3-methylbutanoyl)phenoxy]propyl]piperazine-1-carboxylate	Investigative	44304079	C21H32N2O4	376.5	CCOC(=O)N1CCN(CC1)CCCOC2=CC=C(C=C2)C(=O)CC(C)C	Ki = 69183.1 nM	Poor binder
T81905	Histamine H4 receptor	BX67QY	(2S)-5beta-(4-Imidazolyl)-2,5-dihydrofuran-2alpha-methanamine	Investigative	10820929	C8H11N3O	165.19	C1=C[C@H](O[C@@H]1CN)C2=CN=CN2	EC50 = 85113.8 nM	Poor binder
T81905	Histamine H2 receptor	BXA2W8	Cyclopropyl-[4-[3-[4-[(2R)-pyrrolidine-2-carbonyl]piperazin-1-yl]propoxy]phenyl]methanone	Investigative	44304329	C22H31N3O3	385.5	C1C[C@@H](NC1)C(=O)N2CCN(CC2)CCCOC3=CC=C(C=C3)C(=O)C4CC4	Ki = 53703.18 nM	Poor binder
T81905	Histamine H3 receptor	BXS9L4	1-[4-(2-Pyrrolidin-1-ylethoxy)phenyl]sulfonyl-3-[4-(trifluoromethyl)phenyl]urea	Investigative	60145633	C20H22F3N3O4S	457.5	C1CCN(C1)CCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=C(C=C3)C(F)(F)F	IC50 = 107000 nM	Poor binder
T81905	Histamine H3 receptor	BXZ17O	6-(4-Fluorophenyl)-4-piperazin-1-yl-7H-pyrrolo[2,3-d]pyrimidin-2-amine	Investigative	71519012	C16H17FN6	312.34	C1CN(CCN1)C2=NC(=NC3=C2C=C(N3)C4=CC=C(C=C4)F)N	Ki = 84660 nM	Poor binder
T81905	Histamine H2 receptor	BZ2RD3	(2R)-2-Amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]pentan-1-one	Investigative	44304348	C22H33N3O3	387.5	CCC[C@H](C(=O)N1CCN(CC1)CCCOC2=CC=C(C=C2)C(=O)C3CC3)N	Ki = 60255.96 nM	Poor binder
T81905	Histamine H1 receptor	BZTC89	N-[(3S)-1-[3-[4-(Cyclopropylcarbonyl)phenoxy]propyl]pyrrolidine-3beta-yl]-1-methyl-1H-imidazole-4-sulfonamide	Investigative	44334234	C21H28N4O4S	432.5	CN1C=C(N=C1)S(=O)(=O)N[C@H]2CCN(C2)CCCOC3=CC=C(C=C3)C(=O)C4CC4	Ki = 91000 nM	Poor binder
T81905	Histamine H2 receptor	D05BYD	A-304121	Investigative	9906860	C20H29N3O3	359.5	C[C@H](C(=O)N1CCN(CC1)CCCOC2=CC=C(C=C2)C(=O)C3CC3)N	Ki = 70794.58 nM	Poor binder
T81905	Histamine H1 receptor	D05BYD	A-304121	Investigative	9906860	C20H29N3O3	359.5	C[C@H](C(=O)N1CCN(CC1)CCCOC2=CC=C(C=C2)C(=O)C3CC3)N	Ki = 69183.1 nM	Poor binder