TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T82665	Protein arginine methyltransferase 5	B1FM3R	1-[(2R)-3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-4-phenylpyridin-2-one	Investigative	76684617	C23H24N2O2	360.4	C1CN(CC2=CC=CC=C21)C[C@H](CN3C=CC(=CC3=O)C4=CC=CC=C4)O	EC50 ~ 50000 nM	Poor binder
T82665	Protein arginine methyltransferase 5	B26EXR	Furamidine	Investigative	126437	C18H16N4O	304.3	C1=CC(=CC=C1C2=CC=C(O2)C3=CC=C(C=C3)C(=N)N)C(=N)N	IC50 = 166000 nM	Poor binder
T82665	Protein arginine methyltransferase 5	B29ZVO	6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	Investigative	78357767	C23H35N5O2	413.6	COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCCC3)NCCCCCN4CCCC4)OC	IC50 ~ 100000 nM	Poor binder
T82665	Protein arginine methyltransferase 5	B5TO7B	1-[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-4-(2-methylphenyl)piperazin-2-one	Investigative	76684615	C23H29N3O2	379.5	CC1=CC=CC=C1N2CCN(C(=O)C2)CC(CN3CCC4=CC=CC=C4C3)O	EC50 ~ 50000 nM	Poor binder
T82665	Protein arginine methyltransferase 5	B69BKW	N-[(3-Bromophenyl)methyl]-1-[2-(methylamino)ethyl]piperidin-4-amine	Investigative	137635057	C15H24BrN3	326.27	CNCCN1CCC(CC1)NCC2=CC(=CC=C2)Br	IC50 ~ 50000 nM	Poor binder
T82665	Protein arginine methyltransferase 5	B7X0JK	1-[(2S)-3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-4-phenylpyridin-2-one	Investigative	76684620	C23H24N2O2	360.4	C1CN(CC2=CC=CC=C21)C[C@@H](CN3C=CC(=CC3=O)C4=CC=CC=C4)O	EC50 ~ 50000 nM	Poor binder
T82665	Protein arginine methyltransferase 5	B81KFO	5-[5-(4-Carbamimidoylphenyl)furan-2-yl]pyridine-2-carboximidamide	Investigative	10979651	C17H15N5O	305.33	C1=CC(=CC=C1C2=CC=C(O2)C3=CN=C(C=C3)C(=N)N)C(=N)N	IC50 = 186000 nM	Poor binder
T82665	Protein arginine methyltransferase 5	BD0SZ2	1-[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-4-(2-fluorophenyl)piperazin-2-one	Investigative	76684616	C22H26FN3O2	383.5	C1CN(CC2=CC=CC=C21)CC(CN3CCN(CC3=O)C4=CC=CC=C4F)O	EC50 ~ 50000 nM	Poor binder
T82665	Protein arginine methyltransferase 5	BD3X9I	N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indazole-4-carboxamide	Investigative	67466175	C29H35N7O2	513.6	CC1=CC(=C(C(=O)N1)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)C)C(C)C)C	IC50 ~ 100000 nM	Poor binder
T82665	Protein arginine methyltransferase 5	BG5T4E	N'-[[2-(2-Chlorophenyl)sulfanylphenyl]methyl]-N'-methylethane-1,2-diamine	Investigative	137655207	C16H19ClN2S	306.9	CN(CCN)CC1=CC=CC=C1SC2=CC=CC=C2Cl	IC50 ~ 100000 nM	Poor binder
T82665	Protein arginine methyltransferase 5	BLA4S9	N-[(6-Methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-propan-2-ylindazole-4-carboxamide	Investigative	54596764	C31H39N7O2	541.7	CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)C)C(C)C	IC50 ~ 100000 nM	Poor binder
T82665	Protein arginine methyltransferase 5	BNG2R6	4-[[6-(4-Cyanoanilino)-5-nitropyrimidin-4-yl]amino]benzenecarboximidamide	Investigative	122195095	C18H14N8O2	374.4	C1=CC(=CC=C1C#N)NC2=C(C(=NC=N2)NC3=CC=C(C=C3)C(=N)N)[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T82665	Protein arginine methyltransferase 5	BNY74G	N-Benzyl-1-[2-(methylamino)ethyl]piperidin-4-amine	Investigative	137661881	C15H25N3	247.38	CNCCN1CCC(CC1)NCC2=CC=CC=C2	IC50 ~ 50000 nM	Poor binder
T82665	Protein arginine methyltransferase 5	BVNU32	1-(2-((((2S,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)ethyl)-3-ethylurea	Investigative	122178085	C15H23N7O4S	397.5	CCNC(=O)NCCSC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O	IC50 ~ 50000 nM	Poor binder
T82665	Protein arginine methyltransferase 5	D02TVQ	GSK343	Investigative	71268957	C31H39N7O2	541.7	CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC(=NC=C4)N5CCN(CC5)C)C(C)C	IC50 ~ 100000 nM	Poor binder
T82665	Protein arginine methyltransferase 5	D09CLP	(L-)-S-adenosyl-L-homocysteine	Investigative	439155	C14H20N6O5S	384.41	C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CSCC[C@@H](C(=O)O)N)O)O)N	IC50 ~ 50000 nM	Poor binder