TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T83193 Transient receptor potential cation channel V1 D0BQ8Y Allyl isothiocyanate Approved 5971 C4H5NS 99.16 C=CCN=C=S EC50 = 160000 nM Poor binder T83193 Transient receptor potential cation channel V1 D07AOL PEITC Phase 2 16741 C9H9NS 163.24 C1=CC=C(C=C1)CCN=C=S EC50 = 180000 nM Poor binder T83193 Transient receptor potential cation channel V1 B03AHT 5-[[4-[3-(Hydroxymethyl)phenyl]phenyl]methyl]-N,N-dimethyltetrazole-2-carboxamide Investigative 72197629 C18H19N5O2 337.4 CN(C)C(=O)N1N=C(N=N1)CC2=CC=C(C=C2)C3=CC=CC(=C3)CO IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B0C9DW Sec-Butyl isothiocyanate Investigative 78151 C5H9NS 115.2 CCC(C)N=C=S EC50 = 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B0ID8L [(2Z)-3,7-Dimethylocta-2,6-dienyl] 3-methylbenzoate Investigative 118720717 C18H24O2 272.4 CC1=CC(=CC=C1)C(=O)OC/C=C(/C)\\CCC=C(C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B10IGE 5-[[4-(2-Hydroxyphenyl)phenyl]methyl]-N,N-dimethyltetrazole-2-carboxamide Investigative 72197631 C17H17N5O2 323.35 CN(C)C(=O)N1N=C(N=N1)CC2=CC=C(C=C2)C3=CC=CC=C3O IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B13PZI Geranyl acetate Investigative 1549026 C12H20O2 196.29 CC(=CCC/C(=C/COC(=O)C)/C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B1G9DK Methyl 3-[4-[[2-(dimethylcarbamoyl)tetrazol-5-yl]methyl]phenyl]benzoate Investigative 72197628 C19H19N5O3 365.4 CN(C)C(=O)N1N=C(N=N1)CC2=CC=C(C=C2)C3=CC(=CC=C3)C(=O)OC IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B23TXF 2-Methoxy-4-[2-[(Z)-octadec-9-enyl]tetrazol-5-yl]phenol Investigative 137007155 C26H42N4O2 442.6 CCCCCCCC/C=C\\CCCCCCCCN1N=C(N=N1)C2=CC(=C(C=C2)O)OC IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B29QYJ Chembl4244422 Investigative 145985756 C21H32O2 316.5 CCCCCC1=CC(=C2C[C@H]3[C@@](CCCC3(C)C)(OC2=C1)C)O IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B2DO5U [(2E)-3,7-Dimethylocta-2,6-dienyl] 4-methylbenzoate Investigative 118720705 C18H24O2 272.4 CC1=CC=C(C=C1)C(=O)OC/C=C(\\C)/CCC=C(C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B2FZA1 Nerol Investigative 643820 C10H18O 154.25 CC(=CCC/C(=C\\CO)/C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B39DNQ 5-[[4-[4-(Hydroxymethyl)phenyl]phenyl]methyl]-N,N-dimethyltetrazole-1-carboxamide Investigative 72197269 C18H19N5O2 337.4 CN(C)C(=O)N1C(=NN=N1)CC2=CC=C(C=C2)C3=CC=C(C=C3)CO IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B39NEC 5-[[4-(3-Acetylphenyl)phenyl]methyl]-N,N-dimethyltetrazole-2-carboxamide Investigative 72197447 C19H19N5O2 349.4 CC(=O)C1=CC=CC(=C1)C2=CC=C(C=C2)CC3=NN(N=N3)C(=O)N(C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B3OM4H 1-(4-Tert-butylphenyl)-3-[(2E)-3,7-dimethylocta-2,6-dienyl]urea Investigative 118720715 C21H32N2O 328.5 CC(=CCC/C(=C/CNC(=O)NC1=CC=C(C=C1)C(C)(C)C)/C)C IC50 = 76800 nM Poor binder T83193 Transient receptor potential cation channel V1 B3V4DY N,N-Dimethyl-5-[[4-(3-methylphenyl)phenyl]methyl]tetrazole-2-carboxamide Investigative 72197808 C18H19N5O 321.4 CC1=CC(=CC=C1)C2=CC=C(C=C2)CC3=NN(N=N3)C(=O)N(C)C IC50 = 78900 nM Poor binder T83193 Transient receptor potential cation channel V1 B3WNM7 [(2Z)-3,7-Dimethylocta-2,6-dienyl] 2-(4-methoxyphenyl)acetate Investigative 118720721 C19H26O3 302.4 CC(=CCC/C(=C\\COC(=O)CC1=CC=C(C=C1)OC)/C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B48FGA [(2E)-3,7-Dimethylocta-2,6-dienyl] 2-(4-methoxyphenyl)acetate Investigative 118720710 C19H26O3 302.4 CC(=CCC/C(=C/COC(=O)CC1=CC=C(C=C1)OC)/C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B4DAE7 (4-Tert-butylphenyl) N-[(2Z)-3,7-dimethylocta-2,6-dienyl]carbamate Investigative 118720729 C21H31NO2 329.5 CC(=CCC/C(=C\\CNC(=O)OC1=CC=C(C=C1)C(C)(C)C)/C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B4IHQ7 5-[[4-(2-Hydroxyphenyl)phenyl]methyl]-N,N-dimethyltetrazole-1-carboxamide Investigative 72197270 C17H17N5O2 323.35 CN(C)C(=O)N1C(=NN=N1)CC2=CC=C(C=C2)C3=CC=CC=C3O IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B4P8TJ 5-Hydroxy-1-[4-hydroxy-3,5-di(propan-2-yl)phenyl]decan-3-one Investigative 57394365 C22H36O3 348.5 CCCCCC(CC(=O)CCC1=CC(=C(C(=C1)C(C)C)O)C(C)C)O IC50 ~ 50000 nM Poor binder T83193 Transient receptor potential cation channel V1 B4ZD3F 3,7-Dimethyloct-6-enyl 4-methylbenzoate Investigative 20807401 C18H26O2 274.4 CC1=CC=C(C=C1)C(=O)OCCC(C)CCC=C(C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B5B4CM Methyl 2-[5-[(4-phenylphenyl)methyl]tetrazol-1-yl]acetate Investigative 44448578 C17H16N4O2 308.33 COC(=O)CN1C(=NN=N1)CC2=CC=C(C=C2)C3=CC=CC=C3 EC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B5QW3I [(2Z)-3,7-Dimethylocta-2,6-dienyl] 4-methylbenzoate Investigative 118720716 C18H24O2 272.4 CC1=CC=C(C=C1)C(=O)OC/C=C(/C)\\CCC=C(C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B5YRN7 5-[[4-(4-Hydroxyphenyl)phenyl]methyl]-N,N-dimethyltetrazole-2-carboxamide Investigative 72197633 C17H17N5O2 323.35 CN(C)C(=O)N1N=C(N=N1)CC2=CC=C(C=C2)C3=CC=C(C=C3)O IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B6PB4U N,N-Dimethyl-2-[5-[(4-phenylphenyl)methyl]tetrazol-2-yl]acetamide Investigative 44448647 C18H19N5O 321.4 CN(C)C(=O)CN1N=C(N=N1)CC2=CC=C(C=C2)C3=CC=CC=C3 EC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B6RVI0 N-[[1-(2-Oxopropyl)tetrazol-5-yl]methyl]-4-phenylbenzamide Investigative 44448577 C18H17N5O2 335.4 CC(=O)CN1C(=NN=N1)CNC(=O)C2=CC=C(C=C2)C3=CC=CC=C3 EC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B70OEC 3,7-Dimethyloct-6-enyl 3-phenylpropanoate Investigative 118720733 C19H28O2 288.4 CC(CCC=C(C)C)CCOC(=O)CCC1=CC=CC=C1 IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B7GR8Z 5-[[4-(4-Hydroxyphenyl)phenyl]methyl]-N,N-dimethyltetrazole-1-carboxamide Investigative 72197442 C17H17N5O2 323.35 CN(C)C(=O)N1C(=NN=N1)CC2=CC=C(C=C2)C3=CC=C(C=C3)O IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B7IGH0 Chembl4241477 Investigative 145983507 C28H40O2 408.6 CCCCCC1=CC(=C2CCC(OC2=C1)(C)CCCC(C)(C)C3=CC=C(C=C3)C)O IC50 ~ 50000 nM Poor binder T83193 Transient receptor potential cation channel V1 B7JAK1 [(2Z)-3,7-Dimethylocta-2,6-dienyl] N-(4-tert-butylphenyl)carbamate Investigative 118720730 C21H31NO2 329.5 CC(=CCC/C(=C\\COC(=O)NC1=CC=C(C=C1)C(C)(C)C)/C)C IC50 = 74600 nM Poor binder T83193 Transient receptor potential cation channel V1 B7RH2A N-[(2Z)-3,7-Dimethylocta-2,6-dienyl]-3-phenylpropanamide Investigative 118720726 C19H27NO 285.4 CC(=CCC/C(=C\\CNC(=O)CCC1=CC=CC=C1)/C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B7YXS0 Voacangine hydroxyindolenine Investigative 22296670 C22H28N2O4 384.5 CC[C@H]1C[C@@H]2C[C@@]3([C@H]1N(C2)CC[C@]4(C3=NC5=C4C=C(C=C5)OC)O)C(=O)OC IC50 = 141000 nM Poor binder T83193 Transient receptor potential cation channel V1 B8C9XQ 2-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]benzamide Investigative 89717400 C17H16N2O3 296.32 C1=CC=C(C(=C1)C(=O)NCCC2=CNC3=C2C=C(C=C3)O)O IC50 = 70000 nM Poor binder T83193 Transient receptor potential cation channel V1 B8JKM7 [(1S,15R,17S,18S)-17-Ethyl-7-methoxy-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4(9),5,7-tetraen-1-yl]methanol Investigative 12444907 C21H28N2O2 340.5 CC[C@H]1C[C@@H]2C[C@@]3([C@H]1N(C2)CCC4=C3NC5=C4C=C(C=C5)OC)CO IC50 = 200000 nM Poor binder T83193 Transient receptor potential cation channel V1 B8YA2W [(2Z)-3,7-Dimethylocta-2,6-dienyl] 2-(3-iodophenyl)acetate Investigative 118720722 C18H23IO2 398.3 CC(=CCC/C(=C\\COC(=O)CC1=CC(=CC=C1)I)/C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B94ZHE N-[2-(4-Hydroxyphenyl)ethyl]octanamide Investigative 10967355 C16H25NO2 263.37 CCCCCCCC(=O)NCCC1=CC=C(C=C1)O EC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 B9JS5O 3,7-Dimethyloct-6-enyl 2-(4-chlorophenyl)acetate Investigative 118720732 C18H25ClO2 308.8 CC(CCC=C(C)C)CCOC(=O)CC1=CC=C(C=C1)Cl IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BA54UB Chembl4238978 Investigative 145984205 C21H31IO2 442.4 CCCCCC1=CC(=C2C[C@H]3[C@@](CC[C@H](C3(C)C)I)(OC2=C1)C)O IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BA9MN1 N,N-Dimethyl-5-[[4-(2-methylphenyl)phenyl]methyl]tetrazole-1-carboxamide Investigative 72197444 C18H19N5O 321.4 CC1=CC=CC=C1C2=CC=C(C=C2)CC3=NN=NN3C(=O)N(C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BAL4K8 [(2Z)-3,7-Dimethylocta-2,6-dienyl] 2-(4-methylphenyl)acetate Investigative 118720719 C19H26O2 286.4 CC1=CC=C(C=C1)CC(=O)OC/C=C(/C)\\CCC=C(C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BAW89B [(2E)-3,7-Dimethylocta-2,6-dienyl] 2-(4-chlorophenyl)acetate Investigative 118720709 C18H23ClO2 306.8 CC(=CCC/C(=C/COC(=O)CC1=CC=C(C=C1)Cl)/C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BBZG36 [(2Z)-3,7-Dimethylocta-2,6-dienyl] 2-(4-chlorophenyl)acetate Investigative 118720720 C18H23ClO2 306.8 CC(=CCC/C(=C\\COC(=O)CC1=CC=C(C=C1)Cl)/C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BC9BK4 5-[[4-[3-(Hydroxymethyl)phenyl]phenyl]methyl]-N,N-dimethyltetrazole-1-carboxamide Investigative 72197268 C18H19N5O2 337.4 CN(C)C(=O)N1C(=NN=N1)CC2=CC=C(C=C2)C3=CC=CC(=C3)CO IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BCTM76 5-[[4-[4-(Hydroxymethyl)phenyl]phenyl]methyl]-N,N-dimethyltetrazole-2-carboxamide Investigative 72197630 C18H19N5O2 337.4 CN(C)C(=O)N1N=C(N=N1)CC2=CC=C(C=C2)C3=CC=C(C=C3)CO IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BDF3X9 [(2E)-3,7-Dimethylocta-2,6-dienyl] 3-methylbenzoate Investigative 58543815 C18H24O2 272.4 CC1=CC(=CC=C1)C(=O)OC/C=C(\\C)/CCC=C(C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BDS27Z [(Z,7R)-18-[5-(4-Hydroxy-3-methoxyphenyl)tetrazol-2-yl]octadec-9-en-7-yl] 2-phenylacetate Investigative 137007157 C34H48N4O4 576.8 CCCCCC[C@H](C/C=C\\CCCCCCCCN1N=C(N=N1)C2=CC(=C(C=C2)O)OC)OC(=O)CC3=CC=CC=C3 IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BEG0U1 Neryl acetate Investigative 1549025 C12H20O2 196.29 CC(=CCC/C(=C\\COC(=O)C)/C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BEP58M Citronellol Investigative 8842 C10H20O 156.26 CC(CCC=C(C)C)CCO IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BF2S7L 5-[[4-(3-Hydroxyphenyl)phenyl]methyl]-N,N-dimethyltetrazole-1-carboxamide Investigative 72197441 C17H17N5O2 323.35 CN(C)C(=O)N1C(=NN=N1)CC2=CC=C(C=C2)C3=CC(=CC=C3)O IC50 = 67400 nM Poor binder T83193 Transient receptor potential cation channel V1 BF4R2D 1-[5-[(4-Phenylphenyl)methyl]tetrazol-2-yl]propan-2-one Investigative 44448618 C17H16N4O 292.33 CC(=O)CN1N=C(N=N1)CC2=CC=C(C=C2)C3=CC=CC=C3 EC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BG5RW0 (R)-8-{5-[3-Methyl-4-(trifluoromethyl)phenyl]oxazol-2-ylamino}-1,2,3,4-tetrahydronaphthalen-2-ol Investigative 25270198 C21H19F3N2O2 388.4 CC1=C(OC(=N1)NC2=CC=CC3=C2C[C@@H](CC3)O)C4=CC=C(C=C4)C(F)(F)F IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BG84NW Neryl 3-phenylpropanoate Investigative 118720724 C19H26O2 286.4 CC(=CCC/C(=C\\COC(=O)CCC1=CC=CC=C1)/C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BGX7R8 4-[2-[(Z,12R)-12-Hydroxyoctadec-9-enyl]tetrazol-5-yl]-2-methoxyphenol Investigative 137007156 C26H42N4O3 458.6 CCCCCC[C@H](C/C=C\\CCCCCCCCN1N=C(N=N1)C2=CC(=C(C=C2)O)OC)O IC50 = 57500 nM Poor binder T83193 Transient receptor potential cation channel V1 BH5W2L Methyl 2-[5-[(4-phenylphenyl)methyl]tetrazol-2-yl]acetate Investigative 44448579 C17H16N4O2 308.33 COC(=O)CN1N=C(N=N1)CC2=CC=C(C=C2)C3=CC=CC=C3 EC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BHC56B 5-Hydroxy-1-[4-hydroxy-3,5-di(propan-2-yl)phenyl]-6-phenylhexan-3-one Investigative 57334564 C24H32O3 368.5 CC(C)C1=CC(=CC(=C1O)C(C)C)CCC(=O)CC(CC2=CC=CC=C2)O IC50 ~ 50000 nM Poor binder T83193 Transient receptor potential cation channel V1 BHZ4F0 (4-Tert-butylphenyl) N-[(2E)-3,7-dimethylocta-2,6-dienyl]carbamate Investigative 118720714 C21H31NO2 329.5 CC(=CCC/C(=C/CNC(=O)OC1=CC=C(C=C1)C(C)(C)C)/C)C IC50 = 92300 nM Poor binder T83193 Transient receptor potential cation channel V1 BI1MD3 N-[[2-(Cyanomethyl)tetrazol-5-yl]methyl]-4-phenylbenzamide Investigative 44448505 C17H14N6O 318.33 C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)NCC3=NN(N=N3)CC#N EC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BI89BX 2-[5-[(4-Phenylphenyl)methyl]tetrazol-1-yl]acetonitrile Investigative 44448615 C16H13N5 275.31 C1=CC=C(C=C1)C2=CC=C(C=C2)CC3=NN=NN3CC#N EC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BJ8S1N N,N-Dimethyl-2-[5-[(4-phenylphenyl)methyl]tetrazol-1-yl]acetamide Investigative 44448650 C18H19N5O 321.4 CN(C)C(=O)CN1C(=NN=N1)CC2=CC=C(C=C2)C3=CC=CC=C3 EC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BK7LA8 Benzenepropanoic acid, 3,7-dimethylocta-2,6-dienyl ester Investigative 5366045 C19H26O2 286.4 CC(=CCC/C(=C/COC(=O)CCC1=CC=CC=C1)/C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BK7QN6 5-Benzoyl-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2,3-dihydro-1H-pyrrolizine-1-carboxamide Investigative 118723544 C25H23N3O3 413.5 C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)NCCC4=CNC5=C4C=C(C=C5)O IC50 = 70000 nM Poor binder T83193 Transient receptor potential cation channel V1 BKOP41 N-[(2E)-3,7-Dimethylocta-2,6-dienyl]-3-phenylpropanamide Investigative 118720712 C19H27NO 285.4 CC(=CCC/C(=C/CNC(=O)CCC1=CC=CC=C1)/C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BL40TB N,N-Dimethyl-5-[[4-(4-methylphenyl)phenyl]methyl]tetrazole-1-carboxamide Investigative 72197446 C18H19N5O 321.4 CC1=CC=C(C=C1)C2=CC=C(C=C2)CC3=NN=NN3C(=O)N(C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BL9RP2 N-[[2-[2-(Dimethylamino)-2-oxoethyl]tetrazol-5-yl]methyl]-4-phenylbenzamide Investigative 44448576 C19H20N6O2 364.4 CN(C)C(=O)CN1N=C(N=N1)CNC(=O)C2=CC=C(C=C2)C3=CC=CC=C3 EC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BLVA65 Isopropyl isothiocyanate Investigative 75263 C4H7NS 101.17 CC(C)N=C=S EC50 = 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BM2VC7 1-(1,3-Benzodioxol-5-yl)-5-hydroxy-6-phenylhexan-3-one Investigative 57392653 C19H20O4 312.4 C1OC2=C(O1)C=C(C=C2)CCC(=O)CC(CC3=CC=CC=C3)O IC50 ~ 50000 nM Poor binder T83193 Transient receptor potential cation channel V1 BO1ZU6 4-Methoxyphenyl-(1R,2S,5R)-2-isopropyl-5-methylcyclohexylcarbamate Investigative 46887829 C18H27NO3 305.4 C[C@@H]1CC[C@H]([C@@H](C1)NC(=O)OC2=CC=C(C=C2)OC)C(C)C EC50 = 53800 nM Poor binder T83193 Transient receptor potential cation channel V1 BO5XM1 N,N-Dimethyl-5-[[4-(3-methylphenyl)phenyl]methyl]tetrazole-1-carboxamide Investigative 72197445 C18H19N5O 321.4 CC1=CC(=CC=C1)C2=CC=C(C=C2)CC3=NN=NN3C(=O)N(C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BOS84P N-[[1-(Cyanomethyl)tetrazol-5-yl]methyl]-4-phenylbenzamide Investigative 44448536 C17H14N6O 318.33 C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)NCC3=NN=NN3CC#N EC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BOX84C N,N-Dimethyl-5-[[4-(2-methylphenyl)phenyl]methyl]tetrazole-2-carboxamide Investigative 72197807 C18H19N5O 321.4 CC1=CC=CC=C1C2=CC=C(C=C2)CC3=NN(N=N3)C(=O)N(C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BOY12A 1-(1,3-Benzodioxol-5-yl)-5-hydroxydecan-3-one Investigative 57390833 C17H24O4 292.4 CCCCCC(CC(=O)CCC1=CC2=C(C=C1)OCO2)O IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BP0V8T 1-[5-[(4-Phenylphenyl)methyl]tetrazol-1-yl]propan-2-one Investigative 44448648 C17H16N4O 292.33 CC(=O)CN1C(=NN=N1)CC2=CC=C(C=C2)C3=CC=CC=C3 EC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BP60EU Methyl 3-[4-[[1-(dimethylcarbamoyl)tetrazol-5-yl]methyl]phenyl]benzoate Investigative 72197267 C19H19N5O3 365.4 CN(C)C(=O)N1C(=NN=N1)CC2=CC=C(C=C2)C3=CC(=CC=C3)C(=O)OC IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BPD29W [(2E)-3,7-Dimethylocta-2,6-dienyl] 3,5-bis(trifluoromethyl)benzoate Investigative 118720707 C19H20F6O2 394.4 CC(=CCC/C(=C/COC(=O)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)/C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BPQ18C 5-[[4-(3-Hydroxyphenyl)phenyl]methyl]-N,N-dimethyltetrazole-2-carboxamide Investigative 72197632 C17H17N5O2 323.35 CN(C)C(=O)N1N=C(N=N1)CC2=CC=C(C=C2)C3=CC(=CC=C3)O IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BS0VJ1 5-[[4-(3-Carbamoylphenyl)phenyl]methyl]-N,N-dimethyltetrazole-1-carboxamide Investigative 72197443 C18H18N6O2 350.4 CN(C)C(=O)N1C(=NN=N1)CC2=CC=C(C=C2)C3=CC(=CC=C3)C(=O)N IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BSH5E6 2-[5-[(4-Phenylphenyl)methyl]tetrazol-2-yl]acetonitrile Investigative 44448613 C16H13N5 275.31 C1=CC=C(C=C1)C2=CC=C(C=C2)CC3=NN(N=N3)CC#N EC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BT7A6J 3,7-Dimethyloct-6-enyl 2-(4-methylphenyl)acetate Investigative 118720731 C19H28O2 288.4 CC1=CC=C(C=C1)CC(=O)OCCC(C)CCC=C(C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BTFS13 Citronellyl acetate Investigative 9017 C12H22O2 198.3 CC(CCC=C(C)C)CCOC(=O)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BU05MB [(2E)-3,7-Dimethylocta-2,6-dienyl] 2-(4-methylphenyl)acetate Investigative 118720708 C19H26O2 286.4 CC1=CC=C(C=C1)CC(=O)OC/C=C(\\C)/CCC=C(C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BUX9R8 1-(2-(5-Hydroxy-1H-indol-2-yl)ethyl)-3-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]urea Investigative 46887831 C21H31N3O2 357.5 C[C@@H]1CC[C@H]([C@@H](C1)NC(=O)NCCC2=CC3=C(N2)C=CC(=C3)O)C(C)C EC50 = 52200 nM Poor binder T83193 Transient receptor potential cation channel V1 BV93OU Methyl 2-[5-[[(4-phenylbenzoyl)amino]methyl]tetrazol-2-yl]acetate Investigative 44448494 C18H17N5O3 351.4 COC(=O)CN1N=C(N=N1)CNC(=O)C2=CC=C(C=C2)C3=CC=CC=C3 EC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BW9SG8 N-[[2-(2-Oxopropyl)tetrazol-5-yl]methyl]-4-phenylbenzamide Investigative 44448542 C18H17N5O2 335.4 CC(=O)CN1N=C(N=N1)CNC(=O)C2=CC=C(C=C2)C3=CC=CC=C3 EC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BX2E6M [(2E)-3,7-Dimethylocta-2,6-dienyl] 4-cyanobenzoate Investigative 118720706 C18H21NO2 283.4 CC(=CCC/C(=C/COC(=O)C1=CC=C(C=C1)C#N)/C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BXG72P 5-[[4-(3-Carbamoylphenyl)phenyl]methyl]-N,N-dimethyltetrazole-2-carboxamide Investigative 72197634 C18H18N6O2 350.4 CN(C)C(=O)N1N=C(N=N1)CC2=CC=C(C=C2)C3=CC(=CC=C3)C(=O)N IC50 = 91800 nM Poor binder T83193 Transient receptor potential cation channel V1 BXQU01 Cyclopropanecarboxamide, N-((2E)-3,7-dimethyl-2,6-octadien-1-yl)- Investigative 11658617 C14H23NO 221.34 CC(=CCC/C(=C/CNC(=O)C1CC1)/C)C EC50 = 115000 nM Poor binder T83193 Transient receptor potential cation channel V1 BXYM42 N-[[2-(2-Methylpropyl)tetrazol-5-yl]methyl]-4-phenylbenzamide Investigative 44448540 C19H21N5O 335.4 CC(C)CN1N=C(N=N1)CNC(=O)C2=CC=C(C=C2)C3=CC=CC=C3 EC50 = 53500 nM Poor binder T83193 Transient receptor potential cation channel V1 BYH83N 1,6-Diphenyl-5-hydroxy-3-hexanone Investigative 44585756 C18H20O2 268.3 C1=CC=C(C=C1)CCC(=O)CC(CC2=CC=CC=C2)O IC50 ~ 50000 nM Poor binder T83193 Transient receptor potential cation channel V1 BZ3D5K Schembl20668200 Investigative 57397938 C16H24O2 248.36 CCCCCC(CC(=O)CCC1=CC=CC=C1)O IC50 ~ 50000 nM Poor binder T83193 Transient receptor potential cation channel V1 BZ3KT5 [(2Z)-3,7-Dimethylocta-2,6-dienyl] 4-cyanobenzoate Investigative 118720718 C18H21NO2 283.4 CC(=CCC/C(=C\\COC(=O)C1=CC=C(C=C1)C#N)/C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BZ67OY 4-Hydroxybenzyl isothiocyanate Investigative 160611 C8H7NOS 165.21 C1=CC(=CC=C1CN=C=S)O EC50 = 170000 nM Poor binder T83193 Transient receptor potential cation channel V1 BZD8H9 5-[[4-(3-Acetylphenyl)phenyl]methyl]-N,N-dimethyltetrazole-1-carboxamide Investigative 72197266 C19H19N5O2 349.4 CC(=O)C1=CC=CC(=C1)C2=CC=C(C=C2)CC3=NN=NN3C(=O)N(C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 BZEN24 [(2Z)-3,7-Dimethylocta-2,6-dienyl] 2-naphthalen-2-ylacetate Investigative 118720723 C22H26O2 322.4 CC(=CCC/C(=C\\COC(=O)CC1=CC2=CC=CC=C2C=C1)/C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 D00AJB VOACANGINE Investigative 73255 C22H28N2O3 368.5 CC[C@H]1C[C@H]2C[C@@]3([C@H]1N(C2)CCC4=C3NC5=C4C=C(C=C5)OC)C(=O)OC IC50 = 50000 nM Poor binder T83193 Transient receptor potential cation channel V1 D03SCD 5-Biphenyl-4-ylmethyl-1-isobutyl-1H-tetrazole Investigative 44448616 C18H20N4 292.4 CC(C)CN1C(=NN=N1)CC2=CC=C(C=C2)C3=CC=CC=C3 EC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 D04XXE CORONARIDINE Investigative 73489 C21H26N2O2 338.4 CC[C@H]1C[C@H]2C[C@@]3([C@H]1N(C2)CCC4=C3NC5=CC=CC=C45)C(=O)OC IC50 = 170000 nM Poor binder T83193 Transient receptor potential cation channel V1 D0Q4GB geraniol Investigative 637566 C10H18O 154.25 CC(=CCC/C(=C/CO)/C)C IC50 ~ 100000 nM Poor binder T83193 Transient receptor potential cation channel V1 D0W7XR LY-2183240 Investigative 11507802 C17H17N5O 307.35 CN(C)C(=O)N1C(=NN=N1)CC2=CC=C(C=C2)C3=CC=CC=C3 IC50 ~ 100000 nM Poor binder