TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T83904	NAD-dependent deacetylase sirtuin-2	D00PWQ	KENPAULLONE	Patented	3820	C16H11BrN2O	327.17	C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)Br	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	D04JZE	CAMBINOL	Patented	3246390	C21H16N2O2S	360.4	C1=CC=C(C=C1)C2=C(C(=O)NC(=S)N2)CC3=C(C=CC4=CC=CC=C43)O	IC50 = 51000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	D0YX2B	PMID28460551-Compound-2	Patented	5329102	C22H27FN4O2	398.5	CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\\2/C3=C(C=CC(=C3)F)NC2=O)C	IC50 = 122700 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B09FPJ	4-Tert-butyl-N-[[4-[[2-[2-[2-[2-[2-[2-(dimethylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetyl]amino]phenyl]carbamothioyl]benzamide;hydrochloride	Investigative	57395074	C32H49ClN4O7S	669.3	CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)COCCOCCOCCOCCOCCN(C)C.Cl	IC50 ~ 90000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B0A3DZ	US9365508, C6 (3-CF3,	Investigative	90936478	C23H27F3N4O3S	496.5	CN(C)CCCCC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC(=C(C=C2)OC)C(F)(F)F	IC50 ~ 90000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B0ZIE1	(E)-N-(1-(2-(1H-Indol-3-yl)ethylamino)-2-methyl-1-oxopropan-2-yl)-3-(4-fluorophenyl)acrylamide	Investigative	44562084	C23H24FN3O2	393.5	CC(C)(C(=O)NCCC1=CNC2=CC=CC=C21)NC(=O)/C=C/C3=CC=C(C=C3)F	IC50 = 105000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B0ZMP5	2-(4-Cyanophenylamino)Benzamide	Investigative	21106123	C14H11N3O	237.26	C1=CC=C(C(=C1)C(=O)N)NC2=CC=C(C=C2)C#N	IC50 = 93000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B16CHL	N-Methyl-2-(phenylamino)benzamide	Investigative	12476632	C14H14N2O	226.27	CNC(=O)C1=CC=CC=C1NC2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B1EQ3S	(2S)-2-[[(2S)-6-(Ethanethioylamino)-2-[3-(2-hydroxyphenyl)propanoylamino]hexanoyl]amino]propanoic acid	Investigative	54757896	C20H29N3O5S	423.5	C[C@@H](C(=O)O)NC(=O)[C@H](CCCCNC(=S)C)NC(=O)CCC1=CC=CC=C1O	IC50 = 53000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B1Q8RS	Ser-Asp-Lys(epsilon-thioAc)Ala-Ile	Investigative	44572771	C24H42N6O9S	590.7	CC[C@H](C)[C@@H](C(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(=S)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)N	IC50 = 72800 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B1V7XZ	Sirtinol	Investigative	2827646	C26H22N2O2	394.5	CC(C1=CC=CC=C1)NC(=O)C2=CC=CC=C2N=CC3=C(C=CC4=CC=CC=C43)O	IC50 = 53000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B1XDO9	2-(4-Chloroanilino)benzamide	Investigative	901929	C13H11ClN2O	246.69	C1=CC=C(C(=C1)C(=O)N)NC2=CC=C(C=C2)Cl	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B1YJ3Z	4-(3-(4-(4-Fluorobenzyloxy)phenyl)acrylamido)-N-(2-(5-fluoro-1H-indol-3-yl)ethyl)piperidine-4-carboxamide	Investigative	5811220	C32H32F2N4O3	558.6	C1CNCCC1(C(=O)NCCC2=CNC3=C2C=C(C=C3)F)NC(=O)/C=C/C4=CC=C(C=C4)OCC5=CC=C(C=C5)F	IC50 = 51000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B1ZD0R	N-(2-(1-(Thieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)ethyl)pivalamide	Investigative	71654993	C18H26N4OS	346.5	CC(C)(C)C(=O)NCCC1CCN(CC1)C2=NC=NC3=C2SC=C3	IC50 ~ 50000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B2JUG0	2-Cyano-N-(quinolin-8-yl)-3-(5-(3-(trifluoromethyl)phenyl)furan-2-yl)acrylamide	Investigative	1183103	C24H14F3N3O2	433.4	C1=CC2=C(C(=C1)NC(=O)/C(=C/C3=CC=C(O3)C4=CC(=CC=C4)C(F)(F)F)/C#N)N=CC=C2	IC50 ~ 50000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B2SY9X	Chembl4170414	Investigative	145956292	C25H28N4O4S	480.6	CCOCC(=O)NC1=CC=C(C=C1)OCC2=CC(=CC=C2)NC(=O)CSC3=NC(=CC(=N3)C)C	IC50 = 109500 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B2YI7T	Ethyl 2-[4-(dimethylamino)phenyl]-1-[3-(2-oxopyrrolidin-1-yl)propyl]benzimidazole-5-carboxylate	Investigative	90645142	C25H30N4O3	434.5	CCOC(=O)C1=CC2=C(C=C1)N(C(=N2)C3=CC=C(C=C3)N(C)C)CCCN4CCCC4=O	IC50 = 52780 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B3JM9T	Nicotinamide	Investigative	936	C6H6N2O	122.12	C1=CC(=CN=C1)C(=O)N	IC50 = 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B3K6MR	N-[[4-[5-(Dimethylamino)pentanoylamino]phenyl]carbamothioyl]-3,4,5-trifluorobenzamide	Investigative	49847268	C21H23F3N4O2S	452.5	CN(C)CCCCC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC(=C(C(=C2)F)F)F	IC50 = 52500 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B3MU0W	Ethyl 2-(4-morpholinophenyl)-1H-benzimidazole-5-carboxylate	Investigative	127035147	C20H21N3O3	351.4	CCOC(=O)C1=CC2=C(C=C1)N=C(N2)C3=CC=C(C=C3)N4CCOCC4	IC50 = 52910 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B3TXN4	N-{(S)-1-[2-(5-Benzyloxy-1H-indol-3-yl)-ethylcarbamoyl]-ethyl}-3-phenyl-propionamide	Investigative	44562177	C29H31N3O3	469.6	C[C@@H](C(=O)NCCC1=CNC2=C1C=C(C=C2)OCC3=CC=CC=C3)NC(=O)CCC4=CC=CC=C4	IC50 = 86000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B4AV0B	3-[[3-(Naphthalen-1-yl)1,2,4-oxadiazole-5-carbonyl]amino]-1-[3-trifluoromethylphenyl]thiourea	Investigative	24949071	C21H14F3N5O2S	457.4	C1=CC=C2C(=C1)C=CC=C2C3=NOC(=N3)C(=O)NNC(=S)NC4=CC=CC(=C4)C(F)(F)F	IC50 = 113000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B4C5FO	2-[3-[Methyl-(2-phenylacetyl)amino]anilino]benzamide	Investigative	60165379	C22H21N3O2	359.4	CN(C1=CC=CC(=C1)NC2=CC=CC=C2C(=O)N)C(=O)CC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B4LIC0	Ser-Asp-Lys(epsilon-thioAc)Thr-Ala	Investigative	44572817	C22H38N6O10S	578.6	C[C@H]([C@@H](C(=O)N[C@@H](C)C(=O)O)NC(=O)[C@H](CCCCNC(=S)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)N)O	IC50 = 84600 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B4S3RL	Ethyl N-[4-[(3-cyanophenyl)carbamoylamino]-2,2-dimethyl-3,4-dihydrochromen-6-yl]carbamate	Investigative	137644691	C22H24N4O4	408.4	CCOC(=O)NC1=CC2=C(C=C1)OC(CC2NC(=O)NC3=CC=CC(=C3)C#N)(C)C	IC50 = 51100 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B50AFB	N,N''-Bis(4-hydroxybenzylidene)naphthalene1,4diamine	Investigative	135547540	C24H18N2O2	366.4	C1=CC=C2C(=C1)C(=CC=C2N=CC3=CC=C(C=C3)O)N=CC4=CC=C(C=C4)O	IC50 = 137400 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B52NWT	(S)-N-(1-(2-(1H-Indol-3-yl)ethylamino)-1-oxopropan-2-yl)cinnamamide	Investigative	36655700	C22H23N3O2	361.4	C[C@@H](C(=O)NCCC1=CNC2=CC=CC=C21)NC(=O)/C=C/C3=CC=CC=C3	IC50 = 109000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B58OXK	N-[4-(2-Carbamoylanilino)phenyl]pyridine-4-carboxamide	Investigative	60167419	C19H16N4O2	332.4	C1=CC=C(C(=C1)C(=O)N)NC2=CC=C(C=C2)NC(=O)C3=CC=NC=C3	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B5FV1G	N-[4-(Imidazol-1-ylmethyl)phenyl]-2,4-dioxo-1H-quinazoline-6-sulfonamide	Investigative	46966768	C18H15N5O4S	397.4	C1=CC(=CC=C1CN2C=CN=C2)NS(=O)(=O)C3=CC4=C(C=C3)NC(=O)NC4=O	IC50 = 159000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B5OHK0	N,N''-Bis(3-hydroxybenzylidene)naphthalene1,4diamine	Investigative	16099336	C24H18N2O2	366.4	C1=CC=C2C(=C1)C(=CC=C2N=CC3=CC(=CC=C3)O)N=CC4=CC(=CC=C4)O	IC50 = 195900 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B5PH2K	1,6-Dimethyl-3-(4-methylphenyl)pyrimido[5,4-e][1,2,4]triazine-5,7-dione	Investigative	6459022	C14H13N5O2	283.29	CC1=CC=C(C=C1)C2=NN(C3=NC(=O)N(C(=O)C3=N2)C)C	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B5RG1Y	Tert-butyl N-[2,2-dimethyl-4-[(3-nitrophenyl)carbamoylamino]-3,4-dihydrochromen-6-yl]carbamate	Investigative	72664892	C23H28N4O6	456.5	CC1(CC(C2=C(O1)C=CC(=C2)NC(=O)OC(C)(C)C)NC(=O)NC3=CC(=CC=C3)[N+](=O)[O-])C	IC50 = 99800 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B5TNV3	2-(4-Tert-butylanilino)benzamide	Investigative	71454816	C17H20N2O	268.35	CC(C)(C)C1=CC=C(C=C1)NC2=CC=CC=C2C(=O)N	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B5UKM2	2-[3-(Phenylcarbamoyl)anilino]benzamide	Investigative	60167420	C20H17N3O2	331.4	C1=CC=C(C=C1)NC(=O)C2=CC(=CC=C2)NC3=CC=CC=C3C(=O)N	IC50 = 83000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B5W3XN	Chembl4159477	Investigative	134820906	C26H26N6O3S	502.6	CC1=CC(=NC(=N1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=CC(=C3)NC(=O)C4=CN(N=C4)C)C	IC50 = 93325.43 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B5YH4B	2-(3-Benzyloxyphenylamino)Benzamide	Investigative	60165382	C20H18N2O2	318.4	C1=CC=C(C=C1)COC2=CC=CC(=C2)NC3=CC=CC=C3C(=O)N	IC50 = 54000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B5ZB0G	(2S)-6-Acetamido-2-[[(2S)-2-acetamidopropanoyl]amino]-N-[(2S)-1-(methylamino)-1-oxopropan-2-yl]hexanamide	Investigative	52949842	C17H31N5O5	385.5	C[C@@H](C(=O)N[C@@H](CCCCNC(=O)C)C(=O)N[C@@H](C)C(=O)NC)NC(=O)C	IC50 = 60000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B63MLJ	N-[[4-[5-(Dimethylamino)pentanoylamino]phenyl]carbamothioyl]-3-methylbenzamide;hydrochloride	Investigative	49847271	C22H29ClN4O2S	449	CC1=CC(=CC=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C.Cl	IC50 ~ 90000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B6AZ1B	3-(2-Carbamoylphenylamino)Benzoic Acid	Investigative	43358927	C14H12N2O3	256.26	C1=CC=C(C(=C1)C(=O)N)NC2=CC=CC(=C2)C(=O)O	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B6IS9X	Bauerine C	Investigative	189883	C12H8Cl2N2O	267.11	CN1C2=C(C=CC(=C2Cl)Cl)C3=C1C(=O)NC=C3	IC50 = 87200 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B6QSN8	2-Benzoyl-1H-benzo[f]chromen-3(2H)-one	Investigative	16805603	C20H14O3	302.3	C1C(C(=O)OC2=C1C3=CC=CC=C3C=C2)C(=O)C4=CC=CC=C4	IC50 = 178700 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B6Z8DE	2-(4-Isobutyramidophenylamino)Benzamide	Investigative	60167273	C17H19N3O2	297.35	CC(C)C(=O)NC1=CC=C(C=C1)NC2=CC=CC=C2C(=O)N	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B6ZC3N	5-Butyl-8-(3-methylphenyl)-1,2,3,4-tetrahydropyrido[4,3-b]indole	Investigative	118731177	C22H26N2	318.5	CCCCN1C2=C(CNCC2)C3=C1C=CC(=C3)C4=CC=CC(=C4)C	IC50 = 96000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B78AFR	(S)-2-((S)-2-((S)-2-Acetamidopropanamido)-6-(3-methylbut-2-enamido)hexanamido)propanoic acid	Investigative	52942684	C19H32N4O6	412.5	C[C@@H](C(=O)N[C@@H](CCCCNC(=O)C=C(C)C)C(=O)N[C@@H](C)C(=O)O)NC(=O)C	IC50 = 77000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B7EW0N	2-(Methyl(Phenyl)Amino)Benzamide	Investigative	67523832	C14H14N2O	226.27	CN(C1=CC=CC=C1)C2=CC=CC=C2C(=O)N	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B7IWC5	(2S)-2-[[(2S)-6-(Ethanethioylamino)-2-(3-phenylpropanoylamino)hexanoyl]amino]propanoic acid	Investigative	54757894	C20H29N3O4S	407.5	C[C@@H](C(=O)O)NC(=O)[C@H](CCCCNC(=S)C)NC(=O)CCC1=CC=CC=C1	IC50 = 56000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B7U0PK	(2S)-N-[(2S)-6-Acetamido-1-amino-1-oxohexan-2-yl]-2-[[(2S)-2,6-diacetamidohexanoyl]amino]octanediamide	Investigative	56664966	C26H47N7O7	569.7	CC(=O)NCCCC[C@@H](C(=O)N)NC(=O)[C@H](CCCCCC(=O)N)NC(=O)[C@H](CCCCNC(=O)C)NC(=O)C	IC50 = 190200 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B7UCN6	Chembl4161387	Investigative	145958186	C27H30N4O4S	506.6	CC1=CC(=NC(=N1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=CC(=C3)NC(=O)C4CCOCC4)C	IC50 = 168800 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B7W2KJ	4-Tert-butyl-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamoyl]benzamide;hydrochloride	Investigative	57345649	C25H35ClN4O3	475	CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=O)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C.Cl	IC50 = 88400 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B7YMK9	2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-N-(6-ethoxy-1,3-benzothiazol-2-yl)acetamide	Investigative	3994330	C17H18N4O2S2	374.5	CCOC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC(=CC(=N3)C)C	IC50 = 77800 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B83DSR	Chembl4159773	Investigative	145962932	C26H30N4O4S	494.6	CC1=CC(=NC(=N1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=C(C=C3)NC(=O)OC(C)(C)C)C	IC50 = 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B84ZEY	1-Phenyl-2-(4-methylphenyl)-1H-benzoimidazole-5-carboxylic acid ethyl ester	Investigative	90645144	C23H20N2O2	356.4	CCOC(=O)C1=CC2=C(C=C1)N(C(=N2)C3=CC=C(C=C3)C)C4=CC=CC=C4	IC50 = 60600 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B89JHM	4-(2-Carbamoylphenylamino)Benzoic Acid	Investigative	43358881	C14H12N2O3	256.26	C1=CC=C(C(=C1)C(=O)N)NC2=CC=C(C=C2)C(=O)O	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B8GYW3	Chembl4172158	Investigative	145951161	C25H25N5O3S2	507.6	CC(C)N1C=NC(=N1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=C(C=C3)NC(=O)C4=CC=CS4	IC50 = 141253.75 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B8JE3K	2-(4-Phenylanilino)benzamide	Investigative	45267626	C19H16N2O	288.3	C1=CC=C(C=C1)C2=CC=C(C=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B8K9XL	1-[[3-(4-Tert-butylphenyl)-1,2,4-oxadiazole-5-carbonyl]amino]-3-[3-(trifluoromethyl)phenyl]thiourea	Investigative	2743189	C21H20F3N5O2S	463.5	CC(C)(C)C1=CC=C(C=C1)C2=NOC(=N2)C(=O)NNC(=S)NC3=CC=CC(=C3)C(F)(F)F	IC50 = 57000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B8OFS7	2-(P-Tolylamino)Benzamide	Investigative	71451256	C14H14N2O	226.27	CC1=CC=C(C=C1)NC2=CC=CC=C2C(=O)N	IC50 = 60000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B8QG4F	Tert-butyl N-[4-[(4-cyanophenyl)carbamoylamino]-2,2-dimethyl-3,4-dihydrochromen-6-yl]carbamate	Investigative	72664790	C24H28N4O4	436.5	CC1(CC(C2=C(O1)C=CC(=C2)NC(=O)OC(C)(C)C)NC(=O)NC3=CC=C(C=C3)C#N)C	IC50 = 110200 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B8RA6N	Ethyl 1-(2-hydroxyethyl)-2-(4-piperidin-1-ylphenyl)benzimidazole-5-carboxylate	Investigative	73333808	C23H27N3O3	393.5	CCOC(=O)C1=CC2=C(C=C1)N(C(=N2)C3=CC=C(C=C3)N4CCCCC4)CCO	IC50 = 60340 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B8S5DL	N-[[4-[5-(Dimethylamino)pentanoylamino]phenyl]carbamothioyl]-4-methylbenzamide;hydrochloride	Investigative	49847189	C22H29ClN4O2S	449	CC1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C.Cl	IC50 ~ 90000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B92LHS	[[(2R,3S,4R,5R)-5-(6-Amino-8-phenylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate	Investigative	118719009	C27H31N7O14P2	739.5	C1=CC=C(C=C1)C2=NC3=C(N=CN=C3N2[C@H]4[C@@H]([C@@H]([C@H](O4)COP(=O)(O)OP(=O)([O-])OC[C@@H]5[C@H]([C@H]([C@@H](O5)[N+]6=CC=CC(=C6)C(=O)N)O)O)O)O)N	IC50 = 123000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B9AU7P	Chembl4161556	Investigative	145957468	C25H29N5O3S	479.6	CC1=CC(=NC(=N1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=C(C=C3)NC(=O)CCCN)C	IC50 = 70600 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B9BU4G	2-Phenoxybenzamide	Investigative	3290567	C13H11NO2	213.23	C1=CC=C(C=C1)OC2=CC=CC=C2C(=O)N	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B9KOP4	2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-N-[5-(naphthalen-2-ylmethyl)-1,3-thiazol-2-yl]acetamide	Investigative	127027826	C22H20N4OS2	420.6	CC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC4=CC=CC=C4C=C3)C	IC50 = 65000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B9OK7L	2-(3-Benzamidophenylamino)Benzamide	Investigative	60167424	C20H17N3O2	331.4	C1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=CC=CC=C3C(=O)N	IC50 = 57000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B9UJI3	N-[[4-[5-(Dimethylamino)pentanoylamino]phenyl]carbamothioyl]-2-methylbenzamide	Investigative	49847039	C22H28N4O2S	412.6	CC1=CC=CC=C1C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C	IC50 = 80700 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	B9ZJ4P	N-[4-(2-Carbamoylanilino)phenyl]piperidine-4-carboxamide	Investigative	60167276	C19H22N4O2	338.4	C1CNCCC1C(=O)NC2=CC=C(C=C2)NC3=CC=CC=C3C(=O)N	IC50 = 53000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BA1M6U	2-(4-Acetamidophenylamino)Benzamide	Investigative	60167272	C15H15N3O2	269.3	CC(=O)NC1=CC=C(C=C1)NC2=CC=CC=C2C(=O)N	IC50 = 77000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BA6N5G	Ethyl 3-[[(5S)-6-anilino-6-oxo-5-(phenylmethoxycarbonylamino)hexyl]amino]-3-oxopropanoate	Investigative	44138532	C25H31N3O6	469.5	CCOC(=O)CC(=O)NCCCC[C@@H](C(=O)NC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2	IC50 = 65000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BAJD04	4-Chloro-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide;hydrochloride	Investigative	49847123	C21H26Cl2N4O2S	469.4	CN(C)CCCCC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=C(C=C2)Cl.Cl	IC50 ~ 90000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BAZF92	3,4-Bis(1-(7-hydroxyheptyl)-1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione	Investigative	44418709	C35H43N3O4	569.7	CN1C(=O)C(=C(C1=O)C2=CN(C3=CC=CC=C32)CCCCCCCO)C4=CN(C5=CC=CC=C54)CCCCCCCO	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BB17DF	(2S)-N-[(2S)-5-Acetamido-1-amino-1-oxopentan-2-yl]-6-(carbamothioylamino)-2-[[(2S)-2,5-diacetamidopentanoyl]amino]hexanamide	Investigative	53379498	C23H42N8O6S	558.7	CC(=O)NCCC[C@@H](C(=O)N)NC(=O)[C@H](CCCCNC(=S)N)NC(=O)[C@H](CCCNC(=O)C)NC(=O)C	IC50 = 57200 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BB2GN4	N-(1-(2-(1H-Indol-3-yl)ethylamino)-2-methyl-1-oxopropan-2-yl)cinnamamide	Investigative	44562081	C23H25N3O2	375.5	CC(C)(C(=O)NCCC1=CNC2=CC=CC=C21)NC(=O)/C=C/C3=CC=CC=C3	IC50 = 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BB50NO	(Z)-6,7-Dichloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]indolin-2-one	Investigative	45029060	C15H12Cl2N2O	307.2	CC1=CC(=C(N1)/C=C\\2/C3=C(C(=C(C=C3)Cl)Cl)NC2=O)C	IC50 = 135400 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BBG59M	Cinnamoyl tryptamine	Investigative	823206	C19H18N2O	290.4	C1=CC=C(C=C1)/C=C/C(=O)NCCC2=CNC3=CC=CC=C32	IC50 = 173000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BBH61X	(S)-Methyl 2-((S)-6-acetamido-2-((S)-2-acetamidopropanamido)hexanamido)propanoate	Investigative	52948629	C17H30N4O6	386.4	C[C@@H](C(=O)N[C@@H](CCCCNC(=O)C)C(=O)N[C@@H](C)C(=O)OC)NC(=O)C	IC50 = 180000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BBQ15I	2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-N-[5-[(4-phenylphenyl)methyl]-1,3-thiazol-2-yl]acetamide	Investigative	127026309	C24H22N4OS2	446.6	CC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC=C(C=C3)C4=CC=CC=C4)C	IC50 = 164500 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BC0SU6	2-Anilino-N,N-dimethylbenzamide	Investigative	15701548	C15H16N2O	240.3	CN(C)C(=O)C1=CC=CC=C1NC2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BC5FM3	3-[3-(2-Carbamoylanilino)phenyl]propanoic acid	Investigative	71451255	C16H16N2O3	284.31	C1=CC=C(C(=C1)C(=O)N)NC2=CC=CC(=C2)CCC(=O)O	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BC9Q2Y	2-(4-(Methylthio)Phenylamino)Benzamide	Investigative	71454817	C14H14N2OS	258.339	CSC1=CC=C(C=C1)NC2=CC=CC=C2C(=O)N	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BDF34M	(1R,3R,5R)-7-Benzoyl-6-methoxy-4,4-dimethyl-1,5-bis(3-methylbut-2-enyl)-8,9-dioxobicyclo[3.3.1]non-6-ene-3-carboxylic acid	Investigative	134137237	C30H36O6	492.6	CC(=CC[C@@]12C[C@H](C([C@@](C1=O)(C(=C(C2=O)C(=O)C3=CC=CC=C3)OC)CC=C(C)C)(C)C)C(=O)O)C	IC50 = 150000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BDM98B	10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11-dione	Investigative	46231289	C21H12N2O3	340.3	C1=CC=C(C=C1)N2C(=O)C3=CC4=C(C=CC5=CC=CC=C54)OC3=NC2=O	IC50 = 191200 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BDV04T	2-(M-Tolylamino)Benzamide	Investigative	45268494	C14H14N2O	226.27	CC1=CC(=CC=C1)NC2=CC=CC=C2C(=O)N	IC50 = 72000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BE60CG	2-(Benzylamino)benzamide	Investigative	11345158	C14H14N2O	226.27	C1=CC=C(C=C1)CNC2=CC=CC=C2C(=O)N	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BE91OF	N-[5-[(4-Bromophenyl)methyl]-1,3,4-thiadiazol-2-yl]-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide	Investigative	127027800	C17H16BrN5OS2	450.4	CC1=CC(=NC(=N1)SCC(=O)NC2=NN=C(S2)CC3=CC=C(C=C3)Br)C	IC50 = 167700 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BEG50L	Asp-Lys(epsilon-thioAc)-Thr-Ile	Investigative	44572663	C22H39N5O8S	533.6	CC[C@H](C)[C@@H](C(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCNC(=S)C)NC(=O)[C@H](CC(=O)O)N	IC50 = 83400 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BF04UD	N-(1-(2-(1H-Indol-3-yl)ethylamino)-2-methyl-1-oxopropan-2-yl)-3-(4-methoxyphenyl)acrylamide	Investigative	44427282	C24H27N3O3	405.5	CC(C)(C(=O)NCCC1=CNC2=CC=CC=C21)NC(=O)/C=C/C3=CC=C(C=C3)OC	IC50 = 99000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BF15EI	2,4-Dioxo-N-(4-(pyridin-3-yloxy)phenyl)-1,2,3,4-tetrahydroquinazoline-6-sulfonamide	Investigative	46966788	C19H14N4O5S	410.4	C1=CC(=CN=C1)OC2=CC=C(C=C2)NS(=O)(=O)C3=CC4=C(C=C3)NC(=O)NC4=O	IC50 = 114000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BFX3C0	Benzyl N-[(2S)-1-(cyclohexylamino)-6-(ethanethioylamino)-1-oxohexan-2-yl]carbamate	Investigative	54757989	C22H33N3O3S	419.6	CC(=S)NCCCC[C@@H](C(=O)NC1CCCCC1)NC(=O)OCC2=CC=CC=C2	IC50 = 57200 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BG7E9J	3-[[3-(Naphthalen-1-yl)1,2,4-oxadiazole-5-carbonyl]amino]-1-[4-trifluoromethylphenyl]thiourea	Investigative	24949217	C21H14F3N5O2S	457.4	C1=CC=C2C(=C1)C=CC=C2C3=NOC(=N3)C(=O)NNC(=S)NC4=CC=C(C=C4)C(F)(F)F	IC50 = 74000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BGDA75	2-(4-Phenethylphenylamino)Benzamide	Investigative	60167127	C21H20N2O	316.4	C1=CC=C(C=C1)CCC2=CC=C(C=C2)NC3=CC=CC=C3C(=O)N	IC50 = 88000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BGE62D	5-(5-Butyl-1,2,3,4-tetrahydropyrido[4,3-b]indol-8-yl)pyrimidin-2-amine	Investigative	118731308	C19H23N5	321.4	CCCCN1C2=C(CNCC2)C3=C1C=CC(=C3)C4=CN=C(N=C4)N	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BH2V8E	2-(4-Phenoxyphenylamino)benzamide	Investigative	45267627	C19H16N2O2	304.3	C1=CC=C(C=C1)OC2=CC=C(C=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BHM15B	N-[4-(2-Carbamoylanilino)phenyl]pyridine-2-carboxamide	Investigative	60167277	C19H16N4O2	332.4	C1=CC=C(C(=C1)C(=O)N)NC2=CC=C(C=C2)NC(=O)C3=CC=CC=N3	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BHMI23	Chembl4169706	Investigative	145956014	C26H24N4O4S	488.6	CC1=CC(=NC(=N1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=CC(=C3)NC(=O)C4=CC=CO4)C	IC50 = 122600 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BI0XM7	(2S)-2-[[(2S)-2-Acetamidopropanoyl]amino]-6-(2,2-dimethylpropanoylamino)-N-[(2S)-1-(methylamino)-1-oxopropan-2-yl]hexanamide	Investigative	52946220	C20H37N5O5	427.5	C[C@@H](C(=O)N[C@@H](CCCCNC(=O)C(C)(C)C)C(=O)N[C@@H](C)C(=O)NC)NC(=O)C	IC50 = 66000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BI7H4G	Methyl 3-[3-(2-carbamoylanilino)phenyl]propanoate	Investigative	71449454	C17H18N2O3	298.34	COC(=O)CCC1=CC(=CC=C1)NC2=CC=CC=C2C(=O)N	IC50 = 93000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BI7MZ3	Chembl4166294	Investigative	145956141	C26H24N4O3S2	504.6	CC1=CC(=NC(=N1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=CC(=C3)NC(=O)C4=CC=CS4)C	IC50 = 127700 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BI8D0L	2-Anilinobenzamide	Investigative	96455	C13H12N2O	212.25	C1=CC=C(C=C1)NC2=CC=CC=C2C(=O)N	IC50 = 74000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BI9C4U	3-(5-(2-Chlorophenyl)furan-2-yl)-2-cyano-N-(quinolin-8-yl)acrylamide	Investigative	1183101	C23H14ClN3O2	399.8	C1=CC=C(C(=C1)C2=CC=C(O2)/C=C(\\C#N)/C(=O)NC3=CC=CC4=C3N=CC=C4)Cl	IC50 ~ 50000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BILT08	Chembl4173306	Investigative	145952074	C31H39N5O4S	577.7	CC1=CC(=NC(=N1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=C(C=C3)NC(=O)CCCN[C@@H]4CCCC[C@H]4O)C	IC50 = 173780.08 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BIPG89	2-Chloro-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide;hydrochloride	Investigative	57392690	C21H26Cl2N4O2S	469.4	CN(C)CCCCC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=CC=C2Cl.Cl	IC50 ~ 90000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BIY15T	N,N'-Bis(salicylidene)-p-phenylenediamine	Investigative	219626	C20H16N2O2	316.4	C1=CC=C(C(=C1)C=NC2=CC=C(C=C2)N=CC3=CC=CC=C3O)O	IC50 = 58400 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BJ28GM	2-(4-Methoxyanilino)benzamide	Investigative	13505632	C14H14N2O2	242.27	COC1=CC=C(C=C1)NC2=CC=CC=C2C(=O)N	IC50 = 80000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BJ5XD8	2,4-Dichloro-6-[[2-[[5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]methylsulfanyl]anilino]methylidene]cyclohexa-2,4-dien-1-one	Investigative	2803968	C21H18Cl2N2O3S	449.3	CC1=NC=C(C(=C1O)CO)CSC2=CC=CC=C2N=CC3=C(C(=CC(=C3)Cl)Cl)O	IC50 = 74000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BJ9B0R	Cambinol analog, 6b	Investigative	42617956	C21H15BrN2O2S	439.3	C1=CC=C2C(=C1)C=CC(=C2CC3=C(NC(=S)NC3=O)C4=CC=C(C=C4)Br)O	IC50 ~ 90000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BJ9OI1	Methyl 4-(2-Carbamoylphenylamino)Benzoate	Investigative	71451257	C15H14N2O3	270.28	COC(=O)C1=CC=C(C=C1)NC2=CC=CC=C2C(=O)N	IC50 = 83000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BJF54T	2-Phenylsulfanylbenzamide	Investigative	2728632	C13H11NOS	229.3	C1=CC=C(C=C1)SC2=CC=CC=C2C(=O)N	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BJI6P1	3-[N-(2-Cyanoethyl)-4-[[4-[4-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-1,3-thiazol-2-yl]piperidin-1-yl]methyl]anilino]propanenitrile	Investigative	3809911	C35H43N5S	565.8	CC1(CCC(C2=C1C=CC(=C2)C3=CSC(=N3)C4CCN(CC4)CC5=CC=C(C=C5)N(CCC#N)CCC#N)(C)C)C	IC50 = 136000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BK0BU8	N-[3-(2-Ethylhexoxy)propyl]-4,4-bis(4-hydroxyphenyl)pentanamide	Investigative	3674592	C28H41NO4	455.6	CCCCC(CC)COCCCNC(=O)CCC(C)(C1=CC=C(C=C1)O)C2=CC=C(C=C2)O	IC50 = 200000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BK6Q2C	Ethyl 2-(1,3-benzodioxol-5-yl)-1-(2-hydroxyethyl)benzimidazole-5-carboxylate	Investigative	73333924	C19H18N2O5	354.4	CCOC(=O)C1=CC2=C(C=C1)N(C(=N2)C3=CC4=C(C=C3)OCO4)CCO	IC50 = 56050 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BKT90X	3-Butyl-1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione	Investigative	4238838	C11H15N5O2	249.27	CCCCC1=NN(C2=NC(=O)N(C(=O)C2=N1)C)C	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BL7IH0	2-[3-[Benzoyl(methyl)amino]anilino]benzamide	Investigative	60165377	C21H19N3O2	345.4	CN(C1=CC=CC(=C1)NC2=CC=CC=C2C(=O)N)C(=O)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BLH0V2	(S)-Methyl 2-((S)-2-((S)-2-acetamidopropanamido)-6-(cyclohex-1-enecarboxamido)hexanamido)propanoate	Investigative	52942750	C22H36N4O6	452.5	C[C@@H](C(=O)N[C@@H](CCCCNC(=O)C1=CCCCC1)C(=O)N[C@@H](C)C(=O)OC)NC(=O)C	IC50 = 129000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BLX9Y8	3-[[3-(Tert-Butoxycarbonylamino-phenyl)-1,2,4-oxadiazole-5-carbonyl]amino]-1-(4-(trifluoromethyl)phenyl)thiourea	Investigative	24949372	C22H21F3N6O4S	522.5	CC(C)(C)OC(=O)NC1=CC=CC(=C1)C2=NOC(=N2)C(=O)NNC(=S)NC3=CC=C(C=C3)C(F)(F)F	IC50 = 129000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BM7B5Q	N-[[4-[5-(Dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide;hydrochloride	Investigative	49847185	C21H27ClN4O2S	435	CN(C)CCCCC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=CC=C2.Cl	IC50 ~ 90000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BMAS70	18-(1,2-Dihydroxyethyl)-26-fluoro-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8,10,12,22(27),23,25-nonaene-3,5-dione	Investigative	44418711	C27H24FN3O5	489.5	C1CN2C=C(C3=C2C=CC=C3F)C4=C(C5=CN(CCOC1C(CO)O)C6=CC=CC=C65)C(=O)NC4=O	IC50 ~ 50000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BMO69Y	4-Chlorothieno[3,2-d]pyrimidine-6-carboxamide	Investigative	71654770	C7H4ClN3OS	213.65	C1=C(SC2=C1N=CN=C2Cl)C(=O)N	IC50 ~ 50000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BMR2K9	15-Cyclohexyl-11-oxa-13,15-diazatetracyclo[8.8.0.02,7.012,17]octadeca-1(10),2,4,6,8,12,17-heptaene-14,16-dione	Investigative	70676625	C21H18N2O3	346.4	C1CCC(CC1)N2C(=O)C3=CC4=C(C=CC5=CC=CC=C54)OC3=NC2=O	IC50 = 58500 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BMWN67	2-[3-(2-Hydroxylethyl)phenylamino]benzamide	Investigative	45270186	C15H16N2O2	256.3	C1=CC=C(C(=C1)C(=O)N)NC2=CC=CC(=C2)CCO	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BNO91Y	N-[[4-[5-(Dimethylamino)pentanoylamino]phenyl]carbamothioyl]-4-methoxybenzamide;hydrochloride	Investigative	49847191	C22H29ClN4O3S	465	CN(C)CCCCC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=C(C=C2)OC.Cl	IC50 = 50600 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BO43UD	Lys-Lys(epsilon-thioAc)-Leu	Investigative	44572702	C20H39N5O4S	445.6	CC(C)C[C@@H](C(=O)O)NC(=O)[C@H](CCCCNC(=S)C)NC(=O)[C@H](CCCCN)N	IC50 = 151000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BOC3A1	N-(1-(2-(1H-Indol-3-yl)ethylamino)-2-methyl-1-oxopropan-2-yl)-3-(4-hydroxyphenyl)acrylamide	Investigative	44427283	C23H25N3O3	391.5	CC(C)(C(=O)NCCC1=CNC2=CC=CC=C21)NC(=O)/C=C/C3=CC=C(C=C3)O	IC50 = 50000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BP57WO	11-Methyl-3-nitro-5,6-dihydrobenzo[b][1]benzazepine-8-carboxamide	Investigative	90668300	C16H15N3O3	297.31	CN1C2=C(CCC3=C1C=CC(=C3)[N+](=O)[O-])C=C(C=C2)C(=O)N	IC50 = 77500 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BPD45V	N-(2-(1H-Indol-3-yl)ethyl)-4-(3-(4-(benzyloxy)phenyl)acrylamido)piperidine-4-carboxamide	Investigative	44427280	C32H34N4O3	522.6	C1CNCCC1(C(=O)NCCC2=CNC3=CC=CC=C32)NC(=O)/C=C/C4=CC=C(C=C4)OCC5=CC=CC=C5	IC50 = 63000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BPQ4D5	2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-N-methyl-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide	Investigative	127027828	C23H22N4OS2	434.6	CC1=CC(=NC(=N1)SCC(=O)N(C)C2=NC=C(S2)CC3=CC=CC4=CC=CC=C43)C	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BQ23MO	1,4-Bis[2-(4-hydroxyphenyl)ethylamino]anthracene-9,10-dione	Investigative	2817242	C30H26N2O4	478.5	C1=CC=C2C(=C1)C(=O)C3=C(C=CC(=C3C2=O)NCCC4=CC=C(C=C4)O)NCCC5=CC=C(C=C5)O	IC50 = 56700 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BQ7I8D	Chembl4174893	Investigative	145950856	C31H37N5O5S	591.7	CC1=CC(=NC(=N1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=C(C=C3)NC(=O)C4CCCN4C(=O)OC(C)(C)C)C	IC50 = 75857.76 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BQ9O4R	2-[3-[(2-Phenylacetyl)amino]anilino]benzamide	Investigative	60165378	C21H19N3O2	345.4	C1=CC=C(C=C1)CC(=O)NC2=CC=CC(=C2)NC3=CC=CC=C3C(=O)N	IC50 = 74000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BQN06P	Ser-Asp-Lys(epsilon-thioAc)Leu-Met	Investigative	44572768	C26H46N6O9S2	650.8	CC(C)C[C@@H](C(=O)N[C@@H](CCSC)C(=O)O)NC(=O)[C@H](CCCCNC(=S)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)N	IC50 = 92900 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BQRN75	5-[(2-Hydroxynaphthalen-1-yl)methyl]-6-(2-phenylethyl)-2-sulfanylidene-1H-pyrimidin-4-one	Investigative	53257841	C23H20N2O2S	388.5	C1=CC=C(C=C1)CCC2=C(C(=O)NC(=S)N2)CC3=C(C=CC4=CC=CC=C43)O	IC50 = 50800 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BR0J1E	N-(1-(2-(5-Fluoro-1H-indol-3-yl)ethylamino)-2-methyl-1-oxopropan-2-yl)-3-(4-hydroxyphenyl)acrylamide	Investigative	44427286	C23H24FN3O3	409.5	CC(C)(C(=O)NCCC1=CNC2=C1C=C(C=C2)F)NC(=O)/C=C/C3=CC=C(C=C3)O	IC50 = 80000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BS1QJ7	8-(3-Methylphenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole	Investigative	84193791	C18H18N2	262.3	CC1=CC(=CC=C1)C2=CC3=C(C=C2)NC4=C3CNCC4	IC50 = 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BT26ER	(18R,19R)-18-[(Dimethylamino)methyl]-19,26-difluoro-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8,10,12,22(27),23,25-nonaene-3,5-dione	Investigative	44418712	C28H26F2N4O3	504.5	CN(C)C[C@@H]1[C@@H](CN2C=C(C3=C2C=CC=C3F)C4=C(C5=CN(CCO1)C6=CC=CC=C65)C(=O)NC4=O)F	IC50 ~ 50000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BT4JW6	2-(3-Hydroxyphenyl)sulfanyl-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide	Investigative	127027802	C22H18N2O2S2	406.5	C1=CC=C2C(=C1)C=CC=C2CC3=CN=C(S3)NC(=O)CSC4=CC=CC(=C4)O	IC50 = 143000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BT61CY	2-Cyano-3-(5-(2,3-dichlorophenyl)furan-2-yl)-N-(quinolin-8-yl)acrylamide	Investigative	2130402	C23H13Cl2N3O2	434.3	C1=CC2=C(C(=C1)NC(=O)/C(=C/C3=CC=C(O3)C4=C(C(=CC=C4)Cl)Cl)/C#N)N=CC=C2	IC50 ~ 50000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BTB6S3	2-(4-(Trifluoromethyl)Phenylamino)Benzamide	Investigative	71461991	C14H11F3N2O	280.24	C1=CC=C(C(=C1)C(=O)N)NC2=CC=C(C=C2)C(F)(F)F	IC50 = 69000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BTR39H	[[(2R,3S,4R,5R)-5-[6-Amino-8-(4-methylphenyl)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate	Investigative	53248460	C28H33N7O14P2	753.5	CC1=CC=C(C=C1)C2=NC3=C(N=CN=C3N2[C@H]4[C@@H]([C@@H]([C@H](O4)COP(=O)(O)OP(=O)([O-])OC[C@@H]5[C@H]([C@H]([C@@H](O5)[N+]6=CC=CC(=C6)C(=O)N)O)O)O)O)N	IC50 = 52000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BUB3N5	N-Tert-butyl-6,11-dihydro-5H-benzo[b][1]benzazepine-3-carboxamide	Investigative	90668297	C19H22N2O	294.4	CC(C)(C)NC(=O)C1=CC2=C(C=C1)NC3=CC=CC=C3CC2	IC50 = 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BUEJ15	3,4-Bis(1-benzyl-1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione	Investigative	16094444	C35H27N3O2	521.6	CN1C(=O)C(=C(C1=O)C2=CN(C3=CC=CC=C32)CC4=CC=CC=C4)C5=CN(C6=CC=CC=C65)CC7=CC=CC=C7	IC50 = 78300 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BUF5A1	2-[3-(Trifluoromethyl)anilino]benzamide	Investigative	786469	C14H11F3N2O	280.24	C1=CC=C(C(=C1)C(=O)N)NC2=CC=CC(=C2)C(F)(F)F	IC50 = 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BV03QG	2-[4-[Methyl(phenyl)carbamoyl]anilino]benzamide	Investigative	60167128	C21H19N3O2	345.4	CN(C1=CC=CC=C1)C(=O)C2=CC=C(C=C2)NC3=CC=CC=C3C(=O)N	IC50 = 69000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BV67KZ	2-(3-(4-Tert-butylphenyl)-1,2,4-oxadiazole-5-carbonyl)-N-(4-(trifluoromethyl)phenyl)hydrazinecarbothioamide	Investigative	24949066	C21H20F3N5O2S	463.5	CC(C)(C)C1=CC=C(C=C1)C2=NOC(=N2)C(=O)NNC(=S)NC3=CC=C(C=C3)C(F)(F)F	IC50 = 109000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BVT7G8	2-(3-Hydroxymethylphenylamino)benzamide	Investigative	45269359	C14H14N2O2	242.27	C1=CC=C(C(=C1)C(=O)N)NC2=CC=CC(=C2)CO	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BW27YL	4-[4-[2-(2,2-Dimethylpropanoylamino)ethyl]piperidin-1-yl]thieno[3,2-d]pyrimidine-6-carboxylic acid	Investigative	71654991	C19H26N4O3S	390.5	CC(C)(C)C(=O)NCCC1CCN(CC1)C2=NC=NC3=C2SC(=C3)C(=O)O	IC50 ~ 50000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BW8S4I	2-Methyl-8-(3-methylphenyl)-1,3,4,5-tetrahydropyrido[4,3-b]indole	Investigative	118731178	C19H20N2	276.4	CC1=CC(=CC=C1)C2=CC3=C(C=C2)NC4=C3CN(CC4)C	IC50 = 83000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BWX4F8	Chembl4163559	Investigative	145962276	C26H29N5O3S	491.6	CC1=CC(=NC(=N1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=CC(=C3)NC(=O)C4CCCN4)C	IC50 = 141253.75 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BX04NU	2-[3-[Methyl(phenyl)carbamoyl]anilino]benzamide	Investigative	60167421	C21H19N3O2	345.4	CN(C1=CC=CC=C1)C(=O)C2=CC(=CC=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BX37UM	Asp-Lys(epsilon-thioAc)-Thr	Investigative	44572664	C16H28N4O7S	420.5	C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CCCCNC(=S)C)NC(=O)[C@H](CC(=O)O)N)O	IC50 = 175000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BXN70V	2-[[3-[[2-Hydroxy-3-(hydroxymethyl)phenyl]methylideneamino]-5-(trifluoromethyl)phenyl]iminomethyl]-6-(hydroxymethyl)phenol	Investigative	135967826	C23H19F3N2O4	444.4	C1=CC(=C(C(=C1)C=NC2=CC(=CC(=C2)C(F)(F)F)N=CC3=CC=CC(=C3O)CO)O)CO	IC50 = 91000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BY0N1L	N-(1H-1,2,4-Triazole-3-yl)-3-(naphthalene-2-yl)benzamide	Investigative	118722845	C19H14N4O	314.3	C1=CC=C2C=C(C=CC2=C1)C3=CC(=CC=C3)C(=O)NC4=NC=NN4	IC50 = 57000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BY56PN	SIRT2 Inhibitor, Inactive Control, AGK7	Investigative	1372572	C23H13Cl2N3O2	434.3	C1=CC2=C(C(=C1)NC(=O)/C(=C/C3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)/C#N)N=CC=C2	IC50 ~ 50000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BYB78T	Methyl 3-(2-Carbamoylphenylamino)Benzoate	Investigative	71451254	C15H14N2O3	270.28	COC(=O)C1=CC(=CC=C1)NC2=CC=CC=C2C(=O)N	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BYP6M3	N-[5-(Naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide	Investigative	137226429	C23H22N4O2S2	450.6	CCCC1=CC(=O)NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC=CC4=CC=CC=C43	IC50 = 127200 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BYU73C	2,4-Dioxo-N-[3-(2-pyridin-4-ylethyl)phenyl]-1H-quinazoline-6-sulfonamide	Investigative	46966849	C21H18N4O4S	422.5	C1=CC(=CC(=C1)NS(=O)(=O)C2=CC3=C(C=C2)NC(=O)NC3=O)CCC4=CC=NC=C4	IC50 = 85000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BZ0CY3	3,4-Bis(1-heptyl-1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione	Investigative	16094448	C35H43N3O2	537.7	CCCCCCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)N(C3=O)C)C4=CN(C5=CC=CC=C54)CCCCCCC	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BZ81SU	2-(Naphthalen-2-ylamino)benzamide	Investigative	70089831	C17H14N2O	262.3	C1=CC=C2C=C(C=CC2=C1)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BZ87UF	4-[(2-Chloro-6-hydroxyquinolin-5-yl)methyl]-5-(4-propan-2-ylphenyl)-1,2-dihydropyrazol-3-one	Investigative	90654863	C22H20ClN3O2	393.9	CC(C)C1=CC=C(C=C1)C2=C(C(=O)NN2)CC3=C(C=CC4=C3C=CC(=N4)Cl)O	IC50 = 68000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BZA36L	Chembl4170003	Investigative	145953733	C25H26N4O3S	462.6	C/C=C/C(=O)NC1=CC=C(C=C1)OCC2=CC(=CC=C2)NC(=O)CSC3=NC(=CC(=N3)C)C	IC50 = 89125.09 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BZK1P8	(S)-Methyl 2-((S)-2-((S)-2-acetamidopropanamido)-6-(3-methylbut-2-enamido)hexanamido)propanoate	Investigative	52943833	C20H34N4O6	426.5	C[C@@H](C(=O)N[C@@H](CCCCNC(=O)C=C(C)C)C(=O)N[C@@H](C)C(=O)OC)NC(=O)C	IC50 = 69000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	BZT9W6	3-[3-(2-Carbamoylphenylamino)phenyl]acrylic acid	Investigative	45270178	C16H14N2O3	282.29	C1=CC=C(C(=C1)C(=O)N)NC2=CC=CC(=C2)/C=C/C(=O)O	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	D03APP	diphenylamine-2-carboxylic acid	Investigative	4386	C13H11NO2	213.23	C1=CC=C(C=C1)NC2=CC=CC=C2C(=O)O	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	D08JPU	G6976	Investigative	3501	C24H18N4O	378.4	CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O	IC50 ~ 100000 nM	Poor binder
T83904	NAD-dependent deacetylase sirtuin-2	D09SUO	splitomicin	Investigative	5269	C13H10O2	198.22	C1CC(=O)OC2=C1C3=CC=CC=C3C=C2	IC50 = 112900 nM	Poor binder