TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T85435	Insulin receptor	D07POC	Erlotinib	Approved	176870	C22H23N3O4	393.4	COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	D0E6XR	Dasatinib	Approved	3062316	C22H26ClN7O2S	488	CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	D0B0AX	HIF-1alpha	Phase 4	5328127	C20H24N6O3	396.4	CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=CC(=CC(=C3)OC)OC	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	D0VF6E	PD173074	Phase 2	1401	C28H41N7O3	523.7	CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	D00PWQ	KENPAULLONE	Patented	3820	C16H11BrN2O	327.17	C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)Br	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	D01RYO	Gefitinib	Patented	123631	C22H24ClFN4O3	446.9	COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	B0A8HG	(E)-5-((5-(3,4-Dichlorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione	Investigative	1206254	C14H7Cl2NO3S	340.2	C1=CC(=C(C=C1C2=CC=C(O2)/C=C/3\\C(=O)NC(=O)S3)Cl)Cl	IC50 = 57600 nM	Poor binder
T85435	Insulin receptor	B0FY8K	2-(4-Methylanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379491	C19H16N4O	316.4	CC1=CC=C(C=C1)NC2=NC=C3CC(=O)NC4=CC=CC=C4C3=N2	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B0ME5T	N-(2-Aminophenyl)-4-[[4-(3-bromoanilino)quinazolin-6-yl]oxymethyl]benzamide	Investigative	58191997	C28H22BrN5O2	540.4	C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)COC3=CC4=C(C=C3)N=CN=C4NC5=CC(=CC=C5)Br	IC50 = 150000 nM	Poor binder
T85435	Insulin receptor	B0WLH8	N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide	Investigative	58056356	C17H12N4O2S	336.4	COC1=C(C=C2C=CC=NC2=C1)NC(=O)C3=CSC4=CN=CN=C43	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	B19VXY	N~4~-[5-(Diethylamino)pentan-2-yl]-2-[(E)-2-(2,4,6-trichlorophenyl)ethenyl]quinazoline-4,6-diamine	Investigative	5938113	C25H30Cl3N5	506.9	CCN(CC)CCCC(C)NC1=NC(=NC2=C1C=C(C=C2)N)/C=C/C3=C(C=C(C=C3Cl)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B19WYH	PD158780 Analog 5h	Investigative	5328354	C17H19BrN6	387.3	CN(C)CCNC1=NC=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	B1DNB6	(E)-5-(3-Ethoxy-2-hydroxybenzylidene)thiazolidine-2,4-dione	Investigative	1206279	C12H11NO4S	265.29	CCOC1=CC=CC(=C1O)/C=C/2\\C(=O)NC(=O)S2	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B1KOX8	PD158780 Analog 5k	Investigative	5328357	C20H25BrN6O	445.4	CCN(CC)CC(CNC1=NC=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)O	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	B1VBK3	2-(3-Hydroxy-4-methoxyanilino)-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379712	C20H18N4O4	378.4	COC1=CC2=C(C=C1)C3=NC(=NC=C3CC(=O)N2)NC4=CC(=C(C=C4)OC)O	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B1WVF6	(E)-5-((5-(2,3-Dichlorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione	Investigative	1206240	C14H7Cl2NO3S	340.2	C1=CC(=C(C(=C1)Cl)Cl)C2=CC=C(O2)/C=C/3\\C(=O)NC(=O)S3	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B25LNI	2-(4-Chloroanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379347	C18H13ClN4O	336.8	C1C2=CN=C(N=C2C3=CC=CC=C3NC1=O)NC4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B2ED9P	2-(3-Chloro-4-hydroxyanilino)-5,7-dihydropyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379607	C18H13ClN4O2	352.8	C1C2=CN=C(N=C2C3=CC=CC=C3NC1=O)NC4=CC(=C(C=C4)O)Cl	IC50 = 84000 nM	Poor binder
T85435	Insulin receptor	B2HU4E	1-(Tert-butyl)-3-(6-(2,6-dichlorophenyl)-2-((4-(diethylamino)butyl)amino)pyrido[2,3-d]pyrimidin-7-yl)urea	Investigative	5328135	C26H35Cl2N7O	532.5	CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=C(C=CC=C3Cl)Cl)NC(=O)NC(C)(C)C	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	B2K3MW	4-(4-Hydroxyanilino)-3,5,10,14-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one	Investigative	45379715	C17H13N5O2	319.32	C1C2=CN=C(N=C2C3=C(C=CN=C3)NC1=O)NC4=CC=C(C=C4)O	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B2U1YO	3,8,13,15,17,18-Hexazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one	Investigative	135929507	C12H8N6O	252.23	C1C2=C(C3=C(C=CC=N3)NC1=O)N4C(=NC=N4)N=C2	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B2WE5Z	2-(4-Hydroxyanilino)-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379610	C19H16N4O3	348.4	COC1=CC2=C(C=C1)C3=NC(=NC=C3CC(=O)N2)NC4=CC=C(C=C4)O	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B38VJD	(E)-{4-[2-(5-Chlorobenzothiazol-2-yl)vinyl]phenyl}dimethylamine	Investigative	19596969	C17H15ClN2S	314.8	CN(C)C1=CC=C(C=C1)/C=C/C2=NC3=C(S2)C=CC(=C3)Cl	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B3ZQ9K	4-(4-Ethoxyanilino)-3,5,10,15-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one	Investigative	45379814	C19H17N5O2	347.4	CCOC1=CC=C(C=C1)NC2=NC=C3CC(=O)NC4=C(C3=N2)N=CC=C4	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B43WPI	3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2R)-2,3-dihydroxypropyl]-4-methoxybenzamide	Investigative	57325478	C19H20ClNO4	361.8	COC1=C(C=C(C=C1)C(=O)NC[C@H](CO)O)/C=C/C2=CC=C(C=C2)Cl	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	B4AH7O	2-Anilino-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379344	C18H14N4O	302.3	C1C2=CN=C(N=C2C3=CC=CC=C3NC1=O)NC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B4HPB7	2-(5-Benzyl-1H-pyrazol-3-yl)-1H-indole-6-carboxylicacid isobutyl-methyl-amide	Investigative	135908497	C24H26N4O	386.5	CC(C)CN(C)C(=O)C1=CC2=C(C=C1)C=C(N2)C3=NNC(=C3)CC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B4M2IO	(Z)-5-(3-(2,4-Dichlorobenzyloxy)benzylidene)thiazolidine-2,4-dione	Investigative	1227452	C17H11Cl2NO3S	380.2	C1=CC(=CC(=C1)OCC2=C(C=C(C=C2)Cl)Cl)/C=C\\3/C(=O)NC(=O)S3	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B4S6OA	2-(2-Chloroanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379496	C18H13ClN4O	336.8	C1C2=CN=C(N=C2C3=CC=CC=C3NC1=O)NC4=CC=CC=C4Cl	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B4WH1Z	1-[2-Amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea	Investigative	5328125	C22H28N6O	392.5	CC1=CC(=C(C(=C1C)C2=C(N=C3C(=C2)C=NC(=N3)N)NC(=O)NC(C)(C)C)C)C	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	B58TMC	[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate	Investigative	24753787	C21H22ClN3O6S	479.9	CC1=C(C(=O)OC2=CC(=C(C=C12)Cl)OC(=O)N(C)C)CC3=CC(=CC=C3)NS(=O)(=O)NC	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	B5E1OS	(5E)-5-(4-Ethoxy-3-methoxybenzylidene)-1,3-thiazolidine-2,4-dione	Investigative	1232814	C13H13NO4S	279.31	CCOC1=C(C=C(C=C1)/C=C/2\\C(=O)NC(=O)S2)OC	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B5FPH1	5-[5-(3-Chloro-4-fluoro-phenyl)-furan-2-ylmethylene]-thiazolidine-2,4-dione	Investigative	1225146	C14H7ClFNO3S	323.7	C1=CC(=C(C=C1C2=CC=C(O2)/C=C/3\\C(=O)NC(=O)S3)Cl)F	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B60CAW	(R)-3-(6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)acrylamide	Investigative	46232555	C20H15Cl2FN2O2	405.2	C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=CC3=CC(=CN=C3C=C2)/C=C/C(=O)N	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	B63OLT	4-(4-Ethoxyanilino)-3,5,10,14-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one	Investigative	45379716	C19H17N5O2	347.4	CCOC1=CC=C(C=C1)NC2=NC=C3CC(=O)NC4=C(C3=N2)C=NC=C4	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B63WRS	(E)-5-((5-(2-Bromo-4-methylphenyl)furan-2-yl)methylene)thiazolidine-2,4-dione	Investigative	1774817	C15H10BrNO3S	364.2	CC1=CC(=C(C=C1)C2=CC=C(O2)/C=C/3\\C(=O)NC(=O)S3)Br	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B6EI9X	(E)-5-((5-(4-Fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione	Investigative	1204893	C14H8FNO3S	289.28	C1=CC(=CC=C1C2=CC=C(O2)/C=C/3\\C(=O)NC(=O)S3)F	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B6EL1N	2-(4-Ethoxyanilino)-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379611	C21H20N4O3	376.4	CCOC1=CC=C(C=C1)NC2=NC=C3CC(=O)NC4=C(C3=N2)C=CC(=C4)OC	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B6PE0L	1-[2-[[3-(4-Methylpiperazin-1-yl)propyl]amino]-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea	Investigative	10602350	C30H44N8O	532.7	CC1=CC(=C(C(=C1C)C2=C(N=C3C(=C2)C=NC(=N3)NCCCN4CCN(CC4)C)NC(=O)NC(C)(C)C)C)C	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	B6VPJ1	5-(3-Nitrobenzylidene)thiazolidine-2,4-dione	Investigative	1565908	C10H6N2O4S	250.23	C1=CC(=CC(=C1)[N+](=O)[O-])/C=C/2\\C(=O)NC(=O)S2	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B72QGA	2-(4-Bromoanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379493	C18H13BrN4O	381.2	C1C2=CN=C(N=C2C3=CC=CC=C3NC1=O)NC4=CC=C(C=C4)Br	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B75GAI	2-(4-Methoxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379346	C19H16N4O2	332.4	COC1=CC=C(C=C1)NC2=NC=C3CC(=O)NC4=CC=CC=C4C3=N2	IC50 = 99000 nM	Poor binder
T85435	Insulin receptor	B78GRI	2-(4-Iodoanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379345	C18H13IN4O	428.2	C1C2=CN=C(N=C2C3=CC=CC=C3NC1=O)NC4=CC=C(C=C4)I	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B7N1WR	3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2S)-2,3-dihydroxypropyl]-4-methoxybenzamide	Investigative	57325479	C19H20ClNO4	361.8	COC1=C(C=C(C=C1)C(=O)NC[C@@H](CO)O)/C=C/C2=CC=C(C=C2)Cl	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	B7O6YE	4-(4-Methoxyanilino)-3,5,10,15-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one	Investigative	45379812	C18H15N5O2	333.3	COC1=CC=C(C=C1)NC2=NC=C3CC(=O)NC4=C(C3=N2)N=CC=C4	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B7WZL1	5-Methoxy-8,13,17,18-tetrazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one	Investigative	135929510	C15H12N4O2	280.28	COC1=CC2=C(C=C1)C3=C(CC(=O)N2)C=NC4=CC=NN43	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B7ZDB8	(R)-6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinoline	Investigative	46232443	C17H12Cl2FNO	336.2	C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=CC3=C(C=C2)N=CC=C3	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	B81KFH	2-(3-Hydroxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379495	C18H14N4O2	318.3	C1C2=CN=C(N=C2C3=CC=CC=C3NC1=O)NC4=CC(=CC=C4)O	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B86RXE	N-[4-[(3-Chloro-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl]-5-(4-methyl-1-piperazinyl)-2-pentynamide	Investigative	11518389	C23H23ClFN7O	467.9	CN1CCN(CC1)CCC#CC(=O)NC2=NC=C3C(=C2)C(=NC=N3)NC4=CC(=C(C=C4)F)Cl	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	B8T2JH	5-(3-Bromo-5-ethoxy-4-hydroxy-benzylidene)-thiazolidine-2,4-dione	Investigative	1731078	C12H10BrNO4S	344.18	CCOC1=C(C(=CC(=C1)/C=C/2\\C(=O)NC(=O)S2)Br)O	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B93USM	(Z)-5-((5-(2-Chlorophenyl)furan-2-yl)methylene)-2-thioxothiazolidin-4-one	Investigative	1731052	C14H8ClNO2S2	321.8	C1=CC=C(C(=C1)C2=CC=C(O2)/C=C\\3/C(=O)NC(=S)S3)Cl	IC50 = 79500 nM	Poor binder
T85435	Insulin receptor	B9OES1	1-(3-(8-(Pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea	Investigative	11755812	C26H20F3N7O	503.5	C1=CC(=CC(=C1)NC(=O)NC2=CC=CC(=C2)C(F)(F)F)C3=CN4C=CN=C4C(=N3)NCC5=CC=NC=C5	IC50 = 50000 nM	Poor binder
T85435	Insulin receptor	B9QZ2W	1-(2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-(tert-butyl)urea	Investigative	5328112	C18H18Cl2N6O	405.3	CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=C(C=CC=C3Cl)Cl	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	B9RCI4	2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-propenyl)-1,6-dimethyl-1,8-dihydro-imidazo[4,5-h]isoquinolin-9-one	Investigative	9869943	C25H27Cl2N5O	484.4	CCN(CC)C/C=C/C1=C(C2=C(C3=C(C=C2)N=C(N3C)NC4=C(C=CC=C4Cl)Cl)C(=O)N1)C	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	B9VCN0	2-(2-Bromoanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379605	C18H13BrN4O	381.2	C1C2=CN=C(N=C2C3=CC=CC=C3NC1=O)NC4=CC=CC=C4Br	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BA62KJ	N-(3-Bromophenyl)-1H-imidazo[4,5-g]quinazolin-8-amine	Investigative	2428	C15H10BrN5	340.18	C1=CC(=CC(=C1)Br)NC2=NC=NC3=CC4=C(C=C32)NC=N4	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	BB6Y2U	3,8,15,17,19-Pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione	Investigative	45379342	C14H9N5O3	295.25	C1C2=CC3=C(NC(=O)NC3=O)N=C2C4=C(C=CC=N4)NC1=O	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BBA86V	2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)nicotinamide	Investigative	16223008	C25H16F3N5O2	475.4	C1=CC(=C(N=C1)NC2=CC(=C(C=C2)OC3=C4C=CNC4=NC=C3)F)C(=O)NC5=C(C=C(C=C5)F)F	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	BBO82Y	(5E)-5-(4-Hydroxy-3-iodo-5-methoxybenzylidene)-1,3-thiazolidine-2,4-dione	Investigative	1232262	C11H8INO4S	377.16	COC1=C(C(=CC(=C1)/C=C/2\\C(=O)NC(=O)S2)I)O	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BBYX32	N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-5-[2-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]ethynyl]-6-methylpyrimidin-4-amine	Investigative	56835161	C31H27ClF2N4O	545	CC1=C(C(=NC=N1)NC2=CC(=C(C=C2)OCC3=CC(=CC=C3)F)Cl)C#CC4=CC(=C(C=C4)CN5CCCC5)F	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BC06QB	4-(3-Chloro-4-hydroxyanilino)-3,5,10,15-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one	Investigative	135929542	C17H12ClN5O2	353.8	C1C2=CN=C(N=C2C3=C(C=CC=N3)NC1=O)NC4=CC(=C(C=C4)O)Cl	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BCG4D2	(Z)-5-(2-Fluorobenzylidene)thiazolidine-2,4-dione	Investigative	1237187	C10H6FNO2S	223.23	C1=CC=C(C(=C1)/C=C\\2/C(=O)NC(=O)S2)F	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BD2WL1	16-Phenyl-3,8,13,17,18-pentazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one	Investigative	135929527	C19H13N5O	327.3	C1C2=C(C3=C(C=CC=N3)NC1=O)N4C(=CC(=N4)C5=CC=CC=C5)N=C2	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BD39GS	(Z)-5-(5-Bromo-2-hydroxy-3-methoxybenzylidene)thiazolidine-2,4-dione	Investigative	1206264	C11H8BrNO4S	330.16	COC1=CC(=CC(=C1O)/C=C\\2/C(=O)NC(=O)S2)Br	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BD3B8N	1-[6-(2,6-Dichlorophenyl)-2-[4-(diethylamino)butylamino]pyrido[2,3-d]pyrimidin-7-yl]-3-ethylurea	Investigative	5328134	C24H31Cl2N7O	504.5	CCNC(=O)NC1=C(C=C2C=NC(=NC2=N1)NCCCCN(CC)CC)C3=C(C=CC=C3Cl)Cl	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	BD3G0E	(5Z)-5-[(6-Ethoxy-1,3-benzodioxol-5-yl)methylidene]-1,3-thiazolidine-2,4-dione	Investigative	1231530	C13H11NO5S	293.3	CCOC1=CC2=C(C=C1/C=C\\3/C(=O)NC(=O)S3)OCO2	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BD4G0L	4,8,15,17,19-Pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione	Investigative	45379340	C14H9N5O3	295.25	C1C2=CC3=C(NC(=O)NC3=O)N=C2C4=C(C=CN=C4)NC1=O	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BD58RS	8,15,17,19-Tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2,4,6,11,13(18)-hexaene-9,14,16-trione	Investigative	45379202	C15H10N4O3	294.26	C1C2=CC3=C(NC(=O)NC3=O)N=C2C4=CC=CC=C4NC1=O	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BE87NL	2-(4-Ethoxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379494	C20H18N4O2	346.4	CCOC1=CC=C(C=C1)NC2=NC=C3CC(=O)NC4=CC=CC=C4C3=N2	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BEG6C4	16-Phenyl-4,8,13,17,18-pentazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one	Investigative	135929504	C19H13N5O	327.3	C1C2=C(C3=C(C=CN=C3)NC1=O)N4C(=CC(=N4)C5=CC=CC=C5)N=C2	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BERM04	2-(2-Hydroxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379606	C18H14N4O2	318.3	C1C2=CN=C(N=C2C3=CC=CC=C3NC1=O)NC4=CC=CC=C4O	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BF40DZ	4-(3-Chloro-4-hydroxyanilino)-3,5,10,14-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one	Investigative	45379811	C17H12ClN5O2	353.8	C1C2=CN=C(N=C2C3=C(C=CN=C3)NC1=O)NC4=CC(=C(C=C4)O)Cl	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BF4B7H	8,13,17,18-Tetrazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2,4,6,12,14,16-heptaen-9-one	Investigative	135929508	C14H10N4O	250.25	C1C2=C(C3=CC=CC=C3NC1=O)N4C(=CC=N4)N=C2	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BF9O4L	2-(4-Hydroxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379492	C18H14N4O2	318.3	C1C2=CN=C(N=C2C3=CC=CC=C3NC1=O)NC4=CC=C(C=C4)O	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BG4A6T	4-(3-Hydroxyanilino)-3,5,10,14-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one	Investigative	45379717	C17H13N5O2	319.32	C1C2=CN=C(N=C2C3=C(C=CN=C3)NC1=O)NC4=CC(=CC=C4)O	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BG87SE	15,17-Dimethyl-8,15,17,19-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2,4,6,11,13(18)-hexaene-9,14,16-trione	Investigative	45379203	C17H14N4O3	322.32	CN1C2=C(C=C3CC(=O)NC4=CC=CC=C4C3=N2)C(=O)N(C1=O)C	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BH3T7O	4-(4-Methoxyanilino)-3,5,10,14-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one	Investigative	45379714	C18H15N5O2	333.3	COC1=CC=C(C=C1)NC2=NC=C3CC(=O)NC4=C(C3=N2)C=NC=C4	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BH7XV4	2-(4-Hydroxy-2-methylanilino)-5,7-dihydropyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379608	C19H16N4O2	332.4	CC1=C(C=CC(=C1)O)NC2=NC=C3CC(=O)NC4=CC=CC=C4C3=N2	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BHN9G3	(E)-3-[1-[4-(3-Ethynylanilino)quinazolin-6-yl]sulfonylpyrrol-3-yl]-N-hydroxyprop-2-enamide	Investigative	58191961	C23H17N5O4S	459.5	C#CC1=CC(=CC=C1)NC2=NC=NC3=C2C=C(C=C3)S(=O)(=O)N4C=CC(=C4)/C=C/C(=O)NO	IC50 = 65000 nM	Poor binder
T85435	Insulin receptor	BHRM84	15,17-Dimethyl-4,8,15,17,19-pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione	Investigative	45379341	C16H13N5O3	323.31	CN1C2=C(C=C3CC(=O)NC4=C(C3=N2)C=NC=C4)C(=O)N(C1=O)C	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BHY0E3	5-(4-Ethylbenzylidene)-1,3-thiazolidine-2,4-dione	Investigative	1206018	C12H11NO2S	233.29	CCC1=CC=C(C=C1)/C=C\\2/C(=O)NC(=O)S2	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BI31OX	1-[2-Amino-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea	Investigative	5328117	C20H24N6O	364.4	CC1=C(C(=CC=C1)C)C2=C(N=C3C(=C2)C=NC(=N3)N)NC(=O)NC(C)(C)C	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	BI6V4C	5-(3,5-Dimethoxy-4-hydroxybenzylidene)thiazolidine-2,4-dione	Investigative	1205040	C12H11NO5S	281.29	COC1=CC(=CC(=C1O)OC)/C=C/2\\C(=O)NC(=O)S2	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BIX19Z	5-Methoxy-15,17-dimethyl-8,15,17,19-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione	Investigative	45379205	C18H16N4O4	352.3	CN1C2=C(C=C3CC(=O)NC4=C(C3=N2)C=CC(=C4)OC)C(=O)N(C1=O)C	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BJ4UO8	1-Tert-butyl-3-[6-(2,6-dichlorophenyl)-2-[3-(4-methylpiperazin-1-yl)propylamino]pyrido[2,3-d]pyrimidin-7-yl]urea	Investigative	5328149	C26H34Cl2N8O	545.5	CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)NCCCN3CCN(CC3)C)C4=C(C=CC=C4Cl)Cl	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	BJ57BH	1-[6-(2,6-Dichlorophenyl)-2-[4-(diethylamino)butylamino]pyrido[2,3-d]pyrimidin-7-yl]-3-phenylurea	Investigative	5328137	C28H31Cl2N7O	552.5	CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=C(C=CC=C3Cl)Cl)NC(=O)NC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	BK6XI7	Meridianin E	Investigative	9995236	C12H9BrN4O	305.13	C1=CC(=C2C(=C1O)C(=CN2)C3=NC(=NC=C3)N)Br	IC50 = 80000 nM	Poor binder
T85435	Insulin receptor	BKLI26	1-[2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-ethylurea	Investigative	10738332	C16H14Cl2N6O	377.2	CCNC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=C(C=CC=C3Cl)Cl	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	BO59RW	2-(3-Chloro-4-hydroxyanilino)-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379713	C19H15ClN4O3	382.8	COC1=CC2=C(C=C1)C3=NC(=NC=C3CC(=O)N2)NC4=CC(=C(C=C4)O)Cl	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BP32JS	(Z)-5-(5-Bromo-3-ethoxy-2-hydroxybenzylidene)thiazolidine-2,4-dione	Investigative	1205024	C12H10BrNO4S	344.18	CCOC1=CC(=CC(=C1O)/C=C\\2/C(=O)NC(=O)S2)Br	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BPH30Z	15,17-Dimethyl-3,8,15,17,19-pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione	Investigative	45379343	C16H13N5O3	323.31	CN1C2=C(C=C3CC(=O)NC4=C(C3=N2)N=CC=C4)C(=O)N(C1=O)C	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BPV4H6	2-(6-((R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)cyclopropanecarboxamide	Investigative	46232556	C21H17Cl2FN2O2	419.3	C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=CC3=CC(=CN=C3C=C2)C4CC4C(=O)N	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	BQ3VE6	5-(2,4-Dichloro-benzylidene)-thiazolidine-2,4-dione	Investigative	1230091	C10H5Cl2NO2S	274.12	C1=CC(=C(C=C1Cl)Cl)/C=C\\2/C(=O)NC(=O)S2	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BQ4W3A	2-(4-Methoxyanilino)-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379609	C20H18N4O3	362.4	COC1=CC=C(C=C1)NC2=NC=C3CC(=O)NC4=C(C3=N2)C=CC(=C4)OC	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BQTA68	PD158780 Analog 5n	Investigative	5328360	C19H21BrN6O	429.3	C1COCCN1CCNC2=NC=C3C(=C2)C(=NC=N3)NC4=CC(=CC=C4)Br	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	BR1BN6	4-(3-Hydroxyanilino)-3,5,10,15-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one	Investigative	45379815	C17H13N5O2	319.32	C1C2=CN=C(N=C2C3=C(C=CC=N3)NC1=O)NC4=CC(=CC=C4)O	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BR1F3E	Canertinib dihydrochloride	Investigative	156413	C24H27Cl3FN5O3	558.9	C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4.Cl.Cl	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	BS1V9U	(Z)-5-(3,5-Dibromo-4-methoxybenzylidene)thiazolidine-2,4-dione	Investigative	6155669	C11H7Br2NO3S	393.05	COC1=C(C=C(C=C1Br)/C=C\\2/C(=O)NC(=O)S2)Br	IC50 = 65300 nM	Poor binder
T85435	Insulin receptor	BSE5H6	(E)-5-(3,4-Dichlorobenzylidene)thiazolidine-2,4-dione	Investigative	1206261	C10H5Cl2NO2S	274.12	C1=CC(=C(C=C1/C=C/2\\C(=O)NC(=O)S2)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BSWL64	3,8,13,17,18-Pentazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one	Investigative	135929526	C13H9N5O	251.24	C1C2=C(C3=C(C=CC=N3)NC1=O)N4C(=CC=N4)N=C2	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BUE5R6	5-Methoxy-8,13,15,17,18-pentazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one	Investigative	135929506	C14H11N5O2	281.27	COC1=CC2=C(C=C1)C3=C(CC(=O)N2)C=NC4=NC=NN34	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BULB17	5-Methoxy-8,15,17,19-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione	Investigative	45379204	C16H12N4O4	324.29	COC1=CC2=C(C=C1)C3=NC4=C(C=C3CC(=O)N2)C(=O)NC(=O)N4	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BVFS48	2-(3-Hydroxyanilino)-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379711	C19H16N4O3	348.4	COC1=CC2=C(C=C1)C3=NC(=NC=C3CC(=O)N2)NC4=CC(=CC=C4)O	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BVI90B	Chembl4276946	Investigative	134611886	C12H11Cl2N3O	284.14	CC1=NN(C(=C1C2=CC(=C(C=C2)Cl)Cl)N)C(=O)C	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BWM10N	1-Tert-butyl-3-[6-(2,6-dichlorophenyl)-2-[3-(diethylamino)propylamino]pyrido[2,3-d]pyrimidin-7-yl]urea	Investigative	5328115	C25H33Cl2N7O	518.5	CCN(CC)CCCNC1=NC2=NC(=C(C=C2C=N1)C3=C(C=CC=C3Cl)Cl)NC(=O)NC(C)(C)C	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	BXB35V	4-(4-Hydroxyanilino)-3,5,10,15-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one	Investigative	135929541	C17H13N5O2	319.32	C1C2=CN=C(N=C2C3=C(C=CC=N3)NC1=O)NC4=CC=C(C=C4)O	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BXOV01	1-(2-Amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl)-3-tert-butylurea	Investigative	5329111	C18H20N6O	336.4	CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T85435	Insulin receptor	BY1X8G	16-Phenyl-8,13,17,18-tetrazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2,4,6,12,14,16-heptaen-9-one	Investigative	135929509	C20H14N4O	326.4	C1C2=C(C3=CC=CC=C3NC1=O)N4C(=CC(=N4)C5=CC=CC=C5)N=C2	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BY73IT	(E)-5-(2-(2-Methylbutoxy)benzylidene)thiazolidine-2,4-dione	Investigative	46229161	C15H17NO3S	291.4	CCC(C)COC1=CC=CC=C1/C=C/2\\C(=O)NC(=O)S2	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BY7MP5	5-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-one	Investigative	118723185	C21H19N3O4	377.4	COC1=CC(=CC(=C1OC)OC)C2=NC(=CNC2=O)C3=CNC4=CC=CC=C43	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BZ81YA	(E)-5-((5-(4-Bromophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione	Investigative	1206252	C14H8BrNO3S	350.19	C1=CC(=CC=C1C2=CC=C(O2)/C=C/3\\C(=O)NC(=O)S3)Br	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	BZ9G5K	(E)-5-((6-Bromobenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione	Investigative	1204889	C11H6BrNO4S	328.14	C1OC2=C(O1)C=C(C(=C2)/C=C/3\\C(=O)NC(=O)S3)Br	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	D02XHC	aloisine A	Investigative	448912	C16H17N3O	267.33	CCCCC1=C(NC2=NC=CN=C12)C3=CC=C(C=C3)O	IC50 = 60000 nM	Poor binder
T85435	Insulin receptor	D04NGS	JNJ-7706621	Investigative	5330790	C15H12F2N6O3S	394.4	C1=CC(=C(C(=C1)F)C(=O)N2C(=NC(=N2)NC3=CC=C(C=C3)S(=O)(=O)N)N)F	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	D0YE1X	4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline	Investigative	9927943	C19H19NO5	341.4	COC1=C(C=C(C=C1)OC2=C3C=C(C(=CC3=NC=C2)OC)OC)OC	IC50 ~ 100000 nM	Poor binder
T85435	Insulin receptor	D0YZ7H	JNJ-10198409	Investigative	9797370	C18H16FN3O2	325.3	COC1=C(C=C2C(=C1)CC3=C2NN=C3NC4=CC(=CC=C4)F)OC	IC50 ~ 100000 nM	Poor binder