TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T85467	Prostaglandin E2 receptor EP3	B07RCA	7-[(2R)-2-[(E)-3-[3-(4-Chlorophenyl)phenyl]-3-hydroxyprop-1-enyl]-5-oxopyrrolidin-1-yl]heptanoic acid	Investigative	44290262	C26H30ClNO4	456	C1CC(=O)N([C@H]1/C=C/C(C2=CC=CC(=C2)C3=CC=C(C=C3)Cl)O)CCCCCCC(=O)O	Ki ~ 100000 nM	Poor binder
T85467	Prostaglandin E2 receptor EP3	B1Q8AZ	7-[(R)-2-((E)-3-Biphenyl-3-yl-3-hydroxy-propenyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid	Investigative	44290312	C26H31NO4	421.5	C1CC(=O)N([C@H]1/C=C/C(C2=CC=CC(=C2)C3=CC=CC=C3)O)CCCCCCC(=O)O	Ki ~ 100000 nM	Poor binder
T85467	Prostaglandin E2 receptor EP3	B2HFE5	5-(2-((R)-2-((S,E)-3-Hydroxyoct-1-enyl)-5-oxopyrrolidin-1-yl)ethyl)thiophene-2-carboxylic acid	Investigative	10109445	C19H27NO4S	365.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)N1CCC2=CC=C(S2)C(=O)O)O	Ki ~ 100000 nM	Poor binder
T85467	Prostaglandin E2 receptor EP3	B2VGU9	2-[1-[2-(N-Benzoyl-4-methylanilino)ethyl]piperidin-4-yl]oxyacetic acid	Investigative	127029417	C23H28N2O4	396.5	CC1=CC=C(C=C1)N(CCN2CCC(CC2)OCC(=O)O)C(=O)C3=CC=CC=C3	Ki ~ 50000 nM	Poor binder
T85467	Prostaglandin E2 receptor EP3	B5SGL4	7-[(2R)-2-[(E)-3-[3-(3-Chlorophenyl)phenyl]-3-hydroxyprop-1-enyl]-5-oxopyrrolidin-1-yl]heptanoic acid	Investigative	44290271	C26H30ClNO4	456	C1CC(=O)N([C@H]1/C=C/C(C2=CC=CC(=C2)C3=CC(=CC=C3)Cl)O)CCCCCCC(=O)O	Ki ~ 100000 nM	Poor binder
T85467	Prostaglandin E2 receptor EP3	B78WPV	7-[(2R)-2-[(E)-3-Hydroxy-3-[3-(4-hydroxy-2-methylphenyl)phenyl]prop-1-enyl]-5-oxopyrrolidin-1-yl]heptanoic acid	Investigative	44290257	C27H33NO5	451.6	CC1=C(C=CC(=C1)O)C2=CC(=CC=C2)C(/C=C/[C@H]3CCC(=O)N3CCCCCCC(=O)O)O	Ki ~ 100000 nM	Poor binder
T85467	Prostaglandin E2 receptor EP3	B7A0SE	4-(2-((R)-2-((S,E)-3-Hydroxy-4-(3-(methoxymethyl)phenyl)but-1-enyl)-5-oxopyrrolidin-1-yl)ethyl)benzoic acid	Investigative	11339240	C25H29NO5	423.5	COCC1=CC=CC(=C1)C[C@@H](/C=C/[C@H]2CCC(=O)N2CCC3=CC=C(C=C3)C(=O)O)O	Ki ~ 100000 nM	Poor binder
T85467	Prostaglandin E2 receptor EP3	B92FAC	1-[2-[4-[(6-Oxo-11,12-dihydrobenzo[c][1]benzazocin-5-yl)methyl]phenyl]phenyl]sulfonyl-3-(3-phenylpropyl)urea	Investigative	9960839	C38H35N3O4S	629.8	C1CC2=CC=CC=C2N(C(=O)C3=CC=CC=C31)CC4=CC=C(C=C4)C5=CC=CC=C5S(=O)(=O)NC(=O)NCCCC6=CC=CC=C6	Ki ~ 100000 nM	Poor binder
T85467	Prostaglandin E2 receptor EP3	B93ZPV	7-[(R)-2-((E)-3-Hydroxy-4-phenyl-but-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid	Investigative	44269544	C21H29NO4	359.5	C1CC(=O)N([C@H]1/C=C/C(CC2=CC=CC=C2)O)CCCCCCC(=O)O	Ki = 100000 nM	Poor binder
T85467	Prostaglandin E2 receptor EP3	BE1Y7P	4-[2-[(2S)-2-[(3R)-3-[3-(4-Chloro-2-methylphenyl)phenyl]-3-hydroxypropyl]-5-oxopyrrolidin-1-yl]ethyl]benzoic acid	Investigative	12137443	C29H30ClNO4	492	CC1=C(C=CC(=C1)Cl)C2=CC(=CC=C2)[C@@H](CC[C@H]3CCC(=O)N3CCC4=CC=C(C=C4)C(=O)O)O	Ki = 54000 nM	Poor binder
T85467	Prostaglandin E2 receptor EP3	BF3KD7	4-(2-((R)-2-((S,E)-5-Cyclobutyl-3-hydroxypent-1-enyl)-5-oxopyrrolidin-1-yl)ethyl)benzoic acid	Investigative	11440167	C22H29NO4	371.5	C1CC(C1)CC[C@@H](/C=C/[C@H]2CCC(=O)N2CCC3=CC=C(C=C3)C(=O)O)O	Ki = 79000 nM	Poor binder
T85467	Prostaglandin E2 receptor EP3	BI2PJ9	7-{(R)-2-[(E)-3-Hydroxy-3-(3-phenoxy-phenyl)-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid	Investigative	44290494	C26H31NO5	437.5	C1CC(=O)N([C@H]1/C=C/C(C2=CC(=CC=C2)OC3=CC=CC=C3)O)CCCCCCC(=O)O	Ki ~ 100000 nM	Poor binder
T85467	Prostaglandin E2 receptor EP3	BOD26I	7-[(R)-2-((E)-(S)-4-Cyclobutyl-3-hydroxy-but-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid	Investigative	44290267	C19H31NO4	337.5	C1CC(C1)C[C@@H](/C=C/[C@H]2CCC(=O)N2CCCCCCC(=O)O)O	Ki = 56000 nM	Poor binder
T85467	Prostaglandin E2 receptor EP3	BOD8P4	2-[1-[2-[N-(1,3-Benzodioxole-5-carbonyl)-4-methylanilino]ethyl]piperidin-4-yl]oxyacetic acid;hydrate;hydrochloride	Investigative	127047381	C24H31ClN2O7	495	CC1=CC=C(C=C1)N(CCN2CCC(CC2)OCC(=O)O)C(=O)C3=CC4=C(C=C3)OCO4.O.Cl	Ki ~ 50000 nM	Poor binder
T85467	Prostaglandin E2 receptor EP3	BRS41A	4-(2-((S)-2-((S)-5-Cyclobutyl-3-hydroxypentyl)-5-oxopyrrolidin-1-yl)ethyl)benzoic acid	Investigative	11337782	C22H31NO4	373.5	C1CC(C1)CC[C@@H](CC[C@H]2CCC(=O)N2CCC3=CC=C(C=C3)C(=O)O)O	Ki = 77000 nM	Poor binder
T85467	Prostaglandin E2 receptor EP3	BSF34O	4-(2-((S)-2-((S)-3-Hydroxyoctyl)-5-oxopyrrolidin-1-yl)ethyl)benzoic acid	Investigative	11405770	C21H31NO4	361.5	CCCCC[C@@H](CC[C@H]1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)O	Ki = 90300 nM	Poor binder
T85467	Prostaglandin E2 receptor EP3	BT83RF	7-[(2R)-2-[(E)-3-[3-(2-Chlorophenyl)phenyl]-3-hydroxyprop-1-enyl]-5-oxopyrrolidin-1-yl]heptanoic acid	Investigative	44290272	C26H30ClNO4	456	C1CC(=O)N([C@H]1/C=C/C(C2=CC=CC(=C2)C3=CC=CC=C3Cl)O)CCCCCCC(=O)O	Ki ~ 100000 nM	Poor binder
T85467	Prostaglandin E2 receptor EP3	BTE9C5	7-{(R)-2-[(E)-3-Hydroxy-3-(3-trifluoromethyl-phenyl)-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid	Investigative	44289977	C21H26F3NO4	413.4	C1CC(=O)N([C@H]1/C=C/C(C2=CC(=CC=C2)C(F)(F)F)O)CCCCCCC(=O)O	Ki = 131000 nM	Poor binder
T85467	Prostaglandin E2 receptor EP3	BUG4Q7	7-[(2S)-2-[(3R)-3-Hydroxy-3-[3-(4-hydroxy-2-methylphenyl)phenyl]propyl]-5-oxopyrrolidin-1-yl]heptanoic acid	Investigative	44290263	C27H35NO5	453.6	CC1=C(C=CC(=C1)O)C2=CC(=CC=C2)[C@@H](CC[C@H]3CCC(=O)N3CCCCCCC(=O)O)O	Ki ~ 100000 nM	Poor binder
T85467	Prostaglandin E2 receptor EP3	BV9AM7	1-Benzyl-1-[2-[4-[(6-oxo-11,12-dihydrobenzo[c][1]benzazocin-5-yl)methyl]phenyl]phenyl]sulfonyl-3-(2-phenylethyl)urea	Investigative	15491230	C44H39N3O4S	705.9	C1CC2=CC=CC=C2N(C(=O)C3=CC=CC=C31)CC4=CC=C(C=C4)C5=CC=CC=C5S(=O)(=O)N(CC6=CC=CC=C6)C(=O)NCCC7=CC=CC=C7	Ki ~ 100000 nM	Poor binder
T85467	Prostaglandin E2 receptor EP3	BWE7Q9	1-Methyl-1-[2-[4-[(6-oxo-11,12-dihydrobenzo[c][1]benzazocin-5-yl)methyl]phenyl]phenyl]sulfonyl-3-(2-phenylethyl)urea	Investigative	15491229	C38H35N3O4S	629.8	CN(C(=O)NCCC1=CC=CC=C1)S(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)CN4C5=CC=CC=C5CCC6=CC=CC=C6C4=O	Ki ~ 100000 nM	Poor binder
T85467	Prostaglandin E2 receptor EP3	BX2PY8	1-[2-[4-[(6-Oxo-11,12-dihydrobenzo[c][1]benzazocin-5-yl)methyl]phenyl]phenyl]sulfonyl-3-(2-phenylethyl)urea	Investigative	9830442	C37H33N3O4S	615.7	C1CC2=CC=CC=C2N(C(=O)C3=CC=CC=C31)CC4=CC=C(C=C4)C5=CC=CC=C5S(=O)(=O)NC(=O)NCCC6=CC=CC=C6	Ki = 51200 nM	Poor binder