TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T85733	DNA topoisomerase II beta	D0B7EB	Etoposide	Approved	36462	C29H32O13	588.6	C[C@@H]1OC[C@@H]2[C@@H](O1)[C@@H]([C@H]([C@@H](O2)O[C@H]3[C@H]4COC(=O)[C@@H]4[C@@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O	EC50 ~ 70000 nM	Poor binder
T85733	DNA topoisomerase II beta	B1DP2X	[5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-3-oxo-3,5-dihydro-pyrazolo[4,3-c]quinolin-2-yl]-acetic acid	Investigative	44353863	C22H18F2N4O3	424.4	CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C=C4C3=NN(C4=O)CC(=O)O)C5CC5)F	EC50 ~ 60000 nM	Poor binder
T85733	DNA topoisomerase II beta	B3P4JI	5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2-(tetrahydro-pyran-4-yl)-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one	Investigative	44353647	C25H24F2N4O2	450.5	CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C=C4C3=NN(C4=O)C5CCOCC5)C6CC6)F	EC50 ~ 50000 nM	Poor binder
T85733	DNA topoisomerase II beta	B4F9RP	2-(4-Amino-cyclohexyl)-5-cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one	Investigative	18654132	C26H27F2N5O	463.5	CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C=C4C3=NN(C4=O)C5CCC(CC5)N)C6CC6)F	EC50 ~ 50000 nM	Poor binder
T85733	DNA topoisomerase II beta	B4R6IP	N-{4-[5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-3-oxo-3,5-dihydro-pyrazolo[4,3-c]quinolin-2-yl]-cyclohexyl}-acetamide	Investigative	44353548	C28H29F2N5O2	505.6	CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C=C4C3=NN(C4=O)C5CCC(CC5)NC(=O)C)C6CC6)F	EC50 ~ 51000 nM	Poor binder
T85733	DNA topoisomerase II beta	BAX6N7	1-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-1H-quinolin-4-one	Investigative	10426517	C19H16F2N2O	326.3	CC1=CC(=CC(=N1)C)C2=C(C=C3C(=O)C=CN(C3=C2F)C4CC4)F	EC50 ~ 55000 nM	Poor binder
T85733	DNA topoisomerase II beta	BBW2P9	5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2-(2-hydroxy-ethyl)-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one	Investigative	44353655	C22H20F2N4O2	410.4	CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C=C4C3=NN(C4=O)CCO)C5CC5)F	EC50 ~ 60000 nM	Poor binder
T85733	DNA topoisomerase II beta	BM17XP	5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2-(1-methyl-piperidin-4-yl)-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one	Investigative	44353588	C26H27F2N5O	463.5	CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C=C4C3=NN(C4=O)C5CCN(CC5)C)C6CC6)F	EC50 ~ 50000 nM	Poor binder
T85733	DNA topoisomerase II beta	BN2U1V	5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2-phenyl-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one	Investigative	44352936	C26H20F2N4O	442.5	CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C=C4C3=NN(C4=O)C5=CC=CC=C5)C6CC6)F	EC50 ~ 60000 nM	Poor binder
T85733	DNA topoisomerase II beta	BQKC16	5-Cyclopropyl-2-(4-dimethylamino-cyclohexyl)-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one	Investigative	372648	C28H31F2N5O	491.6	CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C=C4C3=NN(C4=O)C5CCC(CC5)N(C)C)C6CC6)F	EC50 ~ 50000 nM	Poor binder
T85733	DNA topoisomerase II beta	BU96RX	1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxyic acid	Investigative	130078	C20H16F2N2O3	370.3	CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)C4CC4)F	EC50 ~ 54000 nM	Poor binder
T85733	DNA topoisomerase II beta	BXR79F	5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2-methyl-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one	Investigative	44353853	C21H18F2N4O	380.4	CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C=C4C3=NN(C4=O)C)C5CC5)F	EC50 ~ 60000 nM	Poor binder
T85733	DNA topoisomerase II beta	BXU3Q0	5-Cyclopropyl-2-(3-dimethylamino-propyl)-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one	Investigative	44353654	C25H27F2N5O	451.5	CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C=C4C3=NN(C4=O)CCCN(C)C)C5CC5)F	EC50 ~ 50000 nM	Poor binder
T85733	DNA topoisomerase II beta	BY1LE7	5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2-(4-methyl-cyclohexyl)-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one	Investigative	44353648	C27H28F2N4O	462.5	CC1CCC(CC1)N2C(=O)C3=CN(C4=C(C(=C(C=C4C3=N2)F)C5=CC(=NC(=C5)C)C)F)C6CC6	EC50 ~ 50000 nM	Poor binder
T85733	DNA topoisomerase II beta	BYGL63	[5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-3-oxo-3,5-dihydro-pyrazolo[4,3-c]quinolin-2-yl]-acetic acid ethyl ester	Investigative	44353638	C24H22F2N4O3	452.5	CCOC(=O)CN1C(=O)C2=CN(C3=C(C(=C(C=C3C2=N1)F)C4=CC(=NC(=C4)C)C)F)C5CC5	EC50 ~ 60000 nM	Poor binder
T85733	DNA topoisomerase II beta	BZ48KM	2-Cyclohexyl-5-cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one	Investigative	44353499	C26H26F2N4O	448.5	CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C=C4C3=NN(C4=O)C5CCCCC5)C6CC6)F	EC50 ~ 50000 nM	Poor binder