TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T86014	Sphingosine kinase 1	D0X6BX	ABC294640	Phase 2	15604015	C23H25ClN2O	380.9	C1C2CC3(CC1CC(C2)(C3)C(=O)NCC4=CC=NC=C4)C5=CC=C(C=C5)Cl	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	B0DF7M	3-Hydroxy-N-[(E)-[3-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamide	Investigative	127051495	C22H17F3N2O3	414.4	C1=CC=C(C(=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=CC=C3)O)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	B0KA1Y	[(2S)-1-[[4-[2-Methyl-3-[[(2R)-oxolan-2-yl]methyl]benzimidazol-5-yl]phenyl]methyl]pyrrolidin-2-yl]methanol	Investigative	137642521	C25H31N3O2	405.5	CC1=NC2=C(N1C[C@H]3CCCO3)C=C(C=C2)C4=CC=C(C=C4)CN5CCC[C@H]5CO	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	B0O5ME	N-[(E)-[3-[(3-Cyanophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamide	Investigative	127052117	C22H17N3O5	403.4	C1=CC(=CC(=C1)C#N)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 = 85260 nM	Poor binder
T86014	Sphingosine kinase 1	B1C7DK	US9421177, Vpc171147	Investigative	88866045	C20H31N3O3	361.5	CCCCCCCCCOC1=CC=C(C=C1)C(=O)NC2(CC2)/C(=N/O)/N	Ki = 60000 nM	Poor binder
T86014	Sphingosine kinase 1	B1Y4KV	3-Hydroxy-N-[(E)-[3-[(3-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamide	Investigative	127052730	C22H20N2O4	376.4	COC1=CC=CC(=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=CC=C3)O	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	B2I9UF	N-[(E)-[4-[(2-Cyanophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamide	Investigative	127050923	C22H17N3O5	403.4	C1=CC=C(C(=C1)COC2=CC=C(C=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O)C#N	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	B3MZE7	3-Hydroxy-N-[(E)-[4-[(3-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamide	Investigative	127052734	C22H20N2O4	376.4	COC1=CC=CC(=C1)COC2=CC=C(C=C2)/C=N/NC(=O)C3=CC(=CC=C3)O	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	B3ZX6P	N-[(E)-[3-[(2-Fluorophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamide	Investigative	127052719	C21H17FN2O5	396.4	C1=CC=C(C(=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O)F	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	B45KLX	N-[(E)-[3-[(4-Chlorophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamide	Investigative	127053009	C21H17ClN2O5	412.8	C1=CC(=CC(=C1)OCC2=CC=C(C=C2)Cl)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	B4G1LH	[(2S)-1-[[4-[2-Methyl-3-[[(2S)-oxolan-2-yl]methyl]benzimidazol-5-yl]phenyl]methyl]pyrrolidin-2-yl]methanol	Investigative	137636078	C25H31N3O2	405.5	CC1=NC2=C(N1C[C@@H]3CCCO3)C=C(C=C2)C4=CC=C(C=C4)CN5CCC[C@H]5CO	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	B6KT5Z	3,5-Dihydroxy-N-[(E)-[4-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamide	Investigative	127051496	C22H17F3N2O4	430.4	C1=CC=C(C(=C1)COC2=CC=C(C=C2)/C=N/NC(=O)C3=CC(=CC(=C3)O)O)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	B6YOW7	3-{[4-(2-Hydroxyethyl)phenyl]amino}-1-(4-propoxyphenyl)pyrrolidine-2,5-dione	Investigative	2936770	C21H24N2O4	368.4	CCCOC1=CC=C(C=C1)N2C(=O)CC(C2=O)NC3=CC=C(C=C3)CCO	IC50 = 61600 nM	Poor binder
T86014	Sphingosine kinase 1	B76BJM	2-Hydroxyethyl-dimethyl-[4-(4-octylphenyl)cyclohexyl]azanium;iodide	Investigative	57395846	C24H42INO	487.5	CCCCCCCCC1=CC=C(C=C1)C2CCC(CC2)[N+](C)(C)CCO.[I-]	Ki = 70000 nM	Poor binder
T86014	Sphingosine kinase 1	B90WAB	3,5-Dihydroxy-N-[(E)-[3-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamide	Investigative	127051493	C22H17F3N2O4	430.4	C1=CC=C(C(=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=CC(=C3)O)O)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	B94YFS	US9421177, Vpc171117	Investigative	88866044	C18H27N3O3	333.4	CCCCCCCOC1=CC=C(C=C1)C(=O)NC2(CC2)/C(=N/O)/N	Ki ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	B9F3HV	1-[(2S,3R)-1,3-Dihydroxyoctadecan-2-yl]-3-[3-(trifluoromethyl)phenyl]thiourea	Investigative	76325790	C26H43F3N2O2S	504.7	CCCCCCCCCCCCCCC[C@H]([C@H](CO)NC(=S)NC1=CC=CC(=C1)C(F)(F)F)O	IC50 = 69000 nM	Poor binder
T86014	Sphingosine kinase 1	BAL20C	3,4,5-Trihydroxy-N-[(E)-[4-[(4-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamide	Investigative	127049336	C22H20N2O6	408.4	COC1=CC=C(C=C1)COC2=CC=C(C=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	BCLA15	N-[(E)-[3-[(4-Cyanophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamide	Investigative	127049294	C22H17N3O5	403.4	C1=CC(=CC(=C1)OCC2=CC=C(C=C2)C#N)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 = 69440 nM	Poor binder
T86014	Sphingosine kinase 1	BCM2O0	Trimethyl-[4-(4-octylphenyl)cyclohexyl]azanium;iodide	Investigative	56839813	C23H40IN	457.5	CCCCCCCCC1=CC=C(C=C1)C2CCC(CC2)[N+](C)(C)C.[I-]	Ki = 60000 nM	Poor binder
T86014	Sphingosine kinase 1	BD2KF3	2-Methyl-1-[[(2R)-oxolan-2-yl]methyl]-6-[4-(pyrrolidin-1-ylmethyl)phenyl]benzimidazole	Investigative	137660541	C24H29N3O	375.5	CC1=NC2=C(N1C[C@H]3CCCO3)C=C(C=C2)C4=CC=C(C=C4)CN5CCCC5	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	BEST82	Chembl4162455	Investigative	145959201	C22H30N4O3	398.5	CCCCOC(=O)NC1=CC=C(C=C1)C(CN2CCN(CC2)C3=CC=NC=C3)O	IC50 = 55000 nM	Poor binder
T86014	Sphingosine kinase 1	BFIR67	4-Hydroxy-N-[(E)-[3-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamide	Investigative	127050865	C22H17F3N2O3	414.4	C1=CC=C(C(=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC=C(C=C3)O)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	BHIT31	3,4,5-Trihydroxy-N-[(E)-[4-[[3-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamide	Investigative	127050921	C22H17F3N2O5	446.4	C1=CC(=CC(=C1)C(F)(F)F)COC2=CC=C(C=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 = 54720 nM	Poor binder
T86014	Sphingosine kinase 1	BHR86Z	Chembl4173139	Investigative	145952277	C22H30N4O3	398.5	CCCCOC(=O)NC1=CC=CC(=C1)C(CN2CCN(CC2)C3=CC=NC=C3)O	IC50 = 60000 nM	Poor binder
T86014	Sphingosine kinase 1	BIZG91	3,4,5-Trihydroxy-N-[(E)-[3-[[3-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamide	Investigative	127049002	C22H17F3N2O5	446.4	C1=CC(=CC(=C1)C(F)(F)F)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	BJA85N	N-[(E)-[3-[(3-Fluorophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamide	Investigative	127052720	C21H17FN2O5	396.4	C1=CC(=CC(=C1)F)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	BJCN71	US9421177, Vpc95127	Investigative	88866052	C20H31N3O2	345.5	CCCCCCCCC1=CC=C(C=C1)C(=O)N2CCC[C@H]2/C(=N/O)/N	Ki ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	BJT15I	4-Hydroxy-N-[(E)-[4-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamide	Investigative	127050290	C22H17F3N2O3	414.4	C1=CC=C(C(=C1)COC2=CC=C(C=C2)/C=N/NC(=O)C3=CC=C(C=C3)O)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	BKCU16	3,5-Dihydroxy-N-[(E)-[3-[(3-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamide	Investigative	127052728	C22H20N2O5	392.4	COC1=CC=CC(=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=CC(=C3)O)O	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	BL58OE	3-Hydroxy-N-[(E)-[4-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamide	Investigative	127049994	C22H17F3N2O3	414.4	C1=CC=C(C(=C1)COC2=CC=C(C=C2)/C=N/NC(=O)C3=CC(=CC=C3)O)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	BLI6J3	3,4,5-Trihydroxy-N-[(E)-[3-[(4-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamide	Investigative	127052121	C22H20N2O6	408.4	COC1=CC=C(C=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	BLPG87	3,4,5-Trihydroxy-N-[(E)-[3-[(2-methylphenyl)methoxy]phenyl]methylideneamino]benzamide	Investigative	127048670	C22H20N2O5	392.4	CC1=CC=CC=C1COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 = 63240 nM	Poor binder
T86014	Sphingosine kinase 1	BN1KS2	N-[(E)-[3-[(4-Fluorophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamide	Investigative	127052721	C21H17FN2O5	396.4	C1=CC(=CC(=C1)OCC2=CC=C(C=C2)F)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	BNG9I1	Dimethyl-[4-(4-octylphenyl)cyclohexyl]-propan-2-ylazanium;iodide	Investigative	57399302	C25H44IN	485.5	CCCCCCCCC1=CC=C(C=C1)C2CCC(CC2)[N+](C)(C)C(C)C.[I-]	Ki ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	BP34GE	3,4,5-Trihydroxy-N-[(E)-[3-[(3-methylphenyl)methoxy]phenyl]methylideneamino]benzamide	Investigative	127048671	C22H20N2O5	392.4	CC1=CC(=CC=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 = 52100 nM	Poor binder
T86014	Sphingosine kinase 1	BQ43KI	3,5-Dihydroxy-N-[(E)-[4-[(3-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamide	Investigative	127052732	C22H20N2O5	392.4	COC1=CC=CC(=C1)COC2=CC=C(C=C2)/C=N/NC(=O)C3=CC(=CC(=C3)O)O	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	BQGL30	4-Hydroxy-N-[(E)-[4-[(3-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamide	Investigative	127051492	C22H20N2O4	376.4	COC1=CC=CC(=C1)COC2=CC=C(C=C2)/C=N/NC(=O)C3=CC=C(C=C3)O	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	BS1N0U	N'-{(E)-[3-(Benzyloxy)phenyl]methylidene}-1H-benzimidazole-6-carbohydrazide	Investigative	9660619	C22H18N4O2	370.4	C1=CC=C(C=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC4=C(C=C3)N=CN4	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	BVH6F9	N-Methyl-4-(4-octylphenyl)cyclohexan-1-amine	Investigative	57390485	C21H35N	301.5	CCCCCCCCC1=CC=C(C=C1)C2CCC(CC2)NC	Ki ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	BXF3Y9	4-Hydroxy-N-[(E)-[3-[(3-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamide	Investigative	127052731	C22H20N2O4	376.4	COC1=CC=CC(=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC=C(C=C3)O	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	BZFL16	N-[(E)-[3-[(3-Chlorophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamide	Investigative	127053008	C21H17ClN2O5	412.8	C1=CC(=CC(=C1)Cl)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 ~ 100000 nM	Poor binder
T86014	Sphingosine kinase 1	D0H2LN	ROMe	Investigative	71458556	C20H35NO2	321.5	CCCCCCCCC1=CC=C(C=C1)CC[C@@](CO)(COC)N	IC50 ~ 50000 nM	Poor binder
T86014	Sphingosine kinase 1	D0M9DT	DIMETHYLSPINGOSINE	Investigative	5282309	C20H41NO2	327.5	CCCCCCCCCCCCC/C=C/[C@H]([C@H](CO)N(C)C)O	IC50 = 50560 nM	Poor binder