TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T86679	Adenosine A2b receptor	B0UAO3	N-[4-(Furan-2-yl)-11-(3-phenylpropyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-naphthalen-2-ylacetamide	Investigative	45482084	C31H25N7O2	527.6	C1=CC=C(C=C1)CCCN2C=C3C(=N2)N=C(N4C3=NC(=N4)C5=CC=CO5)NC(=O)CC6=CC7=CC=CC=C7C=C6	IC50 ~ 50000 nM	Poor binder
T86679	Adenosine A2b receptor	B10ZFG	N-[2-(Furan-2-yl)-5-oxo-4H-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]benzamide	Investigative	136042243	C15H10N6O3	322.28	C1=CC=C(C=C1)C(=O)NC2=NC(=O)NC3=NC(=NN32)C4=CC=CO4	IC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	B1KFQ4	N-[4-(Furan-2-yl)-11-(3-phenylpropyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-naphthalen-1-ylacetamide	Investigative	10007115	C31H25N7O2	527.6	C1=CC=C(C=C1)CCCN2C=C3C(=N2)N=C(N4C3=NC(=N4)C5=CC=CO5)NC(=O)CC6=CC=CC7=CC=CC=C76	IC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	B25FIR	1-[4-[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-2,2-diphenylethanone	Investigative	51051145	C26H24N8O2	480.5	C1CN(CCN1C2=NC3=NC(=NN3C(=N2)N)C4=CC=CO4)C(=O)C(C5=CC=CC=C5)C6=CC=CC=C6	IC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	B2G6NQ	4-(6-Cyclopentylamino-purin-9-yl)-1-hydroxymethyl-bicyclo[3.1.0]hexane-2,3-diol	Investigative	9906178	C17H23N5O3	345.4	C1CCC(C1)NC2=C3C(=NC=N2)N(C=N3)[C@@H]4[C@H]5C[C@]5([C@H]([C@H]4O)O)CO	Ki = 139000 nM	Poor binder
T86679	Adenosine A2b receptor	B2TH5Y	N-[2-(Furan-2-yl)-5-phenoxy-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]-2-phenylacetamide	Investigative	46885474	C22H16N6O3	412.4	C1=CC=C(C=C1)CC(=O)NC2=NC(=NC3=NC(=NN32)C4=CC=CO4)OC5=CC=CC=C5	EC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	B2XRN6	1-[4-[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-2,2-dimethylpropan-1-one	Investigative	51051146	C17H22N8O2	370.4	CC(C)(C)C(=O)N1CCN(CC1)C2=NC3=NC(=NN3C(=N2)N)C4=CC=CO4	IC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	B2ZIM0	[4-[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-(4-nitrophenyl)methanone	Investigative	51051037	C19H17N9O4	435.4	C1CN(CCN1C2=NC3=NC(=NN3C(=N2)N)C4=CC=CO4)C(=O)C5=CC=C(C=C5)[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	B31EDL	(2R,3R,4S,5R)-2-[6-Amino-8-(2-phenylethynyl)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	Investigative	9999033	C18H17N5O4	367.4	C1=CC=C(C=C1)C#CC2=NC3=C(N=CN=C3N2[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)N	EC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	B3CXN6	(2R,3S,4R,5R)-2-[(3,5-Dimethylpyrazol-1-yl)methyl]-5-[6-[[(3R)-oxolan-3-yl]amino]purin-9-yl]oxolane-3,4-diol	Investigative	137656139	C19H25N7O4	415.4	CC1=CC(=NN1C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N[C@@H]5CCOC5)O)O)C	EC50 ~ 60000 nM	Poor binder
T86679	Adenosine A2b receptor	B3E4GR	1-(5-(Dimethylamino)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl)-3-phenylurea	Investigative	46885551	C17H16N8O2	364.4	CN(C)C1=NC2=NC(=NN2C(=N1)NC(=O)NC3=CC=CC=C3)C4=CC=CO4	EC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	B3W2JG	(3R,4S,5R)-2-[6-(Ethylamino)-2-(2-phenylethynyl)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	Investigative	46875997	C20H21N5O4	395.4	CCNC1=C2C(=NC(=N1)C#CC3=CC=CC=C3)N(C=N2)C4[C@@H]([C@@H]([C@H](O4)CO)O)O	EC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	B50PZE	(2R,3R,4S,5R)-2-[6-(4-Chloro-2-fluoroanilino)-2-(3,5-dimethylphenyl)purin-9-yl]-5-[(3,5-dimethylpyrazol-1-yl)methyl]oxolane-3,4-diol	Investigative	137657382	C29H29ClFN7O3	578	CC1=CC(=CC(=C1)C2=NC(=C3C(=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CN5C(=CC(=N5)C)C)O)O)NC6=C(C=C(C=C6)Cl)F)C	EC50 ~ 60000 nM	Poor binder
T86679	Adenosine A2b receptor	B5OY2B	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[2-[(3R)-3-hydroxy-3-phenylprop-1-ynyl]-6-(methylamino)purin-9-yl]oxolane-3,4-diol	Investigative	11112381	C20H21N5O5	411.4	CNC1=C2C(=NC(=N1)C#C[C@@H](C3=CC=CC=C3)O)N(C=N2)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O	EC50 = 100000 nM	Poor binder
T86679	Adenosine A2b receptor	B5W0GX	N-[5-(Dimethylamino)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]-2-phenylacetamide	Investigative	46885548	C18H17N7O2	363.4	CN(C)C1=NC2=NC(=NN2C(=N1)NC(=O)CC3=CC=CC=C3)C4=CC=CO4	EC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	B5X0ZN	2-(1-Cyclohexyl-3-methyl-4-(quinoxalin-6-yl)-1H-pyrazol-5-ylamino)-5-methoxybenzoic acid	Investigative	52941478	C26H27N5O3	457.5	CC1=NN(C(=C1C2=CC3=NC=CN=C3C=C2)NC4=C(C=C(C=C4)OC)C(=O)O)C5CCCCC5	IC50 ~ 50000 nM	Poor binder
T86679	Adenosine A2b receptor	B6D2FN	(2R,3R,4S,5R)-2-[2-Chloro-6-[[(3R)-oxolan-3-yl]amino]purin-9-yl]-5-[(3,5-dimethylpyrazol-1-yl)methyl]oxolane-3,4-diol	Investigative	137632488	C19H24ClN7O4	449.9	CC1=CC(=NN1C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=C(N=C43)Cl)N[C@@H]5CCOC5)O)O)C	EC50 ~ 60000 nM	Poor binder
T86679	Adenosine A2b receptor	B6QA0C	2-(3-Ethyl-4-(quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid	Investigative	52948995	C27H23N5O2	449.5	CCC1=NN(C(=C1C2=CC3=NC=CN=C3C=C2)NC4=CC=CC=C4C(=O)O)C5=CC=CC=C5C	IC50 ~ 50000 nM	Poor binder
T86679	Adenosine A2b receptor	B6RI7T	CID 9819926	Investigative	9819926	C15H20FN5O4	353.35	C1COCCC1NC2=C3C(=NC=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CF)O)O	Ki ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	B6U2SZ	1-(6-Amino-9H-purin-9-yl)-N-cyclopentyl-1-deoxyribofuranuronamide	Investigative	215610	C15H20N6O4	348.36	C1CCC(C1)NC(=O)[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O	EC50 = 54000 nM	Poor binder
T86679	Adenosine A2b receptor	B6VXZ5	N-[2-(Furan-2-yl)-5-methylsulfanyl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]-2,2-diphenylacetamide	Investigative	46885402	C23H18N6O2S	442.5	CSC1=NC2=NC(=NN2C(=N1)NC(=O)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC=CO5	EC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	B7DBT8	1-[4-[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-2-phenylethanone	Investigative	51050944	C20H20N8O2	404.4	C1CN(CCN1C2=NC3=NC(=NN3C(=N2)N)C4=CC=CO4)C(=O)CC5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	B7KE1U	1-(5-(Dimethylamino)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl)-3-p-tolylurea	Investigative	46885588	C18H18N8O2	378.4	CC1=CC=C(C=C1)NC(=O)NC2=NC(=NC3=NC(=NN32)C4=CC=CO4)N(C)C	EC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	B7NXW0	2-(4-Chlorophenyl)-N-[4-(furan-2-yl)-11-methyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]acetamide	Investigative	45481763	C19H14ClN7O2	407.8	CN1C=C2C(=N1)N=C(N3C2=NC(=N3)C4=CC=CO4)NC(=O)CC5=CC=C(C=C5)Cl	IC50 ~ 50000 nM	Poor binder
T86679	Adenosine A2b receptor	B8YL1N	N-[5-(Dimethylamino)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]-2-(4-methoxyphenyl)acetamide	Investigative	46885549	C19H19N7O3	393.4	CN(C)C1=NC2=NC(=NN2C(=N1)NC(=O)CC3=CC=C(C=C3)OC)C4=CC=CO4	EC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	B8ZGK7	N-[2-(Furan-2-yl)-5-methylsulfanyl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]hexanamide	Investigative	46885470	C15H18N6O2S	346.4	CCCCCC(=O)NC1=NC(=NC2=NC(=NN21)C3=CC=CO3)SC	EC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	B90YUN	1-[4-[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]pentan-1-one	Investigative	51050943	C17H22N8O2	370.4	CCCCC(=O)N1CCN(CC1)C2=NC3=NC(=NN3C(=N2)N)C4=CC=CO4	IC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	B9HPF3	N-[(1R)-2alpha-(Benzyloxy)cyclopentane-1beta-yl]-5'-oxo-5'-(ethylamino)-5'-deoxyadenosine	Investigative	127025959	C24H30N6O5	482.5	CCNC(=O)[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N[C@@H]4CCC[C@H]4OCC5=CC=CC=C5)O)O	EC50 = 125892.54 nM	Poor binder
T86679	Adenosine A2b receptor	B9L5MW	[4-[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-naphthalen-1-ylmethanone	Investigative	51051039	C23H20N8O2	440.5	C1CN(CCN1C2=NC3=NC(=NN3C(=N2)N)C4=CC=CO4)C(=O)C5=CC=CC6=CC=CC=C65	IC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	B9LH0E	8-(1-Hexynyl)adenosine	Investigative	10247091	C16H21N5O4	347.37	CCCCC#CC1=NC2=C(N=CN=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N	EC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	BAB1F9	(2R,3R,4S,5R)-2-[6-(Ethylamino)-2-hex-1-ynylpurin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	Investigative	10970819	C18H25N5O4	375.4	CCCCC#CC1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)NCC	EC50 = 100000 nM	Poor binder
T86679	Adenosine A2b receptor	BANG64	2-(4-(Quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid	Investigative	46175914	C25H19N5O2	421.4	CC1=CC=CC=C1N2C(=C(C=N2)C3=CC4=NC=CN=C4C=C3)NC5=CC=CC=C5C(=O)O	IC50 ~ 50000 nM	Poor binder
T86679	Adenosine A2b receptor	BB10SP	2-(1-Hexynyl)adenosine	Investigative	10020580	C16H21N5O4	347.37	CCCCC#CC1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N	EC50 = 100000 nM	Poor binder
T86679	Adenosine A2b receptor	BCJ26K	N-[4-(Furan-2-yl)-11-(3-phenylpropyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-(4-phenylphenyl)acetamide	Investigative	45482092	C33H27N7O2	553.6	C1=CC=C(C=C1)CCCN2C=C3C(=N2)N=C(N4C3=NC(=N4)C5=CC=CO5)NC(=O)CC6=CC=C(C=C6)C7=CC=CC=C7	IC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	BCM62Q	(2R,3R,4S,5S)-2-[2-Chloro-6-(4-chloro-2-fluoroanilino)purin-9-yl]-5-(chloromethyl)oxolane-3,4-diol	Investigative	137645223	C16H13Cl3FN5O3	448.7	C1=CC(=C(C=C1Cl)F)NC2=C3C(=NC(=N2)Cl)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CCl)O)O	EC50 ~ 60000 nM	Poor binder
T86679	Adenosine A2b receptor	BF2WO3	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[2-(2-phenylethynyl)-6-(propan-2-ylamino)purin-9-yl]oxolane-3,4-diol	Investigative	10862463	C21H23N5O4	409.4	CC(C)NC1=C2C(=NC(=N1)C#CC3=CC=CC=C3)N(C=N2)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O	EC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	BFQS01	5-Chloro-2-(3-methyl-4-(quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid	Investigative	46175652	C26H20ClN5O2	469.9	CC1=CC=CC=C1N2C(=C(C(=N2)C)C3=CC4=NC=CN=C4C=C3)NC5=C(C=C(C=C5)Cl)C(=O)O	IC50 ~ 50000 nM	Poor binder
T86679	Adenosine A2b receptor	BGDM38	(2R,3R,4S,5R)-2-[2-Chloro-6-(4-chloro-2-fluoroanilino)purin-9-yl]-5-[(3,5-dimethylpyrazol-1-yl)methyl]oxolane-3,4-diol	Investigative	137652383	C21H20Cl2FN7O3	508.3	CC1=CC(=NN1C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=C(N=C43)Cl)NC5=C(C=C(C=C5)Cl)F)O)O)C	EC50 ~ 60000 nM	Poor binder
T86679	Adenosine A2b receptor	BGJ6M8	2-(1-(2-Ethylphenyl)-3-methyl-4-(quinoxalin-6-yl)-1H-pyrazol-5-ylamino)-5-methoxybenzoic acid	Investigative	46176000	C28H25N5O3	479.5	CCC1=CC=CC=C1N2C(=C(C(=N2)C)C3=CC4=NC=CN=C4C=C3)NC5=C(C=C(C=C5)OC)C(=O)O	IC50 ~ 50000 nM	Poor binder
T86679	Adenosine A2b receptor	BGS46C	(2R,3R,4S,5R)-2-[2-Hex-1-ynyl-6-(propan-2-ylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	Investigative	11014608	C19H27N5O4	389.4	CCCCC#CC1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)NC(C)C	EC50 = 100000 nM	Poor binder
T86679	Adenosine A2b receptor	BHG46S	5-N-(2-Aminoethyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine;2,2,2-trifluoroacetic acid	Investigative	51051138	C12H13F3N8O3	374.28	C1=COC(=C1)C2=NN3C(=NC(=NC3=N2)NCCN)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	BHJ2A7	N-[11-Ethyl-4-(furan-2-yl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-naphthalen-1-ylacetamide	Investigative	45481765	C24H19N7O2	437.5	CCN1C=C2C(=N1)N=C(N3C2=NC(=N3)C4=CC=CO4)NC(=O)CC5=CC=CC6=CC=CC=C65	IC50 ~ 50000 nM	Poor binder
T86679	Adenosine A2b receptor	BJVU97	N-[2-(Furan-2-yl)-5-methylsulfanyl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]-2-phenylacetamide	Investigative	46885403	C17H14N6O2S	366.4	CSC1=NC2=NC(=NN2C(=N1)NC(=O)CC3=CC=CC=C3)C4=CC=CO4	EC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	BK94XL	(2R,3R,4S,5R)-2-[2-(3,5-Dimethylphenyl)-6-[[(3R)-oxolan-3-yl]amino]purin-9-yl]-5-[(3,5-dimethylpyrazol-1-yl)methyl]oxolane-3,4-diol	Investigative	137645065	C27H33N7O4	519.6	CC1=CC(=CC(=C1)C2=NC(=C3C(=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CN5C(=CC(=N5)C)C)O)O)N[C@@H]6CCOC6)C	EC50 ~ 60000 nM	Poor binder
T86679	Adenosine A2b receptor	BL85OK	Tert-butyl N-[2-[[2-(furan-2-yl)-5-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethylamino]-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]amino]ethyl]carbamate	Investigative	51051245	C22H33N9O5	503.6	CC(C)(C)OC(=O)NCCNC1=NC2=NC(=NN2C(=N1)NCCNC(=O)OC(C)(C)C)C3=CC=CO3	IC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	BLH78M	2-(3-Chlorophenyl)-N-[4-(furan-2-yl)-11-(3-phenylpropyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]acetamide	Investigative	45482074	C27H22ClN7O2	512	C1=CC=C(C=C1)CCCN2C=C3C(=N2)N=C(N4C3=NC(=N4)C5=CC=CO5)NC(=O)CC6=CC(=CC=C6)Cl	IC50 = 50000 nM	Poor binder
T86679	Adenosine A2b receptor	BM8RG0	2-(4-Fluorophenyl)-N-[4-(furan-2-yl)-11-(3-phenylpropyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]acetamide	Investigative	45482077	C27H22FN7O2	495.5	C1=CC=C(C=C1)CCCN2C=C3C(=N2)N=C(N4C3=NC(=N4)C5=CC=CO5)NC(=O)CC6=CC=C(C=C6)F	IC50 ~ 50000 nM	Poor binder
T86679	Adenosine A2b receptor	BN6EA4	(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-(methylamino)-2-(phenylethynyl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol	Investigative	11068963	C19H19N5O4	381.4	CNC1=C2C(=NC(=N1)C#CC3=CC=CC=C3)N(C=N2)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O	EC50 = 100000 nM	Poor binder
T86679	Adenosine A2b receptor	BNT03U	8-(3-Phenyl-3-oxo-1-propenyl)adenosine	Investigative	10250190	C19H19N5O5	397.4	C1=CC=C(C=C1)C(=O)/C=C/C2=NC3=C(N=CN=C3N2[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)N	EC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	BO28DC	2-(1-(2-Chlorophenyl)-3-methyl-4-(quinoxalin-6-yl)-1H-pyrazol-5-ylamino)-5-methoxybenzoic acid	Investigative	46175738	C26H20ClN5O3	485.9	CC1=NN(C(=C1C2=CC3=NC=CN=C3C=C2)NC4=C(C=C(C=C4)OC)C(=O)O)C5=CC=CC=C5Cl	IC50 ~ 50000 nM	Poor binder
T86679	Adenosine A2b receptor	BOAV40	2-(3-Methyl-4-(quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid	Investigative	46175737	C26H21N5O2	435.5	CC1=CC=CC=C1N2C(=C(C(=N2)C)C3=CC4=NC=CN=C4C=C3)NC5=CC=CC=C5C(=O)O	IC50 ~ 50000 nM	Poor binder
T86679	Adenosine A2b receptor	BOL37Q	N-[4-(Furan-2-yl)-11-(2-phenylethyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-naphthalen-2-ylacetamide	Investigative	45481770	C30H23N7O2	513.5	C1=CC=C(C=C1)CCN2C=C3C(=N2)N=C(N4C3=NC(=N4)C5=CC=CO5)NC(=O)CC6=CC7=CC=CC=C7C=C6	IC50 ~ 50000 nM	Poor binder
T86679	Adenosine A2b receptor	BOY0A8	5-Methyl-2-(3-methyl-4-(quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid	Investigative	46175736	C27H23N5O2	449.5	CC1=CC(=C(C=C1)NC2=C(C(=NN2C3=CC=CC=C3C)C)C4=CC5=NC=CN=C5C=C4)C(=O)O	IC50 ~ 50000 nM	Poor binder
T86679	Adenosine A2b receptor	BP31CO	N-[2-(Furan-2-yl)-5-phenoxy-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]-2-(4-methoxyphenyl)acetamide	Investigative	46885516	C23H18N6O4	442.4	COC1=CC=C(C=C1)CC(=O)NC2=NC(=NC3=NC(=NN32)C4=CC=CO4)OC5=CC=CC=C5	EC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	BP82KX	2-(4-(8-Fluoroquinoxalin-6-yl)-3-methyl-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid	Investigative	44631910	C26H20FN5O2	453.5	CC1=CC=CC=C1N2C(=C(C(=N2)C)C3=CC4=NC=CN=C4C(=C3)F)NC5=CC=CC=C5C(=O)O	IC50 ~ 50000 nM	Poor binder
T86679	Adenosine A2b receptor	BQIL20	Ethyl 6-amino-2-(2-phenylethyl)pyrazolo[3,4-d]pyrimidine-4-carboxylate	Investigative	118732285	C16H17N5O2	311.34	CCOC(=O)C1=NC(=NC2=NN(C=C12)CCC3=CC=CC=C3)N	Ki = 60000 nM	Poor binder
T86679	Adenosine A2b receptor	BQWX97	1-[4-[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-3,3-dimethylbutan-1-one	Investigative	51039222	C18H24N8O2	384.4	CC(C)(C)CC(=O)N1CCN(CC1)C2=NC3=NC(=NN3C(=N2)N)C4=CC=CO4	IC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	BR1TS3	1-[4-[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-2,2-dichloroethanone	Investigative	51051036	C14H14Cl2N8O2	397.2	C1CN(CCN1C2=NC3=NC(=NN3C(=N2)N)C4=CC=CO4)C(=O)C(Cl)Cl	IC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	BR4VY8	Methyl 4-[4-[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-4-oxobutanoate	Investigative	51051035	C17H20N8O4	400.4	COC(=O)CCC(=O)N1CCN(CC1)C2=NC3=NC(=NN3C(=N2)N)C4=CC=CO4	IC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	BR7PT4	N-[2-(Furan-2-yl)-5-phenoxy-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]-2,2-diphenylacetamide	Investigative	46885473	C28H20N6O3	488.5	C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC3=NC(=NC4=NC(=NN43)C5=CC=CO5)OC6=CC=CC=C6	EC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	BRM0K6	N-[5-(Dimethylamino)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]hexanamide	Investigative	46885550	C16H21N7O2	343.38	CCCCCC(=O)NC1=NC(=NC2=NC(=NN21)C3=CC=CO3)N(C)C	EC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	BSEP86	1-[4-[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-2-(4-chlorophenyl)ethanone	Investigative	51051040	C20H19ClN8O2	438.9	C1CN(CCN1C2=NC3=NC(=NN3C(=N2)N)C4=CC=CO4)C(=O)CC5=CC=C(C=C5)Cl	IC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	BVK5P1	N-[2-(Furan-2-yl)-5-phenoxy-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]hexanamide	Investigative	46885517	C20H20N6O3	392.4	CCCCCC(=O)NC1=NC(=NC2=NC(=NN21)C3=CC=CO3)OC4=CC=CC=C4	EC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	BW0E4D	(2R,3R,4S,5R)-2-[6-(2-Bicyclo[2.2.1]heptanylamino)-2-(3,5-dimethylphenyl)purin-9-yl]-5-[(3,5-dimethylpyrazol-1-yl)methyl]oxolane-3,4-diol	Investigative	137661322	C30H37N7O3	543.7	CC1=CC(=CC(=C1)C2=NC(=C3C(=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CN5C(=CC(=N5)C)C)O)O)NC6CC7CCC6C7)C	EC50 ~ 60000 nM	Poor binder
T86679	Adenosine A2b receptor	BW7SF1	[4-[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-phenylmethanone	Investigative	51051038	C19H18N8O2	390.4	C1CN(CCN1C2=NC3=NC(=NN3C(=N2)N)C4=CC=CO4)C(=O)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	BWDN12	5-Methoxy-2-(3-methyl-4-(quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid	Investigative	52946211	C27H23N5O3	465.5	CC1=CC=CC=C1N2C(=C(C(=N2)C)C3=CC4=NC=CN=C4C=C3)NC5=C(C=C(C=C5)OC)C(=O)O	IC50 ~ 50000 nM	Poor binder
T86679	Adenosine A2b receptor	BX7VJ5	5-N,7-N-Bis(2-aminoethyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine;2,2,2-trifluoroacetic acid	Investigative	51051246	C16H19F6N9O5	531.37	C1=COC(=C1)C2=NN3C(=N2)N=C(N=C3NCCN)NCCN.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	BXJ4P9	(2R,3R,4S,5R)-2-[6-(4-Chloro-2-fluoroanilino)purin-9-yl]-5-[(3,5-dimethylpyrazol-1-yl)methyl]oxolane-3,4-diol	Investigative	137657570	C21H21ClFN7O3	473.9	CC1=CC(=NN1C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)NC5=C(C=C(C=C5)Cl)F)O)O)C	EC50 ~ 60000 nM	Poor binder
T86679	Adenosine A2b receptor	BXW62N	(2R,3R,4S,5R)-2-[6-(Cyclopentylamino)purin-9-yl]-5-[(3,5-dimethylpyrazol-1-yl)methyl]oxolane-3,4-diol	Investigative	137637451	C20H27N7O3	413.5	CC1=CC(=NN1C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)NC5CCCC5)O)O)C	EC50 ~ 60000 nM	Poor binder
T86679	Adenosine A2b receptor	BY1VU3	N-[5-(Dimethylamino)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]-2,2-diphenylacetamide	Investigative	46885547	C24H21N7O2	439.5	CN(C)C1=NC2=NC(=NN2C(=N1)NC(=O)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC=CO5	EC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	BY4M3L	(2R,3R,4S,5R)-2-(6-Amino-2-(phenylethynyl)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol	Investigative	10248379	C18H17N5O4	367.4	C1=CC=C(C=C1)C#CC2=NC(=C3C(=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)N	EC50 ~ 100000 nM	Poor binder
T86679	Adenosine A2b receptor	BZJ28G	N-[11-Ethyl-4-(furan-2-yl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-(4-phenylphenyl)acetamide	Investigative	45481766	C26H21N7O2	463.5	CCN1C=C2C(=N1)N=C(N3C2=NC(=N3)C4=CC=CO4)NC(=O)CC5=CC=C(C=C5)C6=CC=CC=C6	IC50 ~ 50000 nM	Poor binder
T86679	Adenosine A2b receptor	D01VEU	9-Ethyl-8-phenylethynyl-9H-purin-6-ylamine	Investigative	44300688	C15H13N5	263.3	CCN1C(=NC2=C(N=CN=C21)N)C#CC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder