TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T88285	Lactoylglutathione lyase	D09BHB	Tolmetin	Approved	5509	C15H15NO3	257.279	CC1=CC=C(C=C1)C(=O)C2=CC=C(N2C)CC(=O)O	Ki = 87800 nM	Poor binder
T88285	Lactoylglutathione lyase	D0Z5IU	Sulindac	Approved	1548887	C20H17FO3S	356.4	CC\\1=C(C2=C(/C1=C\\C3=CC=C(C=C3)S(=O)C)C=CC(=C2)F)CC(=O)O	Ki = 77900 nM	Poor binder
T88285	Lactoylglutathione lyase	B1U4EC	Ethyl (2Z)-2-[(3-nitrophenyl)methylidene]-3-oxobutanoate	Investigative	1550161	C13H13NO5	263.25	CCOC(=O)/C(=C\\C1=CC(=CC=C1)[N+](=O)[O-])/C(=O)C	Ki = 65000 nM	Poor binder
T88285	Lactoylglutathione lyase	B5YW7F	2-Amino-5-[[1-(carboxymethylamino)-5-(hydroxyamino)-1,5-dioxopentan-2-yl]amino]-5-oxopentanoic acid	Investigative	390760; 44375268	C12H20N4O8	348.31	C(CC(=O)NC(CCC(=O)NO)C(=O)NCC(=O)O)C(C(=O)O)N	Ki = 92900 nM	Poor binder
T88285	Lactoylglutathione lyase	BC86EV	S-(N-Hydroxycarbamoyl)glutathione	Investigative	10737607	C11H18N4O8S	366.35	C(CC(=O)N[C@@H](CSC(=O)NO)C(=O)NCC(=O)O)[C@@H](C(=O)O)N	Ki = 183000 nM	Poor binder
T88285	Lactoylglutathione lyase	BO7A2R	2-(4-Methoxybenzamido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid	Investigative	2306193	C17H17NO4S	331.4	COC1=CC=C(C=C1)C(=O)NC2=C(C3=C(S2)CCCC3)C(=O)O	IC50 = 54600 nM	Poor binder
T88285	Lactoylglutathione lyase	BPQ4Y7	Ethyl (2Z)-2-[(4-nitrophenyl)methylidene]-3-oxobutanoate	Investigative	5388618	C13H13NO5	263.25	CCOC(=O)/C(=C\\C1=CC=C(C=C1)[N+](=O)[O-])/C(=O)C	Ki = 159000 nM	Poor binder
T88285	Lactoylglutathione lyase	BQPL34	2-Amino-3-[[hydroxy(methyl)carbamoyl]sulfanylmethyl]butanedioic acid	Investigative	44308565	C7H12N2O6S	252.25	CN(C(=O)SCC(C(C(=O)O)N)C(=O)O)O	Ki = 68000 nM	Poor binder
T88285	Lactoylglutathione lyase	BRU8C3	2-[(4-Methoxybenzoyl)amino]benzoic Acid	Investigative	721421	C15H13NO4	271.27	COC1=CC=C(C=C1)C(=O)NC2=CC=CC=C2C(=O)O	IC50 = 93200 nM	Poor binder
T88285	Lactoylglutathione lyase	BT3D5A	2,4-Pentanedione, 3-(m-nitrobenzylidene)-	Investigative	95990	C12H11NO4	233.22	CC(=O)C(=CC1=CC(=CC=C1)[N+](=O)[O-])C(=O)C	Ki = 91000 nM	Poor binder
T88285	Lactoylglutathione lyase	BT4G5C	2-Amino-5-[[1-[(2-ethoxy-2-oxoethyl)amino]-5-[hydroxy(methyl)amino]-1,5-dioxopentan-2-yl]amino]-5-oxopentanoic acid	Investigative	390759; 44375267	C15H26N4O8	390.39	CCOC(=O)CNC(=O)C(CCC(=O)N(C)O)NC(=O)CCC(C(=O)O)N	IC50 = 140500 nM	Poor binder
T88285	Lactoylglutathione lyase	BY9S1P	Zomepirac	Investigative	5733	C15H14ClNO3	291.73	CC1=C(N(C(=C1)CC(=O)O)C)C(=O)C2=CC=C(C=C2)Cl	Ki = 107000 nM	Poor binder