TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T91761	T-cell-specific kinase	B0FU9I	N-(4-(3-(1-Acetylpiperazine-4-carbonyl)benzylthio)pyrimidin-2-yl)-4-(dimethylamino)benzamide	Investigative	44410662	C27H30N6O3S	518.6	CC(=O)N1CCN(CC1)C(=O)C2=CC=CC(=C2)CSC3=NC(=NC=C3)NC(=O)C4=CC=C(C=C4)N(C)C	IC50 ~ 50000 nM	Poor binder
T91761	T-cell-specific kinase	B0WV4G	p38 MAP Kinase Inhibitor IX	Investigative	16730109	C22H17N7O2	411.4	CC1=C(C=C(C=C1)C(=O)NC2=NOC=C2)NC3=C4C=NN(C4=NC=N3)C5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T91761	T-cell-specific kinase	B1KZ5T	1-[(3R)-3-[4-Amino-3-(3-methylsulfonylphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one	Investigative	71450144	C20H22N6O3S	426.5	CS(=O)(=O)C1=CC=CC(=C1)C2=NN(C3=NC=NC(=C23)N)[C@@H]4CCCN(C4)C(=O)C=C	IC50 ~ 100000 nM	Poor binder
T91761	T-cell-specific kinase	B1OZR9	1-(4-(3-(2-(Pyridin-3-ylamino)thiazol-5-ylthio)benzoyl)piperazin-1-yl)ethanone	Investigative	44413075	C21H21N5O2S2	439.6	CC(=O)N1CCN(CC1)C(=O)C2=CC(=CC=C2)SC3=CN=C(S3)NC4=CN=CC=C4	IC50 ~ 50000 nM	Poor binder
T91761	T-cell-specific kinase	B1WZ9O	N-(5-(3-(1-Acetylpiperazine-4-carbonyl)benzylthio)-4H-1,2,4-triazol-3-yl)-4-(dimethylamino)benzamide	Investigative	44410660	C25H29N7O3S	507.6	CC(=O)N1CCN(CC1)C(=O)C2=CC=CC(=C2)CSC3=NNC(=N3)NC(=O)C4=CC=C(C=C4)N(C)C	IC50 ~ 50000 nM	Poor binder
T91761	T-cell-specific kinase	B2EJK4	3-[1-[(3R)-1-Acetylpiperidin-3-yl]-4-aminopyrazolo[3,4-d]pyrimidin-3-yl]-N-[(4-tert-butylphenyl)methyl]benzamide	Investigative	71455519	C30H35N7O2	525.6	CC(=O)N1CCC[C@H](C1)N2C3=NC=NC(=C3C(=N2)C4=CC(=CC=C4)C(=O)NCC5=CC=C(C=C5)C(C)(C)C)N	IC50 ~ 100000 nM	Poor binder
T91761	T-cell-specific kinase	B3K2DR	N-(4-(3-(1-Acetylpiperazine-4-carbonyl)benzylthio)-1,3,5-triazin-2-yl)-4-(dimethylamino)benzamide	Investigative	44410612	C26H29N7O3S	519.6	CC(=O)N1CCN(CC1)C(=O)C2=CC=CC(=C2)CSC3=NC=NC(=N3)NC(=O)C4=CC=C(C=C4)N(C)C	IC50 ~ 50000 nM	Poor binder
T91761	T-cell-specific kinase	B4I0HK	1-[(3R)-3-[4-Amino-3-[4-(trifluoromethyl)phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one	Investigative	71453818	C20H19F3N6O	416.4	C=CC(=O)N1CCC[C@H](C1)N2C3=NC=NC(=C3C(=N2)C4=CC=C(C=C4)C(F)(F)F)N	IC50 = 52458 nM	Poor binder
T91761	T-cell-specific kinase	B4Z5ON	3-[4-Amino-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-methyl-N-(4-propan-2-ylphenyl)benzamide	Investigative	71462674	C30H33N7O2	523.6	CC(C)C1=CC=C(C=C1)N(C)C(=O)C2=CC=CC(=C2)C3=NN(C4=NC=NC(=C34)N)[C@@H]5CCCN(C5)C(=O)C=C	IC50 ~ 100000 nM	Poor binder
T91761	T-cell-specific kinase	B5H7EL	2-(5-Benzyl-1H-pyrazol-3-yl)-3-[(4-hydroxybutylamino)methyl]-N-methyl-1H-indole-6-carboxamide	Investigative	136016424	C25H29N5O2	431.5	CNC(=O)C1=CC2=C(C=C1)C(=C(N2)C3=NNC(=C3)CC4=CC=CC=C4)CNCCCCO	IC50 = 50100 nM	Poor binder
T91761	T-cell-specific kinase	B6K1ZV	N-(3-(6-Methyl-1H-indol-2-yl)-1H-indazol-6-yl)benzamide	Investigative	136030673	C23H18N4O	366.4	CC1=CC2=C(C=C1)C=C(N2)C3=NNC4=C3C=CC(=C4)NC(=O)C5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T91761	T-cell-specific kinase	B73UWQ	3-[4-Amino-1-[(3R)-1-(2-methylprop-2-enoyl)piperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-propan-2-ylphenyl)benzamide	Investigative	71453790	C30H33N7O2	523.6	CC(C)C1=CC=C(C=C1)NC(=O)C2=CC=CC(=C2)C3=NN(C4=NC=NC(=C34)N)[C@@H]5CCCN(C5)C(=O)C(=C)C	IC50 ~ 100000 nM	Poor binder
T91761	T-cell-specific kinase	B7O4QV	3-[4-Amino-1-[(3R)-1-[(E)-4-hydroxybut-2-enoyl]piperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-propan-2-ylphenyl)benzamide	Investigative	71450150	C30H33N7O3	539.6	CC(C)C1=CC=C(C=C1)NC(=O)C2=CC=CC(=C2)C3=NN(C4=NC=NC(=C34)N)[C@@H]5CCCN(C5)C(=O)/C=C/CO	IC50 = 65000 nM	Poor binder
T91761	T-cell-specific kinase	B9AC6H	N-(6-(3-(1-Acetylpiperazine-4-carbonyl)benzylthio)benzo[d]thiazol-2-yl)-4-(dimethylamino)benzamide	Investigative	44410613	C30H31N5O3S2	573.7	CC(=O)N1CCN(CC1)C(=O)C2=CC=CC(=C2)CSC3=CC4=C(C=C3)N=C(S4)NC(=O)C5=CC=C(C=C5)N(C)C	IC50 ~ 50000 nM	Poor binder
T91761	T-cell-specific kinase	B9FP6X	3-[4-Amino-1-[(3R)-1-[(E)-4-[4-(2-aminoethyl)piperazin-1-yl]but-2-enoyl]piperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-propan-2-ylphenyl)benzamide	Investigative	71453784	C36H46N10O2	650.8	CC(C)C1=CC=C(C=C1)NC(=O)C2=CC=CC(=C2)C3=NN(C4=NC=NC(=C34)N)[C@@H]5CCCN(C5)C(=O)/C=C/CN6CCN(CC6)CCN	IC50 ~ 50000 nM	Poor binder
T91761	T-cell-specific kinase	BAU74W	N-(5-(3-(1-Acetylpiperazine-4-carbonyl)benzylthio)-4-methylthiazol-2-yl)-4-(dimethylamino)benzamide	Investigative	44410513	C27H31N5O3S2	537.7	CC1=C(SC(=N1)NC(=O)C2=CC=C(C=C2)N(C)C)SCC3=CC(=CC=C3)C(=O)N4CCN(CC4)C(=O)C	IC50 ~ 50000 nM	Poor binder
T91761	T-cell-specific kinase	BB02HU	N-(5-(3-(1-Acetylpiperazine-4-carbonyl)benzylsulfinyl)thiazol-2-yl)-4-(dimethylamino)benzamide	Investigative	44410614	C26H29N5O4S2	539.7	CC(=O)N1CCN(CC1)C(=O)C2=CC=CC(=C2)CS(=O)C3=CN=C(S3)NC(=O)C4=CC=C(C=C4)N(C)C	IC50 ~ 50000 nM	Poor binder
T91761	T-cell-specific kinase	BDCX13	3-[1-[(3R)-1-Acetylpiperidin-3-yl]-4-aminopyrazolo[3,4-d]pyrimidin-3-yl]-N-[(4-methylphenyl)methyl]benzamide	Investigative	71451977	C27H29N7O2	483.6	CC1=CC=C(C=C1)CNC(=O)C2=CC=CC(=C2)C3=NN(C4=NC=NC(=C34)N)[C@@H]5CCCN(C5)C(=O)C	IC50 ~ 100000 nM	Poor binder
T91761	T-cell-specific kinase	BEBI12	1-[(3R)-3-[4-Amino-3-(4-methylsulfonylphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one	Investigative	71459147	C20H22N6O3S	426.5	CS(=O)(=O)C1=CC=C(C=C1)C2=NN(C3=NC=NC(=C23)N)[C@@H]4CCCN(C4)C(=O)C=C	IC50 ~ 100000 nM	Poor binder
T91761	T-cell-specific kinase	BGT7L9	3-[1-(1-Acetylpiperidin-3-yl)-4-aminopyrazolo[3,4-d]pyrimidin-3-yl]-N-(3-tert-butylphenyl)benzamide	Investigative	71451978	C29H33N7O2	511.6	CC(=O)N1CCCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CC(=CC=C4)C(=O)NC5=CC=CC(=C5)C(C)(C)C)N	IC50 = 53650 nM	Poor binder
T91761	T-cell-specific kinase	BLPG37	N-(5-(3-(1-Acetylpiperazine-4-carbonyl)benzylthio)-1,3,4-thiadiazol-2-yl)-4-(dimethylamino)benzamide	Investigative	44410659	C25H28N6O3S2	524.7	CC(=O)N1CCN(CC1)C(=O)C2=CC=CC(=C2)CSC3=NN=C(S3)NC(=O)C4=CC=C(C=C4)N(C)C	IC50 ~ 50000 nM	Poor binder
T91761	T-cell-specific kinase	BN3Y0E	3-[[5-Cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino]-4-methyl-N-(1,2-oxazol-3-yl)benzamide	Investigative	11235063	C21H21N7O2	403.4	CC1=C(C=C(C=C1)C(=O)NC2=NOC=C2)NC3=C(C(=NC=N3)NC4CCCC4)C#N	IC50 ~ 50000 nM	Poor binder
T91761	T-cell-specific kinase	BNF96P	3-[4-Amino-1-[(3R)-1-cyanopiperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-propan-2-ylphenyl)benzamide	Investigative	71457310	C27H28N8O	480.6	CC(C)C1=CC=C(C=C1)NC(=O)C2=CC=CC(=C2)C3=NN(C4=NC=NC(=C34)N)[C@@H]5CCCN(C5)C#N	IC50 ~ 100000 nM	Poor binder
T91761	T-cell-specific kinase	BNQI71	4-(Dimethylamino)-N-[5-({[3-(phenylcarbamoyl)phenyl]methyl}sulfanyl)-1,3-thiazol-2-yl]benzamide	Investigative	44410667	C26H24N4O2S2	488.6	CN(C)C1=CC=C(C=C1)C(=O)NC2=NC=C(S2)SCC3=CC(=CC=C3)C(=O)NC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T91761	T-cell-specific kinase	BPI07R	3-[4-Amino-1-[(3R)-1-[(E)-4-piperazin-1-ylbut-2-enoyl]piperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-propan-2-ylphenyl)benzamide	Investigative	71457314	C34H41N9O2	607.7	CC(C)C1=CC=C(C=C1)NC(=O)C2=CC=CC(=C2)C3=NN(C4=NC=NC(=C34)N)[C@@H]5CCCN(C5)C(=O)/C=C/CN6CCNCC6	IC50 ~ 100000 nM	Poor binder
T91761	T-cell-specific kinase	BQX9A6	N-Cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5-yl)methylamino)benzamide	Investigative	11632737	C19H17F2N5OS	401.4	C1CC1NC(=O)C2=CC(=C(C=C2F)F)NCC3=CN=C(S3)NC4=CC=CC=N4	IC50 ~ 50000 nM	Poor binder
T91761	T-cell-specific kinase	BRB8W7	4-(Dimethylamino)-N-{5-[({3-[(2-acetamidoethyl)carbamoyl]phenyl}methyl)sulfanyl]-1,3-thiazol-2-yl}benzamide	Investigative	44410617	C24H27N5O3S2	497.6	CC(=O)NCCNC(=O)C1=CC=CC(=C1)CSC2=CN=C(S2)NC(=O)C3=CC=C(C=C3)N(C)C	IC50 ~ 50000 nM	Poor binder
T91761	T-cell-specific kinase	BRL56D	5-Amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarbamoyl)-2-methylphenyl)-1H-pyrazole-4-carboxamide	Investigative	49838879	C21H17FN6O3	420.4	CC1=C(C=C(C=C1)C(=O)NC2=NOC=C2)NC(=O)C3=C(N(N=C3)C4=CC=CC=C4F)N	IC50 ~ 50000 nM	Poor binder
T91761	T-cell-specific kinase	BS92DO	3-[1-(1-Acetylpiperidin-3-yl)-4-aminopyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-propan-2-ylphenyl)benzamide	Investigative	71459145	C28H31N7O2	497.6	CC(C)C1=CC=C(C=C1)NC(=O)C2=CC=CC(=C2)C3=NN(C4=NC=NC(=C34)N)C5CCCN(C5)C(=O)C	IC50 ~ 100000 nM	Poor binder
T91761	T-cell-specific kinase	BTZ3W7	3-[4-Amino-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-pentan-3-ylbenzamide	Investigative	71451982	C25H31N7O2	461.6	CCC(CC)NC(=O)C1=CC=CC(=C1)C2=NN(C3=NC=NC(=C23)N)[C@@H]4CCCN(C4)C(=O)C=C	IC50 ~ 100000 nM	Poor binder
T91761	T-cell-specific kinase	BUHW35	3-(Hydroxymethyl)-N-methyl-N-(2-methylpropyl)-2-(4-phenyl-1H-pyrazol-5-yl)-1H-indole-6-carboxamide	Investigative	136016420	C24H26N4O2	402.5	CC(C)CN(C)C(=O)C1=CC2=C(C=C1)C(=C(N2)C3=C(C=NN3)C4=CC=CC=C4)CO	IC50 ~ 100000 nM	Poor binder
T91761	T-cell-specific kinase	BVQ9I3	3-[(3-Hydroxypropylamino)methyl]-N-methyl-N-(2-methylpropyl)-2-(4-phenyl-1H-pyrazol-5-yl)-1H-indole-6-carboxamide	Investigative	136016419	C27H33N5O2	459.6	CC(C)CN(C)C(=O)C1=CC2=C(C=C1)C(=C(N2)C3=C(C=NN3)C4=CC=CC=C4)CNCCCO	IC50 ~ 100000 nM	Poor binder
T91761	T-cell-specific kinase	BXV26I	3-[1-[(3R)-1-Acetylpiperidin-3-yl]-4-aminopyrazolo[3,4-d]pyrimidin-3-yl]-N-benzylbenzamide	Investigative	71457311	C26H27N7O2	469.5	CC(=O)N1CCC[C@H](C1)N2C3=NC=NC(=C3C(=N2)C4=CC(=CC=C4)C(=O)NCC5=CC=CC=C5)N	IC50 ~ 100000 nM	Poor binder
T91761	T-cell-specific kinase	BZ37RO	3-[4-Amino-1-[(3R)-1-(3-methylbut-2-enoyl)piperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-propan-2-ylphenyl)benzamide	Investigative	71462675	C31H35N7O2	537.7	CC(C)C1=CC=C(C=C1)NC(=O)C2=CC=CC(=C2)C3=NN(C4=NC=NC(=C34)N)[C@@H]5CCCN(C5)C(=O)C=C(C)C	IC50 ~ 100000 nM	Poor binder
T91761	T-cell-specific kinase	BZA9N5	N-(3-(6-Methyl-1H-indol-2-yl)-1H-indazol-6-yl)cyclohexanecarboxamide	Investigative	136030635	C23H24N4O	372.5	CC1=CC2=C(C=C1)C=C(N2)C3=NNC4=C3C=CC(=C4)NC(=O)C5CCCCC5	IC50 ~ 50000 nM	Poor binder
T91761	T-cell-specific kinase	BZR53E	3-[4-Amino-1-[(3R)-1-[(E)-but-2-enoyl]piperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-propan-2-ylphenyl)benzamide	Investigative	71455524	C30H33N7O2	523.6	C/C=C/C(=O)N1CCC[C@H](C1)N2C3=NC=NC(=C3C(=N2)C4=CC(=CC=C4)C(=O)NC5=CC=C(C=C5)C(C)C)N	IC50 ~ 100000 nM	Poor binder
T91761	T-cell-specific kinase	BZRP70	3-[4-Amino-1-[(3R)-1-but-2-ynoylpiperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-propan-2-ylphenyl)benzamide	Investigative	71462672	C30H31N7O2	521.6	CC#CC(=O)N1CCC[C@H](C1)N2C3=NC=NC(=C3C(=N2)C4=CC(=CC=C4)C(=O)NC5=CC=C(C=C5)C(C)C)N	IC50 ~ 100000 nM	Poor binder