TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T92144	Angiopoietin 1 receptor	D0J9ZR	Niclosamide	Approved	4477	C13H8Cl2N2O4	327.12	C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O	IC50 = 67800 nM	Poor binder
T92144	Angiopoietin 1 receptor	B13UPZ	2-(6-Amino-9H-purine-9-yl)-1-(1H-indole-3-yl)ethanone	Investigative	42603880	C15H12N6O	292.3	C1=CC=C2C(=C1)C(=CN2)C(=O)CN3C=NC4=C(N=CN=C43)N	IC50 = 85000 nM	Poor binder
T92144	Angiopoietin 1 receptor	B14NHR	N-(1-Phenylethyl)-4-(2-(6-phenylimidazo[2,1-b]thiazol-5-yl)vinyl)pyrimidin-2-amine	Investigative	44586767	C25H21N5S	423.5	CC(C1=CC=CC=C1)NC2=NC=CC(=N2)/C=C/C3=C(N=C4N3C=CS4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T92144	Angiopoietin 1 receptor	B18WQL	4-[(E)-2-(1-Methyl-2-phenylindol-3-yl)ethenyl]pyrimidin-2-amine	Investigative	44586831	C21H18N4	326.4	CN1C2=CC=CC=C2C(=C1C3=CC=CC=C3)/C=C/C4=NC(=NC=C4)N	IC50 = 83000 nM	Poor binder
T92144	Angiopoietin 1 receptor	B2ZJ3E	4-(2-(1-Methyl-4-phenyl-1H-imidazol-5-yl)cyclopropyl)pyrimidin-2-amine	Investigative	44586929	C17H17N5	291.35	CN1C=NC(=C1C2CC2C3=NC(=NC=C3)N)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T92144	Angiopoietin 1 receptor	B5P9HU	2-Amino-N-(1-methyl-4-phenyl-1H-imidazol-5-yl)pyrimidine-4-carboxamide	Investigative	44586900	C15H14N6O	294.31	CN1C=NC(=C1NC(=O)C2=NC(=NC=C2)N)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T92144	Angiopoietin 1 receptor	B7XZN5	(E/Z)-4-(2-(3-Phenylthiophen-2-yl)vinyl)pyrimidin-2-amine	Investigative	44586833	C16H13N3S	279.4	C1=CC=C(C=C1)C2=C(SC=C2)/C=C/C3=NC(=NC=C3)N	IC50 ~ 100000 nM	Poor binder
T92144	Angiopoietin 1 receptor	B8SJ4Q	(E/Z)-N-Phenyl-4-(2-(6-phenylimidazo[2,1-b]thiazol-5-yl)vinyl)pyrimidin-2-amine	Investigative	44586768	C23H17N5S	395.5	C1=CC=C(C=C1)C2=C(N3C=CSC3=N2)/C=C/C4=NC(=NC=C4)NC5=CC=CC=C5	IC50 = 68000 nM	Poor binder
T92144	Angiopoietin 1 receptor	B98XBU	4-N-(3-Methyl-5-phenylimidazol-4-yl)pyrimidine-2,4-diamine	Investigative	44586898	C14H14N6	266.3	CN1C=NC(=C1NC2=NC(=NC=C2)N)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T92144	Angiopoietin 1 receptor	B9N8WV	N-(2-Aminopyrimidin-4-yl)-1-methyl-4-phenyl-1H-imidazole-5-carboxamide	Investigative	44586899	C15H14N6O	294.31	CN1C=NC(=C1C(=O)NC2=NC(=NC=C2)N)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T92144	Angiopoietin 1 receptor	B9R2NL	1-[5-Tert-Butyl-3-({4-[2-(Dimethylamino)ethyl]-5-Oxo-1,4-Diazepan-1-Yl}carbonyl)thiophen-2-Yl]-3-(2,3-Dichlorophenyl)urea	Investigative	53384644	C25H33Cl2N5O3S	554.5	CC(C)(C)C1=CC(=C(S1)NC(=O)NC2=C(C(=CC=C2)Cl)Cl)C(=O)N3CCC(=O)N(CC3)CCN(C)C	IC50 = 50000 nM	Poor binder
T92144	Angiopoietin 1 receptor	BF6X2P	2-(6-Amino-7H-purine-7-yl)-1-(1H-indole-3-yl)ethanone	Investigative	42604008	C15H12N6O	292.3	C1=CC=C2C(=C1)C(=CN2)C(=O)CN3C=NC4=NC=NC(=C43)N	IC50 = 95000 nM	Poor binder
T92144	Angiopoietin 1 receptor	BI4HE0	N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[2-(triazol-1-yl)ethoxy]quinazolin-4-amine	Investigative	5329032	C19H16BrFN6O2	459.3	COC1=C(C=C2C(=C1)C(=NC=N2)NC3=C(C=C(C=C3)Br)F)OCCN4C=CN=N4	IC50 ~ 100000 nM	Poor binder
T92144	Angiopoietin 1 receptor	BIB1E3	4-(2-(1-Methyl-4-phenyl-1H-imidazol-5-ylamino)ethyl)pyrimidin-2-amine	Investigative	44586928	C16H18N6	294.35	CN1C=NC(=C1NCCC2=NC(=NC=C2)N)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T92144	Angiopoietin 1 receptor	BK72AZ	(E/Z)-4-(2-(2-Phenylthiophen-3-yl)vinyl)pyrimidin-2-amine	Investigative	44586868	C16H13N3S	279.4	C1=CC=C(C=C1)C2=C(C=CS2)/C=C/C3=NC(=NC=C3)N	IC50 ~ 100000 nM	Poor binder
T92144	Angiopoietin 1 receptor	BLW93H	N-(4-(4-Amino-7-(3-(diethylamino)prop-1-enyl)thieno[3,2-c]pyridin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide	Investigative	18451036	C31H33N5O2S	539.7	CCN(CC)C/C=C/C1=CN=C(C2=C1SC=C2C3=CC(=C(C=C3)NC(=O)C4=CC5=CC=CC=C5N4C)OC)N	IC50 ~ 50000 nM	Poor binder
T92144	Angiopoietin 1 receptor	BLX2Q8	{5-[(E)-2-(2-Aminopyrimidin-4-yl)vinyl]-4-phenyl-1H-imidazol-1-yl}acetic acid	Investigative	44586871	C17H15N5O2	321.33	C1=CC=C(C=C1)C2=C(N(C=N2)CC(=O)O)/C=C/C3=NC(=NC=C3)N	IC50 = 68000 nM	Poor binder
T92144	Angiopoietin 1 receptor	BLZ42H	4-[(E)-2-(6-Methylimidazo[2,1-b][1,3]thiazol-5-yl)ethenyl]pyrimidin-2-amine	Investigative	44587324	C12H11N5S	257.32	CC1=C(N2C=CSC2=N1)/C=C/C3=NC(=NC=C3)N	IC50 ~ 100000 nM	Poor binder
T92144	Angiopoietin 1 receptor	BOKW86	2-[(E)-2-(6-Phenylimidazo[2,1-b][1,3]thiazol-5-yl)ethenyl]pyrimidin-4-amine	Investigative	44586829	C17H13N5S	319.4	C1=CC=C(C=C1)C2=C(N3C=CSC3=N2)/C=C/C4=NC=CC(=N4)N	IC50 ~ 100000 nM	Poor binder
T92144	Angiopoietin 1 receptor	BU53YX	N4-((1-Methyl-4-phenyl-1H-imidazol-5-yl)methyl)pyrimidine-2,4-diamine	Investigative	44586901	C15H16N6	280.33	CN1C=NC(=C1CNC2=NC(=NC=C2)N)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T92144	Angiopoietin 1 receptor	BUKT02	4-[(E)-2-(6-Chloroimidazo[2,1-b][1,3]thiazol-5-yl)ethenyl]pyrimidin-2-amine	Investigative	44587325	C11H8ClN5S	277.73	C1=CN=C(N=C1/C=C/C2=C(N=C3N2C=CS3)Cl)N	IC50 ~ 100000 nM	Poor binder
T92144	Angiopoietin 1 receptor	BW27YB	4-[(E)-2-(1-Methyl-5-phenylimidazol-4-yl)ethenyl]pyrimidin-2-amine	Investigative	44586870	C16H15N5	277.32	CN1C=NC(=C1C2=CC=CC=C2)/C=C/C3=NC(=NC=C3)N	IC50 ~ 100000 nM	Poor binder
T92144	Angiopoietin 1 receptor	BY7MP5	5-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-one	Investigative	118723185	C21H19N3O4	377.4	COC1=CC(=CC(=C1OC)OC)C2=NC(=CNC2=O)C3=CNC4=CC=CC=C43	IC50 ~ 100000 nM	Poor binder
T92144	Angiopoietin 1 receptor	BYHM49	Ethyl 3-oxo-3-[[3-[5-(3-phenoxyprop-1-ynyl)thiophen-3-yl]-1,4-dihydroindeno[1,2-c]pyrazol-5-yl]amino]propanoate	Investigative	44440261	C28H23N3O4S	497.6	CCOC(=O)CC(=O)NC1=CC=CC2=C1CC3=C2NN=C3C4=CSC(=C4)C#CCOC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T92144	Angiopoietin 1 receptor	BZ4F6B	5-[(E)-2-(2-Chloropyrimidin-4-yl)vinyl]-6-phenylimidazo[2,1-b][1,3]thiazole	Investigative	11724734	C17H11ClN4S	338.8	C1=CC=C(C=C1)C2=C(N3C=CSC3=N2)/C=C/C4=NC(=NC=C4)Cl	IC50 = 55000 nM	Poor binder
T92144	Angiopoietin 1 receptor	BZ7A5X	(E/Z)-4-(2-(4-Phenyl-1H-pyrazol-5-yl)vinyl)pyrimidin-2-amine	Investigative	44586832	C15H13N5	263.3	C1=CC=C(C=C1)C2=C(NN=C2)/C=C/C3=NC(=NC=C3)N	IC50 = 64000 nM	Poor binder
T92144	Angiopoietin 1 receptor	BZPQ86	4-Amino-5-(4-phenoxyphenyl)-7-(2-aminoethyl)-7H-pyrrolo[2,3-d]pyrimidine	Investigative	22736238	C20H19N5O	345.4	C1=CC=C(C=C1)OC2=CC=C(C=C2)C3=CN(C4=NC=NC(=C34)N)CCN	IC50 ~ 50000 nM	Poor binder
T92144	Angiopoietin 1 receptor	D06WGX	A-770041	Investigative	9549184	C34H39N9O3	621.7	CC(=O)N1CCN(CC1)C2CCC(CC2)N3C4=NC=NC(=C4C(=N3)C5=CC(=C(C=C5)NC(=O)C6=CC7=CC=CC=C7N6C)OC)N	IC50 ~ 50000 nM	Poor binder
T92144	Angiopoietin 1 receptor	D0D6DH	A-432411	Investigative	10125830	C20H16N2O3	332.4	COC1=C(C=CC(=C1)C2=CC3=C(C=C2)/C(=C/C4=CC=CN4)/C(=O)N3)O	IC50 ~ 50000 nM	Poor binder