TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T92828	Endothelin B receptor	D01VUE	BMS-182874	Terminated	122272	C17H19N3O3S	345.4	CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC3=C2C=CC=C3N(C)C	Ki ~ 50000 nM	Poor binder
T92828	Endothelin B receptor	B05MZN	Cyclo(D-Glu-Ala-D-Val-Leu-D-Trp)	Investigative	9894916	C30H42N6O7	598.7	C[C@H]1C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N1)CCC(=O)O)CC2=CNC3=CC=CC=C32)CC(C)C)C(C)C	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B07PXV	N-(4-Bromo-3-methyl-5-isoxazolyl)-2-thiophenesulfonamide	Investigative	15342056	C8H7BrN2O3S2	323.2	CC1=NOC(=C1Br)NS(=O)(=O)C2=CC=CS2	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B0BE2D	2-Phenyl-thiophene-3-sulfonic acid (4-bromo-3-methyl-isoxazol-5-yl)-amide	Investigative	22998396	C14H11BrN2O3S2	399.3	CC1=NOC(=C1Br)NS(=O)(=O)C2=C(SC=C2)C3=CC=CC=C3	IC50 = 74100 nM	Poor binder
T92828	Endothelin B receptor	B0FT5M	3-[(4-Bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]-N-(6-oxo-1H-pyridazin-3-yl)thiophene-2-carboxamide;2,2,2-trifluoroacetic acid	Investigative	44291240	C15H11BrF3N5O7S2	574.3	CC1=NOC(=C1Br)NS(=O)(=O)C2=C(SC=C2)C(=O)NC3=NNC(=O)C=C3.C(=O)(C(F)(F)F)O	IC50 = 81400 nM	Poor binder
T92828	Endothelin B receptor	B0JI6W	3-(2-Methoxy-phenyl)-thiophene-2-sulfonic acid (4-bromo-3-methyl-isoxazol-5-yl)-amide	Investigative	23445506	C15H13BrN2O4S2	429.3	CC1=NOC(=C1Br)NS(=O)(=O)C2=C(C=CS2)C3=CC=CC=C3OC	IC50 = 59100 nM	Poor binder
T92828	Endothelin B receptor	B0NA4C	N-Phenyl-3-[(4-bromo-3-methylisoxazol-5-yl)sulfamoyl]-2-thiophenecarboxamide	Investigative	10503334	C15H12BrN3O4S2	442.3	CC1=NOC(=C1Br)NS(=O)(=O)C2=C(SC=C2)C(=O)NC3=CC=CC=C3	IC50 = 77600 nM	Poor binder
T92828	Endothelin B receptor	B0UIV6	2''-[(Isobutyl-methyl-amino)-methyl]-4''-oxazol-2-yl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide	Investigative	11071062	C26H30N4O4S	494.6	CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=C(C=C(C=C3)C4=NC=CO4)CN(C)CC(C)C	Ki ~ 50000 nM	Poor binder
T92828	Endothelin B receptor	B13VKR	(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-[2-(2-oxo-pyrrolidin-1-yl)-ethyl]-pyrrolidine-3-carboxylic acid	Investigative	9806559	C28H41N3O6	515.6	CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1CCN2CCCC2=O)C(=O)O)C3=CC4=C(C=C3)OCO4	IC50 = 65400 nM	Poor binder
T92828	Endothelin B receptor	B17HPV	2-[(3S,6R,9S,12S,15S)-6-(1H-Indol-3-ylmethyl)-10-methyl-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid	Investigative	44308287	C32H44N6O7	624.7	CC(C)C[C@H]1C(=O)N[C@@H](C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N1C)C(C)C)CC(=O)O)CC3=CNC4=CC=CC=C43	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B17ZCM	(2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-[(1,1-dioxothiazinan-2-yl)methyl]pyrrolidine-3-carboxylic acid	Investigative	44339755	C27H41N3O7S	551.7	CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1CN2CCCCS2(=O)=O)C(=O)O)C3=CC4=C(C=C3)OCO4	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B21XIE	N-(2-Carbamoyl-4,6-dimethoxyphenyl)-3-[(4-chloro-3-methyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxamide	Investigative	44291583	C18H17ClN4O7S2	500.9	CC1=NOC(=C1Cl)NS(=O)(=O)C2=C(SC=C2)C(=O)NC3=C(C=C(C=C3OC)OC)C(=O)N	IC50 = 61000 nM	Poor binder
T92828	Endothelin B receptor	B26CVM	4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide	Investigative	743974	C16H19NO3S	305.4	CC1=CC(=C(C(=C1)C)NS(=O)(=O)C2=CC=C(C=C2)OC)C	EC50 ~ 50118.72 nM	Poor binder
T92828	Endothelin B receptor	B2A6RY	N-(3,4-Dimethyl-5-isoxazolyl)-4'-(1-methyl-2-imidazolyl)biphenyl-2-sulfonamide	Investigative	22103797	C21H20N4O3S	408.5	CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CN4C	Ki = 120000 nM	Poor binder
T92828	Endothelin B receptor	B2I9BG	(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(2-oxazol-2-yl-ethyl)-pyrrolidine-3-carboxylic acid	Investigative	10577306	C27H37N3O6	499.6	CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1CCC2=NC=CO2)C(=O)O)C3=CC4=C(C=C3)OCO4	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B2INY6	3-[(3S,6R,9S,12S,15S)-6-(1H-Indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]propanoic acid	Investigative	44308426	C32H44N6O7	624.7	CC(C)C[C@H]1C(=O)N[C@@H](C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N1)C(C)C)CCC(=O)O)CC3=CNC4=CC=CC=C43	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B32TIF	Methyl 3-[(4-bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxylate	Investigative	10833686	C10H9BrN2O5S2	381.2	CC1=NOC(=C1Br)NS(=O)(=O)C2=C(SC=C2)C(=O)OC	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B38SKA	2-[2-(1,3-Benzodioxol-5-yl)-1-(dimethylamino)ethyl]-N-(4-chloro-3-methyl-1,2-oxazol-5-yl)thiophene-3-sulfonamide;2,2,2-trifluoroacetic acid	Investigative	44291519	C21H21ClF3N3O7S2	584	CC1=NOC(=C1Cl)NS(=O)(=O)C2=C(SC=C2)C(CC3=CC4=C(C=C3)OCO4)N(C)C.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B3CXH1	N-(3,4-Dimethyl-1,2-oxazol-5-yl)-2-[4-(5-methyl-1,3-oxazol-4-yl)phenyl]benzenesulfonamide	Investigative	10811477	C21H19N3O4S	409.5	CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=C(OC=N4)C	Ki = 94000 nM	Poor binder
T92828	Endothelin B receptor	B3IU2G	N-(3,4-Dimethyl-1,2-oxazol-5-yl)-2-[4-(2-methyl-1,3-oxazol-4-yl)phenyl]benzenesulfonamide	Investigative	10549472	C21H19N3O4S	409.5	CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=COC(=N4)C	Ki = 110000 nM	Poor binder
T92828	Endothelin B receptor	B3KTP7	(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(2-methyl-pentyl)-pyrrolidine-3-carboxylic acid	Investigative	10184817	C28H44N2O5	488.7	CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1CC(C)CCC)C(=O)O)C2=CC3=C(C=C2)OCO3	IC50 = 71000 nM	Poor binder
T92828	Endothelin B receptor	B3OF9D	2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazine-1-carbonyl)-thiophene-3-sulfonic acid (4-chloro-3-methyl-isoxazol-5-yl)-amide	Investigative	10554085	C21H21ClN4O6S2	525	CC1=NOC(=C1Cl)NS(=O)(=O)C2=C(SC=C2)C(=O)N3CCN(CC3)CC4=CC5=C(C=C4)OCO5	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B3VOK9	(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(2-propyl-pentyl)-pyrrolidine-3-carboxylic acid	Investigative	10289348	C30H48N2O5	516.7	CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1CC(CCC)CCC)C(=O)O)C2=CC3=C(C=C2)OCO3	IC50 = 95000 nM	Poor binder
T92828	Endothelin B receptor	B3Z7AG	2-[(R)-1-((S)-2-Cyclohexyloxycarbonylamino-4-methyl-pentanoylamino)-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid	Investigative	10554410	C29H38N4O6	538.6	CC1=C(N=C(O1)[C@@H](CC2=CN(C3=CC=CC=C32)C)NC(=O)[C@H](CC(C)C)NC(=O)OC4CCCCC4)C(=O)O	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B4F1CD	2-[(R)-1-[(S)-2-(3-Cyclohexyl-3-methyl-ureido)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid	Investigative	10792783	C30H41N5O5	551.7	CC1=C(N=C(O1)[C@@H](CC2=CN(C3=CC=CC=C32)C)NC(=O)[C@H](CC(C)C)NC(=O)N(C)C4CCCCC4)C(=O)O	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B4F2NZ	Methyl 3-(N-(4-chloro-3-methylisoxazol-5-yl)sulfamoyl)thiophene-2-carboxylate	Investigative	10854399	C10H9ClN2O5S2	336.8	CC1=NOC(=C1Cl)NS(=O)(=O)C2=C(SC=C2)C(=O)OC	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B4JNT7	2-[(R)-1-[[(S)-2-[[[Cyclohexyl(methyl)amino]carbonyl]oxy]-4-methylpentanoyl]amino]-2-(1-methyl-1H-indol-3-yl)ethyl]-5-methyloxazole-4-carboxylic acid	Investigative	9959298	C30H40N4O6	552.7	CC1=C(N=C(O1)[C@@H](CC2=CN(C3=CC=CC=C32)C)NC(=O)[C@H](CC(C)C)OC(=O)N(C)C4CCCCC4)C(=O)O	IC50 = 90000 nM	Poor binder
T92828	Endothelin B receptor	B4QCR3	3-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid 2,4-dimethyl-phenyl ester	Investigative	23445224	C18H18N2O5S2	406.5	CC1=CC(=C(C=C1)OC(=O)C2=C(C=CS2)S(=O)(=O)NC3=C(C(=NO3)C)C)C	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B4W6DK	(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(2-[1,3]dioxan-2-yl-ethyl)-pyrrolidine-3-carboxylic acid	Investigative	10577829	C28H42N2O7	518.6	CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1CCC2OCCCO2)C(=O)O)C3=CC4=C(C=C3)OCO4	IC50 = 62000 nM	Poor binder
T92828	Endothelin B receptor	B52JAV	3-[(4-Bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]-N-(3-methoxyphenyl)thiophene-2-carboxamide;2,2,2-trifluoroacetic acid	Investigative	44291725	C18H15BrF3N3O7S2	586.4	CC1=NOC(=C1Br)NS(=O)(=O)C2=C(SC=C2)C(=O)NC3=CC(=CC=C3)OC.C(=O)(C(F)(F)F)O	IC50 = 63100 nM	Poor binder
T92828	Endothelin B receptor	B56OXE	3-o-Tolyl-thiophene-2-sulfonic acid (4-bromo-3-methyl-isoxazol-5-yl)-amide	Investigative	23445410	C15H13BrN2O3S2	413.3	CC1=CC=CC=C1C2=C(SC=C2)S(=O)(=O)NC3=C(C(=NO3)C)Br	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B58QFA	N-(3,4-Dimethyl-5-isoxazolyl)-4'-(5-pyrimidinyl)biphenyl-2-sulfonamide	Investigative	18660523	C21H18N4O3S	406.5	CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=CN=CN=C4	Ki = 170000 nM	Poor binder
T92828	Endothelin B receptor	B5AF2C	2-[(R)-1-[(S)-2-(3-Cyclohexyl-1-methyl-ureido)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-1H-imidazole-4-carboxylic acid	Investigative	10578601	C30H42N6O4	550.7	CC1=C(N=C(N1)[C@@H](CC2=CN(C3=CC=CC=C32)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)NC4CCCCC4)C(=O)O	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B5G8BP	3-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid	Investigative	10685758	C10H10N2O5S2	302.3	CC1=C(ON=C1C)NS(=O)(=O)C2=C(SC=C2)C(=O)O	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B67SXD	3-p-Tolyl-thiophene-2-sulfonic acid (4-bromo-3-methyl-isoxazol-5-yl)-amide	Investigative	22998508	C15H13BrN2O3S2	413.3	CC1=CC=C(C=C1)C2=C(SC=C2)S(=O)(=O)NC3=C(C(=NO3)C)Br	IC50 = 95550 nM	Poor binder
T92828	Endothelin B receptor	B6C4FZ	2-[(R)-1-((S)-2-Cyclohexyloxycarbonyloxy-4-methyl-pentanoylamino)-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid	Investigative	10626245	C29H37N3O7	539.6	CC1=C(N=C(O1)[C@@H](CC2=CN(C3=CC=CC=C32)C)NC(=O)[C@H](CC(C)C)OC(=O)OC4CCCCC4)C(=O)O	IC50 = 79000 nM	Poor binder
T92828	Endothelin B receptor	B6C9RY	N-(4-Chloro-3-methyl-5-isoxazolyl)-2-[(2-methyl-1,3,4-thiadiazol-5-yl)aminocarbonyl]thiophene-3-sulfonamide	Investigative	10550033	C12H10ClN5O4S3	419.9	CC1=NOC(=C1Cl)NS(=O)(=O)C2=C(SC=C2)C(=O)NC3=NN=C(S3)C	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B6D1FU	(2E,4E)-Hexa-2,4-dienoic acid (5R,9aS,9bS)-1,9b-dihydroxy-6,6,9a-trimethyl-1,3,5,5a,6,7,8,9,9a,9b-decahydro-naphtho[1,2-c]furan-5-yl ester	Investigative	44383536	C21H30O5	362.5	C/C=C/C=C/C(=O)O[C@@H]1C=C2COC([C@@]2([C@@]3(C1C(CCC3)(C)C)C)O)O	IC50 = 70000 nM	Poor binder
T92828	Endothelin B receptor	B6D2NP	3-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid (6-acetyl-benzo[1,3]dioxol-5-yl)-amide	Investigative	10552051	C19H17N3O7S2	463.5	CC1=C(ON=C1C)NS(=O)(=O)C2=C(SC=C2)C(=O)NC3=CC4=C(C=C3C(=O)C)OCO4	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B6E1CW	(2E,4E,6E)-Octa-2,4,6-trienoic acid (5R,9aS,9bS)-9b-hydroxy-6,6,9a-trimethyl-1-oxo-1,3,5,5a,6,7,8,9,9a,9b-decahydro-naphtho[1,2-c]furan-5-yl ester	Investigative	44383592	C23H30O5	386.5	C/C=C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(=O)[C@@]2([C@@]3(C1C(CCC3)(C)C)C)O	IC50 = 50000 nM	Poor binder
T92828	Endothelin B receptor	B6ILX8	(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(2,2,4-trimethyl-pent-3-enyl)-pyrrolidine-3-carboxylic acid	Investigative	10289311	C30H46N2O5	514.7	CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1CC(C)(C)C=C(C)C)C(=O)O)C2=CC3=C(C=C2)OCO3	IC50 = 64000 nM	Poor binder
T92828	Endothelin B receptor	B6MR2H	3-[(4-Bromo-3-methylisoxazol-5-yl)sulfamoyl]-2-thiophenecarboxamide	Investigative	10546830	C9H8BrN3O4S2	366.2	CC1=NOC(=C1Br)NS(=O)(=O)C2=C(SC=C2)C(=O)N	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B6VI7E	[(3R,6S,9R,12S,15R)-6-(1H-Indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]methanesulfonic acid	Investigative	44357212	C30H42N6O8S	646.8	CC(C)C[C@@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@H](C(=O)N1)C(C)C)CS(=O)(=O)O)CC3=CNC4=CC=CC=C43	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B6WS8O	(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(2-[1,3]dioxolan-2-yl-2-methyl-propyl)-pyrrolidine-3-carboxylic acid	Investigative	10554273	C29H44N2O7	532.7	CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1CC(C)(C)C2OCCO2)C(=O)O)C3=CC4=C(C=C3)OCO4	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B78EPF	3-(4-Bromo-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid o-tolyl ester	Investigative	22998438	C16H13BrN2O5S2	457.3	CC1=CC=CC=C1OC(=O)C2=C(C=CS2)S(=O)(=O)NC3=C(C(=NO3)C)Br	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B7K4AP	3-(3-Methoxy-phenyl)-thiophene-2-sulfonic acid (4-bromo-3-methyl-isoxazol-5-yl)-amide	Investigative	23445219	C15H13BrN2O4S2	429.3	CC1=NOC(=C1Br)NS(=O)(=O)C2=C(C=CS2)C3=CC(=CC=C3)OC	IC50 = 56250 nM	Poor binder
T92828	Endothelin B receptor	B7KL4Y	2,5-Dichloro-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulfonamide	Investigative	3795752	C11H10Cl2N2O3S	321.2	CC1=C(ON=C1C)NS(=O)(=O)C2=C(C=CC(=C2)Cl)Cl	IC50 = 80000 nM	Poor binder
T92828	Endothelin B receptor	B7LCP9	N-(3,4-Dimethyl-isoxazol-5-yl)-2,5-dimethyl-benzenesulfonamide	Investigative	44316527	C13H16N2O3S	280.34	CC1=CC(=C(C=C1)C)S(=O)(=O)NC2=C(C(=NO2)C)C	IC50 = 58000 nM	Poor binder
T92828	Endothelin B receptor	B7PK8U	(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-[2-(2-oxo-piperidin-1-yl)-ethyl]-pyrrolidine-3-carboxylic acid	Investigative	10602267	C29H43N3O6	529.7	CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1CCN2CCCCC2=O)C(=O)O)C3=CC4=C(C=C3)OCO4	IC50 = 85000 nM	Poor binder
T92828	Endothelin B receptor	B7YK9O	3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid p-tolyl ester	Investigative	23445505	C16H13ClN2O5S2	412.9	CC1=CC=C(C=C1)OC(=O)C2=C(C=CS2)S(=O)(=O)NC3=C(C(=NO3)C)Cl	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B80QJL	3-[(4-Bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]-N-(2-methoxyphenyl)thiophene-2-carboxamide	Investigative	10576378	C16H14BrN3O5S2	472.3	CC1=NOC(=C1Br)NS(=O)(=O)C2=C(SC=C2)C(=O)NC3=CC=CC=C3OC	IC50 = 61700 nM	Poor binder
T92828	Endothelin B receptor	B8EU5C	2-[(R)-1-((S)-2-Cyclohexylcarbamoyloxy-4-methyl-pentanoylamino)-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-1H-imidazole-4-carboxylic acid	Investigative	10650062	C29H39N5O5	537.6	CC1=C(N=C(N1)[C@@H](CC2=CN(C3=CC=CC=C32)C)NC(=O)[C@H](CC(C)C)OC(=O)NC4CCCCC4)C(=O)O	IC50 = 54000 nM	Poor binder
T92828	Endothelin B receptor	B8EXL5	3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid phenylamide	Investigative	23445325	C15H12ClN3O4S2	397.9	CC1=NOC(=C1Cl)NS(=O)(=O)C2=C(SC=C2)C(=O)NC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B8I7KD	4'-(Benzoxazole-2-yl)-N-(3,4-dimethyl-5-isoxazolyl)biphenyl-2-sulfonamide	Investigative	10813228	C24H19N3O4S	445.5	CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC5=CC=CC=C5O4	Ki = 94000 nM	Poor binder
T92828	Endothelin B receptor	B8O2EB	2-[(R)-1-[(S)-2-(3-Cyclohexyl-1-methyl-ureido)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid	Investigative	10650331	C30H41N5O5	551.7	CC1=C(N=C(O1)[C@@H](CC2=CN(C3=CC=CC=C32)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)NC4CCCCC4)C(=O)O	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B8SMB6	2-(2-Benzo[1,3]dioxol-5-yl-1-hydroxy-1-methyl-ethyl)-thiophene-3-sulfonic acid (4-chloro-3-methyl-isoxazol-5-yl)-amide	Investigative	10647488	C18H17ClN2O6S2	456.9	CC1=NOC(=C1Cl)NS(=O)(=O)C2=C(SC=C2)C(C)(CC3=CC4=C(C=C3)OCO4)O	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	B8UJ2T	(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-pent-3-enyl-pyrrolidine-3-carboxylic acid	Investigative	10648135	C27H40N2O5	472.6	CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1CC/C=C/C)C(=O)O)C2=CC3=C(C=C2)OCO3	IC50 = 67000 nM	Poor binder
T92828	Endothelin B receptor	B8WT6R	N-(3,4-Dimethyl-5-isoxazolyl)-4'-(2-thiazolyl)biphenyl-2-sulfonamide	Investigative	22103743	C20H17N3O3S2	411.5	CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CS4	Ki = 52000 nM	Poor binder
T92828	Endothelin B receptor	B9SC8L	(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(2,2-dimethyl-pentyl)-pyrrolidine-3-carboxylic acid	Investigative	10278777	C29H46N2O5	502.7	CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1CC(C)(C)CCC)C(=O)O)C2=CC3=C(C=C2)OCO3	IC50 = 62000 nM	Poor binder
T92828	Endothelin B receptor	BA3X0H	N-(3,4-Dimethyl-isoxazol-5-yl)-2-(1H-indol-2-yl)-benzenesulfonamide	Investigative	9864017	C19H17N3O3S	367.4	CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC4=CC=CC=C4N3	Ki = 66000 nM	Poor binder
T92828	Endothelin B receptor	BB0U4Z	2-[(R)-1-((R)-2-Cyclohexylcarbamoylmethyl-4-methyl-pentanoylamino)-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid	Investigative	11800505	C30H40N4O5	536.7	CC1=C(N=C(O1)[C@@H](CC2=CN(C3=CC=CC=C32)C)NC(=O)[C@H](CC(C)C)CC(=O)NC4CCCCC4)C(=O)O	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BB1U7E	5-Benzyloxy-3-isopropoxy-benzo[b]thiophene-2-carboxylic acid	Investigative	14673588	C19H18O4S	342.4	CC(C)OC1=C(SC2=C1C=C(C=C2)OCC3=CC=CC=C3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BBN8M6	2-[(R)-1-((R)-2-Cyclohexylcarbamoylmethyl-4-methyl-pentanoylamino)-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-1H-imidazole-4-carboxylic acid	Investigative	10506505	C30H41N5O4	535.7	CC1=C(N=C(N1)[C@@H](CC2=CN(C3=CC=CC=C32)C)NC(=O)[C@H](CC(C)C)CC(=O)NC4CCCCC4)C(=O)O	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BC3PO9	3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid phenyl ester	Investigative	23445562	C15H11ClN2O5S2	398.8	CC1=NOC(=C1Cl)NS(=O)(=O)C2=C(SC=C2)C(=O)OC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BCN8R5	2-[(R)-1-[(S)-2-(2-Cyclohexyl-acetylamino)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid	Investigative	10602451	C30H40N4O5	536.7	CC1=C(N=C(O1)[C@@H](CC2=CN(C3=CC=CC=C32)C)NC(=O)[C@H](CC(C)C)NC(=O)CC4CCCCC4)C(=O)O	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BCV05I	(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-[2-(tetrahydro-pyran-4-yl)-ethyl]-pyrrolidine-3-carboxylic acid	Investigative	10791988	C29H44N2O6	516.7	CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1CCC2CCOCC2)C(=O)O)C3=CC4=C(C=C3)OCO4	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BD1S3N	3-[(4-Chloro-3-methyl-1,2-oxazol-5-yl)sulfamoyl]-N-(2,4-dimethoxyphenyl)thiophene-2-carboxamide;ethyl acetate	Investigative	44291203	C21H24ClN3O8S2	546	CCOC(=O)C.CC1=NOC(=C1Cl)NS(=O)(=O)C2=C(SC=C2)C(=O)NC3=C(C=C(C=C3)OC)OC	IC50 = 51900 nM	Poor binder
T92828	Endothelin B receptor	BD37NJ	5-Bromo-N-(3,4-dimethyl-isoxazol-5-yl)-2-methyl-benzenesulfonamide	Investigative	44316526	C12H13BrN2O3S	345.21	CC1=C(C=C(C=C1)Br)S(=O)(=O)NC2=C(C(=NO2)C)C	IC50 = 59000 nM	Poor binder
T92828	Endothelin B receptor	BD4UT6	2-[(3S,6S,9R,12R,15R)-6-(1H-Indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-thiophen-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid	Investigative	44357391	C32H38N6O7S	650.7	CC(C)C[C@@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@H](C(=O)N1)C3=CC=CS3)CC(=O)O)CC4=CNC5=CC=CC=C54	IC50 = 55000 nM	Poor binder
T92828	Endothelin B receptor	BDCU50	N-(3,4-Dimethyl-5-isoxazolyl)-4'-(4-pyrimidinyl)biphenyl-2-sulfonamide	Investigative	18660522	C21H18N4O3S	406.5	CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=NC=C4	Ki = 130000 nM	Poor binder
T92828	Endothelin B receptor	BDI94X	3-[(4-Bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]-N-methyl-N-phenylthiophene-2-carboxamide;2,2,2-trifluoroacetic acid	Investigative	44291740	C18H15BrF3N3O6S2	570.4	CC1=NOC(=C1Br)NS(=O)(=O)C2=C(SC=C2)C(=O)N(C)C3=CC=CC=C3.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BF0SV2	(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(3-ethyl-pentyl)-pyrrolidine-3-carboxylic acid	Investigative	10696818	C29H46N2O5	502.7	CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1CCC(CC)CC)C(=O)O)C2=CC3=C(C=C2)OCO3	IC50 = 72000 nM	Poor binder
T92828	Endothelin B receptor	BF1UT4	N-(4-Bromo-3-methyl-5-isoxazolyl)thiophene-3-sulfonamide	Investigative	12146375	C8H7BrN2O3S2	323.2	CC1=NOC(=C1Br)NS(=O)(=O)C2=CSC=C2	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BG30PE	2-[(R)-1-[(S)-2-(2-Cyclohexyl-acetylamino)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-1H-imidazole-4-carboxylic acid	Investigative	10626177	C30H41N5O4	535.7	CC1=C(N=C(N1)[C@@H](CC2=CN(C3=CC=CC=C32)C)NC(=O)[C@H](CC(C)C)NC(=O)CC4CCCCC4)C(=O)O	IC50 ~ 90000 nM	Poor binder
T92828	Endothelin B receptor	BG7YC8	3-[(3,4-Dimethyl-1,2-oxazol-5-yl)sulfamoyl]-N-(4-methylphenyl)thiophene-2-carboxamide	Investigative	10548486	C17H17N3O4S2	391.5	CC1=CC=C(C=C1)NC(=O)C2=C(C=CS2)S(=O)(=O)NC3=C(C(=NO3)C)C	IC50 = 67600 nM	Poor binder
T92828	Endothelin B receptor	BGF3V2	N-(3-Hydroxyphenyl)-3-[(4-bromo-3-methylisoxazol-5-yl)sulfamoyl]-2-thiophenecarboxamide	Investigative	10718688	C15H12BrN3O5S2	458.3	CC1=NOC(=C1Br)NS(=O)(=O)C2=C(SC=C2)C(=O)NC3=CC(=CC=C3)O	IC50 = 67500 nM	Poor binder
T92828	Endothelin B receptor	BGI70P	2-[(R)-1-((S)-2-Cyclohexyloxycarbonylamino-4-methyl-pentanoylamino)-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-1H-imidazole-4-carboxylic acid	Investigative	10578300	C29H39N5O5	537.6	CC1=C(N=C(N1)[C@@H](CC2=CN(C3=CC=CC=C32)C)NC(=O)[C@H](CC(C)C)NC(=O)OC4CCCCC4)C(=O)O	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BGMI92	(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-((Z)-2,2-dimethyl-pent-3-enyl)-pyrrolidine-3-carboxylic acid	Investigative	44340049	C29H44N2O5	500.7	CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1CC(C)(C)/C=C\\C)C(=O)O)C2=CC3=C(C=C2)OCO3	IC50 = 92700 nM	Poor binder
T92828	Endothelin B receptor	BGSQ50	3-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid phenylamide	Investigative	23445445	C16H15N3O4S2	377.4	CC1=C(ON=C1C)NS(=O)(=O)C2=C(SC=C2)C(=O)NC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BH4K0Z	3-(4-Bromo-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid m-tolylamide	Investigative	10527774	C16H14BrN3O4S2	456.3	CC1=CC(=CC=C1)NC(=O)C2=C(C=CS2)S(=O)(=O)NC3=C(C(=NO3)C)Br	IC50 = 67400 nM	Poor binder
T92828	Endothelin B receptor	BI34LW	3-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid phenyl ester	Investigative	23445345	C16H14N2O5S2	378.4	CC1=C(ON=C1C)NS(=O)(=O)C2=C(SC=C2)C(=O)OC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BIS21W	3-Chloro-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulfonamide	Investigative	44316993	C11H11ClN2O3S	286.74	CC1=C(ON=C1C)NS(=O)(=O)C2=CC(=CC=C2)Cl	IC50 = 90000 nM	Poor binder
T92828	Endothelin B receptor	BJ08TP	N-(3,4-Dimethyl-isoxazol-5-yl)-4-fluoro-benzenesulfonamide	Investigative	10265127	C11H11FN2O3S	270.28	CC1=C(ON=C1C)NS(=O)(=O)C2=CC=C(C=C2)F	IC50 = 57000 nM	Poor binder
T92828	Endothelin B receptor	BJ1R6E	3-[(4-Chloro-3-methyl-1,2-oxazol-5-yl)sulfamoyl]-N-(5-methyl-1,2-oxazol-3-yl)thiophene-2-carboxamide;2,2,2-trifluoroacetic acid	Investigative	44291461	C15H12ClF3N4O7S2	516.9	CC1=CC(=NO1)NC(=O)C2=C(C=CS2)S(=O)(=O)NC3=C(C(=NO3)C)Cl.C(=O)(C(F)(F)F)O	IC50 = 92100 nM	Poor binder
T92828	Endothelin B receptor	BJR5C7	2-[(R)-1-[(S)-2-(3-Cyclohexyl-ureido)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid	Investigative	10554384	C29H39N5O5	537.6	CC1=C(N=C(O1)[C@@H](CC2=CN(C3=CC=CC=C32)C)NC(=O)[C@H](CC(C)C)NC(=O)NC4CCCCC4)C(=O)O	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BK2T8V	3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid 2,4-dimethyl-phenyl ester	Investigative	23445412	C17H15ClN2O5S2	426.9	CC1=CC(=C(C=C1)OC(=O)C2=C(C=CS2)S(=O)(=O)NC3=C(C(=NO3)C)Cl)C	IC50 = 68400 nM	Poor binder
T92828	Endothelin B receptor	BK3R0V	3-Phenyl-thiophene-2-sulfonic acid (4-bromo-3-methyl-isoxazol-5-yl)-amide	Investigative	23445388	C14H11BrN2O3S2	399.3	CC1=NOC(=C1Br)NS(=O)(=O)C2=C(C=CS2)C3=CC=CC=C3	IC50 = 64450 nM	Poor binder
T92828	Endothelin B receptor	BK97SZ	3-(4-Bromo-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid m-tolyl ester	Investigative	23445317	C16H13BrN2O5S2	457.3	CC1=CC(=CC=C1)OC(=O)C2=C(C=CS2)S(=O)(=O)NC3=C(C(=NO3)C)Br	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BKLE18	3-Chloro-N-(3,4-dimethyl-isoxazol-5-yl)-2-methyl-benzenesulfonamide	Investigative	18617381	C12H13ClN2O3S	300.76	CC1=C(ON=C1C)NS(=O)(=O)C2=C(C(=CC=C2)Cl)C	IC50 = 74000 nM	Poor binder
T92828	Endothelin B receptor	BKX79B	3-(4-Bromo-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid	Investigative	10832763	C9H7BrN2O5S2	367.2	CC1=NOC(=C1Br)NS(=O)(=O)C2=C(SC=C2)C(=O)O	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BM0GZ8	3-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid p-tolyl ester	Investigative	22998439	C17H16N2O5S2	392.5	CC1=CC=C(C=C1)OC(=O)C2=C(C=CS2)S(=O)(=O)NC3=C(C(=NO3)C)C	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BM7A8S	N-(4-Bromo-3-methyl-isoxazol-5-yl)-benzenesulfonamide	Investigative	18617288	C10H9BrN2O3S	317.16	CC1=NOC(=C1Br)NS(=O)(=O)C2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BNH60P	3-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid methyl ester	Investigative	10615322	C11H12N2O5S2	316.4	CC1=C(ON=C1C)NS(=O)(=O)C2=C(SC=C2)C(=O)OC	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BNQI49	[1,1'-Biphenyl]-2-sulfonamide, N-(3,4-dimethyl-5-isoxazolyl)-	Investigative	9840391	C17H16N2O3S	328.4	CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=CC=C3	IC50 = 55000 nM	Poor binder
T92828	Endothelin B receptor	BNZ59M	N-(4-Bromo-3-methyl-1,2-oxazol-5-yl)-3-(4-methoxyphenyl)thiophene-2-sulfonamide	Investigative	44322947	C15H13BrN2O4S2	429.3	CC1=NOC(=C1Br)NS(=O)(=O)C2=C(C=CS2)C3=CC=C(C=C3)OC	IC50 = 62050 nM	Poor binder
T92828	Endothelin B receptor	BNZ5R1	(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(3-[1,3]dioxolan-2-yl-propyl)-pyrrolidine-3-carboxylic acid	Investigative	10649585	C28H42N2O7	518.6	CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1CCCC2OCCO2)C(=O)O)C3=CC4=C(C=C3)OCO4	IC50 = 50000 nM	Poor binder
T92828	Endothelin B receptor	BO6H7A	N-(3,4-Dimethyl-5-isoxazolyl)-4'-(1,3,4-oxadiazole-2-yl)biphenyl-2-sulfonamide	Investigative	22103385	C19H16N4O4S	396.4	CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NN=CO4	Ki = 75000 nM	Poor binder
T92828	Endothelin B receptor	BOCA16	2,4-Dichloro-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulfonamide	Investigative	18617299	C11H10Cl2N2O3S	321.2	CC1=C(ON=C1C)NS(=O)(=O)C2=C(C=C(C=C2)Cl)Cl	IC50 = 105000 nM	Poor binder
T92828	Endothelin B receptor	BOH0C2	(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-[2-(tetrahydro-furan-2-yl)-ethyl]-pyrrolidine-3-carboxylic acid	Investigative	11799636	C28H42N2O6	502.6	CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1CCC2CCCO2)C(=O)O)C3=CC4=C(C=C3)OCO4	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BP0DV5	(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-pent-4-enyl-pyrrolidine-3-carboxylic acid	Investigative	10814318	C27H40N2O5	472.6	CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1CCCC=C)C(=O)O)C2=CC3=C(C=C2)OCO3	IC50 = 60000 nM	Poor binder
T92828	Endothelin B receptor	BP23EK	3-(N-(4-Chloro-3-methylisoxazol-5-yl)sulfamoyl)thiophene-2-carboxylic acid	Investigative	10805820	C9H7ClN2O5S2	322.7	CC1=NOC(=C1Cl)NS(=O)(=O)C2=C(SC=C2)C(=O)O	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BP2LT9	2-[(2S,5S,8S,11S,14R)-14-(1H-Indol-3-ylmethyl)-5-methyl-11-(2-methylpropyl)-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid	Investigative	44308499	C29H40N6O7	584.7	C[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N1)CC(=O)O)CC2=CNC3=CC=CC=C32)CC(C)C)C(C)C	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BQK67J	2-[(3S,6S,9S,12R,15S)-12-(1H-Indol-3-ylmethyl)-6-methyl-2,5,8,11,14-pentaoxo-3-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]acetic acid	Investigative	44308286	C28H36N6O7	568.6	C[C@H]1C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](C(=O)N[C@H](C(=O)N1)CC(=O)O)CC3=CNC4=CC=CC=C43)C(C)C	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BR48HV	3-[(2S,5S,8S,11S,14R)-8-[(2R)-Butan-2-yl]-14-(1H-indol-3-ylmethyl)-5-methyl-11-(2-methylpropyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propanoic acid	Investigative	56668902	C31H44N6O7	612.7	CC[C@@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)C)CCC(=O)O)CC2=CNC3=CC=CC=C32)CC(C)C	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BS12NZ	N-(3,4-Dimethyl-1,2-oxazol-5-yl)-2-[4-(4-methyl-1,3-oxazol-2-yl)phenyl]benzenesulfonamide	Investigative	10835335	C21H19N3O4S	409.5	CC1=COC(=N1)C2=CC=C(C=C2)C3=CC=CC=C3S(=O)(=O)NC4=C(C(=NO4)C)C	Ki = 100000 nM	Poor binder
T92828	Endothelin B receptor	BS14FT	(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethyl]-pyrrolidine-3-carboxylic acid	Investigative	10626031	C28H39N3O7	529.6	CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1CCN2C(=O)CCC2=O)C(=O)O)C3=CC4=C(C=C3)OCO4	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BS5Q8V	N-(3,4-Dimethyl-isoxazol-5-yl)-benzenesulfonamide	Investigative	3370402	C11H12N2O3S	252.29	CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2	IC50 = 88000 nM	Poor binder
T92828	Endothelin B receptor	BS7G8A	3-(2,4-Dimethyl-phenyl)-thiophene-2-sulfonic acid (4-bromo-3-methyl-isoxazol-5-yl)-amide	Investigative	23445498	C16H15BrN2O3S2	427.3	CC1=CC(=C(C=C1)C2=C(SC=C2)S(=O)(=O)NC3=C(C(=NO3)C)Br)C	IC50 = 60300 nM	Poor binder
T92828	Endothelin B receptor	BU47NE	N-(3,4-Dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-5-yl)phenyl]benzenesulfonamide	Investigative	10548722	C20H17N3O4S	395.4	CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=CN=CO4	Ki = 78000 nM	Poor binder
T92828	Endothelin B receptor	BURL35	Acetic acid;3-[[3-[(4-bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carbonyl]amino]benzoic acid	Investigative	44292002	C18H16BrN3O8S2	546.4	CC1=NOC(=C1Br)NS(=O)(=O)C2=C(SC=C2)C(=O)NC3=CC=CC(=C3)C(=O)O.CC(=O)O	IC50 = 117000 nM	Poor binder
T92828	Endothelin B receptor	BVSK32	2-[(3S,6S,9R,12S,15R)-6-(1H-Indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid	Investigative	44357174	C31H42N6O7	610.7	CC(C)C[C@@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@H](C(=O)N1)C(C)C)CC(=O)O)CC3=CNC4=CC=CC=C43	IC50 = 61000 nM	Poor binder
T92828	Endothelin B receptor	BX43IL	N-(4-Bromo-3-methyl-5-isoxazolyl)-2-biphenylsulfonamide	Investigative	15453177	C16H13BrN2O3S	393.3	CC1=NOC(=C1Br)NS(=O)(=O)C2=CC=CC=C2C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BXH68Y	2-{[3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carbonyl]-amino}-3,5-dimethoxy-benzoic acid	Investigative	44291584	C18H16ClN3O8S2	501.9	CC1=NOC(=C1Cl)NS(=O)(=O)C2=C(SC=C2)C(=O)NC3=C(C=C(C=C3OC)OC)C(=O)O	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BXHK94	(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(2-[1,3]dioxolan-2-yl-ethyl)-pyrrolidine-3-carboxylic acid	Investigative	10696876	C27H40N2O7	504.6	CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1CCC2OCCO2)C(=O)O)C3=CC4=C(C=C3)OCO4	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BXYJ27	3-(4-Bromo-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid phenyl ester	Investigative	23445241	C15H11BrN2O5S2	443.3	CC1=NOC(=C1Br)NS(=O)(=O)C2=C(SC=C2)C(=O)OC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BY0UP5	N-Benzyl-3-[(4-bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxamide	Investigative	10766198	C16H14BrN3O4S2	456.3	CC1=NOC(=C1Br)NS(=O)(=O)C2=C(SC=C2)C(=O)NCC3=CC=CC=C3	IC50 = 97700 nM	Poor binder
T92828	Endothelin B receptor	BZ68SV	3-[(2S,5R,8S,11R,14S)-8-[(2S)-Butan-2-yl]-14-(1H-indol-3-ylmethyl)-5-methyl-11-(2-methylpropyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propanoic acid	Investigative	44357035	C31H44N6O7	612.7	CC[C@H](C)[C@H]1C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N1)C)CCC(=O)O)CC2=CNC3=CC=CC=C32)CC(C)C	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BZ7R6N	N-(3,4-Dimethyl-5-isoxazolyl)-4'-(2-imidazolyl)biphenyl-2-sulfonamide	Investigative	22103589	C20H18N4O3S	394.4	CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CN4	Ki = 150000 nM	Poor binder
T92828	Endothelin B receptor	BZJW13	2-{[3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carbonyl]-amino}-3,5-dimethoxy-benzoic acid methyl ester	Investigative	44291602	C19H18ClN3O8S2	515.9	CC1=NOC(=C1Cl)NS(=O)(=O)C2=C(SC=C2)C(=O)NC3=C(C=C(C=C3OC)OC)C(=O)OC	IC50 ~ 100000 nM	Poor binder
T92828	Endothelin B receptor	BZQL70	3-(4-Bromo-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid o-tolylamide	Investigative	10575755	C16H14BrN3O4S2	456.3	CC1=CC=CC=C1NC(=O)C2=C(C=CS2)S(=O)(=O)NC3=C(C(=NO3)C)Br	IC50 ~ 100000 nM	Poor binder