TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T93509 Calcitonin gene-related peptide 1 D0G5ME Telcagepant Phase 2 11319053 C26H27F5N6O3 566.5 C1C[C@H](C(=O)N(C[C@@H]1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5 Ki ~ 100000 nM Poor binder T93509 Calcitonin gene-related peptide 1 B7MSA3 4-Bromo-N-[(3,5-difluorophenyl)methyl]-6-(1,1-dioxothiazinan-2-yl)-3-methoxypyridine-2-carboxamide Investigative 57397325 C18H18BrF2N3O4S 490.3 COC1=C(N=C(C=C1Br)N2CCCCS2(=O)=O)C(=O)NCC3=CC(=CC(=C3)F)F Ki ~ 100000 nM Poor binder T93509 Calcitonin gene-related peptide 1 B8EN4P 2-[4-Bromo-5-hydroxy-6-[(3,5-difluorobenzyl)carbamoyl]-2-pyridinyl]tetrahydro-2H-1,2-thiazine 1,1-dioxide Investigative 9847811 C17H16BrF2N3O4S 476.3 C1CCS(=O)(=O)N(C1)C2=NC(=C(C(=C2)Br)O)C(=O)NCC3=CC(=CC(=C3)F)F Ki ~ 100000 nM Poor binder T93509 Calcitonin gene-related peptide 1 BGR3T4 5-(1,1-Dioxothiazinan-2-yl)-N-[(4-fluorophenyl)methyl]-1,6-naphthyridine-7-carboxamide Investigative 57393755 C20H19FN4O3S 414.5 C1CCS(=O)(=O)N(C1)C2=C3C=CC=NC3=CC(=N2)C(=O)NCC4=CC=C(C=C4)F Ki ~ 100000 nM Poor binder T93509 Calcitonin gene-related peptide 1 BWB1F2 N-[(3,5-Difluorophenyl)methyl]-5-(1,1-dioxothiazinan-2-yl)-8-hydroxyquinoline-7-carboxamide Investigative 57392039 C21H19F2N3O4S 447.5 C1CCS(=O)(=O)N(C1)C2=C3C=CC=NC3=C(C(=C2)C(=O)NCC4=CC(=CC(=C4)F)F)O Ki ~ 100000 nM Poor binder T93509 Calcitonin gene-related peptide 1 BY08OQ (3,5-Difluorophenyl)methyl 5-(1,1-dioxothiazinan-2-yl)-8-hydroxy-1,6-naphthyridine-7-carboxylate Investigative 57402496 C20H17F2N3O5S 449.4 C1CCS(=O)(=O)N(C1)C2=NC(=C(C3=C2C=CC=N3)O)C(=O)OCC4=CC(=CC(=C4)F)F Ki ~ 100000 nM Poor binder