TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T94400	Mycobacterium Thymidine monophosphate kinase	D05RHI	Trifluridine	Approved	6256	C10H11F3N2O5	296.2	C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O	Ki = 97000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	B0SE3V	5,7-Diethyl-3,4-dimethyl-1H-1,6-naphthyridin-2-one	Investigative	19093685	C14H18N2O	230.31	CCC1=CC2=C(C(=C(C(=O)N2)C)C)C(=N1)CC	IC50 = 133000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	B1PE8L	6-(2-Methoxyphenyl)-4-methylsulfanyl-2-oxo-1H-pyridine-3-carbonitrile	Investigative	12412402	C14H12N2O2S	272.32	COC1=CC=CC=C1C2=CC(=C(C(=O)N2)C#N)SC	IC50 ~ 50000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	B48DQT	(E)-3-[4-[(5-Methyl-2,4-dioxo-pyrimidin-1-yl)methyl]phenyl]prop-2-enamide	Investigative	5276666	C15H15N3O3	285.3	CC1=CN(C(=O)NC1=O)CC2=CC=C(C=C2)/C=C/C(=O)N	Ki = 195000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	B4HIF1	4-[4-[(5-Methyl-2,4-dioxo-pyrimidin-1-yl)methyl]phenyl]butanamide	Investigative	11709226	C16H19N3O3	301.34	CC1=CN(C(=O)NC1=O)CC2=CC=C(C=C2)CCCC(=O)N	Ki = 112000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	B4OYD0	3-[4-[(5-Methyl-2,4-dioxopyrimidin-1-yl)methyl]phenyl]propanoic acid	Investigative	5276658	C15H16N2O4	288.3	CC1=CN(C(=O)NC1=O)CC2=CC=C(C=C2)CCC(=O)O	Ki = 55000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	B6CGW4	1-(4-Aminomethyl-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione	Investigative	508215	C11H17N3O4	255.27	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)CN	Ki = 57000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	B6ERW3	6-[4-[(5-Methyl-2,4-dioxopyrimidin-1-yl)methyl]phenyl]hex-5-ynamide	Investigative	11638416	C18H19N3O3	325.4	CC1=CN(C(=O)NC1=O)CC2=CC=C(C=C2)C#CCCCC(=O)N	Ki = 113000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	B75XIM	1-[(2R,3R,4R,5S)-4-(Azidomethyl)-3-fluoro-5-(fluoromethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione	Investigative	5273627	C11H13F2N5O3	301.25	CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CF)CN=[N+]=[N-])F	Ki = 80000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	B87GKO	Methyl 4-[4-[(5-chloro-2,4-dioxo-pyrimidin-1-yl)methyl]phenyl]butanoate	Investigative	44586335	C16H17ClN2O4	336.77	COC(=O)CCCC1=CC=C(C=C1)CN2C=C(C(=O)NC2=O)Cl	Ki = 59000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	B89PUQ	3'-Azido-3'-deoxy-4-thiothymidine	Investigative	3000254	C10H13N5O3S	283.31	CC1=CN(C(=O)NC1=S)[C@H]2C[C@@H]([C@H](O2)CO)N=[N+]=[N-]	Ki ~ 100000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	B8XNT9	1',5'-Anhydro-2',3'-dideoxy-2'-(thymin-1-YL)-6'-O-phosphoryl-D-arabino-hexitol	Investigative	502270	C11H17N2O8P	336.23	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](OC2)COP(=O)(O)O)O	Ki = 150000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	B94OIH	1-Benzyl-5-methyl-1H-pyrimidine-2,4-dione	Investigative	237953	C12H12N2O2	216.24	CC1=CN(C(=O)NC1=O)CC2=CC=CC=C2	Ki = 75000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	B9PU5E	1-[[(2S,3R,5R)-2-(Hydroxymethyl)-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-3-yl]methyl]-3-phenyl-thiourea	Investigative	23635981	C18H22N4O4S	390.5	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)CNC(=S)NC3=CC=CC=C3	Ki = 69000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BA26CN	1-[(2R,3R,4R,5S)-4-(Azidomethyl)-3-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione	Investigative	5273625	C11H14FN5O4	299.26	CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)CN=[N+]=[N-])F	Ki = 165000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BAH3G2	3-[4-[(5-Methyl-2,4-dioxopyrimidin-1-yl)methyl]phenyl]propanamide	Investigative	5276657	C15H17N3O3	287.31	CC1=CN(C(=O)NC1=O)CC2=CC=C(C=C2)CCC(=O)N	Ki = 89000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BC50OT	[(2R,3S,4R,5R)-4-Amino-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl dihydrogen phosphate	Investigative	499785	C10H16N3O8P	337.22	CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)N	Ki = 55000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BC8I7E	2'-Fluorothymidine	Investigative	159498	C10H13FN2O5	260.22	CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)F	Ki = 122000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BC9E1P	5-[4-[(5-Methyl-2,4-dioxo-pyrimidin-1-yl)methyl]phenyl]pentanamide	Investigative	24764256	C17H21N3O3	315.37	CC1=CN(C(=O)NC1=O)CC2=CC=C(C=C2)CCCCC(=O)N	Ki = 55000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BCXH05	3-Benzyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione	Investigative	44586051	C17H20N2O6	348.3	CC1=CN(C(=O)N(C1=O)CC2=CC=CC=C2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O	Ki = 75000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BEFO12	1-[(2R,4S,5R)-5-[[[1-[4-Chloro-3-(trifluoromethyl)phenyl]tetrazol-5-yl]amino]methyl]-4-hydroxy-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione	Investigative	57395360	C18H17ClF3N7O4	487.8	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CNC3=NN=NN3C4=CC(=C(C=C4)Cl)C(F)(F)F)O	Ki = 73000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BEG0R7	1-[[4-(4-Hydroxybutyl)phenyl]methyl]-5-methyl-pyrimidine-2,4-dione	Investigative	11694923	C16H20N2O3	288.34	CC1=CN(C(=O)NC1=O)CC2=CC=C(C=C2)CCCCO	Ki = 51000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BF7R6B	2H-Pyran-3-carbonitrile, 4-(methylthio)-2-oxo-6-(2-thienyl)-	Investigative	10890299	C11H7NO2S2	249.3	CSC1=C(C(=O)OC(=C1)C2=CC=CS2)C#N	IC50 ~ 50000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BHK53O	5-[4-[(5-Methyl-2,4-dioxo-pyrimidin-1-yl)methyl]phenyl]pentanoic Acid	Investigative	11536969	C17H20N2O4	316.35	CC1=CN(C(=O)NC1=O)CC2=CC=C(C=C2)CCCCC(=O)O	Ki = 58000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BJ39XQ	6-[4-[(5-Methyl-2,4-dioxo-pyrimidin-1-yl)methyl]phenyl]hex-5-ynoic Acid	Investigative	11616826	C18H18N2O4	326.3	CC1=CN(C(=O)NC1=O)CC2=CC=C(C=C2)C#CCCCC(=O)O	Ki = 96000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BKP9Y0	1-[[4-(4-Hydroxybut-1-ynyl)phenyl]methyl]-5-methyl-pyrimidine-2,4-dione	Investigative	23119029	C16H16N2O3	284.31	CC1=CN(C(=O)NC1=O)CC2=CC=C(C=C2)C#CCCO	Ki = 70000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BL1GP9	[(2R,3S,5R)-5-[5-(2-Furyl)-2,4-dioxo-pyrimidin-1-yl]-3-hydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate	Investigative	502268	C13H15N2O9P	374.24	C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)C3=CC=CO3)COP(=O)(O)O)O	Ki = 140000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BL9HV0	1-[(3-Fluorophenyl)methyl]-5-methylpyrimidine-2,4-dione	Investigative	5276661	C12H11FN2O2	234.23	CC1=CN(C(=O)NC1=O)CC2=CC(=CC=C2)F	Ki = 90000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BLI2T5	1-[(2R,4S,5R)-4-Hydroxy-5-[2-(1H-tetrazol-5-yl)ethyl]tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione	Investigative	71508269	C12H16N6O4	308.29	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CCC3=NNN=N3)O	Ki = 70000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BMC54Y	Methyl 4-[4-[(5-methyl-2,4-dioxopyrimidin-1-yl)methyl]phenyl]butanoate	Investigative	11695376	C17H20N2O4	316.35	CC1=CN(C(=O)NC1=O)CC2=CC=C(C=C2)CCCC(=O)OC	Ki = 70000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BNH7G3	1-[(4-Chlorophenyl)methyl]-5-methyl-3H-pyrimidine-2,4-dione	Investigative	5276663	C12H11ClN2O2	250.68	CC1=CN(C(=O)NC1=O)CC2=CC=C(C=C2)Cl	Ki = 50000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BNUJ90	1-(3-Azidomethyl-2-chloro-2,3-dideoxy-beta-D-ribofuranosyl)thymine	Investigative	44421255	C11H14ClN5O4	315.71	CC1=CN(C(=O)NC1=O)[C@H]2[C@@H](C([C@H](O2)CO)CN=[N+]=[N-])Cl	Ki = 180000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BO4WL3	1-[(3,4-Difluorophenyl)methyl]-5-methylpyrimidine-2,4-dione	Investigative	5276662	C12H10F2N2O2	252.22	CC1=CN(C(=O)NC1=O)CC2=CC(=C(C=C2)F)F	Ki = 67000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BSR0O3	1-[(2S,3S,4R,5R)-4-Hydroxy-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-3-yl]guanidine	Investigative	510576	C11H17N5O5	299.28	CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)N=C(N)N)O	Ki = 140000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BUC5E2	Methyl 4-[4-[(5-bromo-2,4-dioxo-pyrimidin-1-yl)methyl]phenyl]butanoate	Investigative	44586749	C16H17BrN2O4	381.22	COC(=O)CCCC1=CC=C(C=C1)CN2C=C(C(=O)NC2=O)Br	Ki = 52000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BUPY46	4-[2-Fluoro-4-[(5-methyl-2,4-dioxopyrimidin-1-yl)methyl]phenyl]butanoic acid	Investigative	11558786	C16H17FN2O4	320.31	CC1=CN(C(=O)NC1=O)CC2=CC(=C(C=C2)CCCC(=O)O)F	Ki = 63000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BW0L2U	1-[4-(2-Hydroxy-ethyl)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione	Investigative	510142	C12H18N2O5	270.28	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)CCO	Ki = 156000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BZ0D7W	[(2S,3S,4R,5R)-3-(Azidomethyl)-4-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate	Investigative	3006431	C11H16N5O8P	377.25	CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)CN=[N+]=[N-])O	Ki = 116000 nM	Poor binder
T94400	Mycobacterium Thymidine monophosphate kinase	BZX25R	N-[[(2R,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl]acetamide	Investigative	510573	C12H17N3O5	283.28	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CNC(=O)C)O	Ki = 90000 nM	Poor binder