TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T94479	Ribosomal protein S6 kinase beta-1	B2ZNO7	6-[4-[2-(Azetidin-1-yl)-1-(3,4-dichlorophenyl)ethyl]piperazin-1-yl]-5-(6-piperazin-1-ylpyridin-3-yl)pyrimidin-4-amine	Investigative	89446792	C28H35Cl2N9	568.5	C1CN(C1)CC(C2=CC(=C(C=C2)Cl)Cl)N3CCN(CC3)C4=NC=NC(=C4C5=CN=C(C=C5)N6CCNCC6)N	IC50 ~ 100000 nM	Poor binder
T94479	Ribosomal protein S6 kinase beta-1	B3AX7F	8-Bromo-4-(3-chloro-4-fluoroanilino)-6-[(1-methylimidazol-4-yl)methylamino]quinoline-3-carbonitrile	Investigative	17758574	C21H15BrClFN6	485.7	CN1C=C(N=C1)CNC2=CC3=C(C(=CN=C3C(=C2)Br)C#N)NC4=CC(=C(C=C4)F)Cl	IC50 = 83100 nM	Poor binder
T94479	Ribosomal protein S6 kinase beta-1	B3KLZ6	COC(=O)Cn1cc(cn1)-c1c(N)ncnc1N1CCN(CC1)C(CN1CCC1)c1cccc(c1)C#N	Investigative	118046816	C26H31N9O2	501.6	COC(=O)CN1C=C(C=N1)C2=C(N=CN=C2N3CCN(CC3)C(CN4CCC4)C5=CC=CC(=C5)C#N)N	IC50 ~ 100000 nM	Poor binder
T94479	Ribosomal protein S6 kinase beta-1	B42HTI	N-[2-(Dimethylamino)ethyl]-5-ethyl-2-(1H-indazol-5-ylcarbamoylamino)thiophene-3-carboxamide	Investigative	53321852	C19H24N6O2S	400.5	CCC1=CC(=C(S1)NC(=O)NC2=CC3=C(C=C2)NN=C3)C(=O)NCCN(C)C	IC50 = 62000 nM	Poor binder
T94479	Ribosomal protein S6 kinase beta-1	B6I8YT	5-[3-(Aminomethyl)piperidin-1-yl]quinazoline-8-carboxamide	Investigative	89660494	C15H19N5O	285.34	C1CC(CN(C1)C2=C3C=NC=NC3=C(C=C2)C(=O)N)CN	IC50 = 56000 nM	Poor binder
T94479	Ribosomal protein S6 kinase beta-1	B6WES9	5-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]quinazoline-8-carboxamide	Investigative	89651540	C20H20ClN5O	381.9	CC1=C(C=C(C=C1)Cl)N2CCN(CC2)C3=C4C=NC=NC4=C(C=C3)C(=O)N	IC50 ~ 100000 nM	Poor binder
T94479	Ribosomal protein S6 kinase beta-1	B82MQJ	Aminopyrimidine amide, 13b	Investigative	16118737	C31H30F3N7O2	589.6	CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)C(=O)NC3=CN=C(N=C3)NC4=CC=C(C=C4)N5CCN(CC5)C	IC50 ~ 100000 nM	Poor binder
T94479	Ribosomal protein S6 kinase beta-1	BC3F9U	2-(3-(1H-Indazol-5-yl)ureido)-5-(tert-butyl)thiophene-3-carboxylic acid	Investigative	53317853	C17H18N4O3S	358.4	CC(C)(C)C1=CC(=C(S1)NC(=O)NC2=CC3=C(C=C2)NN=C3)C(=O)O	IC50 = 52000 nM	Poor binder
T94479	Ribosomal protein S6 kinase beta-1	BCO6E2	5-[4-(3,4-Dichlorophenyl)piperazin-1-yl]quinazoline-8-carboxamide	Investigative	89650940	C19H17Cl2N5O	402.3	C1CN(CCN1C2=CC(=C(C=C2)Cl)Cl)C3=C4C=NC=NC4=C(C=C3)C(=O)N	IC50 ~ 100000 nM	Poor binder
T94479	Ribosomal protein S6 kinase beta-1	BKYO21	5-Tert-butyl-N-[(2-fluorophenyl)methyl]-2-(1H-indazol-5-ylcarbamoylamino)thiophene-3-carboxamide	Investigative	53320487	C24H24FN5O2S	465.5	CC(C)(C)C1=CC(=C(S1)NC(=O)NC2=CC3=C(C=C2)NN=C3)C(=O)NCC4=CC=CC=C4F	IC50 = 191000 nM	Poor binder
T94479	Ribosomal protein S6 kinase beta-1	BNA26F	(3S,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one	Investigative	71720141	C18H19N3O	293.4	CN1C[C@@H](C(=O)/C(=C/C2=CC=CC=N2)/C1)CC3=CC=CC=N3	IC50 ~ 100000 nM	Poor binder
T94479	Ribosomal protein S6 kinase beta-1	BQ5LG8	(3R,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one	Investigative	71718330	C18H19N3O	293.4	CN1C[C@H](C(=O)/C(=C/C2=CC=CC=N2)/C1)CC3=CC=CC=N3	IC50 ~ 100000 nM	Poor binder
T94479	Ribosomal protein S6 kinase beta-1	BQEK41	6-[4-[2-(Azetidin-1-yl)-1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethyl]piperazin-1-yl]-5-(6-piperazin-1-ylpyridin-3-yl)pyrimidin-4-amine	Investigative	89446794	C32H43N9	553.7	C1CCC2=C(C1)C=CC(=C2)C(CN3CCC3)N4CCN(CC4)C5=NC=NC(=C5C6=CN=C(C=C6)N7CCNCC7)N	IC50 ~ 100000 nM	Poor binder
T94479	Ribosomal protein S6 kinase beta-1	BRE9O8	8-Bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-1,2,3-triazol-4-ylmethyl)amino]quinoline-3-carbonitrile	Investigative	17758019	C19H12BrClFN7	472.7	C1=CC(=C(C=C1NC2=C3C=C(C=C(C3=NC=C2C#N)Br)NCC4=NNN=C4)Cl)F	IC50 ~ 100000 nM	Poor binder
T94479	Ribosomal protein S6 kinase beta-1	BVM46Q	5-Cyclopropyl-N-[2-(dimethylamino)ethyl]-2-(1H-indazol-5-ylcarbamoylamino)thiophene-3-carboxamide	Investigative	53320539	C20H24N6O2S	412.5	CN(C)CCNC(=O)C1=C(SC(=C1)C2CC2)NC(=O)NC3=CC4=C(C=C3)NN=C4	IC50 = 70000 nM	Poor binder
T94479	Ribosomal protein S6 kinase beta-1	BY06KG	4(3H)-Pyrimidinone,2-[(4-fluorophenyl)amino]-5-[5-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]-2-pyridinyl]-3-methyl-	Investigative	24769780	C33H33FN6O5	612.6	CN1C(=O)C(=CN=C1NC2=CC=C(C=C2)F)C3=NC=C(C=C3)OC4=C5C=C(C(=CC5=NC=C4)OCCCN6CCOCC6)OC	IC50 = 65000 nM	Poor binder
T94479	Ribosomal protein S6 kinase beta-1	BZXD65	N-[2-(Dimethylamino)ethyl]-5-[(1R)-1-hydroxyethyl]-2-(1H-indazol-5-ylcarbamoylamino)thiophene-3-carboxamide	Investigative	53321853	C19H24N6O3S	416.5	C[C@H](C1=CC(=C(S1)NC(=O)NC2=CC3=C(C=C2)NN=C3)C(=O)NCCN(C)C)O	IC50 = 196000 nM	Poor binder
T94479	Ribosomal protein S6 kinase beta-1	D03MUZ	8-chloro-quinoline-3-carbonitrile	Investigative	17759555	C20H13Cl2FN6	427.3	C1=CC(=C(C=C1NC2=C3C=C(C=C(C3=NC=C2C#N)Cl)NCC4=CN=CN4)Cl)F	IC50 ~ 100000 nM	Poor binder