TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T95438	Excitatory amino acid transporter 2	D00ENY	L-Glutamic Acid	Approved	33032	C5H9NO4	147.13	C(CC(=O)O)[C@@H](C(=O)O)N	IC50 = 52000 nM	Poor binder
T95438	Excitatory amino acid transporter 2	B0IB8U	(1R,2S)-2-[(S)-Amino(carboxy)methyl]-2-methylcyclobutane-1-carboxylic acid	Investigative	73348758	C8H13NO4	187.19	C[C@@]1(CC[C@H]1C(=O)O)[C@@H](C(=O)O)N	Ki = 110000 nM	Poor binder
T95438	Excitatory amino acid transporter 2	B1J0VM	2-Amino-4-(4-methoxyphenyl)-5-oxo-7-phenyl-4,6,7,8-tetrahydrochromene-3-carbonitrile	Investigative	2737891	C23H20N2O3	372.4	COC1=CC=C(C=C1)C2C(=C(OC3=C2C(=O)CC(C3)C4=CC=CC=C4)N)C#N	IC50 ~ 100000 nM	Poor binder
T95438	Excitatory amino acid transporter 2	B26SCG	(2S)-2-Amino-3-[(4-tert-butylphenyl)sulfonylamino]butanedioic acid	Investigative	134135313	C14H20N2O6S	344.39	CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC([C@@H](C(=O)O)N)C(=O)O	IC50 = 50000 nM	Poor binder
T95438	Excitatory amino acid transporter 2	B29CWA	Dihydrokainic acid	Investigative	107883	C10H17NO4	215.25	CC(C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O	IC50 = 79432.82 nM	Poor binder
T95438	Excitatory amino acid transporter 2	B3DN1I	(2S)-2-Amino-3-[(2,6-dichlorophenyl)sulfonylamino]butanedioic acid	Investigative	134148109	C10H10Cl2N2O6S	357.2	C1=CC(=C(C(=C1)Cl)S(=O)(=O)NC([C@@H](C(=O)O)N)C(=O)O)Cl	IC50 = 50000 nM	Poor binder
T95438	Excitatory amino acid transporter 2	B9G3MI	(2S,4S)-4-(Hydroxymethyl)glutamic Acid	Investigative	24905651	C6H11NO5	177.16	C([C@@H](CO)C(=O)O)[C@@H](C(=O)O)N	Ki = 125892.54 nM	Poor binder
T95438	Excitatory amino acid transporter 2	BA5F1H	(1R,4S,5R,6S)-3-Azabicyclo[3.3.0]octane-4,6-dicarboxylic acid	Investigative	11543205	C9H13NO4	199.2	C1C[C@@H]([C@H]2[C@@H]1CN[C@@H]2C(=O)O)C(=O)O	Ki = 52000 nM	Poor binder
T95438	Excitatory amino acid transporter 2	BDC30V	(2S)-2-Amino-3-[(2,3,4,5,6-pentafluorophenyl)sulfonylamino]butanedioic acid	Investigative	134144947	C10H7F5N2O6S	378.23	C1(=C(C(=C(C(=C1F)F)S(=O)(=O)NC([C@@H](C(=O)O)N)C(=O)O)F)F)F	IC50 = 100000 nM	Poor binder
T95438	Excitatory amino acid transporter 2	BDIM12	Chembl4168620	Investigative	145953224	C6H8N2O5	188.14	C(C#N)O[C@@H]([C@H](C(=O)O)N)C(=O)O	IC50 = 81283.05 nM	Poor binder
T95438	Excitatory amino acid transporter 2	BDK38S	(2S)-2-Amino-3-(benzylsulfonylamino)butanedioic acid	Investigative	134135682	C11H14N2O6S	302.31	C1=CC=C(C=C1)CS(=O)(=O)NC([C@@H](C(=O)O)N)C(=O)O	IC50 = 60000 nM	Poor binder
T95438	Excitatory amino acid transporter 2	BF7AK0	Chembl4161764	Investigative	145958688	C8H13NO5	203.19	C1CC1CO[C@@H]([C@H](C(=O)O)N)C(=O)O	IC50 = 74131.02 nM	Poor binder
T95438	Excitatory amino acid transporter 2	BODA53	(2S,4R)-4-(2,2-Diphenylethylamino-3-oxopropyl)glutamic acid	Investigative	24905650	C22H26N2O5	398.5	C1=CC=C(C=C1)C(CNC(=O)CC[C@H](C[C@@H](C(=O)O)N)C(=O)O)C2=CC=CC=C2	IC50 = 75000 nM	Poor binder
T95438	Excitatory amino acid transporter 2	BQHT49	(2S)-2-Amino-3-[[4-(trifluoromethyl)phenyl]sulfonylamino]butanedioic acid	Investigative	134131748	C11H11F3N2O6S	356.28	C1=CC(=CC=C1C(F)(F)F)S(=O)(=O)NC([C@@H](C(=O)O)N)C(=O)O	IC50 = 50000 nM	Poor binder
T95438	Excitatory amino acid transporter 2	BRC80P	(2S)-2-Amino-3-benzamidobutanedioic acid	Investigative	134143016	C11H12N2O5	252.22	C1=CC=C(C=C1)C(=O)NC([C@@H](C(=O)O)N)C(=O)O	IC50 = 70000 nM	Poor binder
T95438	Excitatory amino acid transporter 2	BS31QN	2-Amino-4-(4-nitrophenyl)-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chromen-3-yl cyanide	Investigative	2838960	C22H17N3O4	387.4	C1C(CC(=O)C2=C1OC(=C(C2C3=CC=C(C=C3)[N+](=O)[O-])C#N)N)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T95438	Excitatory amino acid transporter 2	BSCD25	(2S)-2-Amino-3-[(4-nitrophenyl)sulfonylamino]butanedioic acid	Investigative	134137403	C10H11N3O8S	333.28	C1=CC(=CC=C1[N+](=O)[O-])S(=O)(=O)NC([C@@H](C(=O)O)N)C(=O)O	IC50 = 50000 nM	Poor binder
T95438	Excitatory amino acid transporter 2	BSRH61	(2S,4R)-4-Pentylglutamic acid	Investigative	10680281	C10H19NO4	217.26	CCCCC[C@H](C[C@@H](C(=O)O)N)C(=O)O	Ki = 67608.3 nM	Poor binder
T95438	Excitatory amino acid transporter 2	BUD1X2	(2S)-2-Amino-4-[4-methyl-3-[3-(trifluoromethyl)phenyl]anilino]-4-oxobutanoic acid	Investigative	71452729	C18H17F3N2O3	366.3	CC1=C(C=C(C=C1)NC(=O)C[C@@H](C(=O)O)N)C2=CC(=CC=C2)C(F)(F)F	IC50 = 67000 nM	Poor binder
T95438	Excitatory amino acid transporter 2	D03UIR	(2S,4R)-4-(3-Methoxy-3-oxopropyl)glutamic Acid	Investigative	24905704	C9H15NO6	233.22	COC(=O)CC[C@H](C[C@@H](C(=O)O)N)C(=O)O	Ki = 158489.32 nM	Poor binder
T95438	Excitatory amino acid transporter 2	D0X3CF	HINOKININ	Investigative	442879	C20H18O6	354.4	C1[C@@H]([C@H](C(=O)O1)CC2=CC3=C(C=C2)OCO3)CC4=CC5=C(C=C4)OCO5	IC50 ~ 100000 nM	Poor binder