TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T96144 DNA topoisomerase II D0B3CT BE-13793C Terminated 9928668 C20H11N3O4 357.3 . EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II B0IB9Y 4-[(Acridin-9-yl)oxy]benzene-1-methanol Investigative 10447591 C20H15NO2 301.3 C1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)OC4=CC=C(C=C4)CO IC50 ~ 100000 nM Poor binder T96144 DNA topoisomerase II B0QN7J 13-(1,3-Dihydroxypropan-2-ylamino)-5,21-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 44273560 C29H28N4O11 608.6 C1=CC2=C(C(=C1)O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC(CO)CO)C6=C(N4C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II B1G8BX N-Methylcarbamic acid 4-[(4-methoxyacridin-9-yl)oxy]benzyl ester Investigative 44338996 C23H20N2O4 388.4 CNC(=O)OCC1=CC=C(C=C1)OC2=C3C=CC=C(C3=NC4=CC=CC=C42)OC IC50 = 50000 nM Poor binder T96144 DNA topoisomerase II B1LG0B 7-(2,6-Dimethylpyridin-4-yl)-6,8-difluoro-4-oxothiochromene-3-carboxylic acid;hydrochloride Investigative 45261142 C17H12ClF2NO3S 383.8 CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)SC=C(C3=O)C(=O)O)F.Cl EC50 ~ 140000 nM Poor binder T96144 DNA topoisomerase II B1NJS2 4-[(Acridin-9-yl)thio]benzene-1-methanol Investigative 10471090 C20H15NOS 317.4 C1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)SC4=CC=C(C=C4)CO IC50 ~ 100000 nM Poor binder T96144 DNA topoisomerase II B1UVI5 N-Isopropylcarbamic acid 4-[(4-methoxyacridin-9-yl)oxy]benzyl ester Investigative 44339222 C25H24N2O4 416.5 CC(C)NC(=O)OCC1=CC=C(C=C1)OC2=C3C=CC=C(C3=NC4=CC=CC=C42)OC IC50 ~ 100000 nM Poor binder T96144 DNA topoisomerase II B20KXH Edotecarin Investigative 9808998 C29H28N4O11 608.6 C1=CC2=C(C=C1O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC(CO)CO)C6=C(N4[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)C=C(C=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II B2N0EW N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]acetamide Investigative 44273654 C28H24N4O10 576.5 CC(=O)NN1C(=O)C2=C3C4=C(C(=CC=C4)O)NC3=C5C(=C2C1=O)C6=C(N5C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II B32UYX Methyl (10S,13R,14R,17R)-17-[(2R,5R)-5,6-dihydroxy-6-methylheptan-2-yl]-4,4,10,13,14-pentamethyl-3-oxo-5,6,7,8,12,15,16,17-octahydrocyclopenta[a]phenanthrene-2-carboxylate Investigative 44399306 C32H50O5 514.7 C[C@H](CC[C@H](C(C)(C)O)O)[C@H]1CC[C@]2([C@@]1(CC=C3C2CCC4[C@@]3(C=C(C(=O)C4(C)C)C(=O)OC)C)C)C IC50 = 66510 nM Poor binder T96144 DNA topoisomerase II B32VJY (13S)-8-(2,6-Dimethylpyridin-4-yl)-7-fluoro-13-methyl-4-oxo-10-oxa-1-azatricyclo[7.4.1.05,14]tetradeca-2,5,7,9(14)-tetraene-3-carboxylic acid Investigative 44292318 C21H19FN2O4 382.4 C[C@H]1CCOC2=C3N1C=C(C(=O)C3=CC(=C2C4=CC(=NC(=C4)C)C)F)C(=O)O EC50 = 150000 nM Poor binder T96144 DNA topoisomerase II B3DOK0 N-[(E)-[1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoroquinolin-4-ylidene]amino]quinolin-3-amine Investigative 44352834 C28H23F2N5 467.5 CC1=CC(=CC(=N1)C)C2=C(C=C3/C(=N/NC4=CC5=CC=CC=C5N=C4)/C=CN(C3=C2F)C6CC6)F EC50 = 92000 nM Poor binder T96144 DNA topoisomerase II B3MJR4 3-[(2S,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-13-(1,3-dihydroxypropan-2-ylamino)-6,20-dihydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 44355186 C28H26N4O10 578.5 C1=CC2=C(C=C1O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC(CO)CO)C6=C(N4[C@@H]7[C@H]([C@@H]([C@H](O7)CO)O)O)C=C(C=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II B3ZC6X 13-(Ethylamino)-5,21-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 44273491 C28H26N4O9 562.5 CCNN1C(=O)C2=C3C4=C(C(=CC=C4)O)NC3=C5C(=C2C1=O)C6=C(N5C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II B46ABW 5,21-Dihydroxy-13-(methylamino)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 44273526 C27H24N4O9 548.5 CNN1C(=O)C2=C3C4=C(C(=CC=C4)O)NC3=C5C(=C2C1=O)C6=C(N5C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II B4BT5H (5S,5Ar,8aR,9R)-5-[(8-amino-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one Investigative 44358947 C29H33NO11 571.6 CC1OCC2C(O1)C(CC(O2)O[C@H]3[C@H]4COC(=O)[C@@H]4[C@@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)N EC50 ~ 100000 nM Poor binder T96144 DNA topoisomerase II B4GVJ9 3-[[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]amino]propanenitrile Investigative 44273598 C29H25N5O9 587.5 C1=CC2=C(C(=C1)O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NCCC#N)C6=C(N4C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II B4VEX2 3-[(2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-13-(1,3-dihydroxypropan-2-ylamino)-6,20-dihydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 13009351 C28H26N4O10 578.5 C1=CC2=C(C=C1O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC(CO)CO)C6=C(N4[C@@H]7[C@@H]([C@@H]([C@H](O7)CO)O)O)C=C(C=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II B5LS7U 1-Cyclopropyl-6,8-difluoro-4-oxo-7-pyridin-3-ylquinoline-3-carboxylic acid Investigative 14969604 C18H12F2N2O3 342.3 C1CC1N2C=C(C(=O)C3=CC(=C(C(=C32)F)C4=CN=CC=C4)F)C(=O)O EC50 = 52000 nM Poor binder T96144 DNA topoisomerase II B5NUM0 13-(1,3-Dihydroxypropan-2-ylamino)-6,20-dihydroxy-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 13009352 C28H26N4O9 562.5 C1[C@@H]([C@H](O[C@H]1N2C3=C(C=CC(=C3)O)C4=C5C(=C6C7=C(C=C(C=C7)O)NC6=C42)C(=O)N(C5=O)NC(CO)CO)CO)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II B64DXM 13-(Dimethylamino)-5,21-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 44273527 C28H26N4O9 562.5 CN(C)N1C(=O)C2=C3C4=C(C(=CC=C4)O)NC3=C5C(=C2C1=O)C6=C(N5C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II B67DCV (10S,13R,14R,17R)-17-[(2R,5R)-5,6-Dihydroxy-6-methylheptan-2-yl]-4,4,10,13,14-pentamethyl-5,6,7,8,12,15,16,17-octahydrocyclopenta[a]phenanthren-3-one Investigative 44399370 C30H48O3 456.7 C[C@H](CC[C@H](C(C)(C)O)O)[C@H]1CC[C@]2([C@@]1(CC=C3C2CCC4[C@@]3(C=CC(=O)C4(C)C)C)C)C IC50 = 149970 nM Poor binder T96144 DNA topoisomerase II B6CG3F 5,21-Dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 21197160 C26H21N3O9 519.5 C1=CC2=C(C(=C1)O)NC3=C4C(=C5C(=C23)C(=O)NC5=O)C6=C(N4C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II B6E3MV 13-(1,3-Dihydroxypropan-2-ylamino)-6,20-dihydroxy-3-[(2R,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 13009346 C28H26N4O10 578.5 C1[C@H]([C@@H]([C@H]([C@@H](O1)N2C3=C(C=CC(=C3)O)C4=C5C(=C6C7=C(C=C(C=C7)O)NC6=C42)C(=O)N(C5=O)NC(CO)CO)O)O)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II B6Q4BW (2S)-7-Fluoro-6-isoquinolin-6-yl-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid Investigative 44292578 C22H15FN2O4 390.4 C[C@H]1COC2=C3N1C=C(C(=O)C3=CC(=C2C4=CC5=C(C=C4)C=NC=C5)F)C(=O)O EC50 = 58000 nM Poor binder T96144 DNA topoisomerase II B6TD7I N-[(7S)-1,2-Dihydroxy-3-methoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide Investigative 10937930 C20H21NO5S 387.5 CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)SC)O)O)OC IC50 ~ 150000 nM Poor binder T96144 DNA topoisomerase II B7IJ6H 2-[[1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-4-oxoquinolin-3-yl]methyl]benzoic acid Investigative 44264761 C27H22F2N2O3 460.5 CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C=C(C3=O)CC4=CC=CC=C4C(=O)O)C5CC5)F EC50 = 200000 nM Poor binder T96144 DNA topoisomerase II B7M0KI N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]formamide Investigative 17874201 C27H22N4O10 562.5 C1=CC2=C(C(=C1)O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC=O)C6=C(N4C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II B8D3JS 3-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-13-(1,3-dihydroxypropan-2-ylamino)-6,20-dihydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 13009345 C28H26N4O10 578.5 C1=CC2=C(C=C1O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC(CO)CO)C6=C(N4[C@H]7[C@@H]([C@H]([C@H](O7)CO)O)O)C=C(C=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II B8F3QT N-Isopropylcarbamic acid 4-[(4-methoxyacridin-9-yl)thio]benzyl ester Investigative 44339418 C25H24N2O3S 432.5 CC(C)NC(=O)OCC1=CC=C(C=C1)SC2=C3C=CC=C(C3=NC4=CC=CC=C42)OC IC50 ~ 100000 nM Poor binder T96144 DNA topoisomerase II B8NUC3 13-(1,3-Dihydroxypropan-2-ylamino)-6,20-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 44355547 C29H28N4O11 608.6 C1=CC2=C(C=C1O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC(CO)CO)C6=C(N4[C@@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)C=C(C=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II B8QN0D N,N'-Digalloyl-1,2-phenylenediamine Investigative 9887873 C20H16N2O8 412.3 C1=CC=C(C(=C1)NC(=O)C2=CC(=C(C(=C2)O)O)O)NC(=O)C3=CC(=C(C(=C3)O)O)O Ki = 74100 nM Poor binder T96144 DNA topoisomerase II B8VQU0 [5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]urea Investigative 44273561 C27H23N5O10 577.5 C1=CC2=C(C(=C1)O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC(=O)N)C6=C(N4C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II B92SFU Succinic acid hydrogen 3-[(3-carboxypropanoyl)amino]-5-[(acridin-9-yl)amino]benzyl ester Investigative 10414142 C28H25N3O7 515.5 C1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)NC4=CC(=CC(=C4)COC(=O)CCC(=O)O)NC(=O)CCC(=O)O IC50 ~ 100000 nM Poor binder T96144 DNA topoisomerase II B9CSL1 (8Ar,9R)-5-[(7-amino-8-hydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one Investigative 44359075 C29H33NO12 587.6 CC1OCC2C(O1)C(C(C(O2)OC3C4COC(=O)[C@@H]4[C@@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)N)O EC50 = 56000 nM Poor binder T96144 DNA topoisomerase II B9J2ED N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]propanamide Investigative 44273646 C29H26N4O10 590.5 CCC(=O)NN1C(=O)C2=C3C4=C(C(=CC=C4)O)NC3=C5C(=C2C1=O)C6=C(N5C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BA0UI8 3-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-13-(1,3-dihydroxypropan-2-ylamino)-6,20-dihydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 10053929 C28H26N4O10 578.5 C1=CC2=C(C=C1O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC(CO)CO)C6=C(N4[C@H]7[C@@H]([C@@H]([C@H](O7)CO)O)O)C=C(C=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BA1O5U (5S,5Ar,8aR,9R)-5-[4-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one Investigative 44359074 C27H32N2O10 544.5 COC1=CC(=CC(=C1O)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](C4=CC5=C(C=C24)OCO5)OC6CC(C(C(O6)CN)O)N EC50 ~ 100000 nM Poor binder T96144 DNA topoisomerase II BA4H6I (5S,5Ar,8aR,9R)-5-[[8-(dimethylamino)-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one Investigative 44359032 C31H37NO11 599.6 CC1OCC2C(O1)C(CC(O2)O[C@H]3[C@H]4COC(=O)[C@@H]4[C@@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)N(C)C EC50 ~ 100000 nM Poor binder T96144 DNA topoisomerase II BB14PH N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]pyridine-2-carboxamide Investigative 44273652 C32H25N5O10 639.6 C1=CC=NC(=C1)C(=O)NN2C(=O)C3=C4C5=C(C(=CC=C5)O)NC4=C6C(=C3C2=O)C7=C(N6C8C(C(C(C(O8)CO)O)O)O)C(=CC=C7)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BD6M2I 1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-3-(2-phenylethyl)quinolin-4-one Investigative 44264968 C27H24F2N2O 430.5 CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C=C(C3=O)CCC4=CC=CC=C4)C5CC5)F EC50 ~ 120000 nM Poor binder T96144 DNA topoisomerase II BDOG68 13-(1,3-Dihydroxypropan-2-ylamino)-6,20-dihydroxy-3-[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 44355295 C29H28N4O11 608.6 C1=CC2=C(C=C1O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC(CO)CO)C6=C(N4[C@H]7[C@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)C=C(C=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BE3PN8 Anticancer agent 3 Investigative 9998338 C20H25N3OS 355.5 CCN(CC)CCNC1=C2C(=C(C=C1)CN)SC3=CC=CC=C3C2=O EC50 = 90000 nM Poor binder T96144 DNA topoisomerase II BE42RB N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]methanesulfonamide Investigative 44273700 C27H24N4O11S 612.6 CS(=O)(=O)NN1C(=O)C2=C3C4=C(C(=CC=C4)O)NC3=C5C(=C2C1=O)C6=C(N5C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BES19F (5S,5Ar,8aR,9R)-5-[[8-(2-aminoethylamino)-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one Investigative 44359116 C31H38N2O11 614.6 CC1OCC2C(O1)C(CC(O2)O[C@H]3[C@H]4COC(=O)[C@@H]4[C@@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)NCCN EC50 ~ 100000 nM Poor binder T96144 DNA topoisomerase II BFDE10 3-[(2S,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-13-(1,3-dihydroxypropan-2-ylamino)-6,20-dihydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 44355276 C28H26N4O10 578.5 C1=CC2=C(C=C1O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC(CO)CO)C6=C(N4[C@@H]7[C@@H]([C@H]([C@H](O7)CO)O)O)C=C(C=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BFRK78 (4S)-4-[(5R,8S,9S,10R,13R,14S,17R)-3-Hydroxy-5,10,13-trimethyl-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid Investigative 76318645 C25H42O3 390.6 C[C@@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@]4([C@@]3(CCC(C4)O)C)C)C IC50 = 62000 nM Poor binder T96144 DNA topoisomerase II BG3S1X 2-[[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]amino]acetic acid Investigative 44273617 C28H24N4O11 592.5 C1=CC2=C(C(=C1)O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NCC(=O)O)C6=C(N4C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BH2QW7 (2S)-7-Fluoro-2-methyl-10-oxo-6-pyridin-4-yl-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid Investigative 44292646 C18H13FN2O4 340.3 C[C@H]1COC2=C3N1C=C(C(=O)C3=CC(=C2C4=CC=NC=C4)F)C(=O)O EC50 = 57000 nM Poor binder T96144 DNA topoisomerase II BIS0P7 3-[(2R,3R,4S,5S)-5-(1,2-Dihydroxyethyl)-3,4-dihydroxyoxolan-2-yl]-13-(1,3-dihydroxypropan-2-ylamino)-6,20-dihydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 44355300 C29H28N4O11 608.6 C1=CC2=C(C=C1O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC(CO)CO)C6=C(N4[C@H]7[C@@H]([C@@H]([C@@H](O7)C(CO)O)O)O)C=C(C=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BJ0PI1 5,21-Dihydroxy-13-[(3-hydroxyphenyl)methylamino]-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 44273599 C33H28N4O10 640.6 C1=CC(=CC(=C1)O)CNN2C(=O)C3=C4C5=C(C(=CC=C5)O)NC4=C6C(=C3C2=O)C7=C(N6C8C(C(C(C(O8)CO)O)O)O)C(=CC=C7)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BJC20B 5,21-Dihydroxy-13-(2-hydroxyethylamino)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 44273597 C28H26N4O10 578.5 C1=CC2=C(C(=C1)O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NCCO)C6=C(N4C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BJM4U2 13-(1,3-Dihydroxypropan-2-ylamino)-6,20-dihydroxy-3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 44355294 C29H28N4O11 608.6 C1=CC2=C(C=C1O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC(CO)CO)C6=C(N4[C@@H]7[C@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)C=C(C=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BJQA59 N-Isopropylcarbamic acid 4-[(acridin-9-yl)thio]benzyl ester Investigative 10453745 C24H22N2O2S 402.5 CC(C)NC(=O)OCC1=CC=C(C=C1)SC2=C3C=CC=CC3=NC4=CC=CC=C42 IC50 = 50000 nM Poor binder T96144 DNA topoisomerase II BK6Q4J 1,4-Dihydro-1-tert-butyl-4-oxo-6,8-difluoro-7-(2,6-dimethylpyridin-4-yl)quinoline-3-carboxylic acid sodium salt Investigative 23692500 C21H19F2N2NaO3 408.4 CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)[O-])C(C)(C)C)F.[Na+] EC50 = 74000 nM Poor binder T96144 DNA topoisomerase II BK9ZA6 4-[[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]amino]benzoic acid Investigative 44273618 C33H26N4O11 654.6 C1=CC2=C(C(=C1)O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC6=CC=C(C=C6)C(=O)O)C7=C(N4C8C(C(C(C(O8)CO)O)O)O)C(=CC=C7)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BKA89I 1-Cyclopropyl-7-(2,6-dimethylpyridin-3-yl)-6,8-difluoro-4-oxoquinoline-3-carboxylic acid Investigative 14969603 C20H16F2N2O3 370.3 CC1=NC(=C(C=C1)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)C4CC4)F)C EC50 = 53000 nM Poor binder T96144 DNA topoisomerase II BL09ID 7-(2,6-Dimethylpyridin-4-yl)-1-ethyl-6,8-difluoro-4-oxoquinoline-3-carboxylic acid Investigative 14969591 C19H16F2N2O3 358.3 CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)C3=CC(=NC(=C3)C)C)F)C(=O)O EC50 = 110000 nM Poor binder T96144 DNA topoisomerase II BLFA90 1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-3-phenylquinolin-4-one Investigative 44264883 C25H20F2N2O 402.4 CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C=C(C3=O)C4=CC=CC=C4)C5CC5)F EC50 ~ 120000 nM Poor binder T96144 DNA topoisomerase II BM10DW (10R,13R,14R,17R)-2-Chloro-17-[(2R,5R)-5,6-dihydroxy-6-methylheptan-2-yl]-4,4,10,13,14-pentamethyl-5,6,7,8,12,15,16,17-octahydrocyclopenta[a]phenanthren-3-one Investigative 44399554 C30H47ClO3 491.1 C[C@H](CC[C@H](C(C)(C)O)O)[C@H]1CC[C@]2([C@@]1(CC=C3C2CCC4[C@@]3(C=C(C(=O)C4(C)C)Cl)C)C)C IC50 = 106800 nM Poor binder T96144 DNA topoisomerase II BMYO53 3-[(2R,4R,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)oxan-2-yl]-13-(1,3-dihydroxypropan-2-ylamino)-6,20-dihydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 13009354 C29H28N4O10 592.6 C1[C@H]([C@@H]([C@H](O[C@H]1N2C3=C(C=CC(=C3)O)C4=C5C(=C6C7=C(C=C(C=C7)O)NC6=C42)C(=O)N(C5=O)NC(CO)CO)CO)O)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BO8T3Y (10S,13R,14R,17R)-17-[(2R,5R)-5,6-Dihydroxy-6-methylheptan-2-yl]-4,4,10,13,14-pentamethyl-3-oxo-5,6,7,8,12,15,16,17-octahydrocyclopenta[a]phenanthrene-2-carbonitrile Investigative 44399503 C31H47NO3 481.7 C[C@H](CC[C@H](C(C)(C)O)O)[C@H]1CC[C@]2([C@@]1(CC=C3C2CCC4[C@@]3(C=C(C(=O)C4(C)C)C#N)C)C)C IC50 = 83230 nM Poor binder T96144 DNA topoisomerase II BOV3S2 (5S,5Ar,8aR,9R)-5-[[(6S)-8-amino-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one Investigative 44359112 C29H33NO11 571.6 CC1OCC2C(O1)C(C[C@H](O2)O[C@H]3[C@H]4COC(=O)[C@@H]4[C@@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)N EC50 ~ 100000 nM Poor binder T96144 DNA topoisomerase II BP69WJ 3-[(2R,3R,4R,5S,6R)-3,4-Dihydroxy-6-(hydroxymethyl)-5-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]-13-(1,3-dihydroxypropan-2-ylamino)-6,20-dihydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 70683609 C35H38N4O16 770.7 C1=CC2=C(C=C1O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC(CO)CO)C6=C(N4[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O[C@@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)O)O)C=C(C=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BQ1ZH6 3-[(2R,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-13-(1,3-dihydroxypropan-2-ylamino)-6,20-dihydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 44355298 C28H26N4O10 578.5 C1=CC2=C(C=C1O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC(CO)CO)C6=C(N4[C@H]7[C@H]([C@@H]([C@H](O7)CO)O)O)C=C(C=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BQK7G2 13-Amino-5,21-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 19037238 C26H22N4O9 534.5 C1=CC2=C(C(=C1)O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)N)C6=C(N4C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BS80IG 13-(1,3-Dihydroxypropan-2-ylamino)-6,20-dihydroxy-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 44355373 C29H28N4O10 592.6 C[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)N2C3=C(C=CC(=C3)O)C4=C5C(=C6C7=C(C=C(C=C7)O)NC6=C42)C(=O)N(C5=O)NC(CO)CO)O)O)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BSVN93 N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]-4-methylbenzenesulfonamide Investigative 44273699 C33H28N4O11S 688.7 CC1=CC=C(C=C1)S(=O)(=O)NN2C(=O)C3=C4C5=C(C(=CC=C5)O)NC4=C6C(=C3C2=O)C7=C(N6C8C(C(C(C(O8)CO)O)O)O)C(=CC=C7)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BUFH53 3-[(2S,4R,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)oxan-2-yl]-13-(1,3-dihydroxypropan-2-ylamino)-6,20-dihydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 13009355 C29H28N4O10 592.6 C1[C@H]([C@@H]([C@H](O[C@@H]1N2C3=C(C=CC(=C3)O)C4=C5C(=C6C7=C(C=C(C=C7)O)NC6=C42)C(=O)N(C5=O)NC(CO)CO)CO)O)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BV4T6A 4-[(4-Methoxyacridin-9-yl)thio]benzene-1-methanol Investigative 44339652 C21H17NO2S 347.4 COC1=CC=CC2=C(C3=CC=CC=C3N=C21)SC4=CC=C(C=C4)CO IC50 = 50000 nM Poor binder T96144 DNA topoisomerase II BVE28X 2-Cyano-N-[5,21-dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]acetamide Investigative 44273605 C29H23N5O10 601.5 C1=CC2=C(C(=C1)O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC(=O)CC#N)C6=C(N4C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BW31JF N-Methylcarbamic acid 4-[(4-methoxyacridin-9-yl)thio]benzyl ester Investigative 44339644 C23H20N2O3S 404.5 CNC(=O)OCC1=CC=C(C=C1)SC2=C3C=CC=C(C3=NC4=CC=CC=C42)OC IC50 ~ 100000 nM Poor binder T96144 DNA topoisomerase II BWT30E (S)-10-(2,6-Dimethyl-4-pyridinyl)-8,9-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid Investigative 14501361 C20H16F2N2O4 386.3 C[C@H]1COC2=C(C(=C(C3=C2N1C=C(C3=O)C(=O)O)F)F)C4=CC(=NC(=C4)C)C EC50 = 50000 nM Poor binder T96144 DNA topoisomerase II BX04UW 13-(1,3-Dihydroxypropan-2-ylamino)-6,20-dihydroxy-3-[(2R,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 44355546 C29H28N4O11 608.6 C1=CC2=C(C=C1O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC(CO)CO)C6=C(N4[C@H]7[C@@H]([C@@H]([C@@H]([C@H](O7)CO)O)O)O)C=C(C=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BX1KF8 5,21-Dihydroxy-13-(propylamino)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 44273600 C29H28N4O9 576.6 CCCNN1C(=O)C2=C3C4=C(C(=CC=C4)O)NC3=C5C(=C2C1=O)C6=C(N5C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BX5C8G 1,4-Dihydro-1-cyclopropyl-4-oxo-6,8-difluoro-7-(4-methylpiperazino)quinoline-3-carboxylic acid Investigative 10618700 C18H19F2N3O3 363.4 CN1CCN(CC1)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)C4CC4)F EC50 = 150000 nM Poor binder T96144 DNA topoisomerase II BXN2F3 (2S)-6-(2,6-Dimethylpyridin-4-yl)-7-fluoro-2-methyl-4,10-dioxo-4lambda4-thia-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid Investigative 44292144 C20H17FN2O4S 400.4 C[C@H]1CS(=O)C2=C3N1C=C(C(=O)C3=CC(=C2C4=CC(=NC(=C4)C)C)F)C(=O)O EC50 = 62000 nM Poor binder T96144 DNA topoisomerase II BXR0Q7 N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]-2-hydroxyacetamide Investigative 44273624 C28H24N4O11 592.5 C1=CC2=C(C(=C1)O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC(=O)CO)C6=C(N4C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BY8ZC9 1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoroquinoline-4-thione Investigative 44352794 C19H16F2N2S 342.4 CC1=CC(=CC(=N1)C)C2=C(C=C3C(=S)C=CN(C3=C2F)C4CC4)F EC50 = 76000 nM Poor binder T96144 DNA topoisomerase II BYD7F2 6-(2,6-Dimethylpyridin-4-yl)-7-fluoro-10-oxospiro[4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-2,1'-cyclopropane]-11-carboxylic acid Investigative 44292667 C21H17FN2O4 380.4 CC1=CC(=CC(=N1)C)C2=C(C=C3C4=C2OCC5(N4C=C(C3=O)C(=O)O)CC5)F EC50 ~ 130000 nM Poor binder T96144 DNA topoisomerase II BZ2R6H 3-[(2R,3R,4S,5R)-5-(1,2-Dihydroxyethyl)-3,4-dihydroxyoxolan-2-yl]-13-(1,3-dihydroxypropan-2-ylamino)-6,20-dihydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione Investigative 44355299 C29H28N4O11 608.6 C1=CC2=C(C=C1O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC(CO)CO)C6=C(N4[C@H]7[C@@H]([C@@H]([C@H](O7)C(CO)O)O)O)C=C(C=C6)O EC50 ~ 50000 nM Poor binder T96144 DNA topoisomerase II BZW82A N-[4-[[1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-4-oxoquinolin-3-yl]methyl]phenyl]acetamide Investigative 44264850 C28H25F2N3O2 473.5 CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C=C(C3=O)CC4=CC=C(C=C4)NC(=O)C)C5CC5)F EC50 ~ 100000 nM Poor binder