TTD | Expression Details

Target General Information
Target ID	T00140
Target Name	Arachidonate 5-lipoxygenase
Synonyms	5-LO; 5-LOX; 5-lipoxygenase; ALOX5
Target Type	Successful
Gene Name	ALOX5
Biochemical Class	Oxidoreductases acting on single donors
UniProt ID	LOX5_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Asthma
Example drug	ABT-761	Phase 3	[526129], [1572592]
Tissue	Nasal and bronchial airway
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.14 Z-score: 0.28 P-value: 9.43E-03
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Rheumatoid arthritis
Example drug	Flobufen	Phase 3	[534411], [1572592]
Tissue	Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.55 Z-score: 2.11 P-value: 1.00E-02
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Psoriasis
Example drug	CMI-392	Phase 2	[526130], [1572592]
Tissue	Skin
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -4.92E-03 Z-score: -0.01 P-value: 5.19E-01
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section	Fold-change: 0.36 Z-score: 1.51 P-value: 3.46E-15
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section Download target gene expression data in the tissue of healthy individual
Disease	Atopic dermatitis
Example drug	ETH615	Discontinued in Phase 2	[546166], [1572592]
Tissue	Skin
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.22 Z-score: -0.78 P-value: 2.96E-03
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Chronic obstructive pulmonary disease
Example drug	MLN-977	Discontinued in Phase 2	[546341], [1572592]
Tissue	Lung tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.18 Z-score: -0.25 P-value: 7.42E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Chronic obstructive pulmonary disease
Example drug	MLN-977	Discontinued in Phase 2	[546341], [1572592]
Tissue	Small airway epithelium
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.43 Z-score: 0.63 P-value: 1.25E-03
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Osteoarthritis
Example drug	Licofelone	Discontinued in Phase 1	[545621], [1572592]
Tissue	Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.26 Z-score: -0.47 P-value: 3.25E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Arteriosclerosis
Example drug	PD-146176	Terminated	[546784], [1572592]
Tissue	Peripheral blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.11 Z-score: -0.24 P-value: 4.99E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Prostate cancer
Tissue	Prostate
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.06 Z-score: -0.15 P-value: 4.15E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Sensitive skin
Tissue	Skin
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.08 Z-score: 0.38 P-value: 8.61E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref
Ref 545621	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003927)
Ref 546166	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006733)
Ref 546341	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007577)
Ref 546784	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010267)
Ref 526129	ABT-761 (Abbott). Curr Opin Investig Drugs. 2001 Jan;2(1):68-71.
Ref 526130	Anti-inflammatory activities of LDP-392, a dual PAF receptor antagonist and 5-lipoxygenase inhibitor. Pharmacol Res. 2001 Sep;44(3):213-20.
Ref 534411	Pharmacological profile of the novel potent antirheumatic 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid. Arzneimittelforschung. 1997 May;47(5):648-52.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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Target expression details

Prof. Feng ZHU

Prof. Yuzong CHEN