Target General Information
Target ID T22939
Target Name Progesterone receptor
Synonyms PR; PGR
Target Type Successful
Gene Name PGR
Biochemical Class Zinc-finger
UniProt ID PRGR_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Endometriosis
Example drug Nestorone transdermal spray Phase 3 [522001], [1572592]
Tissue Endometrium tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -1.47
Z-score: -0.86
P-value: 1.71E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Disease Osteoporosis
Example drug BAY-39-9624 Terminated [547256], [1572592]
Tissue Bone marrow
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.19
Z-score: 1.30
P-value: 5.03E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Disease Preterm birth
Tissue Myometrium
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.03
Z-score: -0.05
P-value: 5.89E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Disease Uterine cancer
Tissue Endometrium tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -3.79
Z-score: -2.50
P-value: 3.26E-38
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: -0.88
Z-score: -1.48
P-value: 8.56E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref
Ref 547256Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014491)
Ref 522001ClinicalTrials.gov (NCT00455156) Study of the Safety, Efficacy and Cycle Control of a Contraceptive Vaginal Ring. U.S. National Institutes of Health.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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