Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T89515 | ||||
| Target Name | Dihydrofolate reductase | ||||
| Synonyms | |||||
| Target Type | Successful | ||||
| Gene Name | DHFR | ||||
| Biochemical Class | Oxidoreductases acting on CH-NH group of donors | ||||
| UniProt ID | DYR_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Acute myelocytic leukemia | ||||
| Example drug | Aminopterin | Withdrawn from market | [550114], [1572592] | ||
| Tissue | Bone marrow | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.54 Z-score: -0.86 P-value: 8.87E-16 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Bladder cancer | ||||
| Tissue | Bladder tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.97 Z-score: 3.88 P-value: 5.11E-06 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Rheumatoid arthritis | ||||
| Tissue | Synovial tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.38 Z-score: 1.46 P-value: 1.08E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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