Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T92072 | ||||
| Target Name | Adenosine A1 receptor | ||||
| Synonyms | A(1) adenosine receptor; ADORA1 | ||||
| Target Type | Successful | ||||
| Gene Name | ADORA1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | AA1R_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Parkinson's disease | ||||
| Example drug | KF-17837 | Phase 1 | [546031], [1572592] | ||
| Tissue | Substantia nigra tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.12 Z-score: -0.48 P-value: 7.60E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Multiple sclerosis | ||||
| Example drug | METHYLTHIOADENOSINE | Terminated | [544778], [1572592] | ||
| Tissue | Spinal cord | ||||
| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: -0.20 Z-score: -0.99 P-value: 3.53E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
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| Disease | Asthma | ||||
| Tissue | Nasal and bronchial airway | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.13 Z-score: -0.36 P-value: 1.74E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Sepsis | ||||
| Tissue | Whole blood | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.09 Z-score: -0.30 P-value: 7.48E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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| Reference | |||||
| Ref 544778 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000987) | ||||
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