Target General Information
Target ID	T95385
Target Name	Interleukin-12 beta
Synonyms	CLMF p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; IL12 subunit p40; Interleukin12 subunit beta; NK cell stimulatory factor chain 2; NKSF2; IL12B
Target Type	Clinical Trial
Gene Name	IL12B
Biochemical Class	Cytokine: interleukin
UniProt ID	IL12B_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Melanoma
Example drug	Ad-RTS-IL-12			Phase 2	[549191], [1572592]
Tissue	Skin
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.13 Z-score: 0.17 P-value: 1.08E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Rheumatoid arthritis
Example drug	ABT-874			Phase 1	[536651], [1572592]
Tissue	Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 1.32E-02 Z-score: 0.07 P-value: 9.01E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 549191	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033476)
Ref 536651	Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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