Target Information

Target General Infomation
Target ID
T09538
Former ID
TTDS00256
Target Name
Alkaline phosphatase, tissue-nonspecific
Gene Name
ALPL
Synonyms
AP-TNAP; Liver/bone/kidney isozyme; TNSALP; ALPL
Target Type
Successful
Disease Anthelmintic [ICD10: B89]
Colon cancer [ICD9: 153, 154; ICD10: C50]
Genetic disease [ICD10: Q00-Q99]
Function
This isozyme may play a role in skeletal mineralization.
BioChemical Class
Phosphoric monoester hydrolases
Target Validation
T09538
UniProt ID
P05186
EC Number
EC 3.1.3.1
Sequence
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE
KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN
RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG
QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV
PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
Drugs and Mode of Action
Drug(s) Asfotase alfa Drug Info Approved Genetic disease [523129]
Levamisole Drug Info Approved Anthelmintic [551871]
Levamisole Drug Info Withdrawn from market Colon cancer [536772], [542225]
Modulator Asfotase alfa Drug Info [531835]
Inhibitor Levamisole Drug Info [536820]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Folate biosynthesis
Metabolic pathways
NetPath Pathway FSH Signaling Pathway
PathWhiz Pathway Vitamin B6 Metabolism
WikiPathways Endochondral Ossification
BDNF signaling pathway
AGE/RAGE pathway
References
Ref 523129ClinicalTrials.gov (NCT01176266) Open-Label Study of Asfotase Alfa in Infants and Children ??5 Years of Age With Hypophosphatasia (HPP). U.S. National Institutes of Health.
Ref 536772New drugs in development for the treatment of endometriosis. Expert Opin Investig Drugs. 2008 Aug;17(8):1187-202.
Ref 542225(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7210).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 531835Enzyme-replacement therapy in life-threatening hypophosphatasia. N Engl J Med. 2012 Mar 8;366(10):904-13.
Ref 536820Characterization of rat heart alkaline phosphatase isoenzymes and modulation of activity. Braz J Med Biol Res. 2008 Jul;41(7):600-9.

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