Target Information

Target General Infomation
Target ID
T24634
Former ID
TTDS00233
Target Name
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Gene Name
murA
Synonyms
EPT; Enoylpyruvate transferase; MurA; MurA protein; UDP-GlcNAcenolpyruvyl transferase; UDP-N-acetylglucosamine enolpyruvyl transferase; murA
Target Type
Successful
Disease Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10: A00-B99]
Gram-positive bacterial infection [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104]
Function
Cell wall formation. Adds enolpyruvyl to UDP-n- acetylglucosamine. Target for the antibiotic phosphomycin.
BioChemical Class
Alkyl aryl transferase
Target Validation
T24634
UniProt ID
P0A749
EC Number
EC 2.5.1.7
Sequence
MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQL
GAKVERNGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGAR
PVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAHIVMDKVSVGATVTIMCAATLAEGTT
IIENAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGGGVYRVLPDRIETGTFLV
AAAISRGKIICRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHP
AFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGAHAEIESNTVICHGVEKL
SGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE
Drugs and Mode of Action
Drug(s) Fosfomycin Drug Info Approved Bacterial infections [536854]
Inhibitor 1-Anilino-8-Naphthalene Sulfonate Drug Info [551393]
Aminomethylcyclohexane Drug Info [551393]
CNICIN Drug Info [528414]
Cyclohexylammonium Ion Drug Info [551393]
CYNAROPICRIN Drug Info [528414]
EUPATORIOPICRIN Drug Info [528414]
Fosfomycin Drug Info [534914], [535690], [535949], [536015]
L-Iso-Aspartate Drug Info [551393]
RWJ-140998 Drug Info [536094]
RWJ-3981 Drug Info [536094]
Uridine-Diphosphate-N-Acetylglucosamine Drug Info [551391]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
DRM DRM Info
References
Ref 536854Has nature already identified all useful antibacterial targets? Curr Opin Microbiol. 2008 Oct;11(5):387-92. Epub 2008 Oct 6.
Ref 528414Bioorg Med Chem Lett. 2006 Nov 1;16(21):5605-9. Epub 2006 Aug 30.Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA.
Ref 534914Lysine 22 in UDP-N-acetylglucosamine enolpyruvyl transferase from Enterobacter cloacae is crucial for enzymatic activity and the formation of covalent adducts with the substrate phosphoenolpyruvate and the antibiotic fosfomycin. Biochemistry. 1999 Oct 5;38(40):13162-9.
Ref 535690In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance. J Bacteriol. 2003 Feb;185(4):1218-28.
Ref 535949Conditional lethal amber mutations in essential Escherichia coli genes. J Bacteriol. 2004 May;186(9):2673-81.
Ref 536015Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product release. J Biol Chem. 2005 Feb 4;280(5):3757-63. Epub 2004 Nov 5.
Ref 536094Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
Ref 551391DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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