Target Information

Target General Infomation
Target ID
T62187
Former ID
TTDR00326
Target Name
Herpes simplex virus helicase-primase
Synonyms
DNA helicase/primase complex protein; DNA replicationprotein UL52; Helicase-primase complex; Herpesvirus helicase primase enzyme; 7
Target Type
Clinical Trial
Disease Herpes simplex virus infection [ICD9: 54; ICD10: B00]
Function
Involved in DNAreplication.
BioChemical Class
Acid anhydrides hydrolase
UniProt ID
Q00040
Sequence
MALNNPNPTIRVLYATDSCVITYSLMLLTGQESSEDAYVISYDWSSELDDLFGSQPRVLD
ADVGDSWDTTDQSDEELLAAALLERKPSVSFCLLSGIVGGASDEPQERIRPMFVCAFLTL
TGARALTKTLLHGHPISSKILLQALVDGDTFQLHNDLILALAITLDNATARTGRTAAAAK
YDPQRGSVKAAILGHST
Drugs and Mode of Action
Drug(s) BAY 57-1293 Drug Info Phase 2 Herpes simplex virus infection [524007]
Inhibitor BAY 57-1293 Drug Info [535990]
BILS 179 BS Drug Info [535421]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
DRM DRM Info
References
Ref 524007ClinicalTrials.gov (NCT01658826) Safety and Efficacy Comparator Trial of a New Drug Against Genital Herpes. U.S. National Institutes of Health.
Ref 535421Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease. Nat Med. 2002 Apr;8(4):386-91.
Ref 535990Helicase primase: targeting the Achilles heel of herpes simplex viruses. Antivir Chem Chemother. 2004 May;15(3):135-40.

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