Target Information

Target General Infomation
Target ID
T85857
Former ID
TTDNC00460
Target Name
Thymic stromal lymphopoietin
Gene Name
TSLP
Synonyms
TSLP
Target Type
Clinical Trial
Disease Asthma [ICD10: J45]
Function
Isoform 2: May act as an antimicrobial peptidein the oral cavity and on the skin.
UniProt ID
Q969D9
Sequence
MFPFALLYVLSVSFRKIFILQLVGLVLTYDFTNCDFEKIKAAYLSTISKDLITYMSGTKS
TEFNNTVSCSNRPHCLTEIQSLTFNPTAGCASLAKEMFAMKTKAALAIWCPGYSETQINA
TQAMKKRRKRKVTTNKCLEQVSQLQGLWRRFNRPLLKQQ
Drugs and Mode of Action
Drug(s) MEDI9929 Drug Info Phase 2 Asthma [524631]
Modulator MEDI9929 Drug Info [550624]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
WikiPathways TSLP Signaling Pathway
References
Ref 524631ClinicalTrials.gov (NCT02054130) Study to Evaluate the Efficacy and Safety of MEDI9929 (AMG 157) in Adult Subjects With Inadequately Controlled, Severe Asthma. U.S. National Institutes of Health.
Ref 550624Human immunoglobulin G2Lambda monoclonal antibody directed against thymic stromal lymphopoietin (MEDI9929). European medicines agency science medicines health (EMEA-001613-PIP01-14). European Union. 2015.

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