Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T96311
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| Former ID |
TTDC00245
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| Target Name |
NEDD8-activating enzyme E1 catalytic subunit
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| Gene Name |
UBA3
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| Synonyms |
NEDD8-activating enzyme E1C; Ubiquitin-activating enzyme 3; Ubiquitin-activating enzyme E1C; Ubiquitin-like modifier-activating enzyme 3; UBA3
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| Target Type |
Research
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| Function |
Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.
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| BioChemical Class |
Carbon-nitrogen ligase
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| Target Validation |
T96311
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| UniProt ID | |||||
| EC Number |
EC 6.3.2.-
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| Sequence |
MADGEEPEKKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST
ESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI GRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYR LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS |
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| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| DRM | DRM Info | ||||
| Pathways | |||||
| BioCyc Pathway | Protein ubiquitylation | ||||
| KEGG Pathway | Ubiquitin mediated proteolysis | ||||
| PANTHER Pathway | Ubiquitin proteasome pathway | ||||
| Pathway Interaction Database | Coregulation of Androgen receptor activity | ||||
| Validated nuclear estrogen receptor beta network | |||||
| Validated nuclear estrogen receptor alpha network | |||||
| Reactome | Dectin-1 mediated noncanonical NF-kB signaling | ||||
| NIK--> | |||||
| noncanonical NF-kB signaling | |||||
| Ubiquitination & | |||||
| Proteasome degradation | |||||
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