Target Information

Target General Infomation
Target ID
T04820
Former ID
TTDR00301
Target Name
Cyclin-dependent protein kinase Pfmrk
Gene Name
Pfmrk
Synonyms
MO15-related protein kinase Pfmrk; Pfmrk
Target Type
Research
Disease Malaria [ICD10: B54]
BioChemical Class
Kinase
Target Validation
T04820
UniProt ID
P90584
EC Number
EC 2.7.1.37
Sequence
MENNSTERYIFKPNFLGEGSYGKVYKAYDTILKKEVAIKKMKLNEISNYIDDCGINFVLL
REIKIMKEIKHKNIMSALDLYCEKDYINLVMEIMDYDLSKIINRKIFLTDSQKKCILLQI
LNGLNVLHKYYFMHRDLSPANIFINKKGEVKLADFGLCTKYGYDMYSDKLFRDKYKKNLN
LTSKVVTLWYRAPELLLGSNKYNSSIDMWSFGCIFAELLLQKALFPGENEIDQLGKIFFL
LGTPNENNWPEALCLPLYTEFTKATKKDFKTYFKIDDDDCIDLLTSFLKLNAHERISAED
AMKHRYFFNDPLPCDISQLPFNDL
Inhibitor (E)-1-(4-Nitro-phenyl)-3-pyridin-2-yl-propenone Drug Info [527246]
2,5-dichloro-N-p-tolylthiophene-3-sulfonamide Drug Info [551239]
2,5-dichloro-N-phenylthiophene-3-sulfonamide Drug Info [551239]
2-chloro-N-(o-tolylcarbamoyl)benzamide Drug Info [551239]
3-[3-(2-Hydroxy-ethoxy)-phenyl]-1H-quinolin-2-one Drug Info [527246]
5-chloro-4-nitrothiophene-2-sulfonamide Drug Info [551239]
5-Nitro-1H-indole-2,3-dione Drug Info [527246]
APIGENIN Drug Info [527246]
KENPAULLONE Drug Info [527246]
N'-(2-fluorobenzoyl)-2-naphthohydrazide Drug Info [551239]
N-(2-aminoethyl)isoquinoline-5-sulfonamide Drug Info [528918]
Oxindole derivative Drug Info [536365]
Thiophene sulfonamide Drug Info [536636]
WR-080539 Drug Info [529988]
WR-089120 Drug Info [529988]
WR-190706 Drug Info [529988]
WR-203581 Drug Info [529988]
WR-289009 Drug Info [529988]
WR-289010 Drug Info [529988]
WR-289012 Drug Info [529988]
WR-289016 Drug Info [529988]
References
Ref 527246J Med Chem. 2004 Oct 21;47(22):5418-26.A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors.
Ref 528918Bioorg Med Chem Lett. 2007 Sep 1;17(17):4961-6. Epub 2007 Jun 12.Evaluation of broad spectrum protein kinase inhibitors to probe the architecture of the malarial cyclin dependent protein kinase Pfmrk.
Ref 529988Bioorg Med Chem Lett. 2009 Apr 1;19(7):1982-5. Epub 2009 Feb 13.Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones.
Ref 536365Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10. Epub 2007 Mar 6.
Ref 536636Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97. Epub 2008 Feb 22.
Ref 551239Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases, Bioorg. Med. Chem. Lett. 20(13):3863-3867 (2010).

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