Target Information

Target General Infomation
Target ID
T07466
Former ID
TTDR00030
Target Name
Glycosyltransferase MurG
Gene Name
murG
Synonyms
MurG; Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; murG
Target Type
Research
Function
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II).
BioChemical Class
Hexosyltransferase
UniProt ID
P17443
EC Number
EC 2.4.1.227
Sequence
MSGQGKRLMVMAGGTGGHVFPGLAVAHHLMAQGWQVRWLGTADRMEADLVPKHGIEIDFI
RISGLRGKGIKALIAAPLRIFNAWRQARAIMKAYKPDVVLGMGGYVSGPGGLAAWSLGIP
VVLHEQNGIAGLTNKWLAKIATKVMQAFPGAFPNAEVVGNPVRTDVLALPLPQQRLAGRE
GPVRVLVVGGSQGARILNQTMPQVAAKLGDSVTIWHQSGKGSQQSVEQAYAEAGQPQHKV
TEFIDDMAAAYAWADVVVCRSGALTVSEIAAAGLPALFVPFQHKDRQQYWNALPLEKAGA
AKIIEQPQLSVDAVANTLAGWSRETLLTMAERARAASIPDATERVANEVSRVARA
Inhibitor Uridine-Diphosphate-N-Acetylgalactosamine Drug Info [551393]
Pathways
PANTHER Pathway Peptidoglycan biosynthesis
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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