Target Information

Target General Infomation
Target ID
T17426
Former ID
TTDR00042
Target Name
Beta-hydroxyacyl-acp dehydratase
Gene Name
PF3D7_1323000
Synonyms
FabZ; PF3D7_1323000
Target Type
Research
BioChemical Class
Carbon-oxygen lyases
Target Validation
T17426
UniProt ID
Q8I6T4
EC Number
EC 4.2.1.-
Sequence
MRFLIIHIAVIVLPFVLMIDVKRENSFFLRHSPKRLYKKADYNNMYDKIIKKQQNRIYDV
SSQINQDNINGQNISFNLTFPNYDTSIDIEDIKKILPHRYPFLLVDKVIYMQPNKTIIGL
KQVSTNEPFFNGHFPQKQIMPGVLQIEALAQLAGILCLKSDDSQKNNLFLFAGVDGVRWK
KPVLPGDTLTMQANLISFKSSLGIAKLSGVGYVNGKVVINISEMTFALSK
Inhibitor (-)-CATECHINGALLATE Drug Info [528213]
2-Hexadecynoic acid Drug Info [531170]
BIOCHANIN Drug Info [528213]
EPIGALOCATECHIN GALLATE Drug Info [528213]
FISETIN Drug Info [528213]
GALLOCATECHIN GALLATE Drug Info [528213]
MORIN Drug Info [528213]
Pathways
KEGG Pathway Fatty acid biosynthesis
Biotin metabolism
Metabolic pathways
Fatty acid metabolism
References
Ref 528213J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
Ref 531170Bioorg Med Chem. 2010 Nov 1;18(21):7475-85. Epub 2010 Sep 18.2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections.

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