Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T19011
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| Former ID |
TTDR00208
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| Target Name |
M-phase inducer phosphatase 3
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| Gene Name |
CDC25C
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| Synonyms |
Cdc25C phosphatase; Dual specificity phosphatase Cdc25C; CDC25C
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| Target Type |
Discontinued
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| Disease | Cancer [ICD9: 140-229; ICD10: C00-C96] | ||||
| Function |
Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.
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| BioChemical Class |
Phosphoric monoester hydrolases
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| Target Validation |
T19011
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| UniProt ID | |||||
| EC Number |
EC 3.1.3.48
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| Sequence |
MSTELFSSTREEGSSGSGPSFRSNQRKMLNLLLERDTSFTVCPDVPRTPVGKFLGDSANL
SILSGGTPKRCLDLSNLSSGEITATQLTTSADLDETGHLDSSGLQEVHLAGMNHDQHLMK CSPAQLLCSTPNGLDRGHRKRDAMCSSSANKENDNGNLVDSEMKYLGSPITTVPKLDKNP NLGEDQAEEISDELMEFSLKDQEAKVSRSGLYRSPSMPENLNRPRLKQVEKFKDNTIPDK VKKKYFSGQGKLRKGLCLKKTVSLCDITITQMLEEDSNQGHLIGDFSKVCALPTVSGKHQ DLKYVNPETVAALLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKK PIVPLDTQKRIIIVFHCEFSSERGPRMCRCLREEDRSLNQYPALYYPELYILKGGYRDFF PEYMELCEPQSYCPMHHQDHKTELLRCRSQSKVQEGERQLREQIALLVKDMSP |
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| Drugs and Mode of Action | |||||
| Pathways | |||||
| KEGG Pathway | Cell cycle | ||||
| Oocyte meiosis | |||||
| Progesterone-mediated oocyte maturation | |||||
| MicroRNAs in cancer | |||||
| PANTHER Pathway | p53 pathway | ||||
| Pathway Interaction Database | ATR signaling pathway | ||||
| ATM pathway | |||||
| PLK1 signaling events | |||||
| PLK3 signaling events | |||||
| Reactome | Polo-like kinase mediated events | ||||
| Cyclin B2 mediated events | |||||
| Activation of ATR in response to replication stress | |||||
| RHO GTPases activate PKNs | |||||
| Cyclin A/B1 associated events during G2/M transition | |||||
| Cdk1 complex | |||||
| WikiPathways | Monoamine Transport | ||||
| DNA Damage Response | |||||
| ATM Signaling Pathway | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Mitotic G2-G2/M phases | |||||
| Cell Cycle | |||||
| Cell Cycle Checkpoints | |||||
| miRNA Regulation of DNA Damage Response | |||||
| References | |||||
| Ref 527263 | Bioorg Med Chem Lett. 2004 Dec 6;14(23):5809-12.Synthesis of small molecule CDC25 phosphatases inhibitors. | ||||
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