Target Information

Target General Infomation
Target ID
T20474
Former ID
TTDR00142
Target Name
DNA topoisomerase
Synonyms
TraE
Target Type
Research
BioChemical Class
DNA topoisomerase
Target Validation
T20474
EC Number
EC 5.99.1.2
Inhibitor 2-Amino-6-(indan-5-ylamino)-3H-pyrimidin-4-one Drug Info [533419]
3-(9-Acridinylamino)-5-(hydroxymethyl)aniline (AHMA) Drug Info [535673]
5-Bromo-6-p-tolylamino-1H-pyrimidine-2,4-dione Drug Info [533419]
6-(3-Bromo-phenylamino)-1H-pyrimidine-2,4-dione Drug Info [533563]
6-(3-Ethyl-phenylamino)-1H-pyrimidine-2,4-dione Drug Info [533563]
6-(3-Iodo-phenylamino)-1H-pyrimidine-2,4-dione Drug Info [533563]
6-(Indan-5-ylamino)-1H-pyrimidine-2,4-dione Drug Info [533563]
6-(Naphthalen-2-ylamino)-1H-pyrimidine-2,4-dione Drug Info [533563]
6-Benzylamino-1H-pyrimidine-2,4-dione Drug Info [533419]
6-Benzylamino-5-bromo-1H-pyrimidine-2,4-dione Drug Info [533419]
6-Benzylamino-5-iodo-1H-pyrimidine-2,4-dione Drug Info [533419]
6-p-Tolylamino-1H-pyrimidine-2,4-dione Drug Info [533563]
AHMA Drug Info [535673]
N*4*-Benzyl-6-chloro-pyrimidine-2,4-diamine Drug Info [533419]
TOPOSTATIN Drug Info [526096]
References
Ref 526096J Nat Prod. 2001 Feb;64(2):204-7.Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba.
Ref 533419J Med Chem. 1986 May;29(5):676-81.Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines.
Ref 533563J Med Chem. 1980 Jan;23(1):34-8.Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils.
Ref 535673Crystallization and preliminary X-ray analysis of anti-cancer agent 3-(9-acridinylamino)-5-(hydroxymethyl)aniline complexed with the DNA hexamer d(CGTACG)2. Biochim Biophys Acta. 2003 Jan 3;1625(1):27-9.

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