Target General Infomation
Target ID
T21945
Former ID
TTDC00304
Target Name
Sodium-dependent noradrenaline transporter
Gene Name
SLC6A2
Synonyms
NET; Norepinephrine transporter; SLC6A2
Target Type
Successful
Disease Attention deficit hyperactivity disorder [ICD9: 314; ICD10: F90]
Attention deficit hyperactivity disorder; Severe mood disorders [ICD9: 296, 314.00, 314.01; ICD10: F30-F39, F90]
Anesthesia; Ocular disease [ICD9:338; ICD10: R20.0, H00-H59]
Attention deficit hyperactivity disorder; Depression; Cocaine addiction [ICD9: 303-304, 304.2, 311, 314.00, 314.01; ICD10: F10-F19, F14.2, F32, F90]
Cancer pain [ICD9: 140-229, 338,780; ICD10: R52, G89]
Chronic low back pain; Neuropathic pain [ICD9: 338, 356.0, 356.8, 724.2, 724.5,780; ICD10: G64, G90.0, M54, M54.5, R52, G89]
Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10: F01-F07, F04, F05, R41.3]
Depression; Attention deficit hyperactivity disorder [ICD9:311, 314; ICD10: F30-F39, F90]
Depression; Anxiety disorder [ICD9:311, 300; ICD10: F30-F39, F32, F40-F42]
Depression; Attention deficit hyperactivity disorder [ICD9: 311, 314.00, 314.01; ICD10: F30-F39, F90]
Depression [ICD9: 311; ICD10: F30-F39]
Depression; Bipolar disorder [ICD9:311, 296.0, 296.1, 296.4, 296.5, 296.6, 296.7, 296.8, 300; ICD10: F30-F39, F31, F40-F42]
Depression; Chronic pain [ICD9: 311, 338,780; ICD10: F30-F39, R52, G89]
Fatigue [ICD10: R53]
Fibromyalgia [ICD9: 729.1; ICD10: M79.7]
Glaucoma [ICD9: 365; ICD10: H40-H42]
Heart failure diagnosis [ICD9: 428; ICD10: I50]
Heart failure [ICD9: 428; ICD10: I50]
Moderate-to-severe acute pain [ICD9: 338,780; ICD10: R52, G89]
Mood disorder [ICD10: F30-F39]
Migraine; Obisity [ICD9: 278, 346; ICD10: E66, G43]
Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10: F32, F33, M32]
Neuroendocrine cancer [ICD10: C7A]
Neuroblastoma [ICD9: 194.0, 194.5, 194.6, 227.0, 227.5, 227.6, 237.3, 255.6; ICD10: C74.1, C74.9, C75.4, C75.5, D35.0, D35.5, D35.6, D44.6, D44.7]
Neurological disease [ICD9: 338, 338.2, 410, 782.3,780; ICD10: I21, I22, R52, R52.1-R52.2, R60.9, G89]
Neuropathic pain [ICD9: 356.0, 356.8; ICD10: G64, G90.0]
Obesity [ICD9: 278; ICD10: E66]
Pain [ICD9: 338, 356.0, 356.8,780; ICD10: G64, G90.0, R52, G89]
Severe mood disorders [ICD9: 296; ICD10: F30-F39]
Smoking cessation [ICD9: 292; ICD10: F17.2]
Unspecified [ICD code not available]
Function
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
BioChemical Class
Neurotransmitter:sodium symporter
Target Validation
T21945
UniProt ID
Sequence
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
Drugs and Mode of Action
Drug(s) Amfepramone Drug Info Approved Obesity [536103]
Amitriptyline Drug Info Approved Depression; Chronic pain [536306], [539289], [551871]
Amoxapine Drug Info Approved Major depressive disorder [538247], [539292], [551871]
Atomoxetine Drug Info Approved Attention deficit hyperactivity disorder [536661], [542125]
Bupropion Drug Info Approved Smoking cessation [551871]
Cocaine Drug Info Approved Anesthesia; Ocular disease [539436], [550681], [551871]
Desipramine Drug Info Approved Depression; Attention deficit hyperactivity disorder [536306], [539526], [551871]
Desvenalfaxine succinate Drug Info Approved Fibromyalgia [536647]
Diethylpropion Drug Info Approved Migraine; Obisity [536661], [542170]
Duloxetine Drug Info Approved Depression [536306], [539298]
Imipramine Drug Info Approved Depression; Anxiety disorder [536306], [540475], [551871]
Iobenguane I 123 injection Drug Info Approved Heart failure diagnosis [524423], [551871]
Iobenguane I-123 Drug Info Approved Neuroendocrine cancer [529941]
Iobenguane I-123 - GE Healthcare Drug Info Approved Unspecified [551871]
Levomilnacipran Drug Info Approved Fibromyalgia [530677], [542458]
Maprotiline Drug Info Approved Major depressive disorder [551871]
Mazindol Drug Info Approved Obesity [468026], [535114]
Milnacipran Drug Info Approved Depression [536580], [542459]
Phenmetrazine Drug Info Approved Obesity [550743]
Phentermine Drug Info Approved Obesity [536710], [542288]
Protriptyline Drug Info Approved Depression; Bipolar disorder [536306], [542305], [551871]
Reboxetine Drug Info Approved Depression [468039], [536306]
Sibutramine Drug Info Approved Obesity [536710], [539665]
Tapentadol hydrochloride Drug Info Approved Moderate-to-severe acute pain [529941]
Trimipramine Drug Info Approved Major depressive disorder [551871]
Ultracet Drug Info Approved Pain [536242]
Venlafaxine Drug Info Approved Depression [537533], [542345]
Hypericum Drug Info Phase 4 Discovery agent [522154]
Amitifadine Drug Info Phase 3 Obesity [527289], [528424]
Bicifadine Drug Info Phase 3 Chronic low back pain; Neuropathic pain [536374]
Bupropion+naltrexone Drug Info Phase 3 Obesity [532233]
Dasotraline Drug Info Phase 3 Mood disorder [524969], [543060]
Roclatan Drug Info Phase 3 Glaucoma [525325]
Suronacrine maleate Drug Info Phase 3 Cognitive disorders [551848]
18F-LMI-1195 Drug Info Phase 2 Heart failure [522972]
DOV 21947 Drug Info Phase 2 Severe mood disorders [536580]
MCT-125 Drug Info Phase 2 Fatigue [548187]
Metaiodobenzylguanidine I-131 Drug Info Phase 2 Neuroblastoma [545811]
METHYLENEDIOXYMETHAMPHETAMINE Drug Info Phase 2 Discovery agent [521857]
Rhopressa Drug Info Phase 2 Glaucoma [533091]
TD-9855 Drug Info Phase 2 Pain [533083]
XEN-2174 Drug Info Phase 2 Cancer pain [548033]
BL-1021 Drug Info Phase 1 Pain [523040]
GSK-1360707 Drug Info Phase 1 Major depressive disorder [523095]
DOV-216303 Drug Info Discontinued in Phase 2 Severe mood disorders [536580]
Esreboxetine Drug Info Discontinued in Phase 2 Fibromyalgia [549540]
GSK372475 Drug Info Discontinued in Phase 2 Attention deficit hyperactivity disorder; Severe mood disorders [533085]
Manifaxine Drug Info Discontinued in Phase 2 Major depressive disorder [546210]
Napitane mesilate Drug Info Discontinued in Phase 2 Major depressive disorder [545865]
NS 2359 Drug Info Discontinued in Phase 2 Attention deficit hyperactivity disorder; Depression; Cocaine addiction [536580]
NS-2389 Drug Info Discontinued in Phase 2 Major depressive disorder [546575]
R-sibutramine metabolite Drug Info Discontinued in Phase 2 Depression; Attention deficit hyperactivity disorder [536580]
Radafaxine Drug Info Discontinued in Phase 2 Major depressive disorder [536295]
SPD-473 Drug Info Discontinued in Phase 2 Mood disorder [546832]
NSD-644 Drug Info Discontinued in Phase 1 Neurological disease [548670]
Radaxafine HCl Drug Info Discontinued in Phase 1 Neuropathic pain [536374]
RG-7166 Drug Info Discontinued in Phase 1 Major depressive disorder [549027]
Inhibitor ((3R,4R)-4-(o-tolyloxy)chroman-3-yl)methanamine Drug Info [529620]
(+/-)-3-((naphthalen-2-yloxy)methyl)pyrrolidine Drug Info [530012]
(2S,3S)-2-(m-Tolyl)-3,5,5-trimethylmorpholin-2-ol Drug Info [530946]
(2S,3S)-2-Phenyl-3,5,5-trimethylmorpholin-2-ol Drug Info [530946]
(R)-1-((S)-morpholin-2-yl)-1,2-diphenylethanol Drug Info [527968]
(R)-2-(2-phenyl-2-(piperazin-1-yl)ethyl)phenol Drug Info [530918]
(R)-3-(naphthalen-2-ylmethoxy)pyrrolidine Drug Info [530012]
(R)-6-(pyrrolidin-3-ylmethoxy)-2-naphthonitrile Drug Info [530012]
(R)-DULOXETINE Drug Info [530368]
(R)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide Drug Info [530367]
(R)-N-isopropyl-N-(pyrrolidin-3-yl)-2-naphthamide Drug Info [530367]
(R)-Norfluoxetine Drug Info [529814]
(S)-3-(naphthalen-2-ylmethoxy)pyrrolidine Drug Info [530012]
(S)-6-(pyrrolidin-3-ylmethoxy)-2-naphthonitrile Drug Info [530012]
(S)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide Drug Info [530367]
(S)-NORDULOXETINE Drug Info [530368]
(S)-Norfluoxetine Drug Info [529814]
1-(1,2-diphenylethyl)piperazine Drug Info [528224]
1-(1,4-diphenylbutan-2-yl)piperazine Drug Info [528226]
1-(1-(2-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) Drug Info [530918]
1-(1-(4-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) Drug Info [530918]
1-(1-phenyl-2-(2-propoxyphenyl)ethyl)piperazine Drug Info [530918]
1-(1-phenyl-2-o-tolylethyl)piperazine Drug Info [528224]
1-(2,3-Dihydro-1H-indol-5-ylmethyl)-propylamine Drug Info [533479]
1-(2-((3-fluorophenoxy)methyl)phenyl)piperazine Drug Info [530474]
1-(2-(2-(DIFLUOROMETHOXY)PHENYL)-1-PHENYLETHYL)PIPERAZINE (ENANTIOMERIC MIX) Drug Info [530918]
1-(2-(2-bromophenyl)-1-phenylethyl)piperazine Drug Info [528224]
1-(2-(2-chlorophenoxy)pyridin-3-yl)piperazine Drug Info [530596]
1-(2-(2-chlorophenyl)-1-phenylethyl)piperazine Drug Info [528224]
1-(2-(2-ethoxyphenyl)-1-phenylethyl)piperazine Drug Info [528224]
1-(2-(2-ethylphenyl)-1-phenylethyl)piperazine Drug Info [528224]
1-(2-(2-fluorobenzyloxy)phenyl)piperazine Drug Info [530474]
1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazine Drug Info [530918]
1-(2-(3-chlorophenyl)-1-phenylethyl)piperazine Drug Info [528224]
1-(2-(3-fluorophenoxy)phenyl)piperazine Drug Info [530474]
1-(2-(3-methoxyphenyl)-1-phenylethyl)piperazine Drug Info [528224]
1-(2-(4-fluorophenoxy)phenyl)piperazine Drug Info [530474]
1-(2-(6-fluoronaphthalen-2-yl)ethyl)piperazine Drug Info [530012]
1-(2-(benzyloxy)phenyl)piperazine Drug Info [530474]
1-(2-(phenoxymethyl)phenyl)piperazine Drug Info [530474]
1-(2-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one Drug Info [528036]
1-(2-phenoxyphenyl)piperazine Drug Info [530474]
1-(3,4-Dichloro-phenyl)-3-diethylamino-indan-5-ol Drug Info [527062]
1-(3,4-Dichloro-phenyl)-3-methylamino-indan-5-ol Drug Info [527062]
1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0]hexane Drug Info [531114]
1-(3-bromophenyl)-2-(tert-butylamino)propan-1-one Drug Info [530728]
1-(3-chlorophenyl)-2-(dimethylamino)propan-1-one Drug Info [530728]
1-(3-chlorophenyl)-2-(piperidin-1-yl)propan-1-one Drug Info [530728]
1-(3-iodophenyl)-2-pyrrolidin-1-yl-pentan-1-one Drug Info [528036]
1-(3-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one Drug Info [528036]
1-(4-bromophenyl)-2-(tert-butylamino)propan-1-one Drug Info [530728]
1-(4-bromophenyl)-2-pyrrolidin-1-yl-pentan-1-one Drug Info [528036]
1-(4-fluorophenyl)-2-pyrrolidin-1-yl-pentan-1-one Drug Info [528036]
1-(4-iodophenyl)-2-pyrrolidin-1-yl-pentan-1-one Drug Info [528036]
1-(4-nitrophenyl)-2-pyrrolidin-1-yl-pentan-1-one Drug Info [528036]
1-naphthalen-2-yl-2-pyrrolidin-1-yl-pentan-1-one Drug Info [528036]
1S,2R-milnacipran Drug Info [529776]
2-((2-iodophenoxy)(phenyl)methyl)morpholine Drug Info [528517]
2-((3-iodophenyl)(o-tolyloxy)methyl)morpholine Drug Info [528517]
2-(2'-Aminoethyl)-5-benzyltetrahydrofuran Drug Info [529955]
2-(2,3-Dihydro-1H-indol-5-yl)-1-methyl-ethylamine Drug Info [533479]
2-(2-chlorophenoxy)-3-(piperidin-4-yl)pyridine Drug Info [530596]
2-(2-fluorophenoxy)-3-(piperidin-4-yl)pyridine Drug Info [530596]
2-(2-methoxyphenoxy)-3-(piperidin-4-yl)pyridine Drug Info [530596]
2-(2-phenyl-2-(piperazin-1-yl)ethyl)benzonitrile Drug Info [528224]
2-(Aminomethyl)-5-(1'-naphthethyl)tetrahydrofuran Drug Info [529955]
2-(Aminomethyl)-5-(1'-naphthyl)tetrahydrofuran Drug Info [529955]
2-(Aminomethyl)-5-(2'-naphthyl)tetrahydrofuran Drug Info [529955]
2-(Aminomethyl)-5-phenethyltetrahydrofuran Drug Info [529955]
2-(N,N-Diethylamino)-3'-chloropropiophenone Drug Info [530442]
2-(N-Cyclopentylamino)-3'-bromopropiophenone Drug Info [530728]
2-(N-Cyclopentylamino)-3'-chloropropiophenone Drug Info [530442]
2-(N-Cyclopentylamino)-3'-fluoropropiophenone Drug Info [530728]
2-(N-Cyclopentylamino)-3'-methoxypropiophenone Drug Info [530728]
2-(N-Cyclopentylamino)-3'-methylpropiophenone Drug Info [530728]
2-(N-Cyclopropylamino)-3-chloropropiophenone Drug Info [530442]
2-(N-Pyrrolidinyl)-3'-bromopropiophenone Drug Info [530728]
2-(N-Pyrrolidinyl)-3'-fluoropropiophenone Drug Info [530728]
2-(N-Pyrrolidinyl)-3'-methoxypropiophenone Drug Info [530728]
2-(N-Pyrrolidinyl)-3'-methylpropiophenone Drug Info [530728]
2-(N-Pyrrolidinyl)-3'-nitropropiophenone Drug Info [530728]
2-(N-tert-Butylamino)-3',4'-dichloropropiophenone Drug Info [530442]
2-(N-tert-Butylamino)-3'-chloroheptanophenone Drug Info [530442]
2-(N-tert-Butylamino)-3'-chlorohexanophenone Drug Info [530442]
2-(N-tert-Butylamino)-3'-chlorooctanophenone Drug Info [530442]
2-(N-tert-Butylamino)-3'-chloropentanophenone Drug Info [530442]
2-(N-tert-Butylamino)propiophenone Drug Info [530442]
2-(tert-butylamino)-1-(3-chlorophenyl)butan-1-one Drug Info [530728]
2-(tert-butylamino)-1-m-tolylpropan-1-one Drug Info [530728]
2-(tert-butylamino)-1-p-tolylpropan-1-one Drug Info [530728]
2-(tert-Butylamino)-3',4'-dichlorobutyrophenone Drug Info [530442]
2-(tert-Butylamino)-3',4'-dichloropentanophenone Drug Info [530442]
2-Amino-1-(4-methylthiophenyl)propane Drug Info [530347]
2-Aminomethyl-5-(p-bromophenyl)tetrahydrofuran Drug Info [529955]
2-Aminomethyl-5-(p-chlorophenyl)tetrahydrofuran Drug Info [529955]
2-Aminomethyl-5-(p-methoxyphenyl)tetrahydrofuran Drug Info [529955]
2-Aminomethyl-5-(p-t-butylphenyl)tetrahydrofuran Drug Info [529955]
2-Aminomethyl-5-(phenyl)tetrahydrofuran Drug Info [529955]
2-phenoxy-3-(piperidin-4-yl)pyridine Drug Info [530596]
2pyrrolidin-1-yl-1-phenylpentan-1-one Drug Info [528036]
3-(1H-indol-1-yl)-N-methyl-3-phenylpropan-1-amine Drug Info [529764]
3-(2-phenyl-2-(piperazin-1-yl)ethyl)benzonitrile Drug Info [528224]
3-(2-phenyl-2-(piperazin-1-yl)ethyl)phenol Drug Info [528224]
3-(3'-furyl)-aniline Drug Info [528735]
3-(piperidin-4-yl)-2-(o-tolyloxy)pyridine Drug Info [530596]
3-p-Tolyl-8-aza-bicyclo[3.2.1]octane Drug Info [525906]
3alpha-(bis-chloro-phenylmethoxy)tropane Drug Info [528473]
4-((naphthalen-2-yloxy)methyl)piperidine Drug Info [530012]
4-(1H-indol-3-yl)-N,N-dimethylcyclohex-3-enamine Drug Info [528760]
4-(2-((3-fluorophenoxy)methyl)phenyl)piperidine Drug Info [530474]
4-(2-(2-fluoro-5-methylphenoxy)phenyl)piperidine Drug Info [530474]
4-(2-(2-fluorobenzyloxy)phenyl)piperidine Drug Info [530474]
4-(2-(3-chlorophenoxy)phenyl)piperidine Drug Info [530474]
4-(2-(3-fluorophenoxy)-4-methylphenyl)piperidine Drug Info [530474]
4-(2-(3-fluorophenoxy)phenyl)piperidine Drug Info [530474]
4-(2-(4-fluorobenzyloxy)phenyl)piperidine Drug Info [530474]
4-(2-(4-fluorophenoxy)-4-methylphenyl)piperidine Drug Info [530474]
4-(2-(4-fluorophenoxy)phenyl)piperidine Drug Info [530474]
4-(2-(benzyloxy)-3-fluorophenyl)piperidine Drug Info [530474]
4-(2-(benzyloxy)-6-fluorophenyl)piperidine Drug Info [530474]
4-(2-(benzyloxy)phenyl)piperidine Drug Info [530474]
4-(2-(phenoxymethyl)phenyl)piperidine Drug Info [530474]
4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine Drug Info [530596]
4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine Drug Info [530474]
4-(2-fluoro-6-(4-fluorophenoxy)phenyl)piperidine Drug Info [530474]
4-(2-fluoro-6-phenoxyphenyl)piperidine Drug Info [530474]
4-(2-phenoxyphenyl)piperidine Drug Info [530474]
4-(3'-furyl)-aniline Drug Info [528735]
4-(3-fluoro-2-phenoxyphenyl)piperidine Drug Info [530474]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one Drug Info [531079]
6-(piperidin-4-ylmethoxy)-2-naphthonitrile Drug Info [530012]
7-(piperidin-4-ylmethoxy)-2-naphthonitrile Drug Info [530012]
8-Methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane Drug Info [525906]
Amfepramone Drug Info [536103]
AMIFLAMINE Drug Info [533479]
Amitifadine Drug Info [543974]
Amitriptyline Drug Info [536774], [537983]
Amoxapine Drug Info [537875]
Atomoxetine Drug Info [536025], [536749]
Biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-amine Drug Info [529592]
Bupropion Drug Info [537422]
Bupropion+naltrexone Drug Info [536710]
Cis-3-phenoxy-2,3-dihydro-1H-inden-1-amine Drug Info [529530]
Cocaine Drug Info [537241]
D-166A Drug Info [529287]
D-211A Drug Info [529287]
D-211B Drug Info [529287]
D-254C Drug Info [529287]
D-257A Drug Info [529287]
D-257C Drug Info [529287]
Dasotraline Drug Info [533235]
Desipramine Drug Info [537457]
Desvenalfaxine succinate Drug Info [536647]
Diethylpropion Drug Info [536130]
DIFLUOROBENZTROPINE Drug Info [528473]
DOV 21947 Drug Info [536580]
DOV-216303 Drug Info [536580]
Duloxetine Drug Info [536331], [537531]
GSK-1360707 Drug Info [532361]
GSK372475 Drug Info [536580]
Hypericum Drug Info [534900]
Imipramine Drug Info [534848], [536967]
Iobenguane I 123 injection Drug Info [529941]
Iobenguane I-123 Drug Info [543974]
Isobutyl-(4-methyl-benzyl)-piperidin-4-yl-amine Drug Info [528048]
KF-A5 Drug Info [529032]
Maprotiline Drug Info [536083]
MCT-125 Drug Info [543974]
MDL-28618 Drug Info [529620]
METHYLENEDIOXYAMPHETAMINE Drug Info [530914]
METHYLENEDIOXYMETHAMPHETAMINE Drug Info [530347]
Milnacipran Drug Info [537622]
N,N-dimethyl(2-phenoxyphenyl)methanamine Drug Info [529278]
N-(2-oxazolemethyl)milnacipran Drug Info [529263]
N-benzyl-N-isobutylpiperidin-4-amine Drug Info [528048]
N-desalkylquetiapine Drug Info [529198]
NISOXETINE Drug Info [529670]
norzotepine Drug Info [530783]
NS 2359 Drug Info [536499]
Para-chloroamphetamine Drug Info [530347]
PF-18298 Drug Info [530918]
PF-3409409 Drug Info [530265]
PF-526014 Drug Info [530918]
Phenmetrazine Drug Info [535503]
Phentermine Drug Info [535068]
POLYGALATENOSIDE B Drug Info [528443]
Protriptyline Drug Info [537742]
PTI-601 Drug Info [543974]
PYROVALERONE Drug Info [528036]
R-NORDULOXETINE Drug Info [530368]
Radafaxine Drug Info [536122], [536295]
Radaxafine HCl Drug Info [536374]
Reboxetine Drug Info [535127]
RG-7166 Drug Info [549028]
RTI-219 Drug Info [528932]
S-34324 Drug Info [527481]
S33005 Drug Info [536286]
SPD-473 Drug Info [527287]
Trans-3-(o-tolyloxy)-2,3-dihydro-1H-inden-1-amine Drug Info [529530]
Trimipramine Drug Info [536168]
Ultracet Drug Info [537457]
Venlafaxine Drug Info [537422]
WAY-256805 Drug Info [529536]
WIN-35065-2 Drug Info [534240]
WIN-35066-2 Drug Info [527309]
WIN_35428 Drug Info [534240]
XEN-2174 Drug Info [527387]
[3-(3,4-Dichloro-phenyl)-indan-1-yl]-methyl-amine Drug Info [527062]
[3H]mazindol Drug Info [527164]
[3H]nisoxetine Drug Info [543974]
{2-[3-(Phenylsulfonyl)-1H-indol-4-yl]ethyl}amine Drug Info [530455]
Enhancer 18F-LMI-1195 Drug Info [532351]
Modulator 3,4-Methylenedioxymethamphetamine Drug Info [551382]
Bicifadine Drug Info
BL-1021 Drug Info
Iobenguane I-123 - GE Healthcare Drug Info [529941]
Levomilnacipran Drug Info [530677]
Manifaxine Drug Info [527845]
Mazindol Drug Info [556264]
Metaiodobenzylguanidine I-131 Drug Info [532685]
MMDA Drug Info [551393]
Napitane mesilate Drug Info
NS-2389 Drug Info [550007]
R-sibutramine metabolite Drug Info
Rhopressa Drug Info [533091]
Roclatan Drug Info [1572591]
Sibutramine Drug Info [556264]
Suronacrine maleate Drug Info
Tapentadol hydrochloride Drug Info [529941]
TD-9855 Drug Info [533083]
Blocker Esreboxetine Drug Info [549974]
Activator NSD-644 Drug Info [551423]
Agonist TQ-1017 Drug Info [551871]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 468026(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4797).
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