Target Information

Target General Infomation
Target ID
T39677
Former ID
TTDR00692
Target Name
Bile-salt-activated lipase
Gene Name
CEL
Synonyms
BAL; BSSL; Bile-salt-stimulated lipase; Carboxyl ester lipase; Cholesterol esterase; Pancreatic cholesterol esterase; Pancreatic lysophospholipase; Sterol esterase; CEL
Target Type
Clinical Trial
Disease Exocrine pancreatic insufficiency [ICD10: K86.8]
Hypercholesterolemia [ICD10: E78]
Pancreatic disease [ICD10: K85-K86]
Type 2 diabetes [ICD9: 250; ICD10: E11]
Function
Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.
BioChemical Class
Carboxylic ester hydrolase
UniProt ID
P19835
EC Number
EC 3.1.1.3
Sequence
MGRLQLVVLGLTCCWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTK
ALENPQPHPGWQGTLKAKNFKKRCLQATITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPV
MIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPG
NYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQS
GVALSPWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPLAGLEYP
MLHYVGFVPVIDGDFIPADPINLYANAADIDYIAGTNNMDGHIFASIDMPAINKGNKKVT
EEDFYKLVSEFTITKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIA
LAQHRANAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTV
SKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLR
YWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSG
APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVP
PTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDS
GAPPVPPTGDSEAAPVPPTDDSKEAQMPAVIRF
Drugs and Mode of Action
Drug(s) Bucelipase alfa Drug Info Phase 3 Exocrine pancreatic insufficiency [523584]
Taurocholic Acid Drug Info Phase 1/2 Type 2 diabetes [467784]
CVT-1 Drug Info Terminated Hypercholesterolemia [525625]
Modulator Bucelipase alfa Drug Info [522422]
CVT-1 Drug Info [525625]
TgBSSL Drug Info [543741]
Inhibitor compound 10f Drug Info [532680]
compound 10l Drug Info [532680]
Taurocholic Acid Drug Info [551393]
Pathways
BioCyc Pathway Triacylglycerol degradation
WikiPathways Lipid digestion, mobilization, and transport
References
Ref 467784(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4547).
Ref 523584ClinicalTrials.gov (NCT01413581) Comparison of rhBSSL With Placebo When Added to Infant Formula or Pasteurized Breast Milk During 4 Weeks of Treatment in Preterm Infants. U.S. National Institutes of Health.
Ref 525625Lack of effect of cholesterol esterase inhibitor CVT-1 on cholesterol absorption and LDL cholesterol in humans. Cardiovasc Drugs Ther. 1999 Sep;13(5):449-54.
Ref 522422ClinicalTrials.gov (NCT00743483) Efficacy of Bucelipase Alfa (BSSL) in Patients With Cystic Fibrosis and Pancreatic Insufficiency. U.S. National Institutes of Health.
Ref 525625Lack of effect of cholesterol esterase inhibitor CVT-1 on cholesterol absorption and LDL cholesterol in humans. Cardiovasc Drugs Ther. 1999 Sep;13(5):449-54.
Ref 532680Synthesis and evaluation of 2-(1H-indol-3-yl)-4-phenylquinolines as inhibitors of cholesterol esterase. Bioorg Med Chem Lett. 2014 Mar 15;24(6):1545-9.
Ref 543741(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2872).
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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