Target Information

Target General Infomation
Target ID
T56035
Former ID
TTDR00051
Target Name
CGMP-dependent protein kinase
Target Type
Research
BioChemical Class
Kinase
Target Validation
T56035
EC Number
EC 2.7.1.37
Inhibitor ARC-1028 Drug Info [529919]
STAUROSPORINONE Drug Info [551244]
TENELLONE A Drug Info [527524]
TENELLONE B Drug Info [527524]
References
Ref 527524J Nat Prod. 2005 Apr;68(4):611-3.Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity.
Ref 529919J Med Chem. 2009 Jan 22;52(2):308-21.Structural analysis of ARC-type inhibitor (ARC-1034) binding to protein kinase A catalytic subunit and rational design of bisubstrate analogue inhibitors of basophilic protein kinases.
Ref 551244Non-glycosidic/non-aminoalkyl-substituted indolocarbazoles as inhibitors of protein kinase C, Bioorg. Med. Chem. Lett. 3(10):1959-1964 (1993).

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