Target Information

Target General Infomation
Target ID
T56367
Former ID
TTDS00167
Target Name
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1
Synonyms
61 kDa Cam-PDE; Cam-PDE 1; Cam-PDE 1A; HCam-1; PDE-I
Target Type
Successful
Disease Acute ischemic stroke [ICD9: 434.91; ICD10: I61-I63]
Function
Has a higher affinity for cgmp than for camp.
BioChemical Class
Phosphoric diester hydrolases
Target Validation
T56367
EC Number
EC 3.1.4.17
Drugs and Mode of Action
Drug(s) Vinpocetine Drug Info Approved Acute ischemic stroke [537150], [540748]
ZAPRINAST Drug Info Terminated Discovery agent [539935], [544527]
Inhibitor 3-Isobutyl-1-methyl-3,9-dihydro-purine-2,6-dione Drug Info [533395]
BUFROLIN Drug Info [533395]
S,S-(2-Hydroxyethyl)Thiocysteine Drug Info [551393]
Vinpocetine Drug Info [537150]
ZAPRINAST Drug Info [527549]
References
Ref 537150Effects of phosphodiesterase inhibitors on contraction induced by endothelin-1 of isolated human prostatic tissue. Urology. 2009 Jun;73(6):1397-401. Epub 2009 Mar 13.
Ref 539935(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2919).
Ref 540748(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5285).
Ref 544527Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000060)
Ref 527549J Med Chem. 2005 May 19;48(10):3449-62.The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.
Ref 533395J Med Chem. 1985 May;28(5):537-45.A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity.
Ref 537150Effects of phosphodiesterase inhibitors on contraction induced by endothelin-1 of isolated human prostatic tissue. Urology. 2009 Jun;73(6):1397-401. Epub 2009 Mar 13.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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