Target Information

Target General Infomation
Target ID
T61317
Former ID
TTDR00657
Target Name
3-oxoacyl-[acyl-carrier protein] reductase
Gene Name
fabG
Synonyms
3-ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase (FabG); fabG
Target Type
Research
BioChemical Class
Short-chain dehydrogenases reductases
Target Validation
T61317
UniProt ID
Q965D6
EC Number
EC 1.1.1.100
Sequence
MSVLHRFYLFFLFTKFFHCYKISYVLKNAKLAPNHAIKNINSLNLLSENKKENYYYCGEN
KVALVTGAGRGIGREIAKMLAKSVSHVICISRTQKSCDSVVDEIKSFGYESSGYAGDVSK
KEEISEVINKILTEHKNVDILVSNAGITRDNLFLRMKNDEWEDVLRTNLNSLFYITQPIS
KRMINNRYGRIINISSIVGLTGNVGQANYSSSKAGVIGFTKSLAKELASRNITVNAIAPG
FISSDMTDKISEQIKKNIISNIPAGRMGTPEEVANLACFLSSDKSGYINGRVFVIDGGLS
P
Inhibitor (-)-CATECHINGALLATE Drug Info [528213]
2-Hexadecynoic acid Drug Info [531170]
CHRYSIN Drug Info [528213]
EPIGALOCATECHIN GALLATE Drug Info [528213]
FISETIN Drug Info [528213]
GALLOCATECHIN GALLATE Drug Info [528213]
ISORHAMNETIN Drug Info [528213]
KAEMPFEROL Drug Info [528213]
MORIN Drug Info [528213]
Cofactor NADPH Drug Info [535711]
References
Ref 528213J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
Ref 531170Bioorg Med Chem. 2010 Nov 1;18(21):7475-85. Epub 2010 Sep 18.2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections.
Ref 535711Functional characterization of beta-ketoacyl-ACP reductase (FabG) from Plasmodium falciparum. Biochem Biophys Res Commun. 2003 Mar 28;303(1):387-92.

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