Target General Infomation
Target ID
T71390
Former ID
TTDR01183
Target Name
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Gene Name
SRD5A2
Synonyms
5 alpha-SR2; 5-alpha reductase 2; SR type 2; Steroid 5-alpha-reductase 2; Type 2 steroid 5alpha-reductase (5alpha-R); SRD5A2
Target Type
Research
Function
Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
BioChemical Class
Oxidoreductases acting on CH-CH group of donors
Target Validation
T71390
UniProt ID
EC Number
EC 1.3.1.22
Sequence
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPS
FAVPAGILARQPLSLFGPPGTVLLGLFCVHYFHRTFVYSLLNRGRPYPAILILRGTAFCT
GNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRI
PQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFE
DYPKSRKALIPFIF
Inhibitor (3-fluoro-4-(4-phenoxybenzoyl)phenyl)acetic acid Drug Info [527979]
(3-methyl-4-(4-phenoxybenzoyl)phenyl)acetic acid Drug Info [527979]
(E)-3-(4-(4-phenoxybenzoyl)phenyl)acrylic acid Drug Info [527979]
19-nor-10-azasteroid skeleton Drug Info [538023]
2,3,5,6-Tetrafluoro-4-pentafluorophenylazo-phenol Drug Info [532449]
3-[4-(4-phenoxybenzoyl)phenyl]propanoic acid Drug Info [527979]
4,4'-dihydroxyoctafluoroazobenzene Drug Info [532449]
4-(4-phenoxybenzoyl)benzoic acid Drug Info [527979]
4-(4-phenoxybenzoyl)phenylacetic acid Drug Info [527979]
4-[3-(benzyloxy)benzoyl]benzoic acid Drug Info [527979]
4-[4-(benzhydryloxy)benzoyl]benzoic acid Drug Info [527979]
4-[4-(benzoylamino)benzoyl]benzoic acid Drug Info [527979]
4-[4-(benzylamino)benzoyl]benzoic acid Drug Info [527979]
4-[4-benzyloxy)benzoyl]benzoic acid Drug Info [527979]
{4-[4-(4-bromophenoxy)benzoyl]phenyl}acetic acid Drug Info [527979]
Pathways
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Allopregnanolone biosynthesis
Androgen biosynthesis
KEGG Pathway Steroid hormone biosynthesis
Prostate cancer
Reactome Androgen biosynthesis
References
Ref 527979J Med Chem. 2006 Jan 26;49(2):748-59.Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids.
Ref 532449J Med Chem. 1990 Sep;33(9):2452-5.Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis.
Ref 53802319-nor-10-azasteroids: a novel class of inhibitors for human steroid 5alpha-reductases 1 and 2. J Med Chem. 1997 Mar 28;40(7):1112-29.
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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