Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T71390
|
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| Former ID |
TTDR01183
|
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| Target Name |
3-oxo-5-alpha-steroid 4-dehydrogenase 2
|
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| Gene Name |
SRD5A2
|
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| Synonyms |
5 alpha-SR2; 5-alpha reductase 2; SR type 2; Steroid 5-alpha-reductase 2; Type 2 steroid 5alpha-reductase (5alpha-R); SRD5A2
|
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| Target Type |
Research
|
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| Function |
Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
|
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| BioChemical Class |
Oxidoreductases acting on CH-CH group of donors
|
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| Target Validation |
T71390
|
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| UniProt ID | |||||
| EC Number |
EC 1.3.1.22
|
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| Sequence |
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPS
FAVPAGILARQPLSLFGPPGTVLLGLFCVHYFHRTFVYSLLNRGRPYPAILILRGTAFCT GNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRI PQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFE DYPKSRKALIPFIF |
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| Inhibitor | (3-fluoro-4-(4-phenoxybenzoyl)phenyl)acetic acid | Drug Info | [527979] | ||
| (3-methyl-4-(4-phenoxybenzoyl)phenyl)acetic acid | Drug Info | [527979] | |||
| (E)-3-(4-(4-phenoxybenzoyl)phenyl)acrylic acid | Drug Info | [527979] | |||
| 19-nor-10-azasteroid skeleton | Drug Info | [538023] | |||
| 2,3,5,6-Tetrafluoro-4-pentafluorophenylazo-phenol | Drug Info | [532449] | |||
| 3-[4-(4-phenoxybenzoyl)phenyl]propanoic acid | Drug Info | [527979] | |||
| 4,4'-dihydroxyoctafluoroazobenzene | Drug Info | [532449] | |||
| 4-(4-phenoxybenzoyl)benzoic acid | Drug Info | [527979] | |||
| 4-(4-phenoxybenzoyl)phenylacetic acid | Drug Info | [527979] | |||
| 4-[3-(benzyloxy)benzoyl]benzoic acid | Drug Info | [527979] | |||
| 4-[4-(benzhydryloxy)benzoyl]benzoic acid | Drug Info | [527979] | |||
| 4-[4-(benzoylamino)benzoyl]benzoic acid | Drug Info | [527979] | |||
| 4-[4-(benzylamino)benzoyl]benzoic acid | Drug Info | [527979] | |||
| 4-[4-benzyloxy)benzoyl]benzoic acid | Drug Info | [527979] | |||
| {4-[4-(4-bromophenoxy)benzoyl]phenyl}acetic acid | Drug Info | [527979] | |||
| Pathways | |||||
| BioCyc Pathway | Superpathway of steroid hormone biosynthesis | ||||
| Allopregnanolone biosynthesis | |||||
| Androgen biosynthesis | |||||
| KEGG Pathway | Steroid hormone biosynthesis | ||||
| Prostate cancer | |||||
| Reactome | Androgen biosynthesis | ||||
| References | |||||
| Ref 527979 | J Med Chem. 2006 Jan 26;49(2):748-59.Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. | ||||
| Ref 532449 | J Med Chem. 1990 Sep;33(9):2452-5.Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis. | ||||
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