Target Information

Target General Infomation
Target ID
T89054
Former ID
TTDR00113
Target Name
Adenylosuccinate synthetase
Gene Name
Adss
Synonyms
AMPSase; AdSS; Adenylosuccinate synthase; IMP--aspartate ligase; Adss
Target Type
Clinical Trial
Function
Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
BioChemical Class
Carbon-nitrogen ligase
UniProt ID
Q9U8D3
EC Number
EC 6.3.4.4
Sequence
MNIFDHQIKNVDKGNVVAILGAQWGDEGKGKIIDMLSEYSDITCRFNGGANAGHTISVND
KKYALHLLPCGVLYDNNISVLGNGMVIHVKSLMEEIESVGGKLLDRLYLSNKAHILFDIH
QIIDSIQETKKLKEGKQIGTTKRGIGPCYSTKASRIGIRLGTLKNFENFKNMYSKLIDHL
MDLYNITEYDKEKELNLFYNYHIKLRDRIVDVISFMNTNLENNKKVLIEGANAAMLDIDF
GTYPYVTSSCTTVGGVFSGLGIHHKKLNLVVGVVKSYLTRVGCGPFLTELNNDVGQYLRE
KGHEYGTTTKRPRRCGWLDIPMLLYVKCINSIDMINLTKLDVLSGLEEILLCVNFKNKKT
GELLEKGCYPVEEEISEEYEPVYEKFSGWKEDISTCNEFDELPENAKKYILAIEKYLKTP
IVWIGVGPNRKNMIVKKNFNLN
Drugs and Mode of Action
Drug(s) Alanosine Drug Info Phase 2 Discovery agent [521559]
Inhibitor (C8-R)-Hydantocidin 5'-Phosphate Drug Info [551393]
(C8-S)-Hydantocidin 5'-Phosphate Drug Info [551393]
(Carboxyhydroxyamino)Ethanoic Acid Drug Info [551393]
6-O-Phosphoryl Inosine Monophosphate Drug Info [551393]
Alanosine Drug Info [536240]
Beta-Mercaptoethanol Drug Info [551393]
Diphosphate Drug Info [551393]
Guanosine-5'-Diphosphate Drug Info [551393]
Hadacidin Drug Info [537908]
Hydantocidin-5'-Monophosphate Drug Info [551393]
Hydantocidin-5'-Phosphate Drug Info [551393]
Inosinic Acid Drug Info [551393]
References
Ref 521559ClinicalTrials.gov (NCT00062283) Alanosine in Treating Patients With Cancer. U.S. National Institutes of Health.
Ref 536240Lack of methylthioadenosine phosphorylase expression in mantle cell lymphoma is associated with shorter survival: implications for a potential targeted therapy. Clin Cancer Res. 2006 Jun 15;12(12):3754-61.
Ref 537908High performance liquid chromatography analysis of hypoxanthine metabolism in mouse oocyte-cumulus cell complexes: effects of purine metabolic perturbants. Biol Reprod. 1994 Jun;50(6):1403-12.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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