Target Information

Target General Infomation
Target ID
T94400
Former ID
TTDR00929
Target Name
Thymidine monophosphate kinase
Gene Name
tmk
Synonyms
DTMPkinase; Deoxythymidine 5'-monophosphate kinase; TMPK; Thymidine 5'-monophosphate kinase; Thymidylate kinase; Thymidylate monophosphate kinase; Thymidylic acid kinase; Thymidylic kinase; tmk
Target Type
Research
Function
Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate (dTTP) synthesis, is essential for DNA synthesis and cellular growth. Has a broad specificity for nucleoside triphosphates, being highly active withATP or dATP as phosphate donors, and less active with ITP, GTP, CTP and UTP.
BioChemical Class
Kinase
Target Validation
T94400
UniProt ID
P9WKE1
EC Number
EC 2.7.4.9
Sequence
MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLA
SSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWV
QRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYA
ELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS
Inhibitor 2',3'-Dideoxythymidine-5'-Monophosphate Drug Info [551393]
3'-Azido-3'-Deoxythymidine-5'-Monophosphate Drug Info [551393]
5'-amino-5'-deoxy-alpha-D-thymidine Drug Info [529076]
5'-deoxythymidine Drug Info [537773]
5-Hydroxymethyluridine-2'-Deoxy-5'-Monophosphate Drug Info [551393]
Acetate Ion Drug Info [551393]
Adenosine-5'-Diphosphate Drug Info [551391]
BROMODEOXYURIDINE Drug Info [529464]
CHLORODEOXYURIDINE Drug Info [529464]
Deoxythymidine Drug Info [551393]
Diphosphate Drug Info [551393]
P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate Drug Info [551391]
Phosphoaminophosphonic Acid-Adenylate Ester Drug Info [551374]
Thymidine-5'-Phosphate Drug Info [551393]
Thymidine-5'-Triphosphate Drug Info [551393]
Pathways
KEGG Pathway Pyrimidine metabolism
Metabolic pathways
References
Ref 529076J Med Chem. 2007 Nov 1;50(22):5281-92. Epub 2007 Oct 2.Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth.
Ref 529464Bioorg Med Chem. 2008 Jun 1;16(11):6075-85. Epub 2008 Apr 25.Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity.
Ref 537773Thymidylate kinase as target enzyme for 5'-deoxythymidine and various 5'-deoxy-5'-halogeno pyrimidine nucleosides. Acta Biol Med Ger. 1969;23(6):Suppl:K 19+.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551391DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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