Drug Information

Drug General Information
Drug ID
D00QGP
Former ID
DIB000453
Drug Name
ERR alpha modulators
Synonyms
Estrogen-related receptor alpha modulators (diabetes); ERR-alpha modulators (diabetes), Johnson & Johnson; Estrogen-related receptor alpha modulators (diabetes), Johnson & Johnson
Indication Non-insulin dependent diabetes [ICD10:E11.9] Investigative [552033]
Company
Johnson & Johnson Pharmaceutical Research & Development LLC
Structure
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2D MOL

3D MOL
Canonical SMILES
C1(=O)/C(=C/c2ccc(c(c2)OC)Oc2ccc(cc2C(F)(F)F)C#N)/SC(=O<br />)N1
Target and Pathway
Target(s) Steroid hormone receptor ERR1 Target Info Modulator [543900]
Reactome PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Nuclear Receptor transcription pathway
WikiPathways Mitochondrial Gene Expression
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Nuclear Receptors
References
Ref 552033Structural determination of estrogen-related receptor gamma in the presence of phenol derivative compounds. J Steroid Biochem Mol Biol. 2008 Jan;108(1-2):44-54. Epub 2007 Sep 14.
Ref 543900(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 622).

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