Drug Information

Drug General Information
Drug ID
D01CXD
Former ID
DNC008730
Drug Name
9-(Aminomethyl)-9,10-dihydroanthracene
Synonyms
C-(9,10-Dihydro-anthracen-9-yl)-methylamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530331]
Structure
Download
2D MOL

3D MOL
Formula
C15H15N
Canonical SMILES
C1C2=CC=CC=C2C(C3=CC=CC=C31)CN
InChI
1S/C15H15N/c16-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)15/h1-8,15H,9-10,16H2
InChIKey
GEICAQNIOJFRQN-UHFFFAOYSA-N
PubChem Compound ID
10398175
Target and Pathway
Target(s) Histamine H1 receptor Target Info Inhibitor [530331]
5-hydroxytryptamine 2A receptor Target Info Inhibitor [525993]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, Other
References
Ref 530331Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. Epub 2009 Aug 13.Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity.
Ref 525993Bioorg Med Chem Lett. 2001 Feb 26;11(4):563-6.Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin receptor.
Ref 530331Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. Epub 2009 Aug 13.Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity.

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