Drug Information

Drug General Information
Drug ID
D01EDO
Former ID
DIB001383
Drug Name
GW-250495
Synonyms
GR-250495; GR-250495X; GW-250495X
Indication Asthma [ICD10:J45] Discontinued in Phase 1 [546754]
Company
Glaxo Wellcome plc
Target and Pathway
Target(s) Steroid hormone receptor ERR1 Target Info Agonist [543900]
Reactome PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Nuclear Receptor transcription pathway
WikiPathways Mitochondrial Gene Expression
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Nuclear Receptors
References
Ref 546754Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010129)
Ref 543900(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 622).

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