Drug Information

Drug General Information
Drug ID
D01GSW
Former ID
DNC008519
Drug Name
ISAINDIGOTONE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526182]
Structure
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2D MOL

3D MOL
Formula
C20H18N2O4
Canonical SMILES
COC1=CC(=CC2=C3NC4=CC=CC=C4C(=O)N3CC2)C=C(C1=O)OC
InChI
1S/C20H18N2O4/c1-25-16-10-12(11-17(26-2)18(16)23)9-13-7-8-22-19(13)21-15-6-4-3-5-14(15)20(22)24/h3-6,9-11,21H,7-8H2,1-2H3
InChIKey
MGPNFYJFABOVFP-UHFFFAOYSA-N
PubChem Compound ID
10405595
Target and Pathway
Target(s) mRNA of human 5-lipoxygenase Target Info Inhibitor [526182]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL4 Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 526182J Nat Prod. 2001 Oct;64(10):1297-300.Inhibition of leukocyte functions by the alkaloid isaindigotone from Isatis indigotica and some new synthetic derivatives.
Ref 526182J Nat Prod. 2001 Oct;64(10):1297-300.Inhibition of leukocyte functions by the alkaloid isaindigotone from Isatis indigotica and some new synthetic derivatives.

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