Drug General Information
Drug ID	D02PFJ
Former ID	DNC011427
Drug Name	1-Methyl-1-(4-pyrrolidin-1-yl-but-2-ynyl)-urea
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527029]
Structure		Download 2D MOL 3D MOL
Formula	C10H17N3O
Canonical SMILES	CN(CC#CCN1CCCC1)C(=O)N
InChI	1S/C10H17N3O/c1-12(10(11)14)6-2-3-7-13-8-4-5-9-13/h4-9H2,1H3,(H2,11,14)
InChIKey	NSYYEAWIQXWYBA-UHFFFAOYSA-N
PubChem Compound ID	15669672
Target and Pathway
Target(s)	Muscarinic acetylcholine receptor M5	Target Info	Inhibitor	[527029]
	Muscarinic acetylcholine receptor M4	Target Info	Inhibitor	[527029]
	Muscarinic acetylcholine receptor M2	Target Info	Inhibitor	[527029]
	Muscarinic acetylcholine receptor M1	Target Info	Inhibitor	[527029]
	Muscarinic acetylcholine receptor M3	Target Info	Inhibitor	[527029]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Cholinergic synapse
	Regulation of actin cytoskeletonhsa04080:Neuroactive ligand-receptor interaction
	Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
	cAMP signaling pathway
	PI3K-Akt signaling pathway
	Regulation of actin cytoskeleton
	Insulin secretion
	Salivary secretion
	Gastric acid secretion
	Pancreatic secretion
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PathWhiz Pathway	Muscle/Heart ContractionPW000565:Gastric Acid Production
Reactome	Muscarinic acetylcholine receptors
	G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
	G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
	Acetylcholine regulates insulin secretion
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signalingWP58:Monoamine GPCRs
	GPCR downstream signalingWP706:SIDS Susceptibility Pathways
	GPCR downstream signaling
	GPCRs, OtherWP58:Monoamine GPCRs
	Secretion of Hydrochloric Acid in Parietal Cells
	Integration of energy metabolism
	GPCRs, Other
References
Ref 527029	J Med Chem. 1992 Aug 21;35(17):3270-9.Urea and 2-imidazolidone derivatives of the muscarinic agents oxotremorine and N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide.
Ref 527029	J Med Chem. 1992 Aug 21;35(17):3270-9.Urea and 2-imidazolidone derivatives of the muscarinic agents oxotremorine and N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide.

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