Drug Information

Drug General Information
Drug ID
D02TYK
Former ID
DNC004718
Drug Name
6-[(E)-2-(4-Fluoro-phenyl)-vinyl]-9H-purine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527421]
Structure
Download
2D MOL

3D MOL
Formula
C13H9FN4
Canonical SMILES
C1=CC(=CC=C1C=CC2=C3C(=NC=N2)N=CN3)F
InChI
1S/C13H9FN4/c14-10-4-1-9(2-5-10)3-6-11-12-13(17-7-15-11)18-8-16-12/h1-8H,(H,15,16,17,18)/b6-3+
InChIKey
QUTNZZOCHSVJRB-ZZXKWVIFSA-N
PubChem Compound ID
44387948
Target and Pathway
Target(s) mRNA of RAF proto-oncogene serine/threonine-protein kinase Target Info Inhibitor [527421]
Mitogen-activated protein kinase 3 Target Info Inhibitor [527421]
BioCyc Pathway MAP kinase cascade
KEGG Pathway MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
PI3K-Akt signaling pathway
Vascular smooth muscle contraction
VEGF signaling pathway
Focal adhesion
Gap junction
Signaling pathways regulating pluripotency of stem cells
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Long-term potentiation
Neurotrophin signaling pathway
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Alcoholism
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancerhsa04010:MAPK signaling pathway
HIF-1 signaling pathway
Oocyte meiosis
mTOR signaling pathway
Adrenergic signaling in cardiomyocytes
Dorso-ventral axis formation
TGF-beta signaling pathway
Axon guidance
Osteoclast differentiation
Adherens junction
Platelet activation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
TNF signaling pathway
Circadian entrainment
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Type II diabetes mellitus
Aldosterone-regulated sodium reabsorption
Alzheimer's disease
Prion diseases
Shigellosis
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Viral carcinogenesis
Thyroid cancer
Choline metabolism in cancer
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
EGFR1 Signaling PathwayNetPath_17:IL5 Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Angiogenesis
B cell activation
EGF receptor signaling pathway
Endothelin signaling pathway
FGF signaling pathway
Inflammation mediated by chemokine and cytokine signaling pathway
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Integrin signalling pathway
Interleukin signaling pathway
PDGF signaling pathway
T cell activation
VEGF signaling pathway
Ras Pathway
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
Apoptosis signaling pathway
Interferon-gamma signaling pathway
Parkinson disease
TGF-beta signaling pathway
Toll receptor signaling pathway
CCKR signaling map ST
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
Endothelins
BCR signaling pathway
GMCSF-mediated signaling events
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
CDC42 signaling events
SHP2 signaling
mTOR signaling pathway
IL2-mediated signaling events
IGF1 pathway
Ras signaling in the CD4+ TCR pathway
Ceramide signaling pathway
ErbB1 downstream signaling
ErbB2/ErbB3 signaling events
PDGFR-beta signaling pathway
p38 signaling mediated by MAPKAP kinases
Nongenotropic Androgen signaling
Internalization of ErbB1
CXCR3-mediated signaling events
Signaling events mediated by Stem cell factor receptor (c-Kit)
Signaling events mediated by VEGFR1 and VEGFR2
Class I PI3K signaling events mediated by Akt
Trk receptor signaling mediated by the MAPK pathway
Downstream signaling in na&#xef
Regulation of retinoblastoma protein
Signaling events mediated by focal adhesion kinasefcer1pathway:Fc-epsilon receptor I signaling in mast cells
Signaling events mediated by PRL
ErbB4 signaling events
S1P3 pathway
EPHB forward signaling
Osteopontin-mediated events
S1P4 pathway
Presenilin action in Notch and Wnt signaling
TRAIL signaling pathway
Signaling events regulated by Ret tyrosine kinase
Angiopoietin receptor Tie2-mediated signaling
S1P1 pathway
Regulation of Telomerase
Netrin-mediated signaling events
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Glucocorticoid receptor regulatory network
Arf6 downstream pathway
EGF receptor (ErbB1) signaling pathway
Integrins in angiogenesis
IFN-gamma pathway
ATF-2 transcription factor network
ALK1 signaling events
Neurotrophic factor-mediated Trk receptor signaling
Syndecan-1-mediated signaling events
Retinoic acid receptors-mediated signaling
VEGFR1 specific signals
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Syndecan-2-mediated signaling events
Cellular roles of Anthrax toxin
S1P2 pathway
VEGFR3 signaling in lymphatic endothelium
Alpha-synuclein signaling
FGF signaling pathway
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast Cells
Insulin Signalling
Reactome Stimuli-sensing channels
GP1b-IX-V activation signalling
CREB phosphorylation through the activation of Ras
CD209 (DC-SIGN) signaling
RAF activation
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathwayR-HSA-110056:MAPK3 (ERK1) activation
RAF-independent MAPK1/3 activation
ISG15 antiviral mechanism
ERK/MAPK targets
Regulation of actin dynamics for phagocytic cup formation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
FCERI mediated MAPK activation
Regulation of HSF1-mediated heat shock response
NCAM signaling for neurite out-growth
Activation of the AP-1 family of transcription factors
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RAF/MAP kinase cascade
Negative regulation of MAPK pathway
Signal attenuation
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Growth hormone receptor signaling
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
TCR Signaling Pathway
Senescence and Autophagy in Cancer
EPO Receptor Signaling
Regulation of Actin Cytoskeleton
IL-2 Signaling Pathway
Insulin Signaling
EGF/EGFR Signaling Pathway
MAPK Cascade
MAPK Signaling Pathway
TGF beta Signaling Pathway
Signaling of Hepatocyte Growth Factor Receptor
Kit receptor signaling pathway
Extracellular vesicle-mediated signaling in recipient cells
IL-3 Signaling Pathway
Cardiac Hypertrophic Response
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
RAF/MAP kinase cascade
Iron uptake and transport
Nanoparticle-mediated activation of receptor signaling
PDGF Pathway
Retinoblastoma (RB) in Cancer
BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Corticotropin-releasing hormone
Interleukin-11 Signaling Pathway
AGE/RAGE pathway
TNF alpha Signaling Pathway
B Cell Receptor Signaling Pathway
Prostate Cancer
Signaling Pathways in Glioblastoma
Endothelin Pathways
TWEAK Signaling Pathway
FSH signaling pathway
Leptin signaling pathway
Rap1 signalling
Integrin-mediated Cell Adhesion
GP1b-IX-V activation signalling
MicroRNAs in cardiomyocyte hypertrophy
IL-5 Signaling PathwayWP75:Toll-like receptor signaling pathway
Serotonin Receptor 4/6/7 and NR3C Signaling
Serotonin HTR1 Group and FOS Pathway
Hypothetical Network for Drug Addiction
TGF Beta Signaling Pathway
IL-4 Signaling Pathway
IL-6 signaling pathway
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
MAP kinase activation in TLR cascade
Fc epsilon receptor (FCERI) signaling
Structural Pathway of Interleukin 1 (IL-1)
Genes and (Common) Pathways Underlying Drug Addiction
Signal Transduction of S1P Receptor
Alpha 6 Beta 4 signaling pathway
Spinal Cord Injury
TSLP Signaling Pathway
IL-9 Signaling Pathway
IL17 signaling pathway
Alzheimers Disease
IL-7 Signaling Pathway
RANKL/RANK Signaling Pathway
IL-1 signaling pathway
Thrombin signalling through proteinase activated receptors (PARs)
Signaling by Insulin receptor
Signaling by FGFR
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
L1CAM interactions
Advanced glycosylation endproduct receptor signaling
Apoptosis Modulation and Signaling
Regulation of toll-like receptor signaling pathway
Osteopontin Signaling
IL-5 Signaling Pathway
References
Ref 527421J Med Chem. 2005 Feb 10;48(3):710-22.Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors.
Ref 527421J Med Chem. 2005 Feb 10;48(3):710-22.Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors.

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