Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02VJJ
|
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| Former ID |
DIB011341
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| Drug Name |
TACE inhibitors
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| Synonyms |
TACE inhibitors (autoimmune/inflammatory disease); TACE inhibitors (autoimmune/inflammatory disease), Merck; TACE inhibitors (inflammation), Schering-Plough
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| Indication | Autoimmune diabetes [ICD10:E08-E13] | Investigative | [552062] | ||
| Company |
Schering-Plough Corp
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| Structure |
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Download2D MOL |
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| Canonical SMILES |
C1(=O)NC(=O)[C@](N1)(CN1C(=O)c2c(C1)ccc(c2)OC)C#Cc1cncc<br />c1
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| Target and Pathway | |||||
| Target(s) | ADAM 17 | Target Info | Inhibitor | [543456] | |
| Pathway Interaction Database | ErbB4 signaling events | ||||
| TNF receptor signaling pathway | |||||
| p75(NTR)-mediated signaling | |||||
| Reactome | Nuclear signaling by ERBB4 | ||||
| Collagen degradation | |||||
| Regulated proteolysis of p75NTR | |||||
| Activated NOTCH1 Transmits Signal to the Nucleus | |||||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 t(7 | |||||
| M1580_K2555) Translocation Mutant | |||||
| Constitutive Signaling by NOTCH1 HD Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
| TNF signaling | |||||
| Growth hormone receptor signaling | |||||
| References | |||||
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